Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fibroblast growth factor receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuroglian | 0.0018 | 0.0326 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.4541 | 0.4541 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.4541 | 0.4541 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0116 | 0.0116 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0326 | 0.0337 |
Onchocerca volvulus | Peroxidasin homolog | 0.0068 | 0.4867 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Brugia malayi | Peroxidasin | 0.0068 | 0.4867 | 0.4867 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4867 | 0.4867 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Schistosoma mansoni | tyrosine kinase | 0.012 | 0.9674 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | TK protein kinase | 0.0124 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0068 | 0.4867 | 0.4867 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.012 | 0.9674 | 1 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.012 | 0.9674 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Brugia malayi | Blistered cuticle protein 3 | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0068 | 0.4867 | 0.4867 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Echinococcus granulosus | peroxidasin | 0.0068 | 0.4867 | 0.5032 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0326 | 0.0337 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.012 | 0.9674 | 1 |
Schistosoma mansoni | peroxidasin | 0.0064 | 0.4541 | 0.4694 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.4541 | 0.4541 |
Brugia malayi | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Schistosoma mansoni | peroxidasin | 0.0064 | 0.4541 | 0.4694 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0064 | 0.4541 | 0.4541 |
Echinococcus granulosus | twitchin | 0.0018 | 0.0326 | 0.0337 |
Echinococcus multilocularis | peroxidasin | 0.0068 | 0.4867 | 0.5032 |
Schistosoma mansoni | nephrin | 0.0018 | 0.0326 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Onchocerca volvulus | Peroxidasin homolog | 0.0068 | 0.4867 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.4541 | 0.4541 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.012 | 0.9674 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0015 | 0.0116 | 0.0116 |
Echinococcus multilocularis | neuroglian | 0.0018 | 0.0326 | 0.0337 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.25 uM | Inhibition of FGFR1 (unknown origin) using KKKSPGEYVNIEFG peptide substrate assessed as incorporation of [32P] into peptide by scintillation counting analysis | ChEMBL. | 25817240 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.