Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Myb 1-like protein | 0.0029 | 0.0075 | 0.5 |
Echinococcus granulosus | geminin | 0.0179 | 0.1236 | 1 |
Brugia malayi | Peroxidasin | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0355 | 0.0943 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0053 | 0.0263 | 0.2419 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.0355 | 0.3264 |
Echinococcus multilocularis | geminin | 0.0179 | 0.1236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0065 | 0.0355 | 1 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Echinococcus multilocularis | peroxidasin | 0.0053 | 0.0263 | 0.1094 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.1236 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0053 | 0.0263 | 0.2419 |
Brugia malayi | Animal haem peroxidase family protein | 0.0053 | 0.0263 | 0.2419 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0029 | 0.0075 | 1 |
Echinococcus granulosus | peroxidasin | 0.0053 | 0.0263 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0355 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1316 | 1 | 0.5 |
Trichomonas vaginalis | MYB, putative | 0.0029 | 0.0075 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0078 | 0.0722 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0355 | 0.1934 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.0945 | 0.7139 | 0.5 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0371 | 0.2713 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.1236 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1316 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0053 | 0.0263 | 0.2419 |
Onchocerca volvulus | 0.016 | 0.1086 | 1 | |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Brugia malayi | Animal haem peroxidase family protein | 0.0053 | 0.0263 | 0.2419 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1316 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0053 | 0.0263 | 0.2419 |
Brugia malayi | Animal haem peroxidase family protein | 0.0053 | 0.0263 | 0.2419 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0355 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0053 | 0.0263 | 0.2419 |
Brugia malayi | Blistered cuticle protein 3 | 0.0053 | 0.0263 | 0.2419 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0371 | 0.2713 | 0.2713 |
Brugia malayi | hypothetical protein | 0.016 | 0.1086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.0355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0355 | 0.1934 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0355 | 0.3264 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0029 | 0.0075 | 1 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.0945 | 0.7139 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0078 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.