Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1111 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0018 | 0.0313 | 0.0186 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0523 | 1 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0523 | 0.1763 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0018 | 0.0313 | 0.0186 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0116 | 0.6906 | 0.8844 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1763 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1111 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0018 | 0.0313 | 0.0056 |
Mycobacterium tuberculosis | Probable reductase | 0.0116 | 0.6906 | 0.8844 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1111 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0129 | 0.7773 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0523 | 0.1111 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.0313 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0523 | 0.1111 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0313 | 0.0906 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0313 | 0.1234 |
Plasmodium falciparum | glutathione reductase | 0.0018 | 0.0313 | 0.0186 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0313 | 0.0186 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0523 | 0.1111 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1111 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.0523 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0313 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0018 | 0.0313 | 0.0186 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0313 | 0.0186 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0313 | 0.0906 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0129 | 0.7773 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.0523 | 0.0259 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0523 | 0.0336 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1763 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.254 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0313 | 0.0186 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0523 | 0.206 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1763 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0271 | 0.0733 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0523 | 0.206 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0018 | 0.0313 | 0.0186 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0313 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0523 | 0.1111 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1111 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0313 | 0.0186 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.0523 | 0.5 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.0313 | 0.0043 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.254 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0313 | 0.0186 |
Leishmania major | trypanothione reductase | 0.0051 | 0.254 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0313 | 0.0186 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1763 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0313 | 0.0186 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0523 | 0.1111 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0018 | 0.0313 | 0.0186 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0018 | 0.0313 | 0.0186 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0523 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0313 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.254 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.254 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0129 | 0.7773 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0523 | 0.0336 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1763 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0523 | 0.1763 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0116 | 0.6906 | 0.8844 |
Plasmodium falciparum | thioredoxin reductase | 0.0018 | 0.0313 | 0.0186 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0523 | 0.1763 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0313 | 0.0906 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0313 | 0.0186 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.254 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0523 | 0.1763 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.254 | 0.3025 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1763 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.254 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.254 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0.0271 | 0.0733 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0116 | 0.6906 | 0.8844 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0.0313 | 0.5 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0018 | 0.0313 | 0.0186 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0313 | 0.0186 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0271 | 0.1068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1763 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.0523 | 0.0259 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0523 | 0.1111 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0313 | 0.0186 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.0523 | 0.1111 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0116 | 0.6906 | 0.8844 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0129 | 0.7773 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0021 | 0.0523 | 0.1111 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.0523 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0271 | 0.1068 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.254 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0313 | 0.0186 |
Brugia malayi | glutathione reductase | 0.0051 | 0.254 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.254 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0313 | 0.0186 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.0523 | 0.1111 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0313 | 0.0186 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1763 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1763 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0523 | 0.1763 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0523 | 0.1763 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0116 | 0.6906 | 0.8844 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0523 | 0.1111 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.254 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.0523 | 0.0259 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0523 | 0.1111 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.254 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.0523 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0313 | 0.0186 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.