Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | pteridine reductase 1 | 0.0339 | 0.4142 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.1174 | 0.8882 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0374 | 0.4624 | 1 |
Leishmania major | pteridine reductase 1 | 0.0339 | 0.4142 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.0842 | 0.637 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0842 | 0.637 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0134 | 0.1322 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0134 | 0.1322 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1174 | 0.8882 |
Echinococcus multilocularis | caspase 2 | 0.0134 | 0.1322 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0374 | 0.4624 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0374 | 0.4624 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0374 | 0.4624 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0374 | 0.4624 | 0.4624 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0411 | 0.3106 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0374 | 0.4624 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0374 | 0.4624 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0374 | 0.4624 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0134 | 0.1322 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0411 | 0.3106 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0038 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0134 | 0.1322 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0038 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.0842 | 0.637 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.0842 | 0.637 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1322 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.0701 | 0.5302 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.1174 | 0.8882 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1322 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0374 | 0.4624 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0038 | 0 | 0.5 |
Onchocerca volvulus | 0.0134 | 0.1322 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0411 | 0.3106 |
Brugia malayi | hypothetical protein | 0.0123 | 0.1174 | 0.8882 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0936 | 0.7076 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.1322 | 1 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0134 | 0.1322 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0089 | 0.0701 | 0.1693 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0134 | 0.1322 | 1 |
Echinococcus granulosus | caspase 2 | 0.0134 | 0.1322 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1174 | 0.8882 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.