Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sterol regulatory element binding protein | 0.146 | 0.3463 | 0.334 |
Loa Loa (eye worm) | hypothetical protein | 0.146 | 0.3463 | 0.334 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.146 | 0.3463 | 0.334 |
Brugia malayi | CHE-14 protein | 0.146 | 0.3463 | 0.3463 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1664 | 0.4101 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3546 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.146 | 0.3463 | 0.334 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1664 | 0.4101 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3546 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.146 | 0.3463 | 0.334 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3546 | 1 | 0.5 |
Schistosoma mansoni | patched 1 | 0.146 | 0.3463 | 0.334 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.146 | 0.3463 | 0.334 |
Loa Loa (eye worm) | hypothetical protein | 0.3546 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.146 | 0.3463 | 0.334 |
Echinococcus granulosus | Protein patched homolog 1 | 0.146 | 0.3463 | 0.334 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1664 | 0.4101 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1664 | 0.4101 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3546 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3546 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3546 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3546 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3546 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.146 | 0.3463 | 0.334 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.146 | 0.3463 | 0.334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.