Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.2707 | 0.5057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0727 | 0.12 | 0.0699 |
Echinococcus granulosus | AMP deaminase 2 | 0.2707 | 0.5057 | 0.3616 |
Leishmania major | AMP deaminase, putative | 0.2707 | 0.5057 | 0.2228 |
Loa Loa (eye worm) | hypothetical protein | 0.5243 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2707 | 0.5057 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.2707 | 0.5057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3264 | 0.6142 | 0.5923 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0819 | 0.1379 | 0.1304 |
Schistosoma mansoni | adenosine deaminase | 0.5243 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.5243 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.0624 | 0.0091 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.2707 | 0.5057 | 0.2228 |
Loa Loa (eye worm) | hypothetical protein | 0.3264 | 0.6142 | 0.5923 |
Trypanosoma brucei | AMP deaminase, putative | 0.2707 | 0.5057 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.5243 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.2707 | 0.5057 | 0.4776 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.127 | 0.2257 | 0.098 |
Plasmodium falciparum | adenosine deaminase | 0.5243 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.5243 | 1 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.2707 | 0.5057 | 0.2228 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2707 | 0.5057 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.2707 | 0.5057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3264 | 0.6142 | 0.5923 |
Schistosoma mansoni | hypothetical protein | 0.127 | 0.2257 | 0.219 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2707 | 0.5057 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.2707 | 0.5057 | 0.2228 |
Leishmania major | adenine aminohydrolase | 0.5243 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.5243 | 1 | 1 |
Echinococcus multilocularis | AMP deaminase 2 | 0.2707 | 0.5057 | 0.4242 |
Mycobacterium ulcerans | adenosine deaminase | 0.5243 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5243 | 1 | 0.5 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.2707 | 0.5057 | 0.2228 |
Schistosoma mansoni | adenosine deaminase-related | 0.5243 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0124 | 0.0024 | 0.0024 |
Trypanosoma brucei | AMP deaminase, putative | 0.2707 | 0.5057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.198 | 0.364 | 0.3279 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5243 | 1 | 1 |
Schistosoma mansoni | AMP deaminase | 0.2707 | 0.5057 | 0.5014 |
Loa Loa (eye worm) | hypothetical protein | 0.127 | 0.2257 | 0.1817 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5243 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2707 | 0.5057 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2707 | 0.5057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.0579 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.3264 | 0.6142 | 0.5923 |
Plasmodium vivax | adenosine deaminase, putative | 0.5243 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0124 | 0.0024 | 0.0024 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.2707 | 0.5057 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5243 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5243 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.5243 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5243 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0124 | 0.0024 | 0.0024 |
Schistosoma mansoni | calcium-activated potassium channel | 0.127 | 0.2257 | 0.219 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0124 | 0.0024 | 0.0024 |
Treponema pallidum | adenosine deaminase | 0.5243 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.