TDR Targets

Basic information

Technical information

TDR Targets ID: 881618
Name: ethyl 4-[(4-butoxyphenyl)sulfonylamino]piperi dine-1-carboxylate
MW: 384.49 | Formula: C18H28N2O5S
H donors: 1 H acceptors: 3 LogP: 2.93 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCOc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)C(=O)OCC
InChi: 1S/C18H28N2O5S/c1-3-5-14-25-16-6-8-17(9-7-16)26(22,23)19-15-10-12-20(13-11-15)18(21)24-4-2/h6-9,15,19H,3-5,10-14H2,1-2H3
InChiKey: MFVSCKRMJHCUQZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[(4-butoxyphenyl)sulfonylamino]-1-piperidinecarboxylic acid ethyl ester
4-[(4-butoxyphenyl)sulfonylamino]piperidine-1-carboxylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.005	0.0069
Echinococcus multilocularis	inositol monophosphatase 1	0.0074	0.0287	0.0268
Brugia malayi	beta-lactamase family protein	0.0037	0.005	0.0376
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.005	0.0376
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0129	0.0245
Toxoplasma gondii	thymidylate kinase	0.0143	0.0722	0.8064
Schistosoma mansoni	hypothetical protein	0.0143	0.0722	0.1577
Onchocerca volvulus		0.0054	0.0157	0.1589
Schistosoma mansoni	phosphoglucomutase	0.0067	0.0242	0.0498
Trichomonas vaginalis	ap endonuclease, putative	0.0057	0.0178	0.0155
Leishmania major	ribonuclease H1, putative	0.0067	0.0242	0.0232
Schistosoma mansoni	ap endonuclease	0.0057	0.0178	0.0356
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0287	0.0288
Mycobacterium ulcerans	thymidylate kinase	0.0143	0.0722	1
Treponema pallidum	ribonuclease H (rnhA)	0.0067	0.0242	0.1164
Echinococcus granulosus	intermediate filament protein	0.0054	0.0157	0.0308
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0074	0.0287	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0037	0.005	0.0376
Toxoplasma gondii	exonuclease III APE	0.0057	0.0178	0.1534
Loa Loa (eye worm)	hypothetical protein	0.0037	0.005	0.0376
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.005	0.0376
Trypanosoma brucei	thymidine kinase	0.134	0.8274	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0253	0.1889
Schistosoma mansoni	hypothetical protein	0.0131	0.0645	0.1403
Schistosoma mansoni	hypothetical protein	0.0173	0.0909	0.1997
Schistosoma mansoni	inositol monophosphatase	0.0074	0.0287	0.0599
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0057	0.0178	0.1902
Trichomonas vaginalis	thymidylate kinase, putative	0.0143	0.0722	0.0817
Leishmania major	thymidine kinase, putative	0.134	0.8274	1
Trypanosoma cruzi	thymidylate kinase, putative	0.0143	0.0722	0.0817
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0169	0.0884	1
Echinococcus multilocularis	geminin	0.0173	0.0909	0.0891
Mycobacterium ulcerans	thymidylate synthase	0.012	0.0575	0.7809
Brugia malayi	beta-lactamase family protein	0.0037	0.005	0.0376
Schistosoma mansoni	lamin	0.0054	0.0157	0.0308
Brugia malayi	RNase H family protein	0.0067	0.0242	0.1801
Echinococcus multilocularis	transfer RNA-Ile	0.0738	0.4476	0.4465
Schistosoma mansoni	phosphoglucomutase	0.0067	0.0242	0.0498
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0057	0.0178	0.1023
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0169	0.0884	1
Onchocerca volvulus		0.0054	0.0157	0.1589
Brugia malayi	Dihydrofolate reductase	0.0049	0.0127	0.0948
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0057	0.0178	0.0155
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0138	0.0107
Trypanosoma brucei	hypothetical protein, conserved	0.0076	0.0297	0.03
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0454	0.3389
Giardia lamblia	CDC8	0.0143	0.0722	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0138	0.103
Schistosoma mansoni	hypothetical protein	0.039	0.2277	0.5065
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0287	0.0288
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.012	0.0575	0.7809
Echinococcus multilocularis	musashi	0.0054	0.0157	0.0138
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0108	0.0197
Plasmodium vivax	thymidylate kinase, putative	0.0143	0.0722	0.8064
Leishmania major	thymidylate kinase-like protein	0.0143	0.0722	0.0817
Schistosoma mansoni	ap endonuclease	0.0057	0.0178	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0032	0.002	0.0148
Trypanosoma brucei	thymidylate kinase, putative	0.0143	0.0722	0.0817
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0131	0.0645	0.0627
Echinococcus granulosus	lamin	0.0054	0.0157	0.0308
Echinococcus granulosus	inositol monophosphatase 1	0.0074	0.0287	0.0599
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0179	0.0156
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0108	0.0197
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0056	0.0174	0.0346
Echinococcus granulosus	thymidine kinase	0.0738	0.4476	1
Brugia malayi	thymidylate kinase	0.0143	0.0722	0.5388
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0138	0.1053
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0169	0.0884	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.012	0.0575	0.1246
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0066	0.0238	0.15
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1341	1
Onchocerca volvulus	Putative thymidylate kinase	0.0143	0.0722	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0129	0.0245
Onchocerca volvulus		0.012	0.0575	0.7809
Trichomonas vaginalis	thymidine kinase, putative	0.134	0.8274	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0129	0.0963
Echinococcus multilocularis	dihydrofolate reductase	0.0049	0.0127	0.0108
Brugia malayi	dihydrofolate reductase family protein	0.0049	0.0127	0.0948
Echinococcus multilocularis	lamin	0.0054	0.0157	0.0138
Leishmania major	hypothetical protein, conserved	0.0056	0.0173	0.015
Giardia lamblia	Thymidine kinase	0.134	0.8274	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0157	0.1172
Loa Loa (eye worm)	thymidylate synthase	0.012	0.0575	0.429
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.012	0.0575	0.4202
Echinococcus granulosus	thymidine kinase	0.0738	0.4476	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0108	0.0197
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0057	0.0178	0.1534
Brugia malayi	hypothetical protein	0.0037	0.005	0.0375
Trichomonas vaginalis	thymidylate kinase, putative	0.0143	0.0722	0.0817
Echinococcus granulosus	ribonuclease H1	0.0067	0.0242	0.0498
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0057	0.0178	0.0538
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0074	0.0287	0.2837
Schistosoma mansoni	thymidylate kinase	0.0143	0.0722	0.1577
Leishmania major	hypothetical protein, conserved	0.0051	0.0138	0.0107
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0142	0.0712	0.0693
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0287	0.0288
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.1299	1
Schistosoma mansoni	dihydrofolate reductase	0.0049	0.0127	0.0241
Schistosoma mansoni	inositol monophosphatase	0.0074	0.0287	0.0599
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0131	0.0645	0.1403
Trypanosoma brucei	unspecified product	0.0076	0.0297	0.03
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0056	0.0173	0.015
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0066	0.0238	0.2788
Echinococcus granulosus	geminin	0.0173	0.0909	0.1997
Schistosoma mansoni	hypothetical protein	0.0069	0.0253	0.0524
Echinococcus multilocularis	thymidylate kinase	0.0143	0.0722	0.0704
Toxoplasma gondii	ribonuclease HI protein	0.0067	0.0242	0.2294
Brugia malayi	hypothetical protein	0.0033	0.0025	0.0186
Trypanosoma cruzi	thymidylate kinase, putative	0.0143	0.0722	0.0817
Trypanosoma brucei	ingi protein (ORF1)	0.0076	0.0297	0.03
Mycobacterium tuberculosis	Hypothetical protein	0.0057	0.0179	0.1026
Brugia malayi	hypothetical protein	0.0241	0.1341	1
Trypanosoma cruzi	ribonuclease H1, putative	0.0067	0.0242	0.0232
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0057	0.0178	0.0155
Trypanosoma brucei	thymidylate kinase, putative	0.0143	0.0722	0.0817
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.005	0.003
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0108	0.0803
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0057	0.0178	0.1329
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0074	0.0287	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0157	0.1172
Schistosoma mansoni	thyroid hormone receptor	0.0142	0.0712	0.1552
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0108	0.0088
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0057	0.0178	0.0159
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.002	0.0148
Echinococcus multilocularis	thymidine kinase	0.0738	0.4476	0.4465
Trichomonas vaginalis	thymidine kinase, putative	0.134	0.8274	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0074	0.0287	0.0288
Loa Loa (eye worm)	thymidylate kinase	0.0143	0.0722	0.5388
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0074	0.0287	0.3518
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0108	0.0803
Chlamydia trachomatis	thymidylate kinase	0.0143	0.0722	1
Schistosoma mansoni	phosphoglucomutase	0.0067	0.0242	0.0498
Trypanosoma cruzi	thymidine kinase, putative	0.134	0.8274	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0057	0.0179	0.0156
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0057	0.0178	0.0156
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0138	0.0107
Entamoeba histolytica	thymidine kinase, putative	0.134	0.8274	1
Brugia malayi	RNase H family protein	0.0067	0.0242	0.1801
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0287	0.0288
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0157	0.1172
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0138	0.1053
Loa Loa (eye worm)	inositol-1	0.0074	0.0287	0.2139
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0253	0.1889
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.005	0.0069
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.002	0.0148
Brugia malayi	hypothetical protein	0.0057	0.0179	0.1332
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0057	0.0178	0.0155
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.005	0.0068
Echinococcus multilocularis	survival motor neuron protein 1	0.0241	0.1341	0.1324
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0138	0.0107
Echinococcus granulosus	survival motor neuron protein 1	0.0241	0.1341	0.2965
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0057	0.0178	0.0356
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0076	0.0297	0.03
Onchocerca volvulus	Ribonuclease H1 homolog	0.0067	0.0242	0.2844
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0108	0.0197
Trichomonas vaginalis	inositol monophosphatase, putative	0.0074	0.0287	0.0288
Schistosoma mansoni	thyroid hormone receptor	0.0142	0.0712	0.1552
Trypanosoma cruzi	thymidine kinase, putative	0.134	0.8274	1
Schistosoma mansoni	hypothetical protein	0.0173	0.0909	0.1997
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0169	0.0884	0.1013
Echinococcus granulosus	Thymidine kinase 2 mitochondrial	0.0738	0.4476	1
Echinococcus multilocularis	ribonuclease H1	0.0067	0.0242	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0037	0.005	0.0376
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.005	0.0069
Loa Loa (eye worm)	dihydrofolate reductase	0.0049	0.0127	0.0948
Plasmodium falciparum	thymidylate kinase	0.0143	0.0722	0.7837
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0056	0.0173	0.015
Schistosoma mansoni	hypothetical protein	0.0037	0.005	0.0068
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.005	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0037	0.005	0.0376
Schistosoma mansoni	lamin	0.0054	0.0157	0.0308
Brugia malayi	beta-lactamase	0.0037	0.005	0.0376
Entamoeba histolytica	Thymidylate kinase, putative	0.0143	0.0722	0.0817
Schistosoma mansoni	lipoxygenase	0.0056	0.0174	0.0346
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0049	0.0127	0.1142
Echinococcus multilocularis	thymidylate synthase	0.012	0.0575	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0037	0.005	0.0376
Echinococcus multilocularis	thymidine kinase	0.0738	0.4476	0.4465
Giardia lamblia	Deoxynucleoside kinase	0.116	0.7134	0.8593
Loa Loa (eye worm)	beta-lactamase	0.0037	0.005	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0037	0.005	0.0376
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0143	0.0722	0.5381
Brugia malayi	thymidylate synthase	0.012	0.0575	0.429
Echinococcus multilocularis	lamin dm0	0.0054	0.0157	0.0138
Echinococcus granulosus	dihydrofolate reductase	0.0049	0.0127	0.0241
Trichomonas vaginalis	ap endonuclease, putative	0.0057	0.0178	0.0155
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0169	0.0884	0.1013
Trypanosoma cruzi	ribonuclease H1, putative	0.0067	0.0242	0.0232
Echinococcus granulosus	thymidylate synthase	0.012	0.0575	0.1246
Brugia malayi	Inositol-1	0.0074	0.0287	0.2139
Giardia lamblia	Ribonuclease H	0.0067	0.0242	0.0078
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.0454	0.3389
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.0454	0.3389
Trypanosoma brucei	ribonuclease H1	0.0067	0.0242	0.0232
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0108	0.0088
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0049	0.0127	0.1142
Trypanosoma brucei	RNA helicase, putative	0.039	0.2277	0.2707
Brugia malayi	intermediate filament protein	0.0054	0.0157	0.1172
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0143	0.0722	1
Schistosoma mansoni	hypothetical protein	0.0107	0.0491	0.1058
Brugia malayi	exodeoxyribonuclease III family protein	0.0057	0.0178	0.1329
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0056	0.0174	0.0155
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0108	0.0197
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0157	0.1172
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0074	0.0287	0.1996
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0169	0.0884	0.1013
Onchocerca volvulus		0.0049	0.0129	0.1171
Treponema pallidum	thymidylate kinase (tmk)	0.0143	0.0722	1
Schistosoma mansoni	thymidylate kinase	0.0143	0.0722	0.1577
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0157	0.0308
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.0454	0.3389
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0057	0.0178	0.0155
Echinococcus granulosus	lamin dm0	0.0054	0.0157	0.0308
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0049	0.0127	0.0614
Trichomonas vaginalis	ribonuclease H1, putative	0.0067	0.0242	0.0232
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.002	0.0148
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0143	0.0722	1
Brugia malayi	RNase H family protein	0.0067	0.0242	0.1801
Echinococcus granulosus	thymidylate kinase	0.0143	0.0722	0.1577
Trypanosoma brucei	ingi protein (ORF1)	0.0076	0.0297	0.03
Schistosoma mansoni	thymidine kinase	0.0738	0.4476	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0151	0.1126
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0067	0.0242	0.1164
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.005	0.0031
Brugia malayi	hypothetical protein	0.0051	0.0138	0.103
Trichomonas vaginalis	thymidine kinase, putative	0.134	0.8274	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 881618