Detailed information for compound 880456

Basic information

Technical information
  • TDR Targets ID: 880456
  • Name: 1-[(5-chloro-2-methoxyphenyl)carbamothioyl]-N ,N-diethylpiperidine-3-carboxamide
  • MW: 383.936 | Formula: C18H26ClN3O2S
  • H donors: 1 H acceptors: 1 LogP: 3 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)C1CCCN(C1)C(=S)Nc1cc(Cl)ccc1OC)CC
  • InChi: 1S/C18H26ClN3O2S/c1-4-21(5-2)17(23)13-7-6-10-22(12-13)18(25)20-15-11-14(19)8-9-16(15)24-3/h8-9,11,13H,4-7,10,12H2,1-3H3,(H,20,25)
  • InChiKey: BVUGEIJJRVNJGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(5-chloro-2-methoxy-phenyl)carbamothioyl]-N,N-diethyl-piperidine-3-carboxamide
  • 1-[[(5-chloro-2-methoxyphenyl)amino]-thioxomethyl]-N,N-diethyl-3-piperidinecarboxamide
  • 1-[(5-chloro-2-methoxy-phenyl)thiocarbamoyl]-N,N-diethyl-nipecotamide
  • Oprea1_007252

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0044 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0044 0.0013
Onchocerca volvulus 0.0202 0.0591 1
Brugia malayi RE15519p 0.003 0.0044 0.0013
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0044 0.0013
Brugia malayi hypothetical protein 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0071 0.0121
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Plasmodium vivax SET domain protein, putative 0.0026 0.003 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0044 0.0016
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0044 0.0016
Echinococcus multilocularis g protein coupled receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0178 0.0513 0.0485
Echinococcus multilocularis fmrfamide receptor 0.003 0.0044 0.0013
Echinococcus granulosus g protein coupled receptor 0.003 0.0044 0.0016
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0044 0.0013
Brugia malayi G-protein coupled receptor 0.003 0.0044 0.0013
Onchocerca volvulus 0.003 0.0044 0.0239
Onchocerca volvulus 0.003 0.0044 0.0239
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0038 0.0071 0.0071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0044 0.0013
Brugia malayi neuropeptide F receptor 0.003 0.0044 0.0013
Echinococcus granulosus neuropeptide s receptor 0.003 0.0044 0.0016
Onchocerca volvulus 0.003 0.0044 0.0239
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0044 0.0013
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0021 0.0014
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus granulosus g protein coupled receptor 0.003 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0021 0.0014
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0044 0.0016
Brugia malayi hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0071 0.0121
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0046 0.0067
Brugia malayi sulfakinin receptor protein 0.003 0.0044 0.0013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0044 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0085 0.0054
Echinococcus granulosus neuropeptide receptor 0.003 0.0044 0.0016
Echinococcus multilocularis fmrfamide receptor 0.003 0.0044 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.1305 0.4087 0.8758
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0044 0.0016
Echinococcus granulosus somatostatin receptor 0.003 0.0044 0.0016
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0071 0.0041
Onchocerca volvulus 0.003 0.0044 0.0239
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0044 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0044 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1487 0.4665 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0043 0.0085 0.0054
Echinococcus multilocularis sterol regulatory element binding protein 0.1305 0.4087 0.4069
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.317 1 0.5
Schistosoma mansoni neuropeptide receptor 0.003 0.0044 0.0013
Schistosoma mansoni adenoreceptor 0.003 0.0044 0.0013
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0044 0.0013
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0044 0.0013
Schistosoma mansoni biogenic amine (5HT) receptor 0.044 0.1344 0.1318
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0044 0.0013
Echinococcus granulosus allatostatin A receptor 0.003 0.0044 0.0016
Schistosoma mansoni opsin-like receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0044 0.0013
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0044 0.0013
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0038 0.0071 0.0041
Schistosoma mansoni neuropeptide receptor 0.003 0.0044 0.0013
Brugia malayi hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0044 0.0013
Echinococcus multilocularis Niemann Pick C1 protein 0.1305 0.4087 0.4069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0044 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0044 0.0013
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0038 0.0071 0.0041
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0038 0.0071 0.5
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0044 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0044 0.0016
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0044 0.0013
Brugia malayi G protein-coupled receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0044 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0044 0.0016
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0044 0.0013
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0044 0.0013
Echinococcus multilocularis sex peptide receptor 0.003 0.0044 0.0013
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0044 0.0013
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0042 0.0011
Onchocerca volvulus 0.003 0.0044 0.0239
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0044 0.0016
Echinococcus granulosus sex peptide receptor 0.003 0.0044 0.0016
Echinococcus multilocularis neuropeptide receptor 0.003 0.0044 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0044 0.0016
Schistosoma mansoni myosin xvIII 0.003 0.0044 0.0013
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0044 0.0239
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0011
Echinococcus multilocularis allatostatin A receptor 0.003 0.0044 0.0013
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.317 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus granulosus neuropeptide receptor 0.003 0.0044 0.0016
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0044 0.0013
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0044 0.0016
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0044 0.0016
Schistosoma mansoni cellular tumor antigen P53 0.0042 0.0083 0.0053
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1487 0.4665 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0046 0.0067
Schistosoma mansoni amine GPCR 0.003 0.0044 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0043 0.0085 0.0054
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Brugia malayi follicle stimulating hormone receptor 0.003 0.0044 0.0013
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.004 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0046 0.0067
Trichomonas vaginalis set domain proteins, putative 0.0202 0.0591 0.124
Schistosoma mansoni opsin-like receptor 0.003 0.0044 0.0013
Schistosoma mansoni hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0044 0.0016
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0044 0.0013
Brugia malayi CHE-14 protein 0.1305 0.4087 0.4069
Onchocerca volvulus 0.003 0.0044 0.0239
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0044 0.0013
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.1487 0.4665 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0031 0.0034
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0044 0.0013
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0044 0.0013
Brugia malayi Dopamine receptor protein 2 0.003 0.0044 0.0013
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0044 0.0016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0044 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0022 0.0015
Echinococcus multilocularis protein patched 0.1305 0.4087 0.4069
Brugia malayi putative neuropeptide receptor 0.003 0.0044 0.0013
Schistosoma mansoni niemann-pick C1 (NPC1) 0.1305 0.4087 0.4069
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0044 0.0013
Onchocerca volvulus 0.003 0.0044 0.0239
Schistosoma mansoni opsin-like receptor 0.003 0.0044 0.0013
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0046 0.0067
Onchocerca volvulus 0.0042 0.0083 0.0947
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.317 1 1
Schistosoma mansoni biogenic amine receptor 0.003 0.0044 0.0013
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0038 0.0071 0.0025
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0044 0.0013
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0044 0.0013
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.317 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0044 0.0013
Brugia malayi Dopamine receptor protein 1 0.003 0.0044 0.0013
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.004 0.0054
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.004 0.0054
Echinococcus granulosus Niemann Pick C1 protein 0.1305 0.4087 0.4071
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0044 0.0016
Onchocerca volvulus 0.003 0.0044 0.0239
Echinococcus multilocularis somatostatin receptor 0.003 0.0044 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Brugia malayi hypothetical protein 0.003 0.0044 0.0013
Schistosoma mansoni histamine h1 receptor 0.003 0.0044 0.0013
Onchocerca volvulus 0.003 0.0044 0.0239
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0044 0.0013
Brugia malayi G-protein coupled receptor 0.003 0.0044 0.0013
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0018 0.0007 0.0007
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.044 0.1344 0.1318
Echinococcus multilocularis neuropeptide receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus multilocularis orexin receptor type 2 0.003 0.0044 0.0013
Schistosoma mansoni amine GPCR 0.003 0.0044 0.0013
Echinococcus multilocularis protein dispatched 1 0.1305 0.4087 0.4069
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0044 0.0016
Onchocerca volvulus 0.003 0.0044 0.0239
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0053 0.0082
Echinococcus granulosus g-protein coupled receptor 0.003 0.0044 0.0016
Brugia malayi Dopamine receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0044 0.0013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0044 0.0013
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0044 0.0239
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0044 0.0013
Echinococcus multilocularis tumor protein p63 0.0289 0.0865 0.0837
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0044 0.0016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0044 0.0013
Echinococcus granulosus fmrfamide receptor 0.003 0.0044 0.0016
Brugia malayi Serotonin receptor 0.0561 0.1729 0.1703
Brugia malayi neuropeptide F receptor 0.003 0.0044 0.0013
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0044 0.0013
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0044 0.0013
Echinococcus multilocularis g protein coupled receptor 0.003 0.0044 0.0013
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.317 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0029 0.004 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0044 0.0013
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0031 0.0046 0.0046
Echinococcus multilocularis g protein coupled receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0044 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.0044 0.0013
Echinococcus granulosus g protein coupled receptor 0.003 0.0044 0.0016
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus granulosus orexin receptor type 2 0.003 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0038 0.0071 0.0071
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0044 0.0016
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0044 0.0013
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0044 0.0013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0044 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0044 0.0013
Echinococcus multilocularis serotonin receptor 0.044 0.1344 0.1318
Brugia malayi hypothetical protein 0.003 0.0044 0.0013
Schistosoma mansoni hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.044 0.1344 0.1318
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0044 0.0013
Schistosoma mansoni amine GPCR 0.0221 0.065 0.0622
Echinococcus granulosus serotonin receptor 0.003 0.0044 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0022 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Brugia malayi hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Onchocerca volvulus 0.003 0.0044 0.0239
Schistosoma mansoni hypothetical protein 0.0029 0.0042 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0044 0.0013
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0044 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0044 0.0016
Schistosoma mansoni neuropeptide receptor 0.003 0.0044 0.0013
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0044 0.0016
Echinococcus granulosus sterol regulatory element binding protein 0.1305 0.4087 0.4071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0044 0.0013
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0038 0.0071 0.0025
Schistosoma mansoni hypothetical protein 0.003 0.0044 0.0013
Onchocerca volvulus 0.003 0.0044 0.0239
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.317 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0044 0.0013
Brugia malayi Serotonin receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.1305 0.4087 0.4069
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0044 0.0013
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1487 0.4665 1
Echinococcus granulosus biogenic amine 5HT receptor 0.044 0.1344 0.132
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0044 0.0013
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.003 0.0003
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0044 0.0013
Brugia malayi GnHR receptor homolog 0.003 0.0044 0.0013
Schistosoma mansoni neuropeptide receptor 0.003 0.0044 0.0013
Brugia malayi AKH receptor 0.003 0.0044 0.0013
Onchocerca volvulus 0.003 0.0044 0.0239
Brugia malayi Pre-SET motif family protein 0.0178 0.0513 0.0485
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0044 0.0013
Echinococcus granulosus tumor protein p63 0.0289 0.0865 0.084
Schistosoma mansoni amine GPCR 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Brugia malayi hypothetical protein 0.003 0.0044 0.0013
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0044 0.0013
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0038 0.0071 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.004 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Onchocerca volvulus 0.003 0.0044 0.0239
Brugia malayi larval opioid receptor 0.003 0.0044 0.0013
Echinococcus multilocularis serotonin receptor 0.044 0.1344 0.1318
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.004 0.0054
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0038 0.0071 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.004 0.0054
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0044 0.0016
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Brugia malayi hypothetical protein 0.003 0.0044 0.0013
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.317 1 1
Schistosoma mansoni biogenic amine receptor 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Brugia malayi hypothetical protein 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0046 0.0067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0043 0.0085 0.0054
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Schistosoma mansoni amine GPCR 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0071 0.0121
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.317 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0044 0.0013
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0044 0.0013
Brugia malayi Melatonin receptor type 1A 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0022 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0044 0.0013
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0038 0.0071 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0044 0.0013
Schistosoma mansoni hypothetical protein 0.003 0.0044 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0083 0.0053
Brugia malayi hypothetical protein 0.003 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Echinococcus granulosus Protein patched homolog 1 0.1305 0.4087 0.4071
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0044 0.0016
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0044 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0044 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Brugia malayi ORL1-like opioid receptor 0.003 0.0044 0.0013
Onchocerca volvulus 0.003 0.0044 0.0239
Onchocerca volvulus 0.003 0.0044 0.0239
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0044 0.0013
Schistosoma mansoni patched 1 0.1305 0.4087 0.4069
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Schistosoma mansoni biogenic amine receptor 0.003 0.0044 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0028 0.0029
Echinococcus granulosus hypothetical protein 0.003 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0013
Onchocerca volvulus 0.003 0.0044 0.0239
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0071 0.0041
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0038 0.0071 0.0044
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0044 0.0016
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.317 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.1305 0.4087 0.4069

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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