Detailed information for compound 881353

Basic information

Technical information
  • TDR Targets ID: 881353
  • Name: 2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3 -yl)-N-[(3-methoxy-4-propan-2-yloxyphenyl)met hylideneamino]acetamide
  • MW: 428.505 | Formula: C21H24N4O4S
  • H donors: 1 H acceptors: 2 LogP: 3.39 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C=NNC(=O)Cn2cnc3c(c2=O)c(C)c(s3)C)ccc1OC(C)C
  • InChi: 1S/C21H24N4O4S/c1-12(2)29-16-7-6-15(8-17(16)28-5)9-23-24-18(26)10-25-11-22-20-19(21(25)27)13(3)14(4)30-20/h6-9,11-12H,10H2,1-5H3,(H,24,26)/b23-9+
  • InChiKey: AWYJEUGZSKQMRA-NUGSKGIGSA-N  

Network

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Synonyms

  • 2-(5,6-dimethyl-4-oxo-thieno[2,3-d]pyrimidin-3-yl)-N-[(4-isopropoxy-3-methoxy-phenyl)methyleneamino]acetamide
  • 2-(5,6-dimethyl-4-oxo-3-thieno[2,3-d]pyrimidinyl)-N-[(4-isopropoxy-3-methoxyphenyl)methyleneamino]acetamide
  • N-[(4-isopropoxy-3-methoxy-benzylidene)amino]-2-(4-keto-5,6-dimethyl-thieno[2,3-d]pyrimidin-3-yl)acetamide
  • 2-(5,6-dimethyl-4-oxo-thieno[2,3-d]pyrimidin-3-yl)-N-[(3-methoxy-4-propan-2-yloxy-phenyl)methylideneamino]ethanamide
  • ST5203636

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0096 0.0389
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0016 0.0009 0.0077
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0028 0.007 0.0196
Trypanosoma brucei glucosidase, putative 0.0036 0.0114 0.2591
Schistosoma mansoni atypical protein kinase C 0.0015 0.0001 0.0002
Brugia malayi isocitrate dehydrogenase 0.0016 0.0006 0.0025
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.3696
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0045 0.0159 0.0447
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0164 0.0668
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0045 0.0159 0.0447
Plasmodium falciparum glutathione reductase 0.0094 0.0421 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0159 0.0648
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0211 0.0592
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0019 0.0309
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0159 0.6717
Brugia malayi RNA binding protein 0.0062 0.0253 0.103
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.0137 0.0556
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1367 0.7159 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Echinococcus granulosus protein kinase c epsilon type 0.0016 0.0007 0.002
Trichomonas vaginalis MYB3r3, putative 0.0038 0.0124 0.5134
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0045 0.0159 0.3696
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0233 0.0947
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0193 0.4498
Schistosoma mansoni smad1 5 8 and 0.0033 0.0096 0.0268
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0421 0.118
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0124 0.5134
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.2151
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0323 0.1631 0.6631
Schistosoma mansoni Smad4 0.0033 0.0096 0.0268
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0496 0.1391
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0193 0.054
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0114 0.2591
Echinococcus granulosus GPCR family 2 0.0016 0.0005 0.0014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0095 0.0086
Schistosoma mansoni hypothetical protein 0.0108 0.0496 0.1391
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0536 0.2764 0.2757
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0095 0.385
Echinococcus granulosus Smad4 0.0033 0.0096 0.0268
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0193 0.4498
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0124 0.5134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.2151
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.0783 0.2195
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0114 0.4666
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0193 0.4499
Onchocerca volvulus 0.0094 0.042 0.2768
Loa Loa (eye worm) hypothetical protein 0.0044 0.0158 0.0643
Trypanosoma brucei unspecified product 0.004 0.0137 0.3144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0137 0.3144
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.3696
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0193 0.4499
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0019 0.0309
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0253 0.071
Giardia lamblia Myb 1-like protein 0.0038 0.0125 0.0622
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0096 0.0389
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.0284
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0124 0.5134
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0019 0.0309
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0421 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0114 0.2143
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0095 0.2151
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0233 0.5464
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.3696
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0183 0.0744
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0233 0.0947
Plasmodium falciparum thioredoxin reductase 0.0094 0.0421 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0045 0.0159 0.3696
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0193 0.8206
Brugia malayi MH1 domain containing protein 0.0018 0.0018 0.0075
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0193 0.0987
Loa Loa (eye worm) PDE1B protein 0.0045 0.0159 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0159 0.6717
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0239 0.1186 0.0208
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0253 0.103
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0016 0.0009 0.0077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0019 0.0309
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0193 0.4498
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.3696
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0114 0.2591
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0193 0.4499
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0114 0.0462
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0233 1
Schistosoma mansoni hypothetical protein 0.068 0.3523 0.988
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0022 0.0383
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0014
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0193 0.054
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0014
Schistosoma mansoni hypothetical protein 0.0023 0.0044 0.0123
Brugia malayi MH2 domain containing protein 0.0479 0.2459 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0006 0.0017
Echinococcus multilocularis protein kinase c iota type 0.0015 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0108 0.0496 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0095 0.0324
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0193 0.054
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0019 0.0309
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0017 0.0015 0.0207
Echinococcus granulosus dna polymerase kappa 0.0059 0.0233 0.0653
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0536 0.2764 1
Brugia malayi hypothetical protein 0.0051 0.0193 0.0784
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0045 0.0159 0.3696
Entamoeba histolytica hypothetical protein 0.0108 0.0496 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0096 0.0268
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0159 0.3696
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0536 0.2764 0.2694
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0022 0.0567
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0022 0.0068
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0193 0.8206
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0367 0.1867 0.5237
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0019 0.0053
Schistosoma mansoni DNA polymerase eta 0.0084 0.0368 0.1033
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0096 0.0268
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0028 0.007 0.0196
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0114 0.2143
Brugia malayi hypothetical protein 0.0301 0.1518 0.6173
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0233 0.0653
Echinococcus granulosus calcium transporting atpase 0.0025 0.0053 0.0147
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0159 0.3696
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Brugia malayi hypothetical protein 0.0122 0.057 0.2316
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.0014
Brugia malayi Thioredoxin reductase 0.0094 0.0421 0.1712
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0239 0.1186 0.1649
Loa Loa (eye worm) hypothetical protein 0.0034 0.0101 0.0409
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0154 0.3575
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0233 0.0653
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0159 0.0447
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0095 0.385
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.2151
Giardia lamblia DNA damage repair protein 0.0018 0.0019 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Echinococcus multilocularis geminin 0.068 0.3523 0.988
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0233 0.5464
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Giardia lamblia DINP protein human, muc B family 0.0059 0.0233 0.1203
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0019 0.0025 0.0101
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0783 0.2195
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0016 0.0009 0.0038
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0114 0.4666
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0114 0.0462
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0367 0.1867 0.675
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0383
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0783 0.3183
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0159 0.3696
Onchocerca volvulus Huntingtin homolog 0.0122 0.057 0.3751
Giardia lamblia hypothetical protein 0.0045 0.0159 0.0808
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0233 0.0224
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0193 0.4499
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0096 0.0268
Plasmodium falciparum calcium-transporting ATPase 0.0025 0.0053 0.1119
Loa Loa (eye worm) hypothetical protein 0.0049 0.0183 0.0744
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0019 0.0309
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0045 0.0159 0.0447
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0159 0.3696
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0124 0.2358
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0233 0.5464
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.0127 0.0355
Echinococcus granulosus microtubule associated protein 2 0.0688 0.3566 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0193 0.4498
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0028 0.007 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0095 0.2151
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0006 0.0025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0022 0.0261
Brugia malayi MH2 domain containing protein 0.0033 0.0096 0.0389
Leishmania major DNA polymerase eta, putative 0.0044 0.0154 0.3575
Brugia malayi MAP kinase sur-1 0.0051 0.0193 0.0784
Entamoeba histolytica hypothetical protein 0.0108 0.0496 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0367 0.1867 0.5237
Echinococcus granulosus dna polymerase eta 0.0084 0.0368 0.1033
Loa Loa (eye worm) transcription factor SMAD2 0.0479 0.2459 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0044 0.0123
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0045 0.0159 0.0447
Loa Loa (eye worm) hypothetical protein 0.0051 0.0193 0.0784
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0016 0.0009 0.0077
Trichomonas vaginalis C-MYB, putative 0.0038 0.0124 0.5134
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0253 0.071
Loa Loa (eye worm) hypothetical protein 0.0122 0.057 0.2316
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0253 0.071
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0019 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0193 0.8206
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0095 0.2151
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0783 0.3183
Brugia malayi glutathione reductase 0.0094 0.0421 0.1712
Toxoplasma gondii exonuclease III APE 0.0019 0.0022 0.0058
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0095 0.0074
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0114 0.4666
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0017
Plasmodium vivax calcium-transporting ATPase, putative 0.0028 0.007 0.1536
Loa Loa (eye worm) hypothetical protein 0.0045 0.0159 0.0648
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0137 0.3144
Leishmania major calcium-translocating P-type ATPase 0.0028 0.007 0.1536
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0101 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0164 0.0461
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Onchocerca volvulus 0.0301 0.1518 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0028 0.007 0.1536
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0045 0.0159 0.3696
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0095 0.0125
Brugia malayi MH2 domain containing protein 0.0033 0.0096 0.0389
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0053 0.0147
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1903 1 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0159 0.0447
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0028 0.007 0.0196
Leishmania major DNA polymerase kappa, putative 0.0018 0.0019 0.0309
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0019 0.0046
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0253 0.103
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0239 0.1186 0.1649
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0159 0.6717
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0045 0.0159 0.3696
Leishmania major DNA damage repair protein, putative 0.0018 0.0019 0.0309
Plasmodium falciparum phosphodiesterase delta, putative 0.0045 0.0159 0.3696
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0095 0.2151
Plasmodium falciparum glutathione reductase 0.0033 0.0095 0.2151
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0045 0.0159 0.0447
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0114 0.4666
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0019 0.0309
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0114 0.0319
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0022 0.009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0193 0.054
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0045 0.0159 0.3696
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.3696
Loa Loa (eye worm) hypothetical protein 0.0301 0.1518 0.6173
Trypanosoma brucei unspecified product 0.004 0.0137 0.3144
Echinococcus multilocularis Smad4 0.0033 0.0096 0.0268
Echinococcus multilocularis protein kinase c epsilon type 0.0016 0.0007 0.002
Echinococcus granulosus protein kinase C gamma type 0.0049 0.018 0.0505
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0095 0.2151
Schistosoma mansoni ATPase 0.0028 0.007 0.0196
Schistosoma mansoni smad1 5 8 and 0.0033 0.0096 0.0268
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0114 0.4666
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0045
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0215 0.1059 0.1472
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0005 0.0021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Echinococcus multilocularis calcium transporting atpase 0.0025 0.0053 0.0147
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0095 0.0074
Trichomonas vaginalis MYB, putative 0.0038 0.0125 0.5177
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0193 0.0784
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0022 0.0062
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0137 0.3144
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0367 0.1867 0.5237
Loa Loa (eye worm) hypothetical protein 0.0039 0.0127 0.0515
Loa Loa (eye worm) hypothetical protein 0.0367 0.1867 0.7593
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.3696
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0095 0.2151
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0114 0.4666
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0095 0.2151
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.007 0.2707
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Brugia malayi ImpB/MucB/SamB family protein 0.0084 0.0368 0.1497
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0164 0.0461
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0045 0.0159 0.3696
Leishmania major DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.2151
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0045 0.0159 0.0447
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0124 0.5134
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0233 0.0224
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0095 0.0086
Plasmodium vivax P-type ATPase4, putative 0.0028 0.007 0.1536
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0114 0.2591
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0077
Schistosoma mansoni ATPase 0.0028 0.007 0.0196
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0028 0.007 0.1536
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0183 0.0744
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0017
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0421 0.058
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0007 0.002
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0016 0.0009 0.0026
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.0127 0.0355
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0028 0.007 0.0231
Mycobacterium ulcerans hypothetical protein 0.0018 0.0019 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0159 0.3696
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0159 0.0447
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0045 0.0159 0.0447
Brugia malayi polk-prov protein 0.0018 0.0019 0.0077
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0045 0.0159 0.0447
Schistosoma mansoni alpha-glucosidase 0.014 0.0663 0.186
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0016 0.0009 0.0077
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0421 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0253 0.071
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0323 0.1631 0.6631
Brugia malayi hypothetical protein 0.0108 0.0496 0.2016
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0383
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0045 0.0159 0.0447
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0006 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0114 0.4666
Schistosoma mansoni hypothetical protein 0.0034 0.0101 0.0282
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0323 0.1631 0.4573
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0096 0.0268
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0095 0.2151
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0193 0.4499
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0095 0.0086
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0124 0.5134
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0215 0.1059 0.1472
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.3566 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0045 0.0159 0.0648
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.007 0.2707
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0253 0.071
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0022 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0159 0.3696
Plasmodium vivax phosphodiesterase gamma, putative 0.0045 0.0159 0.3696
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0022 0.0567
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0022 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0159 0.3696
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0019 0.0046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Onchocerca volvulus 0.0016 0.0009 0.0062
Brugia malayi TAR-binding protein 0.0062 0.0253 0.103
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0211 0.0592
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Loa Loa (eye worm) hypothetical protein 0.0045 0.0159 0.0648
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0159 0.6717
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0215 0.1059 0.1472
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0114 0.0319
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0019 0.0309
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0016 0.0009 0.0077
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0053 0.0214
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0233 0.0317
Treponema pallidum NADH oxidase 0.0033 0.0095 0.0074
Toxoplasma gondii P-type ATPase4, putative 0.0016 0.0009 0.0012
Brugia malayi MH1 domain containing protein 0.0018 0.0018 0.0075
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0045 0.0159 0.3696
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0006 0.0017
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0783 0.2195
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0016 0.0009 0.0077
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0016 0.0009 0.0012
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.3696
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0005 0.0021
Schistosoma mansoni smad 0.0033 0.0096 0.0268
Trypanosoma brucei unspecified product 0.0059 0.0233 0.5464
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0193 0.4498
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0124 0.2358
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0323 0.1631 0.4573
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0095 0.2151
Schistosoma mansoni hypothetical protein 0.068 0.3523 0.988
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0062
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0114 0.4666
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0095 0.2151
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0233 0.0653
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0045 0.0159 0.0648
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0019 0.0309
Echinococcus granulosus smad 0.0033 0.0096 0.0268
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.3566 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.2151
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0159 0.6717
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0164 0.0461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0164 0.0668
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0124 0.5134
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.005 0.0202
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0193 0.4498
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0022 0.009
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0233 1
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0014
Echinococcus granulosus Protein kinase C brain isozyme 0.0054 0.0211 0.0592
Loa Loa (eye worm) Smad1 0.0033 0.0096 0.0389
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0019 0.0025 0.0101
Toxoplasma gondii thioredoxin reductase 0.0094 0.0421 0.1504
Trichomonas vaginalis C-MYB, putative 0.0038 0.0124 0.5134
Leishmania major hypothetical protein, conserved 0.0045 0.0159 0.3696
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0038 0.0125 0.0431
Leishmania major trypanothione reductase 0.0094 0.0421 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0005 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0095 0.0267
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0159 0.0447
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.0368 0.873
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0045 0.0159 0.0447
Giardia lamblia Hypothetical protein 0.0045 0.0159 0.0808
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0095 0.2151
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0164 0.0461
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0019 0.0309
Loa Loa (eye worm) hypothetical protein 0.0122 0.057 0.2316
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0367 0.1867 0.5237
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0193 0.0677
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0044 0.0123
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0193 0.4499
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0045 0.0159 0.3696
Onchocerca volvulus Huntingtin homolog 0.0122 0.057 0.3751
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0125 0.5177
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0253 0.103
Trypanosoma brucei trypanothione reductase 0.0094 0.0421 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0045 0.0159 0.0447
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0095 0.2151
Loa Loa (eye worm) nuclear factor I 0.0018 0.0018 0.0075
Echinococcus multilocularis dna polymerase eta 0.0084 0.0368 0.1033
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0053 0.0147
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0005 0.0021
Mycobacterium tuberculosis Probable dehydrogenase 0.0215 0.1059 0.1472
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.0014
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0193 0.054
Brugia malayi Protein kinase c protein 2 0.0046 0.0168 0.0683
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0022 0.0022
Schistosoma mansoni smad1 5 8 and 0.0033 0.0096 0.0268
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0045 0.0159 0.3696
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0124 0.5134
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1903 1 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0114 0.039
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0017
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0159 0.3696
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0164 0.0461
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0159 0.6717
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0159 0.3696
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0233 0.4593
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0095 0.0267
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0045 0.0159 0.0648
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0233 0.5464
Entamoeba histolytica hypothetical protein 0.0108 0.0496 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0045 0.0159 0.0447
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0124 0.2358
Leishmania major hypothetical protein, conserved 0.0045 0.0159 0.3696
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Echinococcus granulosus protein kinase c iota type 0.0015 0.0001 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0095 0.2151
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0159 0.0447
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0253 0.071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0022 0.0383
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0367 0.1867 0.5237
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0019 0.0309
Plasmodium vivax glutathione reductase, putative 0.0094 0.0421 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0016 0.0009 0.0077
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0045 0.0159 0.0447
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0114 0.4666
Loa Loa (eye worm) hypothetical protein 0.0045 0.0159 0.0648
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0016 0.0009 0.0026
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1367 0.7159 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0233 0.0317
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0421 0.1712
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0075
Brugia malayi MH1 domain containing protein 0.0033 0.0096 0.0389
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0159 0.0447
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0496 0.1391
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.2151
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0154 0.0538
Mycobacterium tuberculosis Probable reductase 0.0215 0.1059 0.1472
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0095 0.0267
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0028 0.007 0.0061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0038
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0233 0.0653
Loa Loa (eye worm) RNA binding protein 0.0062 0.0253 0.103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.2151
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0193 0.0677
Echinococcus multilocularis smad 0.0033 0.0096 0.0268
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0159 0.0648
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0496 0.1391
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0025 0.0053 0.0147
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0006 0.0017
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1903 1 1
Brugia malayi hypothetical protein 0.0033 0.0097 0.0395
Loa Loa (eye worm) hypothetical protein 0.0084 0.0368 0.1497
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0124 0.2358
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0536 0.2764 0.2794
Brugia malayi MH1 domain containing protein 0.0033 0.0096 0.0389
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0045 0.0159 0.0648
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0016 0.0007 0.0029
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0096 0.0268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.2151
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0062
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0095 0.0388
Plasmodium falciparum thioredoxin reductase 0.0033 0.0095 0.2151
Trypanosoma brucei DNA polymerase eta, putative 0.0084 0.0368 0.873
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0367 0.1867 1
Schistosoma mansoni alpha-glucosidase 0.014 0.0663 0.186
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0045 0.0159 0.3696
Echinococcus granulosus tar DNA binding protein 0.0062 0.0253 0.071
Echinococcus multilocularis serine threonine protein kinase 0.0049 0.018 0.0505
Plasmodium falciparum phosphodiesterase gamma, putative 0.0045 0.0159 0.3696
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0045 0.0159 0.3696
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0124 0.2358
Loa Loa (eye worm) glutathione reductase 0.0094 0.0421 0.1712
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0022 0.0383
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0054 0.0211 0.0592
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0095 0.0463
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.005 0.0202
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0019 0.0309
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0095 0.0324
Schistosoma mansoni alpha glucosidase 0.0036 0.0114 0.0319
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0159 0.3696
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0159 0.0648
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0193 0.4498
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0193 0.8206
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.0127 0.0355
Leishmania major hypothetical protein, conserved 0.0051 0.0193 0.4499
Trypanosoma brucei protein kinase, putative 0.0051 0.0193 0.4498
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0124 0.5134
Trypanosoma brucei calcium-translocating P-type ATPase 0.0025 0.0053 0.1119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.0014
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0159 0.6717
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0045 0.0159 0.0447
Leishmania major DNA polymerase eta, putative 0.0084 0.0368 0.873
Mycobacterium tuberculosis Probable oxidoreductase 0.0239 0.1186 0.1649
Brugia malayi Na,K-ATPase alpha subunit 0.0016 0.0009 0.0038
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0022 0.0383
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0045 0.0159 0.0447
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0164 0.0461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0164 0.0461
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Loa Loa (eye worm) MH2 domain-containing protein 0.0479 0.2459 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0233 0.0653
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Echinococcus granulosus geminin 0.068 0.3523 0.988
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0159 0.3696
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0183 0.0744
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0125 0.5177
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0215 0.1059 0.1472
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0045 0.0159 0.0447
Brugia malayi Smad1 0.0033 0.0096 0.0389
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0159 0.6717
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0159 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0233 0.5464
Brugia malayi protein kinase C II. 0.0016 0.0007 0.0029
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0016 0.0009 0.0026
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0421 0.118
Trichomonas vaginalis MYB72, putative 0.0038 0.0124 0.5134

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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