Detailed information for compound 879431

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.865 | Formula: C14H15ClN2OS2
  • H donors: 1 H acceptors: 2 LogP: 3.86 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCCNC(=O)c1csc(n1)c1cccc(c1)Cl
  • InChi: 1S/C14H15ClN2OS2/c1-19-7-3-6-16-13(18)12-9-20-14(17-12)10-4-2-5-11(15)8-10/h2,4-5,8-9H,3,6-7H2,1H3,(H,16,18)
  • InChiKey: ZLHZGNLUEGBXQE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Schistosoma mansoni hypothetical protein 0.0076 0.1419 0.1634
Brugia malayi Bloom's syndrome protein homolog 0.0051 0.0767 0.1288
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0002 0.0002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0511 0.0281
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0002 0.0002
Leishmania major trypanothione reductase 0.01 0.2034 0.4221
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0511 0.0858
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0083 0.1594 0.1594
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0511 0.1094
Trypanosoma cruzi heat shock protein 85, putative 0.0083 0.1594 0.3231
Schistosoma mansoni hypothetical protein 0.0033 0.0319 0.0368
Trypanosoma brucei heat shock protein 90, putative 0.0097 0.1954 0.4042
Leishmania major DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0019 0.0022
Echinococcus multilocularis heat shock protein 0.0097 0.1954 0.1954
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Entamoeba histolytica recQ family helicase, putative 0.0027 0.0159 0.0341
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0002 0.0002
Trypanosoma cruzi Heat shock protein 83, putative 0.0097 0.1954 0.4042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.2174 0.3648
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0511 0.0589
Trichomonas vaginalis CAMK family protein kinase 0.02 0.4601 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0019 0.0022
Echinococcus granulosus endoplasmin 0.0091 0.1801 0.1801
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1249 0.1439
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0832 0.0934
Trichomonas vaginalis CAMK family protein kinase 0.02 0.4601 1
Echinococcus granulosus dna polymerase kappa 0.0041 0.0511 0.0511
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0002 0.0002
Plasmodium falciparum glutathione reductase 0.0035 0.0352 0.0395
Brugia malayi hypothetical protein 0.0021 0.0002 0.0003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0352 0.0436
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0352 0.0436
Trypanosoma brucei heat shock protein 84, putative 0.0064 0.1117 0.2158
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0002 0.0003
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0352 0.0436
Echinococcus granulosus serine:threonine protein kinase PLK1 0.02 0.4601 0.4601
Echinococcus multilocularis bloom syndrome protein 0.0051 0.0767 0.0767
Trichomonas vaginalis DNA helicase recq, putative 0.0051 0.0767 0.1664
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0002 0.0002
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0002 0.0002
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0511 0.0511
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0002 0.0002
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0045 0.0608 0.0683
Brugia malayi serine/threonine-protein kinase plk-2 0.02 0.4601 0.7723
Giardia lamblia DINP protein human, muc B family 0.0041 0.0511 0.111
Plasmodium vivax glutathione reductase, putative 0.01 0.2034 0.1973
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0352 0.0395
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0002 0.0002
Schistosoma mansoni endoplasmin 0.0097 0.1954 0.2251
Schistosoma mansoni hypothetical protein 0.0024 0.0076 0.0087
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0002 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.1315 0.2208
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.5957 0.9869
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0034 0.0334 0.0374
Plasmodium vivax heat shock protein 90, putative 0.0064 0.1117 0.0903
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0319 0.0319
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.02 0.4601 0.4601
Toxoplasma gondii heat shock protein HSP90 0.0097 0.1954 0.2193
Loa Loa (eye worm) TAR-binding protein 0.0069 0.1249 0.207
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0185 0.0059
Schistosoma mansoni blooms syndrome DNA helicase 0.004 0.0492 0.0567
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Brugia malayi Thioredoxin reductase 0.01 0.2034 0.3414
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0002 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0076 0.0076
Brugia malayi PXA domain containing protein 0.0021 0.0002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Echinococcus multilocularis geminin 0.0358 0.8682 0.8682
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.533 0.8837
Onchocerca volvulus Serine\/threonine kinase homolog 0.02 0.4601 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1249 0.1439
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0253 0.5985 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0091 0.1801 0.2572
Entamoeba histolytica hypothetical protein 0.0076 0.1419 0.308
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0352 0.0436
Plasmodium falciparum thioredoxin reductase 0.01 0.2034 0.2282
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1249 0.1439
Trichomonas vaginalis heat shock protein, putative 0.007 0.127 0.2758
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0002 0.0002
Schistosoma mansoni heat shock protein 0.0097 0.1954 0.2251
Schistosoma mansoni hypothetical protein 0.0358 0.8682 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Entamoeba histolytica hypothetical protein 0.0076 0.1419 0.308
Echinococcus multilocularis GPCR, family 2 0.0033 0.0319 0.0319
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0832 0.0934
Schistosoma mansoni hypothetical protein 0.0033 0.0319 0.0368
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0053 0.0832 0.1379
Echinococcus multilocularis dna polymerase eta 0.0041 0.0511 0.0511
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0352 0.0762
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0511 0.0793
Loa Loa (eye worm) hypothetical protein 0.0154 0.3417 0.5661
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2005 0.4356
Trypanosoma cruzi heat shock protein 85, putative 0.0097 0.1954 0.4042
Giardia lamblia Heat shock protein HSP 90-alpha 0.0097 0.1954 0.4247
Mycobacterium tuberculosis Probable oxidoreductase 0.0253 0.5985 1
Onchocerca volvulus 0.0154 0.3417 0.6601
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0352 0.0762
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0352 0.0766
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0319 0.0319
Brugia malayi heat shock protein 90 0.0097 0.1954 0.328
Giardia lamblia Grp94/Hsp90 0.0091 0.1801 0.3914
Plasmodium falciparum glutathione reductase 0.01 0.2034 0.2282
Toxoplasma gondii heat shock protein 75, putative 0.0064 0.1117 0.1254
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.2034 0.4221
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Plasmodium falciparum heat shock protein 90 0.0097 0.1954 0.2193
Echinococcus granulosus heat shock protein 90 0.0083 0.1594 0.1594
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Treponema pallidum heat shock protein 90 0.0091 0.1801 1
Echinococcus multilocularis heat shock protein 90 0.0097 0.1954 0.1954
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0002 0.0003
Brugia malayi hypothetical protein 0.0034 0.0346 0.0581
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0352 0.0592
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0832 0.1517
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.1419 0.1419
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.2174 0.3601
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2005 0.4356
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0002 0.0002
Echinococcus granulosus heat shock protein 90 0.0097 0.1954 0.1954
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0076 0.0076
Mycobacterium tuberculosis Probable reductase 0.0228 0.533 0.8837
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Schistosoma mansoni heat shock protein 0.0097 0.1954 0.2251
Schistosoma mansoni DNA polymerase eta 0.0041 0.0511 0.0589
Toxoplasma gondii thioredoxin reductase 0.01 0.2034 0.2282
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0511 0.0589
Plasmodium vivax heat shock protein, putative 0.0367 0.8911 1
Leishmania major DNA polymerase eta, putative 0.0041 0.0511 0.0793
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0253 0.5985 1
Trichomonas vaginalis heat shock protein, putative 0.0083 0.1594 0.3462
Trypanosoma cruzi heat shock protein 90, putative 0.0097 0.1954 0.4042
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.533 0.8837
Schistosoma mansoni hypothetical protein 0.0033 0.0319 0.0368
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0159 0.0341
Trypanosoma brucei unspecified product 0.0028 0.0185 0.0059
Entamoeba histolytica heat shock protein 90, putative 0.0097 0.1954 0.4245
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0002 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.02 0.4601 1
Trypanosoma cruzi polo-like protein kinase, putative 0.02 0.4601 1
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0002 0.0002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0511 0.0511
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0002 0.0003
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0019 0.0031
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0511 0.1107
Plasmodium falciparum endoplasmin, putative 0.007 0.127 0.1426
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0352 0.0395
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0352 0.5
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0511 0.0511
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0002 0.0002
Trypanosoma cruzi heat shock protein, putative 0.0064 0.1117 0.2158
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0116 0.0194
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0352 0.0436
Trypanosoma cruzi heat shock protein 85, putative 0.0097 0.1954 0.4042
Entamoeba histolytica heat shock protein 90, putative 0.0097 0.1954 0.4245
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0185 0.0059
Loa Loa (eye worm) glutathione reductase 0.01 0.2034 0.3369
Trypanosoma cruzi heat shock protein 90, putative 0.0083 0.1594 0.3231
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0832 0.057
Trichomonas vaginalis CAMK family protein kinase 0.02 0.4601 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0352 0.0436
Plasmodium falciparum heat shock protein 90, putative 0.0056 0.091 0.1021
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0352 0.0436
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0019 0.0022
Trypanosoma cruzi polo-like protein kinase, putative 0.02 0.4601 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0064 0.1117 0.2425
Trypanosoma cruzi heat shock protein 85, putative 0.0097 0.1954 0.4042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0319 0.0319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0352 0.0436
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.1419 0.1634
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0319 0.0536
Giardia lamblia Heat shock protein HSP 90-alpha 0.0083 0.1594 0.3464
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0019 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0832 0.0934
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0352 0.0436
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0002 0.0002
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.533 0.8837
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0002 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0511 0.1094
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0352 0.0436
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0511 0.0793
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Echinococcus multilocularis expressed protein 0.0409 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.533 0.8435
Loa Loa (eye worm) RecQ helicase 0.0051 0.0767 0.1271
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0185 0.0059
Mycobacterium ulcerans heat shock protein 90 0.0091 0.1801 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.02 0.4601 1
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Schistosoma mansoni hypothetical protein 0.0033 0.0319 0.0368
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0511 0.0846
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.0505 0.0779
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0319 0.0536
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0002 0.0002
Brugia malayi Endoplasmin precursor 0.0097 0.1954 0.328
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Trypanosoma brucei heat shock protein, putative 0.0097 0.1954 0.4042
Loa Loa (eye worm) RNA binding protein 0.0069 0.1249 0.207
Schistosoma mansoni hypothetical protein 0.0072 0.1315 0.1515
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0352 0.0406
Trichomonas vaginalis CAMK family protein kinase 0.02 0.4601 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0253 0.5985 1
Echinococcus granulosus tar DNA binding protein 0.0069 0.1249 0.1249
Loa Loa (eye worm) heat shock protein 90 0.0097 0.1954 0.3237
Echinococcus granulosus bloom syndrome protein 0.0051 0.0767 0.0767
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.1249 0.207
Echinococcus granulosus dna polymerase eta 0.0041 0.0511 0.0511
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.533 0.8837
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.2034 0.2034
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0511 0.1107
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0511 0.0793
Schistosoma mansoni hypothetical protein 0.0358 0.8682 1
Loa Loa (eye worm) endoplasmin 0.0097 0.1954 0.3237
Trichomonas vaginalis DNA helicase recq1, putative 0.0051 0.0767 0.1664
Brugia malayi hypothetical protein 0.0076 0.1419 0.2381
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0832 0.1517
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0019 0.0031
Brugia malayi MH2 domain containing protein 0.0252 0.5957 1
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0002 0.0002
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0064 0.1117 0.1117
Brugia malayi RNA binding protein 0.0069 0.1249 0.2097
Trichomonas vaginalis heat shock protein, putative 0.0056 0.091 0.1975
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.0529
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0832 0.1517
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0064 0.1117 0.1117
Trichomonas vaginalis heat shock protein, putative 0.0091 0.1801 0.3912
Toxoplasma gondii Hsp90 domain-containing protein 0.0367 0.8911 1
Echinococcus granulosus heat shock protein 0.0097 0.1954 0.1954
Leishmania major heat shock protein, putative 0.0064 0.1117 0.2158
Loa Loa (eye worm) heat shock protein 75 0.0064 0.1117 0.1851
Trypanosoma brucei heat shock protein, putative 0.0097 0.1954 0.4042
Plasmodium falciparum thioredoxin reductase 0.0035 0.0352 0.0395
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0002 0.0003
Trypanosoma brucei heat shock protein, putative 0.0097 0.1954 0.4042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Trypanosoma brucei Heat shock protein 83, putative 0.0097 0.1954 0.4042
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0511 0.0793
Trypanosoma brucei polo-like protein kinase 0.02 0.4601 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.02 0.4601 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0091 0.1801 0.3697
Echinococcus multilocularis endoplasmin 0.0091 0.1801 0.1801
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0002 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.02 0.4601 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0116 0.0194
Plasmodium vivax endoplasmin, putative 0.0097 0.1954 0.188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0352 0.0436
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.2034 0.2985
Trypanosoma brucei heat shock protein, putative 0.0097 0.1954 0.4042
Trichomonas vaginalis heat shock protein, putative 0.0091 0.1801 0.3912
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0352 0.001
Schistosoma mansoni kinase 0.0101 0.2073 0.2388
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0002 0.0002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0319 0.0529
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0091 0.1801 1
Giardia lamblia Kinase, PLK 0.02 0.4601 1
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0002 0.0002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0352 0.0352
Brugia malayi hypothetical protein 0.0154 0.3417 0.5736
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.2034 0.2034
Trypanosoma brucei heat shock protein, putative 0.0097 0.1954 0.4042
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0352 0.0352
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0352 0.0436
Trypanosoma brucei heat shock protein, putative 0.0097 0.1954 0.4042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0511 0.0281
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0019 0.0031
Schistosoma mansoni endoplasmin 0.0097 0.1954 0.2251
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Plasmodium falciparum heat shock protein 90, putative 0.0367 0.8911 1
Schistosoma mansoni serine/threonine protein kinase 0.02 0.4601 0.53
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0511 0.1107
Plasmodium vivax heat shock protein 86, putative 0.0097 0.1954 0.188
Trypanosoma brucei unspecified product 0.0028 0.0185 0.0059
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.1419 0.1419
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0352 0.0436
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.02 0.4601 0.7622
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0511 0.0793
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0352 0.0395
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Trypanosoma brucei heat shock protein, putative 0.0097 0.1954 0.4042
Trichomonas vaginalis endoplasmin, putative 0.007 0.127 0.2758
Trichomonas vaginalis heat shock protein, putative 0.0097 0.1954 0.4245
Entamoeba histolytica hypothetical protein 0.0076 0.1419 0.308
Schistosoma mansoni heat shock protein 0.0064 0.1117 0.1287
Brugia malayi Hsp90 protein 0.0064 0.1117 0.1875
Brugia malayi PXA domain containing protein 0.0021 0.0002 0.0003
Loa Loa (eye worm) thioredoxin reductase 0.01 0.2034 0.3369
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0352 0.0436
Brugia malayi TAR-binding protein 0.0069 0.1249 0.2097
Echinococcus granulosus GPCR family 2 0.0033 0.0319 0.0319
Echinococcus multilocularis heat shock protein 90 0.0083 0.1594 0.1594
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.5957 0.9869
Brugia malayi hypothetical protein 0.0053 0.0832 0.1397
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0511 0.0858
Entamoeba histolytica hypothetical protein 0.0076 0.1419 0.308
Trypanosoma brucei heat shock protein, putative 0.0097 0.1954 0.4042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0352 0.0436
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1249 0.1439
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.533 0.8837
Echinococcus granulosus geminin 0.0358 0.8682 0.8682
Trypanosoma brucei trypanothione reductase 0.01 0.2034 0.4221
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0352 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.1249 0.2097
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0319 0.0319
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.2174 0.3648
Loa Loa (eye worm) hypothetical protein 0.0072 0.1315 0.2179
Trypanosoma brucei unspecified product 0.0041 0.0511 0.0793
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0002 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1249 0.1439
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0352 0.0436
Trypanosoma brucei heat shock protein 90, putative 0.0097 0.1954 0.4042
Toxoplasma gondii heat shock protein 90, putative 0.0097 0.1954 0.2193
Loa Loa (eye worm) hypothetical protein 0.0255 0.6036 1
Leishmania major hypothetical protein, conserved 0.0053 0.0832 0.1517
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0511 0.0793
Brugia malayi glutathione reductase 0.01 0.2034 0.3414
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0352 0.0395
Trichomonas vaginalis CAMK family protein kinase 0.02 0.4601 1
Brugia malayi hypothetical protein 0.0021 0.0002 0.0003
Echinococcus multilocularis tar DNA binding protein 0.0069 0.1249 0.1249
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0002 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0511 0.0846
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0352 0.0436
Loa Loa (eye worm) hypothetical protein 0.0105 0.2174 0.3601
Leishmania major heat shock protein 83-1 0.0097 0.1954 0.4042
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0002 0.0003
Plasmodium vivax thioredoxin reductase, putative 0.01 0.2034 0.1973
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0511 0.0793

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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