TDR Targets

Basic information

Technical information

TDR Targets ID: 881182
Name: 2-(2-methoxyethoxy)-1-[8-(1-methylindole-2-ca rbonyl)-3,8-diazaspiro[4.5]decan-3-yl]ethanon e
MW: 413.51 | Formula: C23H31N3O4
H donors: 0 H acceptors: 2 LogP: 1.76 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COCCOCC(=O)N1CCC2(C1)CCN(CC2)C(=O)c1cc2c(n1C)cccc2
InChi: 1S/C23H31N3O4/c1-24-19-6-4-3-5-18(19)15-20(24)22(28)25-10-7-23(8-11-25)9-12-26(17-23)21(27)16-30-14-13-29-2/h3-6,15H,7-14,16-17H2,1-2H3
InChiKey: HFUOMOOWMJXEKT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2-methoxyethoxy)-1-[8-[(1-methyl-2-indolyl)-oxomethyl]-3,8-diazaspiro[4.5]decan-3-yl]ethanone
2-(2-methoxyethoxy)-1-[8-(1-methylindol-2-yl)carbonyl-3,8-diazaspiro[4.5]decan-3-yl]ethanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide receptor A26	0.0039	0.2343	0.429
Onchocerca volvulus		0.0039	0.2343	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0039	0.2343	0.429
Onchocerca volvulus		0.0039	0.2343	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0862	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Echinococcus granulosus	neuropeptide s receptor	0.0039	0.2343	0.429
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.4745	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.2343	0.429
Brugia malayi	hypothetical protein	0.0039	0.2343	0.1907
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0538	0.6244
Brugia malayi	Serotonin receptor	0.0039	0.2343	0.1907
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0039	0.2343	0.429
Echinococcus granulosus	somatostatin receptor	0.0039	0.2343	0.429
Onchocerca volvulus		0.0039	0.2343	1
Brugia malayi	Melatonin receptor type 1A	0.0039	0.2343	0.1907
Echinococcus granulosus	g protein coupled receptor	0.0039	0.2343	0.429
Echinococcus granulosus	neuropeptide FF receptor 2	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.2343	0.429
Loa Loa (eye worm)	melatonin receptor type 1A	0.0039	0.2343	0.1907
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.2343	0.429
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0023	0.0862	0.0769
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.2343	0.429
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0862	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2343	0.429
Schistosoma mansoni	neuropeptide f receptor 76f	0.0039	0.2343	0.429
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0538	0.5
Brugia malayi	sulfakinin receptor protein	0.0039	0.2343	0.1907
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Schistosoma mansoni	myosin xvIII	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0115	0.9224	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.2343	0.429
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.2343	0.429
Echinococcus granulosus	fmrfamide receptor	0.0039	0.2343	0.429
Echinococcus multilocularis	allatostatin A receptor	0.0039	0.2343	0.429
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2343	0.429
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Entamoeba histolytica	hypothetical protein	0.0023	0.0862	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0538	0.6244
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Brugia malayi	larval opioid receptor	0.0039	0.2343	0.1907
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0039	0.2343	0.429
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0039	0.2343	0.429
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0039	0.2343	0.429
Onchocerca volvulus		0.0039	0.2343	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Brugia malayi	G-protein coupled receptor	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Onchocerca volvulus		0.0039	0.2343	1
Onchocerca volvulus		0.0039	0.2343	1
Echinococcus granulosus	serotonin receptor	0.0039	0.2343	0.429
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0538	0.6244
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Brugia malayi	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	g-protein coupled receptor	0.0039	0.2343	0.429
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.2343	0.429
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0039	0.2343	0.429
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0039	0.2343	1
Brugia malayi	putative neuropeptide receptor	0.0039	0.2343	0.1907
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Onchocerca volvulus		0.0039	0.2343	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0039	0.2343	0.1907
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Brugia malayi	Dopamine receptor protein 1	0.0039	0.2343	0.1907
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.2343	0.429
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2343	0.429
Brugia malayi	G protein-coupled receptor	0.0039	0.2343	0.1907
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0039	0.2343	0.429
Brugia malayi	G-protein coupled receptor	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0039	0.2343	0.429
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0115	0.9224	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Echinococcus granulosus	biogenic amine 5HT receptor	0.0039	0.2343	0.429
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Trypanosoma brucei	unspecified product	0.0019	0.0538	0.6244
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.2343	0.429
Brugia malayi	RNA binding protein	0.0066	0.4745	0.4446
Echinococcus multilocularis	serotonin receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0039	0.2343	0.1907
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.4745	0.4446
Mycobacterium leprae	HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS (HOLO-ACP SYNTHASE) (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) (CoA:APO-[ACYL-CARRIE	0.0092	0.7166	1
Echinococcus granulosus	g-protein coupled receptor	0.0039	0.2343	0.429
Brugia malayi	Dopamine receptor	0.0039	0.2343	0.1907
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0039	0.2343	0.429
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.2343	0.429
Echinococcus multilocularis	somatostatin receptor	0.0039	0.2343	0.429
Schistosoma mansoni	neuropeptide receptor	0.0039	0.2343	0.429
Brugia malayi	GnHR receptor homolog	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.2343	0.429
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0023	0.0862	0.0342
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0039	0.2343	0.429
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0538	0.6244
Onchocerca volvulus		0.0039	0.2343	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.2343	0.429
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.4745	0.4446
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.4745	1
Brugia malayi	hypothetical protein	0.0039	0.2343	0.1907
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0115	0.9224	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.2343	0.429
Echinococcus granulosus	neuropeptide receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	dro:myosuppressin receptor	0.0039	0.2343	0.429
Brugia malayi	ORL1-like opioid receptor	0.0039	0.2343	0.1907
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.2343	0.429
Echinococcus granulosus	g protein coupled receptor	0.0039	0.2343	0.429
Echinococcus granulosus	neuropeptide receptor	0.0039	0.2343	0.429
Schistosoma mansoni	neuropeptide receptor	0.0039	0.2343	0.429
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0039	0.2343	0.1907
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0039	0.2343	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.2343	0.429
Brugia malayi	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.2343	0.429
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0115	0.9224	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	1	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0039	0.2343	0.429
Echinococcus multilocularis	G protein coupled receptor 139	0.0039	0.2343	0.429
Onchocerca volvulus		0.0039	0.2343	1
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.4745	1
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.2343	0.429
Echinococcus granulosus	7tm_1 domain containing protein	0.0039	0.2343	0.429
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0862	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.2343	0.429
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0538	0.5
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0538	0.5
Schistosoma mansoni	amine GPCR	0.0039	0.2343	0.429
Brugia malayi	hypothetical protein	0.0039	0.2343	0.1907
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.2343	0.429
Onchocerca volvulus		0.0039	0.2343	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0538	0.6244
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.2343	0.429
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0538	0.6244
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0538	0.6244
Schistosoma mansoni	neuropeptide receptor	0.0039	0.2343	0.429
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0538	0.6244
Onchocerca volvulus		0.0039	0.2343	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0538	0.6244
Echinococcus multilocularis	serotonin receptor	0.0039	0.2343	0.429
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2343	0.429
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0538	0.6244
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.2343	0.1907
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.2343	0.429
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0039	0.2343	0.429
Schistosoma mansoni	biogenic amine receptor	0.0039	0.2343	0.429
Brugia malayi	G protein-coupled receptor F59B2.13	0.0039	0.2343	0.1907
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.2343	0.429
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.2343	0.429
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0039	0.2343	0.429
Echinococcus granulosus	biogenic amine 5HT receptor	0.0039	0.2343	0.429
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0538	0.6244
Brugia malayi	follicle stimulating hormone receptor	0.0039	0.2343	0.1907
Schistosoma mansoni	neuropeptide receptor	0.0039	0.2343	0.429
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	orexin receptor type 2	0.0039	0.2343	0.429
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0115	0.9224	0.5
Echinococcus granulosus	sex peptide receptor	0.0039	0.2343	0.429
Brugia malayi	AKH receptor	0.0039	0.2343	0.1907
Echinococcus granulosus	dro:myosuppressin receptor	0.0039	0.2343	0.429
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0538	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	TYRA-2 protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0039	0.2343	0.429
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0862	1
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0862	1
Brugia malayi	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.2343	0.429
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Echinococcus multilocularis	sex peptide receptor	0.0039	0.2343	0.429
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0039	0.2343	0.1907
Echinococcus granulosus	L aminoadipate semialdehyde	0.0023	0.0862	0.0769
Echinococcus granulosus	neuropeptide receptor A26	0.0039	0.2343	0.429
Echinococcus multilocularis	neuropeptide s receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.0862	0.0373
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.4745	1
Onchocerca volvulus		0.0039	0.2343	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0039	0.2343	0.1907
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.4745	1
Brugia malayi	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus granulosus	G protein coupled receptor 139	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.2343	0.429
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.2343	0.429
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0538	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus granulosus	7TM GPCR rhodopsin	0.0039	0.2343	0.429
Schistosoma mansoni	hypothetical protein	0.0039	0.2343	0.429
Brugia malayi	putative neuropeptide receptor NPR1	0.0039	0.2343	0.1907
Schistosoma mansoni	amine GPCR	0.0039	0.2343	0.429
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.2343	0.1907
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0039	0.2343	0.1907
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0538	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0538	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0538	0.6244
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0115	0.9224	0.5
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0538	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Brugia malayi	Serotonin receptor	0.0039	0.2343	0.1907
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2343	0.429
Schistosoma mansoni	amine GPCR	0.0039	0.2343	0.429
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.2343	0.429
Brugia malayi	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	histamine h1 receptor	0.0039	0.2343	0.429
Schistosoma mansoni	opsin-like receptor	0.0039	0.2343	0.429
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0039	0.2343	0.429
Onchocerca volvulus		0.0039	0.2343	1
Onchocerca volvulus		0.0039	0.2343	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0538	0.6244
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0039	0.2343	0.1907
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0538	0.6244
Brugia malayi	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	adenoreceptor	0.0039	0.2343	0.429
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.2343	0.429
Brugia malayi	hypothetical protein	0.0039	0.2343	0.1907
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0039	0.2343	0.1907
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0039	0.2343	0.1907
Echinococcus granulosus	hypothetical protein	0.0039	0.2343	0.429
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0039	0.2343	0.429
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0023	0.0862	0.0769
Schistosoma mansoni	hypothetical protein	0.0039	0.2343	0.429
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0039	0.2343	0.429
Schistosoma mansoni	hypothetical protein	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Brugia malayi	TAR-binding protein	0.0066	0.4745	0.4446
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	amine GPCR	0.0039	0.2343	0.429
Onchocerca volvulus		0.0039	0.2343	1
Schistosoma mansoni	amine GPCR	0.0039	0.2343	0.429
Echinococcus granulosus	tar DNA binding protein	0.0066	0.4745	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	growth hormone secretagogue receptor	0.0039	0.2343	0.429
Schistosoma mansoni	biogenic amine receptor	0.0039	0.2343	0.429
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0039	0.2343	0.429
Echinococcus granulosus	g protein coupled receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	opsin-like receptor	0.0039	0.2343	0.429
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0115	0.9224	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.4745	0.4446
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.4745	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0039	0.2343	0.1907
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0039	0.2343	0.429
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0039	0.2343	0.429
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.0948	0.0433
Onchocerca volvulus		0.0039	0.2343	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.2343	0.429
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.2343	0.429
Brugia malayi	Cytochrome P450 family protein	0.0024	0.0948	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Schistosoma mansoni	biogenic amine receptor	0.0039	0.2343	0.429
Brugia malayi	neuropeptide F receptor	0.0039	0.2343	0.1907
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0039	0.2343	0.429
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2343	0.1907
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0039	0.2343	0.429
Echinococcus granulosus	allatostatin A receptor	0.0039	0.2343	0.429
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0039	0.2343	0.429
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.2343	0.429
Echinococcus granulosus	orexin receptor type 2	0.0039	0.2343	0.429
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.2343	0.429
Brugia malayi	Dopamine receptor protein 2	0.0039	0.2343	0.1907
Onchocerca volvulus		0.0039	0.2343	1
Loa Loa (eye worm)	RNA binding protein	0.0066	0.4745	0.4446
Schistosoma mansoni	hypothetical protein	0.0039	0.2343	0.429
Brugia malayi	RE15519p	0.0039	0.2343	0.1907
Schistosoma mansoni	opsin-like receptor	0.0039	0.2343	0.429
Brugia malayi	neuropeptide F receptor	0.0039	0.2343	0.1907

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 881182