Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.06 | 0.3727 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1536 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1536 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1536 | 1 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1536 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1536 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1536 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1536 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.1536 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.06 | 0.3727 | 0.3727 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1536 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.06 | 0.3727 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1536 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1536 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1536 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.157 | 0.157 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.06 | 0.3727 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.06 | 0.3727 | 1 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.06 | 0.3727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.06 | 0.3727 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.06 | 0.3727 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.06 | 0.3727 | 1 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.06 | 0.3727 | 0.3727 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.06 | 0.3727 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1536 | 1 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.06 | 0.3727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1536 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.06 | 0.3727 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22387.2114 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.