Detailed information for compound 879006

Basic information

Technical information
  • TDR Targets ID: 879006
  • Name: 5-[(2E)-2-[(3-bromo-4-methoxyphenyl)methylide ne]hydrazinyl]-2H-1,2,4-triazin-3-one
  • MW: 324.133 | Formula: C11H10BrN5O2
  • H donors: 2 H acceptors: 4 LogP: 1.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Br)C=NNc1cnnc(n1)O
  • InChi: 1S/C11H10BrN5O2/c1-19-9-3-2-7(4-8(9)12)5-13-16-10-6-14-17-11(18)15-10/h2-6H,1H3,(H2,15,16,17,18)/b13-5+
  • InChiKey: UGAMUGGKNBQFNM-WLRTZDKTSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[(N'E)-N'-[(3-bromo-4-methoxy-phenyl)methylene]hydrazino]-2H-1,2,4-triazin-3-one
  • 5-[(N'E)-N'-[(3-bromo-4-methoxyphenyl)methylene]hydrazino]-2H-1,2,4-triazin-3-one
  • 5-[(N'E)-N'-(3-bromo-4-methoxy-benzylidene)hydrazino]-2H-1,2,4-triazin-3-one
  • 5-[(2E)-2-[(3-bromo-4-methoxy-phenyl)methylidene]hydrazinyl]-2H-1,2,4-triazin-3-one
  • ST5192649

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0236 0.0087 0.0087
Schistosoma mansoni amine GPCR 0.0248 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0236 0.0087 0.0087
Leishmania major C-8 sterol isomerase-like protein 0.0411 0.0498 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0276 0.0181 0.0181
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0236 0.0087 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Loa Loa (eye worm) peptidase family M1 containing protein 0.0236 0.0087 0.0087
Onchocerca volvulus 0.0236 0.0087 0.5
Onchocerca volvulus 0.0236 0.0087 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0236 0.0087 0.0087
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0236 0.0087 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0236 0.0087 0.0087
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0258 0.0138 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0276 0.0181 0.0181
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Schistosoma mansoni aminopeptidase A (M01 family) 0.0236 0.0087 0.0087
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.4443 1 1
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0236 0.0087 0.5
Loa Loa (eye worm) hypothetical protein 0.021 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0411 0.0498 0.0498
Echinococcus multilocularis leukotriene A 4 hydrolase 0.4443 1 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.0095 0.0095
Echinococcus granulosus aminopeptidase N 0.0236 0.0087 0.0087
Toxoplasma gondii aminopeptidase N, putative 0.0236 0.0087 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Onchocerca volvulus 0.0236 0.0087 0.5
Loa Loa (eye worm) hypothetical protein 0.0236 0.0087 0.0087
Toxoplasma gondii aminopeptidase n, putative 0.0236 0.0087 0.5
Mycobacterium ulcerans aminopeptidase N PepN 0.0236 0.0087 0.5
Mycobacterium ulcerans aminopeptidase N PepN 0.0236 0.0087 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0301 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0236 0.0087 0.0087
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0411 0.0498 0.0966
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0276 0.0181 0.022
Loa Loa (eye worm) leukotriene A4 hydrolase 0.4443 1 1
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0236 0.0087 0.5
Entamoeba histolytica aminopeptidase, putative 0.0236 0.0087 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Schistosoma mansoni voltage-gated potassium channel 0.0301 0.024 0.024
Loa Loa (eye worm) aminopeptidase N 0.0236 0.0087 0.0087
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0411 0.0498 1
Toxoplasma gondii aminopeptidase N protein 0.0236 0.0087 0.5
Brugia malayi hypothetical protein 0.2043 0.4344 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0236 0.0087 0.0087
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0236 0.0087 0.0087
Trypanosoma brucei C-8 sterol isomerase, putative 0.0411 0.0498 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0236 0.0087 0.0087
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0276 0.0181 0.0181
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0258 0.0138 1
Echinococcus multilocularis aminopeptidase N 0.0236 0.0087 0.0087

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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