Detailed information for compound 881524

Basic information

Technical information
  • TDR Targets ID: 881524
  • Name: ethyl 3-[(7-methyl-4-oxo-5,6,7,8-tetrahydro-[ 1]benzothiolo[2,3-d]triazin-3-yl)methyl]benzo ate
  • MW: 383.464 | Formula: C20H21N3O3S
  • H donors: 0 H acceptors: 2 LogP: 4.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cccc(c1)Cn1nnc2c(c1=O)c1CCC(Cc1s2)C
  • InChi: 1S/C20H21N3O3S/c1-3-26-20(25)14-6-4-5-13(10-14)11-23-19(24)17-15-8-7-12(2)9-16(15)27-18(17)21-22-23/h4-6,10,12H,3,7-9,11H2,1-2H3
  • InChiKey: QSTGCYIXBYXVMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 3-[(7-methyl-4-oxo-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]triazin-3-yl)methyl]benzoate
  • 3-[(7-methyl-4-oxo-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]triazin-3-yl)methyl]benzoic acid ethyl ester
  • 3-[(4-keto-7-methyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]triazin-3-yl)methyl]benzoic acid ethyl ester
  • ethyl 3-[(7-methyl-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d][1,2,3]triazin-3-yl)methyl]benzoate
  • ST5327548

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1059 0.105
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0027
Trichomonas vaginalis synaptotagmin, putative 0.0021 0.0152 0.0314
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0142 0.1482 0.1473
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Schistosoma mansoni diacylglycerol kinase theta 0.01 0.1025 0.1016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.013 0.012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.013 0.0141
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0033 0.0022
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0363 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.013 0.012
Echinococcus multilocularis copine 9 0.0021 0.0152 0.0142
Brugia malayi hypothetical protein 0.0009 0.0021 0.0013
Schistosoma mansoni synaptotagmin 0.0021 0.0152 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0152 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.013 0.0141
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.01 0.1025 0.1237
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.0021 0.0152 0.1022
Loa Loa (eye worm) hypothetical protein 0.01 0.1025 0.1237
Brugia malayi hypothetical protein 0.0009 0.0021 0.0013
Onchocerca volvulus 0.0021 0.0152 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Brugia malayi RhoGAP domain containing protein 0.0104 0.1069 0.1251
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Loa Loa (eye worm) C2 domain-containing protein 0.0021 0.0152 0.0173
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0026 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Echinococcus granulosus FTZ F1 alpha 0.0019 0.013 0.012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Brugia malayi nuclear hormone receptor 0.0019 0.013 0.0141
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.013 0.0146
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0021 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.013 0.0141
Brugia malayi ecdysone receptor 0.0009 0.0021 0.0013
Echinococcus multilocularis synaptotagmin 0.0021 0.0152 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0152 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Schistosoma mansoni synaptotagmin 0.0021 0.0152 0.0142
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.013 0.012
Echinococcus multilocularis copine 9 0.0021 0.0152 0.0142
Leishmania major c2 domain protein, putative 0.0021 0.0152 1
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.1482 0.1473
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0308 0.0298
Echinococcus multilocularis tyrosine protein kinase Abl 0.0009 0.0023 0.0012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0363 0.0353
Echinococcus granulosus protein kinase C gamma type 0.0815 0.8898 0.8897
Schistosoma mansoni rac gtpase activating protein 0.01 0.1025 0.1016
Leishmania major hypothetical protein, conserved 0.0021 0.0152 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Echinococcus multilocularis synaptotagmin 2 0.0021 0.0152 0.0142
Echinococcus multilocularis calpain 5 0.0021 0.0152 0.0142
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.004 0.0363 0.0353
Entamoeba histolytica hypothetical protein 0.0021 0.0152 0.1022
Loa Loa (eye worm) C2 domain-containing protein 0.0021 0.0152 0.0173
Brugia malayi p70 ribosomal S6 kinase beta 0.0142 0.1482 0.1738
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0027
Brugia malayi Pre-SET motif family protein 0.0036 0.032 0.0366
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.032 0.031
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0021 0.0011
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.013 0.012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0103 0.1059 0.1239
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0021 0.0152 0.0168
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.032 0.031
Schistosoma mansoni serine/threonine protein kinase 0.0262 0.2812 0.2805
Brugia malayi Hr1 repeat family protein 0.0142 0.1482 0.1738
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0173 0.0379
Schistosoma mansoni thyroid hormone receptor 0.0019 0.013 0.012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.013 0.012
Schistosoma mansoni hypothetical protein 0.0021 0.0152 0.0142
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0021 0.0013
Brugia malayi RhoGEF domain containing protein 0.01 0.1025 0.1199
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0026 0.0016
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Schistosoma mansoni copine 0.0021 0.0152 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.013 0.0141
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0021 0.0152 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.013 0.0141
Echinococcus multilocularis N chimaerin 0.0104 0.1069 0.106
Trichomonas vaginalis vab10 spectraplakin, putative 0.0021 0.0152 0.0314
Entamoeba histolytica diacylglycerol kinase, putative 0.01 0.1025 0.6917
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0021 0.0011
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0021 0.0152 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0146
Schistosoma mansoni synaptotagmin 12 0.0021 0.0152 0.0142
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0033 0.0022
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Echinococcus granulosus protein piccolo 0.0021 0.0152 0.0142
Trichomonas vaginalis copine, putative 0.0021 0.0152 0.0314
Brugia malayi steroid hormone receptor 0.0019 0.013 0.0141
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0021 0.0152 0.0314
Brugia malayi diacylglycerol kinase 0.01 0.1025 0.1199
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.01 0.1025 0.1237
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0677 0.7374 0.8977
Brugia malayi nuclear receptor NHR-88 0.0019 0.013 0.0141
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0152 0.0672
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0021 0.0013
Echinococcus granulosus N chimaerin 0.0104 0.1069 0.106
Echinococcus multilocularis myotubularin protein 13 0.01 0.1025 0.1016
Schistosoma mansoni otoferlin 0.0021 0.0152 0.0142
Trichomonas vaginalis synaptotagmin, putative 0.0021 0.0152 0.0314
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.032 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Entamoeba histolytica hypothetical protein, conserved 0.0021 0.0152 0.1022
Trypanosoma cruzi synaptotagmin, putative 0.0021 0.0152 1
Entamoeba histolytica C2 domain containing protein 0.0021 0.0152 0.1022
Loa Loa (eye worm) AGC/NDR protein kinase 0.0142 0.1482 0.1794
Echinococcus multilocularis serine:threonine protein kinase 38 0.0142 0.1482 0.1473
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0104 0.1069 0.106
Loa Loa (eye worm) AGC/AKT protein kinase 0.0142 0.1482 0.1794
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Loa Loa (eye worm) Nedd4-PD 0.0021 0.0152 0.0173
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0021 0.0152 0.0142
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0021 0.0011
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Echinococcus multilocularis Diacylglycerol kinase theta 0.01 0.1025 0.1016
Schistosoma mansoni glutaminase 0.029 0.3113 0.3106
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0103 0.1059 0.1278
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0021 0.0152 0.0496
Onchocerca volvulus 0.0009 0.0021 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0146
Trypanosoma brucei C2 domain containing protein, putative 0.0021 0.0152 0.0672
Leishmania major hypothetical protein, conserved 0.0021 0.0152 1
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0021 0.0152 0.0142
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.009 0.0437
Trichomonas vaginalis copine, putative 0.0021 0.0152 0.0314
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0021 0.0011
Schistosoma mansoni tyrosine kinase 0.0009 0.0023 0.0012
Entamoeba histolytica C2 domain containing protein 0.0021 0.0152 0.1022
Toxoplasma gondii AGC kinase 0.0142 0.1482 1
Echinococcus granulosus myoferlin 0.0021 0.0152 0.0142
Echinococcus granulosus protein kinase c epsilon type 0.0262 0.2812 0.2805
Entamoeba histolytica hypothetical protein 0.0021 0.0152 0.1022
Schistosoma mansoni synaptotagmin 0.0021 0.0152 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0173 0.0379
Trichomonas vaginalis synaptotagmin, putative 0.0021 0.0152 0.0314
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0021 0.0152 0.0314
Loa Loa (eye worm) hypothetical protein 0.01 0.1025 0.1237
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Leishmania major hypothetical protein, conserved 0.0021 0.0152 1
Brugia malayi RhoGAP domain containing protein 0.01 0.1025 0.1199
Entamoeba histolytica protein kinase, putative 0.0032 0.0276 0.1857
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0021 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.013 0.012
Brugia malayi protein-tyrosine kinase 0.0036 0.032 0.0366
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0021 0.0152 0.0142
Entamoeba histolytica hypothetical protein 0.0021 0.0152 0.1022
Brugia malayi calpain 5 0.0021 0.0152 0.0168
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0021 0.0152 0.0142
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.013 0.012
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Toxoplasma gondii hypothetical protein 0.0021 0.0152 0.0866
Schistosoma mansoni mctp-related 0.0021 0.0152 0.0142
Loa Loa (eye worm) hypothetical protein 0.01 0.1025 0.1237
Trypanosoma brucei predicted C2 domain protein 0.0021 0.0152 0.0672
Brugia malayi C1-like domain containing protein 0.0103 0.1059 0.1239
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0021 0.0011
Onchocerca volvulus 0.0286 0.3073 1
Schistosoma mansoni synaptotagmin-like protein 0.0021 0.0152 0.0142
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.013 0.012
Entamoeba histolytica C2 domain containing protein 0.0021 0.0152 0.1022
Loa Loa (eye worm) TK protein kinase 0.0036 0.032 0.0378
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3073 0.987
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Schistosoma mansoni DNA helicase recq1 0.0009 0.0026 0.0016
Brugia malayi Synapse defective protein 1 0.0021 0.0152 0.0168
Echinococcus granulosus active breakpoint cluster region 0.0021 0.0152 0.0142
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0021 0.0152 0.0142
Trypanosoma cruzi synaptotagmin, putative 0.0021 0.0152 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0033 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.013 0.012
Schistosoma mansoni diacylglycerol kinase theta 0.01 0.1025 0.1016
Leishmania major copine i-like protein 0.0021 0.0152 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.013 0.012
Echinococcus multilocularis synaptotagmin 0.0021 0.0152 0.0142
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0173 0.0162
Echinococcus multilocularis neural cell expressed, developmentally 0.0021 0.0152 0.0142
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.004 0.0363 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.013 0.0141
Echinococcus granulosus UNCoordinated family member unc 13 0.0021 0.0152 0.0142
Echinococcus granulosus synaptotagmin 15 0.0021 0.0152 0.0142
Trichomonas vaginalis copine, putative 0.0021 0.0152 0.0314
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0021 0.0013
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0142 0.1482 0.1473
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0021 0.0152 0.0142
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.013 0.012
Trypanosoma brucei C2 domain containing protein, putative 0.0021 0.0152 0.0672
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.032 0.031
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0021 0.0152 0.0672
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Echinococcus granulosus copine 9 0.0021 0.0152 0.0142
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.032 0.031
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0363 0.0353
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.032 0.0311
Schistosoma mansoni protein kinase C mu 0.01 0.1025 0.1016
Schistosoma mansoni rho gtpase activating protein 0.0021 0.0152 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0363 0.0353
Trypanosoma brucei C2 domain containing protein, putative 0.0021 0.0152 0.0672
Echinococcus granulosus otoferlin 0.0021 0.0152 0.0142
Trypanosoma brucei C2 domain containing protein, putative 0.0021 0.0152 0.0672
Loa Loa (eye worm) C2 domain-containing protein 0.0021 0.0152 0.0173
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Loa Loa (eye worm) hypothetical protein 0.013 0.1353 0.1637
Entamoeba histolytica C2 domain containing protein 0.0021 0.0152 0.1022
Brugia malayi Protein kinase domain containing protein 0.0103 0.1059 0.1239
Brugia malayi Protein kinase domain containing protein 0.0142 0.1482 0.1738
Loa Loa (eye worm) hypothetical protein 0.01 0.1025 0.1237
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0142 0.1482 0.1473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.013 0.0146
Loa Loa (eye worm) hypothetical protein 0.01 0.1025 0.1237
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0021 0.0013
Loa Loa (eye worm) hypothetical protein 0.01 0.1025 0.1237
Echinococcus multilocularis active breakpoint cluster region 0.0021 0.0152 0.0142
Echinococcus multilocularis protein kinase c iota type 0.0242 0.2584 0.2576
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Echinococcus multilocularis 0.0021 0.0152 0.0142
Plasmodium vivax ferlin, putative 0.0021 0.0152 0.2647
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0021 0.0152 0.0142
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0021 0.0011
Trichomonas vaginalis synaptotagmin, putative 0.0021 0.0152 0.0314
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0103 0.1059 0.105
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0104 0.1069 0.106
Echinococcus multilocularis extended synaptotagmin 2 0.0021 0.0152 0.0142
Entamoeba histolytica hypothetical protein 0.01 0.1025 0.6917
Brugia malayi hypothetical protein 0.001 0.0033 0.0026
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0009 0.0023 0.0012
Schistosoma mansoni atypical protein kinase C 0.0242 0.2584 0.2576
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.032 0.0311
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Schistosoma mansoni hypothetical protein 0.0021 0.0152 0.0142
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0021 0.0152 0.0314
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0276 0.0266
Echinococcus granulosus Diacylglycerol kinase theta 0.01 0.1025 0.1016
Trichomonas vaginalis ion channel nompc, putative 0.0021 0.0152 0.0314
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0152 0.0142
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0021 0.0152 0.0314
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0142 0.1482 0.1794
Brugia malayi Copine VIII 0.0021 0.0152 0.0168
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0142 0.1482 0.1794
Loa Loa (eye worm) raf kinase 0.01 0.1025 0.1237
Entamoeba histolytica C2 domain containing protein 0.0021 0.0152 0.1022
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0021 0.0152 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Plasmodium vivax double C2-like domain-containing protein, putative 0.0021 0.0152 0.2647
Echinococcus granulosus extended synaptotagmin 2 0.0021 0.0152 0.0142
Brugia malayi protein kinase C3,putative 0.0103 0.1059 0.1239
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0021 0.0152 0.0314
Toxoplasma gondii ferlin family protein 0.0021 0.0152 0.0866
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0021 0.0152 0.0142
Brugia malayi tailless protein 0.0009 0.0021 0.0013
Loa Loa (eye worm) hypothetical protein 0.01 0.1025 0.1237
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0363 0.0353
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0363 0.0353
Echinococcus granulosus copine 9 0.0021 0.0152 0.0142
Entamoeba histolytica C2 domain containing protein 0.0021 0.0152 0.1022
Entamoeba histolytica hypothetical protein 0.0021 0.0152 0.1022
Plasmodium falciparum double C2-like domain-containing protein 0.0021 0.0152 1
Leishmania major hypothetical protein, conserved 0.0021 0.0152 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.004 0.0363 0.0353
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Schistosoma mansoni nuclear receptor 0.0009 0.0021 0.0011
Entamoeba histolytica protein kinase, putative 0.0142 0.1482 1
Entamoeba histolytica C2 domain protein, putative 0.0021 0.0152 0.1022
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0021 0.0152 0.0142
Echinococcus granulosus protein kinase c iota type 0.0242 0.2584 0.2576
Trypanosoma cruzi cAMP binding protein, putative 0.0021 0.0152 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.013 0.012
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0021 0.0068
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0021 0.0013
Brugia malayi hypothetical protein 0.001 0.0033 0.0026
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0142 0.9198
Leishmania major hypothetical protein, conserved 0.0021 0.0152 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.013 0.0141
Echinococcus multilocularis serine threonine protein kinase 0.0815 0.8898 0.8897
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0021 0.0152 0.0142
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0021 0.0152 0.0142
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0021 0.0152 0.0314
Loa Loa (eye worm) hypothetical protein 0.0653 0.7111 0.8657
Schistosoma mansoni hypothetical protein 0.0021 0.0152 0.0142
Echinococcus granulosus NDR protein kinase 0.0142 0.1482 0.1473
Loa Loa (eye worm) hypothetical protein 0.0009 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0021 0.0152 0.0173
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0363 0.0353
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.013 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.013 0.0141
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.013 0.012
Loa Loa (eye worm) synaptotagmin-1 0.0021 0.0152 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0152 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0033 0.0027
Echinococcus granulosus serine:threonine protein kinase N2 0.0142 0.1482 0.1473
Echinococcus granulosus c src tyrosine kinase 0.0009 0.0023 0.0012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0021 0.0013
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0021 0.0011
Onchocerca volvulus 0.0036 0.032 0.1043
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0021 0.0152 0.0314
Trypanosoma cruzi C2 domain containing protein, putative 0.0021 0.0152 1
Brugia malayi diacylglycerol kinase 0.01 0.1025 0.1199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.013 0.0146
Brugia malayi ecdysteroid receptor 0.0019 0.013 0.0141
Loa Loa (eye worm) SRC-1 0.004 0.0363 0.043
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0152 1
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.013 0.012
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0021 0.0152 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.013 0.012
Leishmania major hypothetical protein, conserved 0.0021 0.0152 1
Brugia malayi protein kinase C II. 0.0262 0.2812 0.331
Schistosoma mansoni synaptotagmin 0.0021 0.0152 0.0142
Plasmodium falciparum ferlin, putative 0.0021 0.0152 1
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.1482 0.1473
Schistosoma mansoni coup transcription factor 0.0019 0.013 0.012
Trypanosoma brucei predicted C2 domain protein 0.0021 0.0152 0.0672
Loa Loa (eye worm) copine family protein 0.0021 0.0152 0.0173
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0021 0.0152 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Brugia malayi Pleckstrin Homology Domain 0.01 0.1025 0.1199
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.013 0.012
Brugia malayi Protein kinase domain containing protein 0.0142 0.1482 0.1738
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0021 0.0152 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Schistosoma mansoni synaptotagmin 12 0.0021 0.0152 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Loa Loa (eye worm) hypothetical protein 0.0036 0.032 0.0378
Loa Loa (eye worm) AGC/PKN protein kinase 0.0142 0.1482 0.1794
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.012 0.011
Entamoeba histolytica C2 domain containing protein 0.0021 0.0152 0.1022
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0021 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0152 0.0672
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0021 0.0152 0.0142
Trichomonas vaginalis annexin VII, putative 0.0021 0.0152 0.0314
Loa Loa (eye worm) variant SH3 domain-containing protein 0.01 0.1025 0.1237
Echinococcus multilocularis raf serine:threonine protein kinase 0.0101 0.1038 0.1028
Plasmodium vivax SET domain protein, putative 0.0036 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0146
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.013 0.012
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0021 0.0011
Entamoeba histolytica protein kinase, putative 0.0024 0.0186 0.1249
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.013 0.0146
Entamoeba histolytica C2 domain containing protein 0.0021 0.0152 0.1022
Schistosoma mansoni unc-13 (munc13) 0.0021 0.0152 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0021 0.0152 0.0142
Echinococcus granulosus unc 13 munc13 0.0121 0.1254 0.1245
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.013 0.012
Entamoeba histolytica protein kinase, putative 0.0142 0.1482 1
Loa Loa (eye worm) C2 domain-containing protein 0.0021 0.0152 0.0173
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Plasmodium falciparum ferlin, putative 0.0021 0.0152 1
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0021 0.0152 0.0142
Brugia malayi SRC-1 0.004 0.0363 0.0416
Trichomonas vaginalis glutaminase, putative 0.029 0.3113 1
Loa Loa (eye worm) DR-78 0.0009 0.0021 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0146
Brugia malayi LD23056p 0.0021 0.0152 0.0168
Trypanosoma brucei rac serine-threonine kinase, putative 0.0142 0.1482 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0021 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Echinococcus granulosus tyrosine protein kinase Lyn 0.0043 0.0396 0.0387
Brugia malayi nuclear receptor RXR 0.001 0.0033 0.0026
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0103 0.1059 0.105
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0026 0.00000000032158
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.0021 0.0152 0.0672
Schistosoma mansoni hypothetical protein 0.0021 0.0152 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0025 0.0196 0.0227
Echinococcus multilocularis RNA directed DNA polymerase 0.0653 0.7111 0.7108
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.013 0.0423
Brugia malayi glutaminase DH11.1 0.029 0.3113 0.3665
Brugia malayi Ras association domain family 1 isoform A 0.01 0.1025 0.1199
Brugia malayi conserved hypotetical protein 0.0009 0.0021 0.0013
Echinococcus granulosus synaptotagmin 0.0021 0.0152 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.013 0.0146
Echinococcus multilocularis synaptotagmin protein 4 0.0021 0.0152 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Onchocerca volvulus 0.0019 0.013 0.0423
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0021 0.0152 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.013 0.012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0152 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0021 0.0011
Brugia malayi WW domain containing protein 0.0021 0.0152 0.0168
Brugia malayi nuclear receptor NHR-67 0.0009 0.0021 0.0013
Entamoeba histolytica hypothetical protein 0.0021 0.0152 0.1022
Onchocerca volvulus 0.0121 0.1254 0.4081
Onchocerca volvulus 0.0021 0.0152 0.0496
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Echinococcus granulosus synaptotagmin 0.0021 0.0152 0.0142
Loa Loa (eye worm) hypothetical protein 0.013 0.1353 0.1637
Onchocerca volvulus 0.0021 0.0152 0.0496
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.013 0.0141
Schistosoma mansoni hypothetical protein 0.01 0.1025 0.1016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.013 0.012
Schistosoma mansoni tyrosine kinase 0.004 0.0363 0.0353
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Brugia malayi nuclear hormone receptor 0.0009 0.0021 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Loa Loa (eye worm) hypothetical protein 0.0018 0.0122 0.0136
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0146
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0103 0.1059 0.1278
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0173 0.0192
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0009 0.0023 0.0012
Echinococcus granulosus Rac GTPase activating protein 1 0.01 0.1025 0.1016
Schistosoma mansoni protein kinase C 0.0121 0.1254 0.1245
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0021 0.0152 0.0142
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0021 0.0152 0.0173
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1038 0.1028
Echinococcus granulosus synaptotagmin 2 0.0021 0.0152 0.0142
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0276 0.0266
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Echinococcus multilocularis synaptotagmin 0.0021 0.0152 0.0142
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.032 0.2021
Onchocerca volvulus 0.0021 0.0152 0.0496
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0021 0.0152 0.0672
Brugia malayi nuclear receptor RXR 0.0009 0.0021 0.0013
Schistosoma mansoni synaptotagmin 0.0021 0.0152 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0152 1
Entamoeba histolytica protein kinase, putative 0.0142 0.1482 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0146
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0653 0.7111 0.7108
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.013 0.0141
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0306 0.0296
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.013 0.0141
Toxoplasma gondii diacylglycerol kinase, putative 0.01 0.1025 0.6864
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0021 0.0013
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0262 0.2812 0.3416
Echinococcus multilocularis synaptotagmin 0.0021 0.0152 0.0142
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0142 0.1482 0.1473
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.013 0.0141
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.013 0.012
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0152 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.013 0.012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0033 0.0022
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0021 0.0013
Brugia malayi Synaptotagmin I 0.0021 0.0152 0.0168
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.013 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Brugia malayi NEDD4.2 0.0021 0.0152 0.0168
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0026 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0019 0.013 0.012
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0021 0.0152 0.0142
Echinococcus multilocularis serine:threonine protein kinase N2 0.0142 0.1482 0.1473
Echinococcus multilocularis serine:threonine protein kinase N2 0.0142 0.1482 0.1473
Onchocerca volvulus Huntingtin homolog 0.013 0.1353 0.4402
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Loa Loa (eye worm) glutaminase 2 0.029 0.3113 0.3783
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Plasmodium vivax ferlin, putative 0.0021 0.0152 0.2647
Schistosoma mansoni fer-1-related 0.0021 0.0152 0.0142
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.013 0.0141
Toxoplasma gondii hypothetical protein 0.0021 0.0152 0.0866
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0033 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.013 0.0141
Schistosoma mansoni glut4 vesicle protein-related 0.0021 0.0152 0.0142
Entamoeba histolytica DENN domain protein 0.0021 0.0152 0.1022
Echinococcus granulosus synaptotagmin 0.0021 0.0152 0.0142
Echinococcus granulosus intersectin 2 0.0025 0.0195 0.0185
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0121 0.1254 0.1245
Schistosoma mansoni serine/threonine protein kinase 0.0915 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0021 0.0152 0.0142
Entamoeba histolytica diacylglycerol kinase, putative 0.01 0.1025 0.6917
Onchocerca volvulus 0.0021 0.0152 0.0496
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.032 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Trichomonas vaginalis copine, putative 0.0021 0.0152 0.0314
Entamoeba histolytica hypothetical protein, conserved 0.0021 0.0152 0.1022
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0146
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Echinococcus granulosus protein kinase c eta type 0.01 0.1025 0.1016
Schistosoma mansoni serine/threonine protein kinase 0.0915 1 1
Loa Loa (eye worm) TK protein kinase 0.0032 0.0276 0.0324
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.013 0.012
Trichomonas vaginalis synaptotagmin, putative 0.0021 0.0152 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Echinococcus multilocularis synaptotagmin 15 0.0021 0.0152 0.0142
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Echinococcus granulosus synaptotagmin 0.0021 0.0152 0.0142
Loa Loa (eye worm) hypothetical protein 0.0142 0.1482 0.1794
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1059 0.105
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0009 0.0023 0.0012
Loa Loa (eye worm) RasGEF domain-containing protein 0.01 0.1025 0.1237
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Trichomonas vaginalis copine, putative 0.0021 0.0152 0.0314
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0021 0.0011
Echinococcus granulosus calpain 5 0.0021 0.0152 0.0142
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0057 0.0375
Schistosoma mansoni protein kinase C mu 0.0103 0.1059 0.105
Brugia malayi Protein kinase domain containing protein 0.0142 0.1482 0.1738
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0021 0.0152 1
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.0013
Onchocerca volvulus 0.01 0.1025 0.3336
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2691 0.3268
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0021 0.0152 0.0314
Toxoplasma gondii Elicitor-responsive protein, putative 0.0021 0.0152 0.0866
Trypanosoma brucei synaptotagmin, putative 0.0021 0.0152 0.0672
Echinococcus granulosus neural cell expressed developmentally 0.0021 0.0152 0.0142
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.032 0.0311
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0021 0.0152 0.0142
Entamoeba histolytica hypothetical protein 0.0021 0.0152 0.1022
Schistosoma mansoni tyrosine kinase 0.004 0.0363 0.0353
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0142 0.1482 0.1794
Echinococcus granulosus synaptotagmin 0.0021 0.0152 0.0142
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0021 0.0013
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.013 0.012
Echinococcus granulosus raf serine:threonine protein kinase 0.0101 0.1038 0.1028
Brugia malayi Copine family protein 0.0021 0.0152 0.0168
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.013 0.0423
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.032 0.0311
Onchocerca volvulus 0.0021 0.0152 0.0496
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.004 0.0363 0.0353
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0915 1 1
Leishmania major hypothetical protein, conserved 0.0021 0.0152 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.004 0.0363 0.0353
Leishmania major hypothetical protein, conserved 0.0021 0.0152 1
Trypanosoma brucei predicted C2 domain protein 0.0021 0.0152 0.0672
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0104 0.1069 0.106
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0021 0.0152 0.0866
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0021 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0027
Toxoplasma gondii Sma protein 0.0021 0.0152 0.0866
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0021 0.0152 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.013 0.0146
Onchocerca volvulus Huntingtin homolog 0.013 0.1353 0.4402
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0142 0.1482 0.1473
Brugia malayi hypothetical protein 0.013 0.1353 0.1586
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Echinococcus granulosus myotubularin protein 13 0.01 0.1025 0.1016
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0152 0.2647
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0026 0.0019
Schistosoma mansoni vav2 0.0104 0.1069 0.106
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0026 0.002
Echinococcus multilocularis tyrosine protein kinase Fgr 0.004 0.0363 0.0353
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0021 0.0152 0.0142
Brugia malayi nuclear receptor NHR-88 0.0009 0.0021 0.0013
Echinococcus granulosus RNA directed DNA polymerase 0.0653 0.7111 0.7108
Echinococcus granulosus synaptotagmin protein 4 0.0021 0.0152 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.1482 0.1473
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.004 0.0363 0.0353
Schistosoma mansoni synaptotagmin 0.0021 0.0152 0.0142
Leishmania major c2 domain protein, putative 0.0021 0.0152 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0363 0.0353
Echinococcus multilocularis protein kinase c epsilon type 0.0262 0.2812 0.2805
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.1482 0.1473
Echinococcus granulosus tyrosine kinase 0.0036 0.032 0.031
Brugia malayi Protein kinase c protein 2 0.0777 0.8475 1
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.032 0.0311
Mycobacterium ulcerans glutaminase 0.029 0.3113 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0152 0.0168
Trichomonas vaginalis synaptotagmin, putative 0.0021 0.0152 0.0314
Echinococcus granulosus Immunoglobulin E set 0.0021 0.0152 0.0142
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0104 0.1069 0.1291
Echinococcus multilocularis myoferlin 0.0021 0.0152 0.0142
Leishmania major phospholipase c-like protein 0.0021 0.0152 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0026 0.0016
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0308 0.0298
Echinococcus multilocularis unc 13 (munc13) 0.0121 0.1254 0.1245
Echinococcus multilocularis Rac GTPase activating protein 1 0.01 0.1025 0.1016
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0138 0.1448 0.4553
Schistosoma mansoni tyrosine kinase 0.0009 0.0023 0.0012
Schistosoma mansoni rabphilin-3a 0.0021 0.0152 0.0142
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.013 0.012
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0021 0.0152 0.0142
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0142 0.1482 0.1473
Trichomonas vaginalis synaptotagmin, putative 0.0021 0.0152 0.0314
Echinococcus multilocularis protein piccolo 0.0021 0.0152 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Brugia malayi C2 domain containing protein 0.0021 0.0152 0.0168
Loa Loa (eye worm) hypothetical protein 0.01 0.1025 0.1237
Schistosoma mansoni nuclear receptor 0.0009 0.0021 0.0011
Schistosoma mansoni DNA helicase recq5 0.0009 0.0026 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0021 0.0152 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.013 0.0146
Trypanosoma brucei cAMP binding protein, putative 0.0021 0.0152 0.0672
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0146
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Entamoeba histolytica protein kinase, putative 0.0142 0.1482 1
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0152 1
Onchocerca volvulus Putative cc2d1b protein 0.0021 0.0152 0.0496
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0104 0.1069 0.106
Loa Loa (eye worm) hypothetical protein 0.0121 0.1254 0.1516
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0021 0.0152 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0121 0.1254 0.1245
Onchocerca volvulus 0.0009 0.0021 0.0068
Trichomonas vaginalis Proline-rich protein, putative 0.0021 0.0152 0.0314
Echinococcus granulosus bloom syndrome protein 0.0023 0.0173 0.0162
Toxoplasma gondii hypothetical protein 0.0021 0.0152 0.0866
Schistosoma mansoni hypothetical protein 0.0021 0.0152 0.0142
Schistosoma mansoni hypothetical protein 0.0055 0.0527 0.0517
Schistosoma mansoni nuclear hormone receptor 0.0019 0.013 0.012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0026 0.0016
Schistosoma mansoni unc-13 (munc13) 0.0121 0.1254 0.1245
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.013 0.0141
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1482 0.4663
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.032 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.013 0.0146
Loa Loa (eye worm) RecQ helicase 0.0023 0.0173 0.0198
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0033 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0152 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0009 0.0023 0.0015
Brugia malayi Pre-SET motif family protein 0.0251 0.2691 0.3167
Loa Loa (eye worm) C2 domain-containing protein 0.0021 0.0152 0.0173
Entamoeba histolytica calcium-binding protein, putative 0.0021 0.0152 0.1022
Echinococcus multilocularis intersectin 2 0.0025 0.0195 0.0185
Schistosoma mansoni serine/threonine kinase 0.0142 0.1482 0.1473
Loa Loa (eye worm) hypothetical protein 0.01 0.1025 0.1237
Echinococcus multilocularis synaptotagmin 0.0021 0.0152 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0152 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.013 0.0141
Echinococcus multilocularis protein kinase c eta type 0.01 0.1025 0.1016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0021 0.0011
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0021 0.0011
Brugia malayi Variant SH3 domain containing protein 0.0104 0.1069 0.1251
Loa Loa (eye worm) glutaminase 0.029 0.3113 0.3783
Entamoeba histolytica C2 domain containing protein 0.0021 0.0152 0.1022
Toxoplasma gondii C2 domain-containing protein 0.0021 0.0152 0.0866
Brugia malayi phospholipase C homolog 0.0021 0.0152 0.0168
Loa Loa (eye worm) C2 domain-containing protein 0.0021 0.0152 0.0173
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0021 0.0152 0.0142
Schistosoma mansoni unc-13 (munc13) 0.0121 0.1254 0.1245
Brugia malayi Synaptotagmin protein 3 0.0021 0.0152 0.0168
Entamoeba histolytica protein kinase, putative 0.0024 0.0186 0.1249
Brugia malayi Synapse defective protein 1 0.0021 0.0152 0.0168
Loa Loa (eye worm) hypothetical protein 0.0753 0.8213 1
Schistosoma mansoni zinc finger protein 0.0009 0.0021 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0021 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0173
Onchocerca volvulus 0.0021 0.0152 0.0496
Echinococcus multilocularis tyrosine protein kinase Src64B 0.004 0.0363 0.0353
Onchocerca volvulus 0.01 0.1025 0.3336
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0142 0.1482 0.1794
Echinococcus multilocularis c src tyrosine kinase 0.0009 0.0023 0.0012
Brugia malayi Variant SH3 domain containing protein 0.0025 0.0196 0.022

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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