Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.3341 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0546 | 0.0546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3341 | 0.3341 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0546 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.3341 | 0.3341 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0546 | 0.0546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3341 | 0.3341 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0546 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3341 | 0.3341 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0546 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0546 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.3341 | 0.3341 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3341 | 0.3341 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.3341 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.3341 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.3341 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0061 | 0.3341 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0546 | 0.0546 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0546 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0546 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0546 | 0.1634 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0546 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0546 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0546 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0546 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0546 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0546 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0546 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0546 | 0.0546 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0546 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0546 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0546 | 0.1634 |
Echinococcus multilocularis | geminin | 0.0164 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0061 | 0.3341 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.