Detailed information for compound 880354

Basic information

Technical information
  • TDR Targets ID: 880354
  • Name: [5-[[4-(3-chlorophenyl)piperazin-1-yl]methyl] furan-2-yl]methyl acetate
  • MW: 348.824 | Formula: C18H21ClN2O3
  • H donors: 0 H acceptors: 1 LogP: 2.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)OCc1ccc(o1)CN1CCN(CC1)c1cccc(c1)Cl
  • InChi: 1S/C18H21ClN2O3/c1-14(22)23-13-18-6-5-17(24-18)12-20-7-9-21(10-8-20)16-4-2-3-15(19)11-16/h2-6,11H,7-10,12-13H2,1H3
  • InChiKey: RWWDNVBAQKIUSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [5-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-2-furyl]methyl acetate
  • acetic acid [5-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-2-furyl]methyl ester
  • acetic acid [5-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-2-furyl]methyl ester
  • [5-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]furan-2-yl]methyl ethanoate
  • Oprea1_155799

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0082 0.0709 0.0706
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.4771 0.4971
Loa Loa (eye worm) hypothetical protein 0.0052 0.0358 0.037
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0043 0.0249 0.0297
Echinococcus granulosus Nuclear hormone receptor HR96 0.0056 0.0398 0.0477
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.0025
Trypanosoma brucei cytochrome P450, putative 0.0047 0.0298 0.1388
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0031 0.011 0.0184
Loa Loa (eye worm) hypothetical protein 0.0118 0.1135 0.118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0152 0.0171
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0037 0.0178 0.0808
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0501 0.0498
Echinococcus multilocularis tar DNA binding protein 0.0075 0.0627 0.0624
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0292 0.0304
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0037 0.0178 0.0308
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0043 0.0249 0.0297
Loa Loa (eye worm) hypothetical protein 0.0118 0.1135 0.118
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0118 0.1135 0.1361
Loa Loa (eye worm) hypoxia-induced factor 1 0.0441 0.496 0.5167
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0031 0.011 0.0491
Loa Loa (eye worm) hypothetical protein 0.0065 0.0513 0.0532
Trypanosoma cruzi p450 reductase, putative 0.0082 0.0709 0.3364
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0298 0.1388
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0182
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0476 0.0571
Schistosoma mansoni tyrosinase precursor 0.0089 0.0792 0.0947
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0152 0.0469
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0476 0.0473
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0047 0.0298 0.0954
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0513 0.0922
Brugia malayi Cytochrome P450 family protein 0.0047 0.0298 0.0311
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0488 0.1581
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0146 0.1467 0.1528
Leishmania major protein kinase, putative 0.0037 0.0178 0.0808
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0152 0.0681
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0501 0.0602
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0438 0.1416
Echinococcus granulosus Protein patched homolog 1 0.006 0.0451 0.0541
Schistosoma mansoni single-minded 0.0142 0.1426 0.1713
Brugia malayi steroid hormone receptor 0.0118 0.1135 0.1183
Schistosoma mansoni jun-related protein 0.0066 0.0521 0.0618
Loa Loa (eye worm) hypothetical protein 0.0198 0.2088 0.2173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0118 0.1135 0.118
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.2146 0.2236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0118 0.1135 0.118
Echinococcus multilocularis ecdysone induced protein 78C 0.0118 0.1135 0.1133
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0031 0.011 0.0483
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0438 0.0518
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0477 0.0565
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.2403 0.2502
Schistosoma mansoni hypothetical protein 0.0064 0.0501 0.0594
Schistosoma mansoni tyrosinase precursor 0.0089 0.0792 0.0947
Brugia malayi Common central domain of tyrosinase family protein 0.0089 0.0792 0.0826
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0082 0.0709 0.0853
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0118 0.1135 0.1133
Onchocerca volvulus 0.0089 0.0792 0.0679
Loa Loa (eye worm) hypothetical protein 0.0146 0.1467 0.1526
Loa Loa (eye worm) DR-78 0.0056 0.0398 0.0412
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0298 0.0308
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0043 0.0249 0.0438
Brugia malayi follicle stimulating hormone receptor 0.0225 0.2403 0.2504
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.002 0.0021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.001 0.0007
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0082 0.0709 0.2313
Echinococcus granulosus thyroid hormone receptor alpha 0.0056 0.0398 0.0477
Giardia lamblia Hypothetical protein 0.0073 0.0599 0.3475
Schistosoma mansoni lamin 0.0052 0.0358 0.0421
Plasmodium falciparum nitric oxide synthase, putative 0.0082 0.0709 0.4062
Plasmodium vivax flavodoxin domain containing protein 0.0073 0.0599 0.3405
Brugia malayi nuclear receptor NHR-88 0.0118 0.1135 0.1183
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0476 0.2173
Brugia malayi hypothetical protein 0.0056 0.0398 0.0415
Brugia malayi EGF-like domain containing protein 0.0024 0.002 0.0021
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0062 0.0477 0.0474
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0327 0.0324
Brugia malayi hypothetical protein 0.0064 0.0494 0.0515
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0249 0.115
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0028 0.0087
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0062 0.0477 0.0573
Schistosoma mansoni coup transcription factor 0.0118 0.1135 0.1361
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0118 0.1135 0.1361
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0118 0.1135 0.1133
Onchocerca volvulus 0.0065 0.0513 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0178 0.0308
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0118 0.1135 0.1369
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0792 0.0826
Leishmania major cytochrome p450-like protein 0.0047 0.0298 0.1388
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.0249 0.115
Loa Loa (eye worm) tyrosinase 1 0.0089 0.0792 0.0823
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.0513 0.0922
Brugia malayi tailless protein 0.0056 0.0398 0.0415
Brugia malayi hypothetical protein 0.0104 0.0974 0.1015
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0043 0.0249 0.115
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0198 0.2088 1
Brugia malayi nuclear hormone receptor 0.0056 0.0398 0.0415
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0513 0.2893
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0198 0.2088 0.381
Echinococcus granulosus ecdysone induced protein 78C 0.0118 0.1135 0.1369
Leishmania major protein kinase, putative 0.0037 0.0178 0.0808
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0051 0.0338 0.0397
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.0513 0.0922
Schistosoma mansoni patched 1 0.006 0.0451 0.0533
Schistosoma mansoni nuclear hormone receptor 0.0118 0.1135 0.1361
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.0178 0.0808
Echinococcus granulosus intermediate filament protein 0.0052 0.0358 0.0429
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0018
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0037 0.0178 0.0308
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0152 0.0149
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Schistosoma mansoni retinoic acid receptor RXR 0.0721 0.8277 1
Echinococcus granulosus dna polymerase eta 0.0023 0.001 0.0008
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0043 0.0249 0.115
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0166 0.1704 0.3106
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0501 0.0522
Brugia malayi ecdysone receptor 0.0056 0.0398 0.0415
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2372 0.7818
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0152 0.018
Schistosoma mansoni hypothetical protein 0.0064 0.0501 0.0594
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0152 0.026
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0152 0.026
Loa Loa (eye worm) hypothetical protein 0.0089 0.0792 0.0823
Loa Loa (eye worm) hypothetical protein 0.0026 0.0048 0.0047
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0438 0.0526
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.002 0.0018
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0056 0.0398 0.0395
Loa Loa (eye worm) hypothetical protein 0.0166 0.1704 0.1773
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0037 0.0178 0.0175
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0056 0.0398 0.0261
Loa Loa (eye worm) hypothetical protein 0.0065 0.0513 0.0532
Echinococcus multilocularis geminin 0.0712 0.8175 0.8175
Loa Loa (eye worm) intermediate filament protein 0.0052 0.0358 0.037
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0146 0.1467 0.701
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0056 0.0398 0.0469
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0152 0.0469
Brugia malayi Pre-SET motif family protein 0.0425 0.4771 0.4972
Schistosoma mansoni NADPH flavin oxidoreductase 0.0041 0.0228 0.0264
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0031 0.011 0.0184
Trichomonas vaginalis guanylate cyclase, putative 0.0037 0.0178 0.0308
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0166 0.1704 0.3106
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0043 0.0249 0.0246
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0037 0.0178 0.0808
Echinococcus multilocularis protein patched 0.006 0.0451 0.0448
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.001 0.001
Trichomonas vaginalis sulfite reductase, putative 0.0082 0.0709 0.1281
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.002 0.0021
Brugia malayi Nuclear hormone receptor E75 0.0056 0.0398 0.0415
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0513 0.242
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0118 0.1135 0.1133
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0152 0.0737
Trichomonas vaginalis esterase, putative 0.0035 0.0152 0.026
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0056 0.0398 0.0477
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0089 0.0792 0.0826
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0031 0.011 0.0184
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0038 0.0043
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.002 0.0017
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0028 0.0087
Onchocerca volvulus 0.0105 0.0988 0.0886
Loa Loa (eye worm) hypothetical protein 0.0062 0.0476 0.0493
Brugia malayi beta-lactamase family protein 0.0035 0.0152 0.0158
Echinococcus granulosus synaptic glycoprotein sc2 0.0065 0.0513 0.0616
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0118 0.1135 0.1183
Schistosoma mansoni lamin 0.0052 0.0358 0.0421
Echinococcus granulosus slit 2 protein 0.0024 0.002 0.0021
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0166 0.1704 1
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0068 0.055 0.3186
Echinococcus multilocularis cpg binding protein 0.0068 0.0549 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0118 0.1135 0.118
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0488 0.0578
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0118 0.1135 0.1042
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0068 0.055 0.099
Brugia malayi hypothetical protein 0.0062 0.0477 0.0497
Brugia malayi CHE-14 protein 0.006 0.0451 0.047
Brugia malayi nuclear receptor RXR 0.0056 0.0398 0.0415
Echinococcus granulosus cpg binding protein 0.0068 0.0549 0.066
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0062 0.0477 0.0494
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0118 0.1135 0.1133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0118 0.1135 0.118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0327 0.0384
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0056 0.0398 0.0261
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0627 0.0747
Brugia malayi Pre-SET motif family protein 0.0062 0.0476 0.0496
Mycobacterium ulcerans hypothetical protein 0.0035 0.0152 0.0469
Echinococcus multilocularis aryl hydrocarbon receptor 0.0037 0.0178 0.0175
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0721 0.8277 1
Mycobacterium ulcerans putative regulatory protein 0.0105 0.0988 0.3237
Leishmania major p450 reductase, putative 0.0082 0.0709 0.3364
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0198 0.2088 0.381
Loa Loa (eye worm) hypothetical protein 0.0118 0.1135 0.118
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.002 0.0013
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0037 0.0178 0.0308
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0166 0.1704 0.1702
Echinococcus multilocularis synaptic glycoprotein sc2 0.0065 0.0513 0.051
Mycobacterium tuberculosis Conserved protein 0.0035 0.0152 0.0469
Onchocerca volvulus 0.0064 0.0494 0.0363
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0028 0.0087
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0071 0.0074
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0152 0.0158
Echinococcus multilocularis GPCR, family 2 0.0064 0.0501 0.0498
Loa Loa (eye worm) flavodoxin family protein 0.0031 0.011 0.0112
Onchocerca volvulus 0.0062 0.0476 0.0343
Giardia lamblia Rab geranylgeranyltransferase 0.0166 0.1704 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0056 0.0398 0.0412
Brugia malayi beta-lactamase 0.0035 0.0152 0.0158
Schistosoma mansoni steroid hormone receptor ad4bp 0.0118 0.1135 0.1361
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0082 0.0709 0.3364
Loa Loa (eye worm) hypothetical protein 0.0228 0.2445 0.2546
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0327 0.0384
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0155
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0031 0.011 0.0483
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0627 0.0747
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0166 0.1704 0.2056
Echinococcus multilocularis nuclear receptor nhr 48 0.0056 0.0398 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0118 0.1135 0.1183
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0513 0.2893
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0043 0.0249 0.115
Brugia malayi ShTK domain containing protein 0.0089 0.0792 0.0826
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0438 0.1416
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.2146 0.2236
Echinococcus multilocularis slit 2 protein 0.0024 0.002 0.0017
Loa Loa (eye worm) FAD binding domain-containing protein 0.0082 0.0709 0.0736
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0082 0.0709 0.3364
Brugia malayi nuclear receptor RXR 0.0062 0.0477 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0118 0.1135 0.1183
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0118 0.1135 0.1369
Leishmania major hypothetical protein, conserved 0.0031 0.011 0.0483
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Echinococcus granulosus pikachurin 0.0024 0.002 0.0021
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0513 0.242
Loa Loa (eye worm) hypothetical protein 0.0051 0.0347 0.0359
Echinococcus granulosus lamin dm0 0.0052 0.0358 0.0429
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0166 0.1704 0.8154
Echinococcus granulosus methionine synthase reductase 0.0051 0.0338 0.0405
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.0249 0.115
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0152 0.0469
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0155
Schistosoma mansoni cpg binding protein 0.0068 0.0549 0.0652
Giardia lamblia Synaptic glycoprotein SC2 0.0065 0.0513 0.2968
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0198 0.2088 1
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0073 0.0599 0.1079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0398 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0118 0.1135 0.1183
Entamoeba histolytica hypothetical protein 0.0143 0.1439 0.6876
Mycobacterium ulcerans hypothetical protein 0.0198 0.2088 0.6878
Echinococcus granulosus GPCR family 2 0.0064 0.0501 0.0602
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0065 0.0513 0.2354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0476 0.0563
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0043 0.0249 0.0259
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0152 0.0469
Brugia malayi photoreceptor-specific nuclear receptor 0.0118 0.1135 0.1183
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0118 0.1135 0.1183
Echinococcus multilocularis protein dispatched 1 0.006 0.0451 0.0448
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0118 0.1135 0.1361
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0438 0.2059
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0152 0.0469
Schistosoma mansoni hypothetical protein 0.0712 0.8175 0.9877
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0118 0.1135 0.1183
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0477 0.0497
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0082 0.0709 0.3364
Onchocerca volvulus 0.0052 0.0358 0.0219
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.2445 0.2443
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0037 0.0178 0.0308
Schistosoma mansoni cpg binding protein 0.0068 0.0549 0.0652
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0438 0.0518
Schistosoma mansoni nuclear hormone receptor 0.0056 0.0398 0.0469
Brugia malayi RNA recognition motif domain containing protein 0.0075 0.0627 0.0654
Echinococcus multilocularis thyroid hormone receptor alpha 0.0118 0.1135 0.1133
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0513 0.0922
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0065 0.0513 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.0451 0.0467
Echinococcus multilocularis dnaJ subfamily B 0.0484 0.5471 0.5469
Onchocerca volvulus 0.0052 0.0358 0.0219
Loa Loa (eye worm) steroid hormone receptor 0.0118 0.1135 0.118
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0118 0.1135 0.1361
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0249 0.115
Onchocerca volvulus 0.0047 0.0292 0.0148
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0031 0.011 0.0483
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0488 0.0508
Echinococcus multilocularis pikachurin 0.0024 0.002 0.0017
Brugia malayi laminin alpha chain 0.0024 0.002 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0476 0.0563
Echinococcus granulosus Niemann Pick C1 protein 0.006 0.0451 0.0541
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0043 0.0249 0.115
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0198 0.2088 1
Schistosoma mansoni zinc finger protein 0.0056 0.0398 0.0469
Giardia lamblia Rab geranylgeranyltransferase 0.0043 0.0249 0.141
Entamoeba histolytica type A flavoprotein, putative 0.0031 0.011 0.0483
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0627 0.0747
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0166 0.1704 0.3106
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0152 0.0469
Brugia malayi FAD binding domain containing protein 0.0082 0.0709 0.0739
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0082 0.0709 0.3364
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0118 0.1135 0.1183
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0037 0.0178 0.0308
Brugia malayi intermediate filament protein 0.0052 0.0358 0.0373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0476 0.0563
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0066 0.0519 0.0616
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0488 0.2299
Loa Loa (eye worm) hypothetical protein 0.0203 0.2146 0.2234
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0327 0.0338
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.0249 0.115
Loa Loa (eye worm) hypothetical protein 0.0118 0.1135 0.118
Onchocerca volvulus 0.0118 0.1135 0.1042
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0438 0.0435
Schistosoma mansoni hypothetical protein 0.0066 0.0521 0.0618
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0488 0.0485
Plasmodium vivax polyprenol reductase, putative 0.0065 0.0513 0.2893
Brugia malayi nuclear hormone receptor 0.0118 0.1135 0.1183
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0488 0.1581
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0476 0.0563
Brugia malayi flavodoxin family protein 0.0082 0.0709 0.0739
Loa Loa (eye worm) hypothetical protein 0.0062 0.0477 0.0494
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0065 0.0513 0.2354
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0071 0.0071
Schistosoma mansoni nuclear receptor 0.0056 0.0398 0.0469
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0065 0.0513 0.242
Echinococcus multilocularis Niemann Pick C1 protein 0.006 0.0451 0.0448
Mycobacterium ulcerans beta-lactamase 0.0035 0.0152 0.0469
Brugia malayi ecdysteroid receptor 0.0832 0.9596 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0118 0.1135 0.118
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0082 0.0709 0.3364
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0043 0.0249 0.0256
Toxoplasma gondii flavodoxin domain-containing protein 0.0041 0.0221 0.0935
Onchocerca volvulus 0.0056 0.0398 0.0261
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.2445 0.2952
Brugia malayi CXXC zinc finger family protein 0.0065 0.0505 0.0527
Onchocerca volvulus 0.0089 0.0792 0.0679
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0627 0.0747
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0065 0.0513 0.0616
Onchocerca volvulus 0.0043 0.0249 0.0103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.2146 0.2234
Onchocerca volvulus 0.0089 0.0792 0.0679
Brugia malayi Steroid receptor seven-up type 2 0.0118 0.1135 0.1183
Toxoplasma gondii ABC1 family protein 0.0035 0.0152 0.06
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0298 0.1388
Loa Loa (eye worm) hypothetical protein 0.0024 0.0027 0.0025
Schistosoma mansoni RAR-like nuclear receptor 0.0118 0.1135 0.1361
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0056 0.0398 0.0395
Entamoeba histolytica hypothetical protein 0.0143 0.1439 0.6876
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0118 0.1135 0.118
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0026
Loa Loa (eye worm) RNA binding protein 0.0075 0.0627 0.0651
Echinococcus granulosus lamin 0.0052 0.0358 0.0429
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0152 0.0469
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0146 0.1467 0.1464
Schistosoma mansoni aryl hydrocarbon receptor 0.0142 0.1426 0.1713
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0065 0.0513 0.242
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.1384 0.1443
Loa Loa (eye worm) hypothetical protein 0.0118 0.1135 0.118
Brugia malayi nuclear hormone receptor family member odr-7 0.0056 0.0398 0.0415
Onchocerca volvulus 0.0089 0.0792 0.0679
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0501 0.0602
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0152 0.0681
Echinococcus multilocularis sterol regulatory element binding protein 0.006 0.0451 0.0448
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0037 0.0178 0.0211
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0792 0.0823
Loa Loa (eye worm) hypothetical protein 0.0832 0.9596 1
Trichomonas vaginalis adenylate cyclase, putative 0.0037 0.0178 0.0308
Loa Loa (eye worm) hypothetical protein 0.0089 0.0792 0.0823
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0037 0.0178 0.0808
Schistosoma mansoni thyroid hormone receptor 0.0118 0.1135 0.1361
Brugia malayi hypothetical protein 0.0024 0.0028 0.0029
Brugia malayi orphan nuclear receptor NR2E1 0.0056 0.0398 0.0415
Schistosoma mansoni hypothetical protein 0.0484 0.5471 0.6606
Schistosoma mansoni survival motor neuron protein 0.0047 0.0292 0.0341
Loa Loa (eye worm) hypothetical protein 0.0104 0.0974 0.1013
Brugia malayi hypothetical protein 0.0143 0.1439 0.1499
Schistosoma mansoni diflavin oxidoreductase 0.0041 0.0221 0.0255
Brugia malayi bHLH-PAS transcription factor 0.0105 0.0988 0.103
Mycobacterium ulcerans short chain dehydrogenase 0.0278 0.3031 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.0178 0.0808
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0166 0.1704 0.1776
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0143 0.1439 0.1436
Echinococcus granulosus geminin 0.0712 0.8175 0.9878
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0082 0.0709 0.3364
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0082 0.0709 0.0853
Trichomonas vaginalis set domain proteins, putative 0.0483 0.5464 1
Chlamydia trachomatis sulfite reductase 0.0051 0.0338 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0118 0.1135 0.1361
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0298 0.0308
Loa Loa (eye worm) hypothetical protein 0.0104 0.0974 0.1013
Schistosoma mansoni transcription factor LCR-F1 0.0143 0.1439 0.1728
Loa Loa (eye worm) nuclear hormone receptor 0.0056 0.0398 0.0412
Mycobacterium ulcerans lipase LipD 0.0035 0.0152 0.0469
Echinococcus granulosus aryl hydrocarbon receptor 0.0037 0.0178 0.0211
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0477 0.0497
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0146 0.1467 0.701
Schistosoma mansoni hypothetical protein 0.0064 0.0501 0.0594
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0037 0.0178 0.0808
Schistosoma mansoni intermediate filament proteins 0.0052 0.0358 0.0421
Brugia malayi TAR-binding protein 0.0075 0.0627 0.0654
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0488 0.0586
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0118 0.1135 0.1361
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0037 0.0178 0.0808
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.001 0.0007
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0082 0.0709 0.3364
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0139 0.139 0.167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0118 0.1135 0.1183
Brugia malayi nuclear hormone receptor family member nhr-6 0.0056 0.0398 0.0415
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0198 0.2088 0.381
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0146 0.1467 0.701
Echinococcus multilocularis FTZ F1 alpha 0.0118 0.1135 0.1133
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0065 0.0513 0.051
Onchocerca volvulus 0.0065 0.0505 0.0375
Schistosoma mansoni hypothetical protein 0.0139 0.1384 0.1662
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0068 0.055 0.099
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.001 0.0008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0118 0.1135 0.1133
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0476 0.0473
Brugia malayi RNA binding protein 0.0075 0.0627 0.0654
Echinococcus multilocularis lamin dm0 0.0052 0.0358 0.0355
Echinococcus multilocularis musashi 0.0052 0.0358 0.0355
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0062 0.0477 0.0565
Schistosoma mansoni nuclear receptor nhr-48 0.0056 0.0398 0.0469
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0118 0.1135 0.1183
Echinococcus multilocularis dna polymerase eta 0.0023 0.001 0.0007
Schistosoma mansoni slit 0.0024 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.006 0.0451 0.0467
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0327 0.0341
Brugia malayi Synaptic glycoprotein SC2 0.0065 0.0513 0.0535
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0152 0.0681
Brugia malayi hypothetical protein 0.0228 0.2445 0.2549
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0438 0.1416
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0701 0.0843
Toxoplasma gondii hypothetical protein 0.0043 0.0249 0.1072
Plasmodium falciparum polyprenol reductase, putative 0.0065 0.0513 0.2893
Loa Loa (eye worm) hypothetical protein 0.0118 0.1135 0.118
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0198 0.2088 1
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0627 0.0747
Treponema pallidum flavodoxin 0.0031 0.011 0.5
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0031 0.011 0.0483
Echinococcus multilocularis transfer RNA-Lys 0.0105 0.0988 0.0985
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0451 0.0808
Loa Loa (eye worm) hypothetical protein 0.0139 0.1384 0.144
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0152 0.026
Entamoeba histolytica hypothetical protein 0.0143 0.1439 0.6876
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0082 0.0709 0.3364
Leishmania major hypothetical protein, conserved 0.0035 0.0152 0.0681
Echinococcus granulosus tar DNA binding protein 0.0075 0.0627 0.0754
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0018
Brugia malayi Nuclear hormone receptor E75 0.0056 0.0398 0.0415
Schistosoma mansoni hypothetical protein 0.0712 0.8175 0.9877
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0327 0.0324
Entamoeba histolytica hypothetical protein 0.0065 0.0513 0.242
Schistosoma mansoni eyes absent homolog 0.0104 0.0974 0.1166
Loa Loa (eye worm) hypothetical protein 0.0064 0.0501 0.0519
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0166 0.1704 0.1773
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0118 0.1135 0.1183
Echinococcus granulosus jun protein 0.0081 0.0701 0.0843
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0118 0.1135 0.1369
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0043 0.0249 0.0246
Onchocerca volvulus Protein ultraspiracle homolog 0.0118 0.1135 0.1042
Onchocerca volvulus 0.0483 0.5464 0.5625
Loa Loa (eye worm) nuclear receptor NHR-67 0.0056 0.0398 0.0412
Mycobacterium leprae Possible regulatory protein 0.0037 0.0178 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0118 0.1135 0.1369
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0355 0.0367
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0501 0.0522
Loa Loa (eye worm) CYP4Cod1 0.0047 0.0298 0.0308
Loa Loa (eye worm) hypothetical protein 0.0079 0.0674 0.07
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0792 0.0826
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0198 0.2088 1
Giardia lamblia Nitric oxide synthase, inducible 0.0073 0.0599 0.3475
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0249 0.115
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0178 0.0308
Echinococcus granulosus dna polymerase kappa 0.0023 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0062 0.0477 0.0494
Schistosoma mansoni nuclear hormone receptor 0.0056 0.0398 0.0469
Echinococcus granulosus sterol regulatory element binding protein 0.006 0.0451 0.0541
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0118 0.1135 0.118
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0031 0.011 0.0184
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0198 0.2088 0.2176
Trichomonas vaginalis guanylate cyclase, putative 0.0037 0.0178 0.0308
Brugia malayi Cytochrome P450 family protein 0.0058 0.0428 0.0446
Brugia malayi nuclear receptor NHR-67 0.0056 0.0398 0.0415
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0062 0.0477 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0178 0.0308
Entamoeba histolytica hypothetical protein 0.0143 0.1439 0.6876
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0155
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0123 0.1195 0.2172
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0438 0.1989
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0043 0.0249 0.1318
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Brugia malayi hypothetical protein 0.0062 0.0477 0.0497
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0118 0.1135 0.1369
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0118 0.1135 0.1183
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0082 0.0709 0.0706
Mycobacterium tuberculosis Conserved protein 0.0035 0.0152 0.0469
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0146 0.1467 0.4821
Loa Loa (eye worm) beta-lactamase 0.0035 0.0152 0.0155
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0031 0.011 0.0491
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0701 0.0698
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0043 0.0249 0.1318
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0056 0.0398 0.0415
Loa Loa (eye worm) CXXC zinc finger family protein 0.0065 0.0505 0.0524
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0327 0.0392
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0438 0.1416
Echinococcus multilocularis jun protein 0.0081 0.0701 0.0698
Brugia malayi hypoxia-induced factor 1 0.0441 0.496 0.5169
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0152 0.0155
Echinococcus granulosus dnaJ subfamily B 0.0484 0.5471 0.6608
Echinococcus granulosus FTZ F1 alpha 0.0118 0.1135 0.1369
Brugia malayi Cytochrome P450 family protein 0.0047 0.0298 0.0311
Loa Loa (eye worm) hypothetical protein 0.0478 0.5398 0.5624
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0792 0.0823
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0198 0.2088 1
Plasmodium vivax hypothetical protein, conserved 0.0031 0.011 0.0491
Echinococcus granulosus nuclear receptor nhr 48 0.0056 0.0398 0.0477
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0146 0.1467 0.701
Echinococcus granulosus single minded 2 0.0105 0.0988 0.119
Echinococcus multilocularis dna polymerase kappa 0.0023 0.001 0.0007
Schistosoma mansoni cpg binding protein 0.0065 0.0505 0.0599
Brugia malayi Nuclear hormone receptor-like 1 0.0118 0.1135 0.1183
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.002 0.0021
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.0358 0.037
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0037 0.0178 0.0182
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0068 0.055 0.099
Schistosoma mansoni niemann-pick C1 (NPC1) 0.006 0.0451 0.0533
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.1217 0.5772
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.0513 0.0922
Brugia malayi hypothetical protein 0.0056 0.0398 0.0415
Loa Loa (eye worm) hypothetical protein 0.0062 0.0477 0.0494
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0432 0.0519
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0065 0.0513 0.0608
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0152 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0513 0.0922
Brugia malayi beta-lactamase family protein 0.0035 0.0152 0.0158
Entamoeba histolytica type A flavoprotein, putative 0.0031 0.011 0.0483
Onchocerca volvulus 0.0056 0.0398 0.0261
Loa Loa (eye worm) TAR-binding protein 0.0075 0.0627 0.0651
Leishmania major hypothetical protein, conserved 0.0024 0.0028 0.0087
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0075 0.0627 0.0651
Entamoeba histolytica type A flavoprotein, putative 0.0031 0.011 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0118 0.1135 0.1183
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0118 0.1135 0.1183
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.001 0.001
Toxoplasma gondii hypothetical protein 0.0123 0.1195 0.5665
Loa Loa (eye worm) FAD binding domain-containing protein 0.0051 0.0338 0.0349
Schistosoma mansoni hypothetical protein 0.0064 0.0501 0.0594
Schistosoma mansoni thyroid hormone receptor 0.0118 0.1135 0.1361
Onchocerca volvulus 0.0037 0.0178 0.0028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0501 0.0519
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0143 0.1439 0.1735
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0327 0.0392
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0152 0.0469
Loa Loa (eye worm) hypothetical protein 0.0118 0.1135 0.118
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0792 0.0826
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0166 0.1704 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0398 0.0477
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0146 0.1467 0.1769
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Entamoeba histolytica type A flavoprotein, putative 0.0031 0.011 0.0483
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0659 0.7539 0.7539
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0155
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.0358 0.0373
Schistosoma mansoni hypothetical protein 0.0047 0.0292 0.0341
Loa Loa (eye worm) hypothetical protein 0.0082 0.0709 0.0736
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0501 0.0498
Schistosoma mansoni cytochrome P450 reductase 0.0082 0.0709 0.0845
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0488 0.1581
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0327 0.0384
Brugia malayi conserved hypotetical protein 0.0056 0.0398 0.0415
Brugia malayi flavodoxin family protein 0.0031 0.011 0.0115
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0152 0.0171
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0056 0.0398 0.0469
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0155
Plasmodium vivax SET domain protein, putative 0.0062 0.0476 0.2671
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.002 0.0013
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0152 0.026
Schistosoma mansoni nuclear receptor 0.0056 0.0398 0.0469
Brugia malayi nuclear receptor NHR-88 0.0056 0.0398 0.0415
Leishmania major cytochrome P450 reductase, putative 0.0073 0.0599 0.2833
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0082 0.0709 0.4062
Mycobacterium tuberculosis Conserved protein 0.0035 0.0152 0.0469
Mycobacterium tuberculosis Probable oxidoreductase 0.0278 0.3031 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0118 0.1135 0.1133
Loa Loa (eye worm) hypothetical protein 0.0062 0.0477 0.0494
Echinococcus multilocularis lamin 0.0052 0.0358 0.0355
Schistosoma mansoni hypothetical protein 0.0143 0.1439 0.1728
Echinococcus multilocularis methionine synthase reductase 0.0051 0.0338 0.0335
Brugia malayi FAD binding domain containing protein 0.0051 0.0338 0.0352
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0152 0.026
Echinococcus granulosus Nuclear hormone receptor HR96 0.0056 0.0398 0.0477
Schistosoma mansoni cell polarity protein 0.0024 0.002 0.0013
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0056 0.0398 0.0395
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0043 0.0249 0.115
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0155
Brugia malayi bZIP transcription factor family protein 0.0081 0.0701 0.073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0118 0.1135 0.1369
Toxoplasma gondii flavodoxin domain-containing protein 0.0041 0.0221 0.0935
Onchocerca volvulus Bile acid receptor homolog 0.0832 0.9596 1
Entamoeba histolytica type A flavoprotein, putative 0.0031 0.011 0.0483
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0166 0.1704 0.2049
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0146 0.1467 0.1762
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0428 0.0443
Brugia malayi PAS domain containing protein 0.0142 0.1426 0.1486
Brugia malayi hypothetical protein 0.0478 0.5398 0.5625
Loa Loa (eye worm) hypothetical protein 0.0056 0.0398 0.0412

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.