Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.1056 | 0.8057 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0623 | 0.2664 | 0.3306 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0861 | 0.5625 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0861 | 0.5625 | 0.6866 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0623 | 0.2664 | 0.3725 |
Loa Loa (eye worm) | hypothetical protein | 0.1056 | 0.8057 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0623 | 0.2664 | 0.3725 |
Brugia malayi | Kringle domain containing protein | 0.0623 | 0.2664 | 0.3306 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0944 | 0.6654 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1212 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0861 | 0.5625 | 0.8381 |
Onchocerca volvulus | 0.0706 | 0.3692 | 0.1907 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0623 | 0.2664 | 0.2664 |
Schistosoma mansoni | hypothetical protein | 0.0623 | 0.2664 | 0.3052 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1212 | 1 | 1 |
Onchocerca volvulus | 0.1056 | 0.8057 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1056 | 0.8057 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1212 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0861 | 0.5625 | 0.8381 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0861 | 0.5625 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0944 | 0.6654 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0861 | 0.5625 | 0.549 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1056 | 0.8057 | 1 |
Brugia malayi | thymidylate synthase | 0.0861 | 0.5625 | 0.6981 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0 | 0.5 |
Onchocerca volvulus | 0.0861 | 0.5625 | 0.549 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1212 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1056 | 0.8057 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1212 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0861 | 0.5625 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.