Detailed information for compound 881467

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.425 | Formula: C18H18N4O4S
  • H donors: 2 H acceptors: 3 LogP: 2.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1sc2c(c1)c(=O)n(cn2)CC(=O)N/N=C/c1ccc(c(c1)OC)O
  • InChi: 1S/C18H18N4O4S/c1-3-12-7-13-17(27-12)19-10-22(18(13)25)9-16(24)21-20-8-11-4-5-14(23)15(6-11)26-2/h4-8,10,23H,3,9H2,1-2H3,(H,21,24)/b20-8+
  • InChiKey: AZZIYTSVSSBMDR-DNTJNYDQSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni notch 0.0017 0.0009 0.0019
Echinococcus granulosus fibropellin Ia 0.0017 0.0009 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0039 0.0246
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Echinococcus granulosus heat shock protein 90 0.0032 0.0119 0.0248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0039 0.0246
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0025 0.0044
Trichomonas vaginalis endoplasmin, putative 0.0019 0.003 0.0278
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0009 0.0032
Brugia malayi heat shock protein 90 0.0032 0.0119 0.0739
Brugia malayi EGF-like domain containing protein 0.0017 0.0009 0.0056
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0262 0.1635
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0156
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0072 0.01
Echinococcus granulosus expressed conserved protein 0.009 0.0544 0.1138
Echinococcus multilocularis protein patched 0.0041 0.0188 0.0333
Echinococcus multilocularis notch 0.0017 0.0009 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0019
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0005 0.0011
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0119 0.0432
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0072 0.2869
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Echinococcus granulosus slit 2 protein 0.0017 0.0009 0.0019
Trichomonas vaginalis pc-MYB2, putative 0.0019 0.0027 0.01
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) hypothetical protein 0.0119 0.0756 0.4716
Echinococcus granulosus protein jagged 2 0.0017 0.0009 0.0019
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.4779 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0391 0.2739 0.3768
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0039 0.0246
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0039 0.0284
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0009 0.0019
Echinococcus multilocularis endoplasmin 0.0025 0.0072 0.0127
Brugia malayi hypothetical protein 0.0051 0.0262 0.1635
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0039 0.0083
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0025 0.0052
Echinococcus granulosus dna polymerase eta 0.0019 0.0025 0.0052
Onchocerca volvulus 0.0051 0.0262 0.2367
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0119 1
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0586 0.3653
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0246
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0025 0.2095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0039 0.0246
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0 0.0001
Schistosoma mansoni hypothetical protein 0.004 0.0177 0.037
Brugia malayi nuclear hormone receptor 0.0021 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0246
Echinococcus granulosus delta-like protein 1 0.0017 0.0009 0.0019
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0039 0.0083
Loa Loa (eye worm) hypothetical protein 0.0119 0.0756 0.4716
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0262 0.2367
Loa Loa (eye worm) notch protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0025 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0039 0.0083
Schistosoma mansoni slit 0.0017 0.0009 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0039 0.0246
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0119 1
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0262 0.1635
Schistosoma mansoni hypothetical protein 0.0033 0.013 0.0271
Brugia malayi EGF-like domain containing protein 0.0017 0.0009 0.0056
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0039 0.0246
Echinococcus granulosus peroxidasin 0.0051 0.0262 0.0549
Schistosoma mansoni hypothetical protein 0.004 0.0177 0.037
Echinococcus granulosus protein jagged 1 0.0017 0.0009 0.0019
Brugia malayi hypothetical protein 0.0119 0.0756 0.4716
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0262 0.1635
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0039 0.007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0246
Onchocerca volvulus Huntingtin homolog 0.0119 0.0756 0.6987
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0027 0.01
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0019
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0039 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0027 0.01
Echinococcus multilocularis geminin 0.0348 0.2424 0.4302
Brugia malayi Isocitrate dehydrogenase 0.0015 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0188 0.0393
Brugia malayi hypothetical protein 0.0025 0.0067 0.0417
Onchocerca volvulus Dual oxidase homolog 0.0051 0.0262 0.2367
Schistosoma mansoni notch 0.0017 0.0009 0.0019
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0005 0.0011
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0009 0.0016
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0039 0.0083
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0246
Echinococcus granulosus microtubule associated protein 2 0.0671 0.4779 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0997 0.7149 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0025 0.2095
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0119 0.0432
Brugia malayi Delta serrate ligand family protein 0.0017 0.0009 0.0056
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0072 0.6037
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0027 0.01
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0032
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0005 0.0032
Schistosoma mansoni hypothetical protein 0.004 0.0177 0.037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Trichomonas vaginalis heat shock protein, putative 0.0019 0.003 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0242 0.1506
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0009 0.0019
Onchocerca volvulus Peroxidase homolog 0.0051 0.0262 0.2367
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0586 0.1226
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0039 0.0083
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0262 0.1635
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0119 0.1668
Onchocerca volvulus 0.0021 0.0039 0.0284
Onchocerca volvulus 0.0051 0.0262 0.2367
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0039 0.0083
Onchocerca volvulus Huntingtin homolog 0.0119 0.0756 0.6987
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0119 1
Schistosoma mansoni cell polarity protein 0.0017 0.0009 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0039 0.0284
Trichomonas vaginalis C-MYB, putative 0.0019 0.0027 0.01
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1388 1 1
Brugia malayi notch-like transmembrane receptor 0.0017 0.0009 0.0056
Brugia malayi Smad1 0.0016 0.0005 0.0032
Onchocerca volvulus 0.0051 0.0262 0.2367
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0009 0.0019
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0119 0.1668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0009 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0039 0.0246
Brugia malayi hypothetical protein 0.0163 0.1079 0.6725
Schistosoma mansoni smad 0.0016 0.0005 0.0011
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0119 1
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0009 0.0019
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0039 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0391 0.2739 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0039 0.007
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0039 0.0083
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Schistosoma mansoni peroxidasin 0.0051 0.0262 0.0549
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0009 0.0016
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0019 0.0027 0.0099
Onchocerca volvulus Chorion peroxidase homolog 0.0051 0.0262 0.2367
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0009 0.0016
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0025 0.0044
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0119 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0039 0.0083
Schistosoma mansoni hypothetical protein 0.028 0.193 0.4039
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.5635 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0067 0.5632
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0019
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0039 0.0083
Brugia malayi ecdysteroid receptor 0.0021 0.0039 0.0246
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0039 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0246
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0009 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0067 0.5632
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Schistosoma mansoni hypothetical protein 0.0348 0.2424 0.5073
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0039 0.0083
Onchocerca volvulus 0.0163 0.1079 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0072 0.6037
Leishmania major hypothetical protein, conserved 0.0025 0.0067 0.5632
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0067 0.5632
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1604 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0039 0.0083
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0262 0.2367
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0039 0.0246
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0242 0.1506
Echinococcus multilocularis protein jagged 1 0.0017 0.0009 0.0016
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0188 0.0333
Schistosoma mansoni hypothetical protein 0.0348 0.2424 0.5073
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0011
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0025 0.2095
Echinococcus granulosus heat shock protein 90 0.0025 0.0072 0.015
Echinococcus multilocularis protein dispatched 1 0.0047 0.023 0.0408
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0262 0.1635
Trichomonas vaginalis C-MYB, putative 0.0019 0.0027 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0039 0.0246
Echinococcus multilocularis protein jagged 1 0.0017 0.0009 0.0016
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0039 0.007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0039 0.0083
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0027 0.01
Loa Loa (eye worm) Smad1 0.0016 0.0005 0.0032
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0119 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0039 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0039 0.0246
Schistosoma mansoni Smad4 0.0016 0.0005 0.0011
Brugia malayi Blistered cuticle protein 3 0.0051 0.0262 0.1635
Schistosoma mansoni coup transcription factor 0.0021 0.0039 0.0083
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0039 0.0284
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0119 1
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0119 0.0739
Giardia lamblia Myb 1-like protein 0.0019 0.0027 0.1663
Schistosoma mansoni septate junction protein 0.0017 0.0009 0.0019
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.013 0.0809
Schistosoma mansoni notch 0.0017 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.005 0.0255 0.159
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0119 1
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0262 0.1635
Trichomonas vaginalis MYB3r3, putative 0.0019 0.0027 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Schistosoma mansoni smad1 5 8 and 0.0016 0.0005 0.0011
Schistosoma mansoni notch 0.0017 0.0009 0.0019
Loa Loa (eye worm) blistered cuticle protein 3 0.0051 0.0262 0.1635
Brugia malayi EGF-like domain containing protein 0.0017 0.0009 0.0056
Schistosoma mansoni patched 1 0.0041 0.0188 0.0393
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0262 0.1635
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0039 0.0083
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0262 0.1635
Brugia malayi EGF-like domain containing protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Brugia malayi CHE-14 protein 0.0041 0.0188 0.117
Echinococcus multilocularis expressed conserved protein 0.009 0.0544 0.0965
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0072 0.2869
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0039 0.0246
Echinococcus multilocularis dna polymerase eta 0.0019 0.0025 0.0044
Plasmodium falciparum endoplasmin, putative 0.0019 0.003 0.2478
Echinococcus multilocularis Smad4 0.0016 0.0005 0.0009
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1388 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0005 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.0809
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0025 0.2095
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0027 0.01
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0005 0.0011
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0586 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0025 0.0035
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1388 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0242 0.1506
Echinococcus granulosus geminin 0.0348 0.2424 0.5073
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0072 0.015
Schistosoma mansoni heat shock protein 0.0032 0.0119 0.0248
Echinococcus granulosus Smad4 0.0016 0.0005 0.0011
Echinococcus granulosus notch 0.0017 0.0009 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0039 0.0246
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0039 0.0083
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0597 0.1249
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0262 0.1635
Brugia malayi Endoplasmin precursor 0.0032 0.0119 0.0739
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0246
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0067 0.5632
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0009 0.0016
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0027 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0039 0.0246
Schistosoma mansoni hypothetical protein 0.004 0.0177 0.037
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0025 0.0052
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0025 0.0156
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0025 0.0156
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0027 0.0029
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0039 0.0083
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0019
Schistosoma mansoni peroxidasin 0.0051 0.0262 0.0549
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0885 0.1571
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0246
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0027 0.0141
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0039 0.0083
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Leishmania major DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Plasmodium vivax endoplasmin, putative 0.0032 0.0119 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0039 0.0246
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0039 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0039 0.0246
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Echinococcus multilocularis heat shock protein 90 0.0032 0.0119 0.021
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1604 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0997 0.7149 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0188 0.117
Echinococcus multilocularis X box binding protein 1 0.028 0.193 0.3425
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Schistosoma mansoni heat shock protein 0.0032 0.0119 0.0248
Brugia malayi Peroxidasin 0.0051 0.0262 0.1635
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0072 0.6037
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0005 0.0009
Trichomonas vaginalis pc-MYB2, putative 0.0019 0.0027 0.01
Brugia malayi EGF-like domain containing protein 0.0017 0.0009 0.0056
Brugia malayi Muscle positioning protein 4 0.0017 0.0009 0.0056
Brugia malayi steroid hormone receptor 0.0021 0.0039 0.0246
Schistosoma mansoni endoplasmin 0.0032 0.0119 0.0248
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.4779 0.848
Giardia lamblia Grp94/Hsp90 0.0025 0.0072 0.5716
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Leishmania major DNA polymerase eta, putative 0.0019 0.0025 0.2095
Brugia malayi EGF-like domain containing protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Trichomonas vaginalis MYB, putative 0.0019 0.0027 0.0141
Echinococcus granulosus neural cadherin 0.0017 0.0009 0.0019
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0067 0.5632
Loa Loa (eye worm) hypothetical protein 0.0041 0.0188 0.117
Echinococcus granulosus X box binding protein 1 0.028 0.193 0.4039
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) endoplasmin 0.0032 0.0119 0.0739
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0119 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0391 0.2739 0.2721
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0039 0.007
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0067 0.5632
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0039 0.007
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0072 0.0047
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0119 0.5753
Echinococcus multilocularis slit 2 protein 0.0017 0.0009 0.0016
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0027 0.01
Echinococcus granulosus smad 0.0016 0.0005 0.0011
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0027 0.0029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0039 0.0083
Echinococcus multilocularis protein jagged 2 0.0017 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) hypothetical protein 0.0163 0.1079 0.6725
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0885 0.1853
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0246
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0027 0.0029
Echinococcus multilocularis smad 0.0016 0.0005 0.0009
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0025 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0005 0.0009
Giardia lamblia DINP protein human, muc B family 0.0019 0.0025 0.1455
Echinococcus granulosus heat shock protein 0.0032 0.0119 0.0248
Echinococcus multilocularis heat shock protein 0.0032 0.0119 0.021
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Brugia malayi EGF-like domain containing protein 0.0017 0.0009 0.0056
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0039 0.0246
Brugia malayi Cadherin domain containing protein 0.0017 0.0009 0.0056
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0027 0.0141
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0039 0.007
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Loa Loa (eye worm) Notch2 0.0017 0.0009 0.0056
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0119 1
Echinococcus multilocularis neural cadherin 0.0017 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Brugia malayi Cadherin domain containing protein 0.0017 0.0009 0.0056
Schistosoma mansoni notch 0.0017 0.0009 0.0019
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0025 0.2095
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Echinococcus granulosus dna polymerase kappa 0.0019 0.0025 0.0052
Echinococcus granulosus endoplasmin 0.0025 0.0072 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0019
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0032
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0025 0.0035
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Echinococcus granulosus protein jagged 2 0.0017 0.0009 0.0019
Trypanosoma brucei unspecified product 0.0019 0.0025 0.2095
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0009 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0039 0.0246
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0009 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0586 0.104
Loa Loa (eye worm) hypothetical protein 0.0048 0.0242 0.1506
Brugia malayi MH2 domain containing protein 0.0236 0.1604 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0025 0.2095
Echinococcus multilocularis peroxidasin 0.0051 0.0262 0.0465
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0025 0.0156
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056
Echinococcus granulosus protein jagged 1 0.0017 0.0009 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.2095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0039 0.0246
Onchocerca volvulus Peroxidase homolog 0.0051 0.0262 0.2367
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0019
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0024 0.2027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0039 0.007
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0072 0.5716
Echinococcus multilocularis fibropellin Ia 0.0017 0.0009 0.0016
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0027 0.0029
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.1635
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0032
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0009 0.0016
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0072 0.2869
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0039 0.0246
Schistosoma mansoni endoplasmin 0.0032 0.0119 0.0248
Loa Loa (eye worm) hypothetical protein 0.0096 0.0586 0.3653
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0039 0.007
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0188 0.0393
Echinococcus multilocularis heat shock protein 90 0.0025 0.0072 0.0127
Brugia malayi hypothetical protein 0.0016 0.0004 0.0022
Trichomonas vaginalis MYB72, putative 0.0019 0.0027 0.01
Plasmodium falciparum heat shock protein 90 0.0032 0.0119 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0067 0.0243
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0039 0.007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0039 0.0083
Brugia malayi isocitrate dehydrogenase 0.0015 0 0.0001
Schistosoma mansoni notch 0.0017 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0056

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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