Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | jumonji domain containing protein | 0.0031 | 0.0077 | 0.0077 |
Onchocerca volvulus | Alhambra homolog | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0442 | 0.3703 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0046 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0073 | 0.0445 | 0.0445 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1155 | 1 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0027 | 0.0041 | 0.0041 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.0313 | 0.0313 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1155 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1155 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0046 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0442 | 0.3703 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0027 | 0.0046 | 0.0046 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0073 | 0.0445 | 0.0445 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1155 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0046 | 0.5 |
Giardia lamblia | PHD finger protein 15 | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0027 | 0.0041 | 0.0041 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0027 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0046 | 0.0208 | 0.0208 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0027 | 0.0046 | 0.0046 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0027 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1155 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0027 | 0.0046 | 0.0046 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0442 | 0.3703 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0073 | 0.0445 | 0.0445 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0046 | 0.0046 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0031 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0027 | 0.0041 | 0.0041 |
Echinococcus granulosus | dihydrofolate reductase | 0.1155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.014 | 0.014 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0442 | 0.3703 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0046 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0046 | 0.0046 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1155 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0442 | 0.3703 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1155 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0442 | 0.3703 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1155 | 1 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0027 | 0.0041 | 0.0041 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.