Detailed information for compound 879916

Basic information

Technical information
  • TDR Targets ID: 879916
  • Name: 5-chloro-N-[(3-fluoro-4-methylphenyl)methyl]- 1,3-dimethylpyrazole-4-sulfonamide
  • MW: 331.794 | Formula: C13H15ClFN3O2S
  • H donors: 1 H acceptors: 3 LogP: 2.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nn(c(c1S(=O)(=O)NCc1ccc(c(c1)F)C)Cl)C
  • InChi: 1S/C13H15ClFN3O2S/c1-8-4-5-10(6-11(8)15)7-16-21(19,20)12-9(2)17-18(3)13(12)14/h4-6,16H,7H2,1-3H3
  • InChiKey: DFRQRVHRGYLBQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-chloro-N-[(3-fluoro-4-methyl-phenyl)methyl]-1,3-dimethyl-pyrazole-4-sulfonamide
  • 5-chloro-N-[(3-fluoro-4-methylphenyl)methyl]-1,3-dimethyl-4-pyrazolesulfonamide
  • 5-chloro-N-(3-fluoro-4-methyl-benzyl)-1,3-dimethyl-pyrazole-4-sulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0112 0.0395 0.1034
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0046 0.0026 0.0026
Echinococcus granulosus geminin 0.0164 0.0684 0.0684
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1825 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0046 0.0026 0.0026
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0113 0.0398 0.0398
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0723 0.3819 1
Onchocerca volvulus 0.0046 0.0026 0.0691
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Loa Loa (eye worm) carboxylesterase 0.0069 0.0152 0.0152
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0407 0.2046 0.2046
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0161 0.0668 0.0668
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0046 0.0026 0.0691
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0046 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Echinococcus multilocularis para nitrobenzyl esterase 0.0069 0.0152 0.0152
Onchocerca volvulus 0.0046 0.0026 0.0691
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Echinococcus granulosus Niemann Pick C1 protein 0.0634 0.3322 0.3322
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0008 0.001
Onchocerca volvulus 0.0046 0.0026 0.0691
Giardia lamblia Protein tyrosine phosphatase 0.0046 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0161 0.0668 0.0668
Trichomonas vaginalis pten, drome, putative 0.0046 0.0026 0.0068
Echinococcus multilocularis acetylcholinesterase 0.0407 0.2046 0.2046
Onchocerca volvulus 0.0046 0.0026 0.0691
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.1541 0.8404 0.8404
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0152
Echinococcus granulosus Glycosyl transferase family 35 0.0108 0.0374 0.0374
Echinococcus multilocularis protein patched 0.0634 0.3322 0.3322
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Echinococcus multilocularis FTZ F1 alpha 0.0098 0.0318 0.0318
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.1541 0.8404 1
Echinococcus granulosus acetylcholinesterase 0.0407 0.2046 0.2046
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0046 0.0026 0.0691
Schistosoma mansoni protein tyrosine phosphatase 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0046 0.0026 0.0691
Brugia malayi Carboxylesterase family protein 0.0407 0.2046 0.2046
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0161 0.0668 0.1748
Trypanosoma cruzi protein farnesyltransferase, putative 0.0112 0.0395 0.047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0581 0.0691
Echinococcus multilocularis neuroligin 0.0069 0.0152 0.0152
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0046 0.0026 0.0026
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0046 0.0026 0.0031
Brugia malayi hypothetical protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Mycobacterium tuberculosis Carboxylesterase LipT 0.0069 0.0152 0.0434
Loa Loa (eye worm) carboxylesterase 0.0069 0.0152 0.0152
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0046 0.0026 0.0026
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0112 0.0395 0.0395
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.1541 0.8404 0.8404
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0112 0.0395 0.1034
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0046 0.0026 0.0031
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Echinococcus multilocularis glycogen phosphorylase 0.0108 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0046 0.0026 0.0691
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0112 0.0395 0.047
Onchocerca volvulus 0.0069 0.0152 0.4058
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0046 0.0026 0.0026
Trichomonas vaginalis glycogen phosphorylase, putative 0.0108 0.0374 0.0978
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0098 0.0318 0.0318
Schistosoma mansoni hypothetical protein 0.0164 0.0684 0.0684
Schistosoma mansoni glycogen phosphorylase 0.0047 0.0029 0.0029
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.1487 0.1769
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Toxoplasma gondii hypothetical protein 0.0119 0.0434 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0098 0.0318 0.0318
Echinococcus multilocularis hypothetical protein 0.0046 0.0026 0.0026
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0231 0.1064 0.1064
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0112 0.0395 0.0395
Brugia malayi Protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0152
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0046 0.0026 0.0026
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0008 0.001
Echinococcus granulosus glycogen phosphorylase 0.0108 0.0374 0.0374
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Echinococcus granulosus Protein patched homolog 1 0.0634 0.3322 0.3322
Schistosoma mansoni patched 1 0.0634 0.3322 0.3322
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.0026 0.0026
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0069 0.0152 0.4058
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0046 0.0026 0.0387
Brugia malayi Protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0079 0.0209 0.0209
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0046 0.0026 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0673 0.2276
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0046 0.0026 0.0026
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0046 0.0026 0.0026
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0046 0.0026 0.0026
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0046 0.0026 0.0026
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.1541 0.8404 1
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0723 0.3819 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0407 0.2046 0.2046
Schistosoma mansoni acetylcholinesterase 0.0069 0.0152 0.0152
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.1541 0.8404 0.8404
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0161 0.0668 0.0668
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0069 0.0152 0.0152
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0046 0.0026 0.0026
Schistosoma mansoni glycogen phosphorylase 0.0108 0.0374 0.0374
Schistosoma mansoni hypothetical protein 0.0164 0.0684 0.0684
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0723 0.3819 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0046 0.0026 0.0031
Brugia malayi Carboxylesterase family protein 0.0069 0.0152 0.0152
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0046 0.0026 0.0031
Echinococcus granulosus carboxylesterase 5A 0.0407 0.2046 0.2046
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0112 0.0395 0.9104
Onchocerca volvulus 0.0046 0.0026 0.0691
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0161 0.0668 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0112 0.0395 0.1034
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0046 0.0026 0.0026
Giardia lamblia Rab geranylgeranyltransferase 0.0161 0.0668 0.1748
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0152
Brugia malayi Carboxylesterase family protein 0.0069 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Chlamydia trachomatis glycogen phosphorylase 0.0108 0.0374 0.5
Mycobacterium ulcerans carboxylesterase, LipT 0.0069 0.0152 0.0146
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0046 0.0026 0.0026
Brugia malayi hypothetical protein 0.0069 0.0152 0.0152
Echinococcus multilocularis acetylcholinesterase 0.0407 0.2046 0.2046
Onchocerca volvulus 0.0046 0.0026 0.0691
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Echinococcus granulosus acetylcholinesterase 0.0407 0.2046 0.2046
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0046 0.0026 0.0026
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0098 0.0318 0.0318
Echinococcus multilocularis Glycosyl transferase, family 35 0.0108 0.0374 0.0374
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Echinococcus granulosus glycogen phosphorylase 0.0108 0.0374 0.0374
Brugia malayi Carboxylesterase family protein 0.0407 0.2046 0.2046
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0046 0.0026 0.0026
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0152 0.0152
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Echinococcus granulosus FTZ F1 alpha 0.0391 0.1959 0.1959
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0152
Onchocerca volvulus 0.0046 0.0026 0.0691
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0046 0.0026 0.0026
Echinococcus multilocularis Niemann Pick C1 protein 0.0634 0.3322 0.3322
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.1541 0.8404 1
Echinococcus multilocularis geminin 0.0164 0.0684 0.0684
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0112 0.0395 0.1034
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0046 0.0026 0.0691
Schistosoma mansoni neuroligin 3 (S09 family) 0.0069 0.0152 0.0152
Echinococcus granulosus BC026374 protein S09 family 0.0069 0.0152 0.0152
Onchocerca volvulus 0.0046 0.0026 0.0691
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1273 0.6905 0.6905
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0112 0.0395 0.5917
Onchocerca volvulus 0.0046 0.0026 0.0691
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0152
Onchocerca volvulus 0.0046 0.0026 0.0691
Schistosoma mansoni pcd6 interacting protein-related 0.0046 0.0026 0.0026
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0046 0.0026 0.0387
Brugia malayi carbohydrate phosphorylase 0.0108 0.0374 0.0374
Loa Loa (eye worm) carboxylesterase 0.0407 0.2046 0.2046
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.1487 0.1769
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0046 0.0026 0.0026
Echinococcus multilocularis protein dispatched 1 0.0634 0.3322 0.3322
Brugia malayi Protein-tyrosine phosphatase 1 0.0046 0.0026 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0008 0.001
Schistosoma mansoni BC026374 protein (S09 family) 0.0069 0.0152 0.0152
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0046 0.0026 0.0387
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0581 0.0691
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.1541 0.8404 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0046 0.0026 0.0691
Mycobacterium ulcerans hypothetical protein 0.0162 0.0673 0.0769
Echinococcus multilocularis BC026374 protein (S09 family) 0.0069 0.0152 0.0152
Schistosoma mansoni protein tyrosine phosphatase 0.0046 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Giardia lamblia Prenyltransferase 0.0112 0.0395 0.1034
Onchocerca volvulus 0.0046 0.0026 0.0691
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0112 0.0395 0.1034
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0046 0.0026 0.0691
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1825 1 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0407 0.2046 0.2046
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0161 0.0668 0.0668
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0112 0.0395 0.0395
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0046 0.0026 0.0026
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Trypanosoma cruzi protein farnesyltransferase, putative 0.0112 0.0395 0.047
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.1487 0.1769
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0098 0.0318 0.0318
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0634 0.3322 0.3322
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0161 0.0668 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.0026 0.0026
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0069 0.0152 0.0152
Leishmania major tyrosine specific protein phosphatase, putative 0.0046 0.0026 0.0031
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0119 0.0434 0.1136
Onchocerca volvulus 0.0069 0.0152 0.4058
Entamoeba histolytica glycogenphosphorylase, putative 0.0047 0.0029 0.0433
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0046 0.0026 0.0026
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0112 0.0395 0.5917
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0112 0.0395 0.5917
Onchocerca volvulus 0.0069 0.0152 0.4058
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0491 0.2522 0.2522
Onchocerca volvulus 0.0046 0.0026 0.0691
Trypanosoma brucei protein tyrosine phosphatase 1 0.0046 0.0026 0.0031
Leishmania major farnesyltransferase beta subunit 0.0112 0.0395 0.047
Trichomonas vaginalis spcc417.12 protein, putative 0.0069 0.0152 0.0397
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0407 0.2046 0.2046
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.1487 0.1769
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0161 0.0668 0.0668
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.1541 0.8404 0.8404
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0069 0.0152 0.0397
Echinococcus multilocularis 0.0046 0.0026 0.0026
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.1541 0.8404 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Echinococcus granulosus sterol regulatory element binding protein 0.0634 0.3322 0.3322
Loa Loa (eye worm) hypothetical protein 0.1541 0.8404 0.8404
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0152 0.0152
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0581 0.0691
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0634 0.3322 0.3322
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0152 0.0152
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0152
Brugia malayi Carboxylesterase family protein 0.0069 0.0152 0.0152
Schistosoma mansoni protein tyrosine phosphatase 0.0046 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) protein tyrosine phosphatase 0.0046 0.0026 0.0026
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0112 0.0395 0.0395
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0112 0.0395 0.1034
Giardia lamblia Glycogen phosphorylase 0.0108 0.0374 0.0978
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0201 0.0201
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0098 0.0318 0.0318
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0634 0.3322 0.3322
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0161 0.0668 0.1748
Echinococcus granulosus microsomal glutathione S transferase 3 0.0113 0.0398 0.0398
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Schistosoma mansoni microsomal glutathione s-transferase 0.0113 0.0398 0.0398
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0082 0.0224 0.3363
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0046 0.0026 0.0026
Toxoplasma gondii MAPEG family protein 0.0113 0.0398 0.9168
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0046 0.0026 0.0026
Entamoeba histolytica glycogen phosphorylase, putative 0.0108 0.0374 0.5596
Onchocerca volvulus 0.0046 0.0026 0.0691
Echinococcus multilocularis carboxylesterase 5A 0.0407 0.2046 0.2046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0098 0.0318 0.0318
Mycobacterium tuberculosis Probable oxidoreductase 0.0551 0.2857 1
Echinococcus granulosus protein tyrosine phosphatase n9 0.0046 0.0026 0.0026
Toxoplasma gondii hypothetical protein 0.0049 0.0044 0.1011
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1825 1 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0201 0.0201
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0029 0.0433
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0161 0.0668 0.0668
Echinococcus granulosus neuroligin 0.0069 0.0152 0.0152
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0112 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Brugia malayi Carboxylesterase family protein 0.0069 0.0152 0.0152
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Mycobacterium ulcerans short chain dehydrogenase 0.0551 0.2857 0.3377
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0029 0.0433
Loa Loa (eye worm) glycogen phosphorylase 0.0108 0.0374 0.0374
Echinococcus multilocularis sterol regulatory element binding protein 0.0634 0.3322 0.3322
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0046 0.0026 0.0026
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0046 0.0026 0.0026
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0046 0.0026 0.0026
Onchocerca volvulus 4.1 G protein, putative homolog 0.0046 0.0026 0.0691
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0161 0.0668 1
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0046 0.0026 0.0026
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0161 0.0668 0.1748
Onchocerca volvulus 0.0069 0.0152 0.4058
Schistosoma mansoni gliotactin 0.0069 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0046 0.0026 0.0026
Echinococcus multilocularis glycogen phosphorylase 0.0108 0.0374 0.0374
Brugia malayi hypothetical protein 0.0046 0.0026 0.0026
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0046 0.0026 0.0691
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0046 0.0026 0.0026
Brugia malayi CHE-14 protein 0.0634 0.3322 0.3322
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Brugia malayi hypothetical protein 0.0046 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0634 0.3322 0.8701
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0152 0.0434
Schistosoma mansoni glycogen phosphorylase 0.0108 0.0374 0.0374
Entamoeba histolytica glycogen phosphorylase, putative 0.0108 0.0374 0.5596
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0723 0.3819 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0046 0.0026 0.0691
Trichomonas vaginalis glycogen phosphorylase, putative 0.0108 0.0374 0.0978
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1825 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0046 0.0026 0.0026
Brugia malayi hypothetical protein 0.0046 0.0026 0.0026
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0152 0.0434
Brugia malayi hypothetical protein 0.0046 0.0026 0.0026
Echinococcus granulosus para nitrobenzyl esterase 0.0069 0.0152 0.0152
Onchocerca volvulus Glycogen phosphorylase homolog 0.0108 0.0374 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0046 0.0026 0.0026
Onchocerca volvulus 0.0046 0.0026 0.0691

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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