Detailed information for compound 88146

Basic information

Technical information
  • TDR Targets ID: 88146
  • Name: (E)-3-[2-(trifluoromethyl)phenyl]-1-(3,4,5-tr imethoxyphenyl)prop-2-en-1-one
  • MW: 366.331 | Formula: C19H17F3O4
  • H donors: 0 H acceptors: 1 LogP: 4.49 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)/C=C/c1ccccc1C(F)(F)F
  • InChi: 1S/C19H17F3O4/c1-24-16-10-13(11-17(25-2)18(16)26-3)15(23)9-8-12-6-4-5-7-14(12)19(20,21)22/h4-11H,1-3H3/b9-8+
  • InChiKey: VNWRUEWCRKSXRV-CMDGGOBGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-[2-(trifluoromethyl)phenyl]-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one
  • T5394879

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0032 0.0276 0.0491
Loa Loa (eye worm) peptidase family M1 containing protein 0.0025 0.0189 0.0354
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0711 0.2818
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0189 0.0354
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0016 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0016 0.0028
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0346 0.0838
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0619 0.1138
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0184 0.1493
Leishmania major hypothetical protein, conserved 0.0038 0.0346 0.6881
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0346 0.0838
Loa Loa (eye worm) hypothetical protein 0.007 0.0711 0.1337
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0184 0.9201
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0016 0.0064
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0479 0.0477
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0346 0.0345
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0028
Loa Loa (eye worm) hypothetical protein 0.0038 0.0346 0.0648
Leishmania major hypothetical protein, conserved 0.0024 0.0184 0.3089
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0016 0.0064
Brugia malayi hypothetical protein 0.0024 0.0184 0.073
Mycobacterium tuberculosis Conserved protein 0.0038 0.0346 0.0838
Schistosoma mansoni hypothetical protein 0.0032 0.0276 0.0491
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0189 0.3206
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0307 0.5969
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0307 0.5969
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0127 0.1741
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0479 1
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0189 0.3206
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0189 0.2852
Echinococcus granulosus dnaJ subfamily B 0.0397 0.4487 0.8443
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1728 0.6846
Echinococcus granulosus cpg binding protein 0.0029 0.0242 0.0453
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.2739 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0025 0.0189 0.0327
Brugia malayi TAR-binding protein 0.0062 0.0619 0.2452
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0189 0.3206
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0016 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0479 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0307 0.5969
Echinococcus granulosus GPCR family 2 0.0032 0.0276 0.0518
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0619 0.2452
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1728 0.1727
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0016 0.0015
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0189 0.2852
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0016 0.0028
Brugia malayi beta-lactamase 0.0038 0.0346 0.137
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0479 0.0873
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0479 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0276 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0016 0.0064
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0127 0.0126
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0189 0.3206
Loa Loa (eye worm) hypothetical protein 0.0103 0.1086 0.2042
Loa Loa (eye worm) beta-lactamase 0.0038 0.0346 0.0648
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0184 0.3089
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0016 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0276 0.0518
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0189 0.0354
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0512 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0346 0.5691
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0127 0.0502
Schistosoma mansoni ap endonuclease 0.002 0.0127 0.0209
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0016 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0016 0.0028
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0189 0.0188
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0189 0.3206
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0025 0.0189 0.0327
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0996 0.1849
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0189 0.3206
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0346 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0346 0.6881
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0346 0.0648
Entamoeba histolytica aminopeptidase, putative 0.0025 0.0189 0.5371
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0307 0.5969
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0127 0.2916
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0346 0.6881
Loa Loa (eye worm) hypothetical protein 0.0038 0.0346 0.0648
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0016 0.0015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0346 0.0838
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0016 0.0028
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0307 0.0575
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0479 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0189 0.0188
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0584 0.1073
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0619 0.1163
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0479 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0189 0.3206
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0346 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0346 0.0622
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0189 0.3206
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0127 0.0236
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0016 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0016 0.0064
Schistosoma mansoni hypothetical protein 0.0347 0.3901 0.7333
Loa Loa (eye worm) RNA binding protein 0.0062 0.0619 0.1163
Schistosoma mansoni hypothetical protein 0.0032 0.0276 0.0491
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0276 0.0275
Loa Loa (eye worm) hypothetical protein 0.0038 0.0346 0.0648
Schistosoma mansoni hypothetical protein 0.0347 0.3901 0.7333
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0016 0.0064
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0189 0.2852
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0016 0.0028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.0354
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0016 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0307 0.5969
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0016 0.0015
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0189 0.075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1086 0.4303
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0184 0.3089
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0016 0.0028
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0053 0.0387
Schistosoma mansoni hypothetical protein 0.0032 0.0276 0.0491
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0189 0.3206
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0028
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0189 0.3206
Mycobacterium ulcerans lipase LipD 0.0038 0.0346 1
Schistosoma mansoni alpha-glucosidase 0.0136 0.1474 0.2751
Mycobacterium tuberculosis Conserved protein 0.0038 0.0346 0.0838
Brugia malayi steroid hormone receptor 0.001 0.0016 0.0064
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.2524 0.4749
Brugia malayi TATA binding protein associated factor 0.0025 0.0189 0.075
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0307 0.5969
Brugia malayi MAP kinase sur-1 0.005 0.0479 0.1896
Schistosoma mansoni hypothetical protein 0.007 0.0711 0.1312
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0016 0.0028
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0189 0.0354
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0469 0.5314 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0479 1
Brugia malayi hypothetical protein 0.0025 0.0189 0.075
Onchocerca volvulus 0.0038 0.0346 0.3499
Echinococcus multilocularis aminopeptidase N 0.0025 0.0189 0.0188
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0307 0.1216
Toxoplasma gondii aminopeptidase N protein 0.0025 0.0189 0.1623
Brugia malayi RNA binding protein 0.0062 0.0619 0.2452
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0479 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1728 0.1727
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0184 0.9201
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0346 0.0838
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0016 0.0064
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0307 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0996 0.1849
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0346 0.6881
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0346 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0189 0.3206
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1728 0.325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0016 0.0064
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0184 0.2624
Echinococcus granulosus aminopeptidase N 0.0025 0.0189 0.0354
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0016 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0016 0.0064
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0307 0.5969
Brugia malayi beta-lactamase family protein 0.0038 0.0346 0.137
Brugia malayi nuclear hormone receptor 0.001 0.0016 0.0064
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0189 0.0188
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0028
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0127 0.1741
Schistosoma mansoni alpha glucosidase 0.0035 0.0307 0.0549
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0127 0.1741
Echinococcus granulosus leukotriene A 4 hydrolase 0.0469 0.5314 1
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0189 0.075
Loa Loa (eye worm) hypothetical protein 0.0038 0.0346 0.0648
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0127 0.1741
Schistosoma mansoni ap endonuclease 0.002 0.0127 0.0209
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1728 0.325
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0025 0.0189 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0016 0.0064
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0053 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.0354
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0996 0.3945
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.0354
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0346 0.6881
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0996 0.1849
Onchocerca volvulus 0.0025 0.0189 0.1837
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0127 0.5
Mycobacterium ulcerans hypothetical protein 0.0038 0.0346 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0189 0.2852
Brugia malayi ecdysteroid receptor 0.001 0.0016 0.0064
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0307 0.5969
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0479 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0016 0.0064
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0479 0.0899
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.0189 0.0327
Mycobacterium ulcerans beta-lactamase 0.0038 0.0346 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0184 0.0344
Onchocerca volvulus 0.0092 0.0958 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0996 0.1872
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0307 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0016 0.0028
Onchocerca volvulus 0.0038 0.0346 0.3499
Echinococcus granulosus FTZ F1 alpha 0.001 0.0016 0.0028
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0346 0.0838
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0479 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0346 0.6881
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0307 0.5969
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0016 0.0028
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0307 0.5969
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0346 0.6881
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0996 0.0995
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0016 0.0064
Loa Loa (eye worm) aminopeptidase N 0.0025 0.0189 0.0354
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0189 0.3206
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0224 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0016 0.0028
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0189 0.0188
Mycobacterium tuberculosis Conserved protein 0.0038 0.0346 0.0838
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0025 0.0189 0.0188
Trypanosoma brucei glucosidase, putative 0.0035 0.0307 0.5969
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0469 0.5314 0.5313
Onchocerca volvulus 0.0025 0.0189 0.1837
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0479 1
Onchocerca volvulus 0.0025 0.0189 0.1837
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0189 0.0354
Loa Loa (eye worm) hypothetical protein 0.0032 0.0276 0.0518
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1086 0.4303
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0996 0.0995
Echinococcus granulosus geminin 0.0347 0.3901 0.7341
Schistosoma mansoni cpg binding protein 0.0029 0.0242 0.0426
Trypanosoma cruzi Aminopeptidase M1, putative 0.0025 0.0189 0.3206
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0479 1
Toxoplasma gondii aminopeptidase N, putative 0.0025 0.0189 0.1623
Brugia malayi nuclear receptor NHR-88 0.001 0.0016 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0016 0.0064
Brugia malayi follicle stimulating hormone receptor 0.0227 0.2524 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0619 0.1163
Toxoplasma gondii aminopeptidase n, putative 0.0025 0.0189 0.1623
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0189 0.3206
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.4487 0.4486
Trypanosoma brucei protein kinase, putative 0.005 0.0479 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0307 0.4682
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0189 0.3206
Loa Loa (eye worm) hypothetical protein 0.0038 0.0346 0.0648
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0346 0.137
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0346 0.0838
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0016 0.0064
Schistosoma mansoni cpg binding protein 0.0029 0.0242 0.0426
Echinococcus multilocularis GPCR, family 2 0.0032 0.0276 0.0275
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0028 0.0027
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0189 0.0188
Onchocerca volvulus 0.0038 0.0346 0.3499
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0307 0.5969
Brugia malayi hypothetical protein 0.0016 0.0084 0.0333
Brugia malayi CXXC zinc finger family protein 0.0028 0.0224 0.0886
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0016 0.0028
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0189 0.3206
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0479 0.0899
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0127 0.0236
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0619 0.1138
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0307 0.0575
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0996 0.1872
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0189 0.0354
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0346 0.6881
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0016 0.0064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0346 0.0622
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0346 0.0838
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0276 0.1095
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.0189 0.0327
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0127 0.5
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0028 0.0051
Mycobacterium leprae Probable lipase LipE 0.0038 0.0346 0.5
Echinococcus granulosus tar DNA binding protein 0.0062 0.0619 0.1163
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0479 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0346 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0016 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0184 0.3089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0016 0.0064
Trichomonas vaginalis esterase, putative 0.0038 0.0346 0.6881
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0189 0.3206
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0469 0.5314 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0307 0.5969
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0996 0.1872
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0619 0.0618
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0097
Onchocerca volvulus 0.0028 0.0224 0.2202
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1086 0.2042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0016 0.0028
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.0189 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0619 0.1138
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0189 0.075
Schistosoma mansoni hypothetical protein 0.0011 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0346 0.0648
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0619 0.1138
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0127 0.1741
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0346 0.6881
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0276 0.0518
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0189 0.0354
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0479 0.0899
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0479 0.0477
Echinococcus multilocularis geminin 0.0347 0.3901 0.39
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0189 0.3206
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0479 0.9144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0016 0.0028
Schistosoma mansoni alpha-glucosidase 0.0136 0.1474 0.2751
Schistosoma mansoni hypothetical protein 0.0397 0.4487 0.8438
Brugia malayi hypothetical protein 0.0025 0.0189 0.075
Echinococcus multilocularis cpg binding protein 0.0029 0.0242 0.0241
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0619 0.1138
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0276 0.1095
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0127 0.1741
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0276 0.0518
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0307 0.0306
Brugia malayi hypothetical protein 0.0216 0.239 0.9468
Brugia malayi beta-lactamase family protein 0.0038 0.0346 0.137
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0189 0.0354
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0189 0.3206
Schistosoma mansoni cpg binding protein 0.0028 0.0224 0.0391
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0346 0.0648
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0016 0.0028

Activities

Activity type Activity value Assay description Source Reference
ED (functional) = 100 ug ml-1 In vitro antimitotic activity against HeLa cells after 6 hours exposure ChEMBL. 2362275
ED (functional) = 100 ug ml-1 In vitro antimitotic activity against HeLa cells after 6 hours exposure ChEMBL. 2362275
FC (functional) = 3 Induction of Nrf2-mediated GCLM gene expression in human BEAS2B cells at 10 uM after 16 hrs by RT-PCR analysis relative to untreated control ChEMBL. 21539383
FC (functional) = 3.1 Induction of Nrf2-mediated NQO1 gene expression in human BEAS2B cells at 10 uM after 16 hrs by RT-PCR analysis relative to untreated control ChEMBL. 21539383

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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