Detailed information for compound 881851

Basic information

Technical information
  • TDR Targets ID: 881851
  • Name: 3-(3,5-dichlorophenyl)-1-[2-(4-sulfamoylpheny l)ethyl]thiourea
  • MW: 404.335 | Formula: C15H15Cl2N3O2S2
  • H donors: 3 H acceptors: 2 LogP: 3.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(Nc1cc(Cl)cc(c1)Cl)NCCc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C15H15Cl2N3O2S2/c16-11-7-12(17)9-13(8-11)20-15(23)19-6-5-10-1-3-14(4-2-10)24(18,21)22/h1-4,7-9H,5-6H2,(H2,18,21,22)(H2,19,20,23)
  • InChiKey: VMCJYDFZBCJHOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC07325724

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0233 0.1724 0.4298
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0463 0.0455
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0221 0.0212
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0334 0.0326
Loa Loa (eye worm) hypothetical protein 0.0163 0.1175 0.2911
Loa Loa (eye worm) hypothetical protein 0.0072 0.0463 0.1135
Echinococcus multilocularis zinc finger protein 0.0019 0.0045 0.0037
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0179 0.017
Loa Loa (eye worm) adenosylhomocysteinase 0.0524 0.4012 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0432 0.1058
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0524 0.4012 1
Schistosoma mansoni zinc finger protein 0.0019 0.0045 0.0037
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0524 0.4012 1
Echinococcus multilocularis GA binding protein alpha chain 0.0065 0.041 0.0401
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.062 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0174 0.0206
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0118 0.0109
Schistosoma mansoni gabp alpha 0.0065 0.041 0.0401
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0221 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0206 0.0491
Trichomonas vaginalis chromobox protein, putative 0.0063 0.039 0.0758
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0068 0.0059
Brugia malayi jmjC domain containing protein 0.0092 0.062 0.1545
Trichomonas vaginalis glucosylceramidase, putative 0.0233 0.1724 0.4162
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0065 0.041 0.1001
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0138 0.0323
Trichomonas vaginalis glucosylceramidase, putative 0.0233 0.1724 0.4162
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0056 0.0334 0.0556
Schistosoma mansoni hypothetical protein 0.002 0.0053 0.0045
Toxoplasma gondii adenosylhomocysteinase, putative 0.0524 0.4012 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0221 0.0212
Brugia malayi Heterochromatin protein 1 0.0063 0.039 0.0973
Trichomonas vaginalis glucosylceramidase, putative 0.0153 0.1096 0.2559
Entamoeba histolytica adenosylhomocysteinase, putative 0.0524 0.4012 1
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0204 0.0196
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0195 0.0259
Brugia malayi N-terminal motif family protein 0.0163 0.1175 0.2927
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0524 0.4012 0.5
Echinococcus granulosus adenosylhomocysteinase 0.0524 0.4012 0.4007
Schistosoma mansoni ets-related 0.0198 0.1453 0.1445
Schistosoma mansoni chromobox protein 0.0063 0.039 0.0382
Echinococcus multilocularis chromobox protein 1 0.0063 0.039 0.0382
Loa Loa (eye worm) hypothetical protein 0.008 0.0522 0.1282
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0031 0.0055
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.0411
Schistosoma mansoni hypothetical protein 0.0028 0.0118 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0153 0.1096 0.2559
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0169 0.016
Leishmania major S-adenosylhomocysteine hydrolase 0.0524 0.4012 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.022 0.0527
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0195 0.0259
Brugia malayi Pre-SET motif family protein 0.0056 0.0334 0.0833
Echinococcus multilocularis microtubule associated protein 2 0.1286 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0138 0.0345
Brugia malayi jmjC domain containing protein 0.0036 0.0179 0.0446
Plasmodium vivax SET domain protein, putative 0.0056 0.0334 0.0556
Trichomonas vaginalis glucosylceramidase, putative 0.0153 0.1096 0.2559
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0524 0.4012 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0195 0.0248
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0057 0.0349 0.034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0221 0.0212
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.062 0.0611
Schistosoma mansoni microtubule-associated protein tau 0.1286 1 1
Trichomonas vaginalis set domain proteins, putative 0.0441 0.3365 0.8349
Echinococcus granulosus chromobox protein 1 0.0063 0.039 0.0382
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0118 0.0272
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.025 0.0623
Brugia malayi PHD-finger family protein 0.0028 0.0118 0.0294
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0524 0.4012 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0164 0.0156
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0026 0.0017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0056 0.0334 0.0326
Trichomonas vaginalis glucosylceramidase, putative 0.0153 0.1096 0.2559
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0009 0.0022
Giardia lamblia PHD finger protein 15 0.0028 0.0118 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0221 0.0212
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0524 0.4012 1
Schistosoma mansoni hypothetical protein 0.0163 0.1179 0.1171
Loa Loa (eye worm) hypothetical protein 0.0028 0.0114 0.0262
Schistosoma mansoni adenosylhomocysteinase 0.0324 0.2444 0.2437
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0388 0.2944 0.7332
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0026 0.0017
Loa Loa (eye worm) hypothetical protein 0.0048 0.0276 0.0666
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0035 0.0174 0.0184
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0524 0.4012 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0118 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0233 0.1724 0.4162
Onchocerca volvulus Alhambra homolog 0.0028 0.0118 0.0012
Brugia malayi Bromodomain containing protein 0.0072 0.0465 0.1158
Trichomonas vaginalis glucosylceramidase, putative 0.0153 0.1096 0.2559
Trichomonas vaginalis glucosylceramidase, putative 0.0161 0.1161 0.2724
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0463 0.0455
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0026 0.0017
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0163 0.1175 0.3262
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0524 0.4012 0.5
Echinococcus granulosus zinc finger protein 0.0019 0.0045 0.0037
Brugia malayi Ets-domain containing protein 0.0065 0.041 0.1021
Brugia malayi Ets-domain containing protein 0.0065 0.041 0.1021
Schistosoma mansoni adenosylhomocysteinase 0.0524 0.4012 0.4007
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0068 0.0059
Brugia malayi PHD-finger family protein 0.0024 0.0086 0.0214
Trichomonas vaginalis glucosylceramidase, putative 0.0233 0.1724 0.4162
Onchocerca volvulus 0.0066 0.0415 0.0926
Trichomonas vaginalis glucosylceramidase, putative 0.0233 0.1724 0.4162
Echinococcus granulosus GA binding protein alpha chain 0.0065 0.041 0.0401
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0179 0.0424
Onchocerca volvulus 0.0441 0.3365 1
Trichomonas vaginalis glucosylceramidase, putative 0.0161 0.1161 0.2724
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0221 0.0212
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0118 0.0109
Echinococcus multilocularis peregrin 0.003 0.0136 0.0127
Echinococcus multilocularis adenosylhomocysteinase 0.0524 0.4012 0.4007
Echinococcus multilocularis geminin 0.0163 0.1179 0.1171
Echinococcus granulosus chromobox protein 1 0.0063 0.039 0.0382
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0164 0.1189 0.2797
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0179 0.017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0169 0.016
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0353 0.0859
Loa Loa (eye worm) heterochromatin protein 1 0.0063 0.039 0.0952
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0068 0.0059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0072 0.0463 0.0455
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.025 0.0623
Schistosoma mansoni adenosylhomocysteinase 0.0324 0.2444 0.2437
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0179 0.017
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.0602
Brugia malayi Pre-SET motif family protein 0.0388 0.2944 0.7338
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0054 0.0318 0.031
Onchocerca volvulus Glucosylceramidase homolog 0.0153 0.1096 0.3021
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0471 0.0463
Brugia malayi Bromodomain containing protein 0.003 0.0136 0.0339
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0057 0.0349 0.034
Echinococcus granulosus geminin 0.0163 0.1179 0.1171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0221 0.0212
Brugia malayi chromobox protein homolog 3 0.0035 0.0174 0.0433
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0221 0.053
Schistosoma mansoni hypothetical protein 0.0163 0.1179 0.1171
Schistosoma mansoni zinc finger protein 0.0015 0.0013 0.0004
Loa Loa (eye worm) fli-1 protein 0.0198 0.1453 0.3606
Brugia malayi Bromodomain containing protein 0.0037 0.0187 0.0466
Loa Loa (eye worm) hypothetical protein 0.0056 0.0335 0.0815
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0524 0.4012 1
Echinococcus granulosus peregrin 0.003 0.0136 0.0127
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0053 0.0111
Schistosoma mansoni chromobox protein 0.0063 0.039 0.0382
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0233 0.1724 0.4285
Schistosoma mansoni adenosylhomocysteinase 0.0324 0.2444 0.2437
Loa Loa (eye worm) hypothetical protein 0.0037 0.0188 0.0446
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0009 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0415 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0174 0.0206
Brugia malayi Fli-1 protein 0.0198 0.1453 0.3621
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0524 0.4012 0.5
Schistosoma mansoni bromodomain containing protein 0.0061 0.0376 0.0367
Trichomonas vaginalis glucosylceramidase, putative 0.0153 0.1096 0.2559
Schistosoma mansoni adenosylhomocysteinase 0.0324 0.2444 0.2437
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0221 0.0551
Echinococcus granulosus histone lysine methyltransferase setb 0.0072 0.0463 0.0455
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.025 0.0602
Plasmodium falciparum adenosylhomocysteinase 0.0524 0.4012 1
Schistosoma mansoni hypothetical protein 0.0031 0.0138 0.013
Echinococcus multilocularis chromobox protein 1 0.0063 0.039 0.0382
Trichomonas vaginalis chromobox protein, putative 0.0063 0.039 0.0758
Trichomonas vaginalis glucosylceramidase, putative 0.0153 0.1096 0.2559
Brugia malayi Adenosylhomocysteinase 0.0524 0.4012 1
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0204 0.0196
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0272
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0026 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0233 0.1724 0.4162

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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