Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0087 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0087 | 1 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0066 | 0.0572 | 0.0572 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0066 | 0.0572 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0087 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0087 | 1 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0087 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0087 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0087 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0087 | 1 | 0.5 |
Plasmodium falciparum | calcium-dependent protein kinase 3 | 0.0066 | 0.059 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0087 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0087 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0087 | 1 | 0.5 |
Echinococcus multilocularis | 0.0087 | 1 | 1 | |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0087 | 1 | 0.5 |
Plasmodium vivax | calcium-dependent protein kinase 4, putative | 0.0066 | 0.059 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0087 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0087 | 1 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0087 | 1 | 1 |
Brugia malayi | cytochrome P450 | 0.0087 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0087 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0087 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0066 | 0.0572 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0066 | 0.0572 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0087 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0087 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0087 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0087 | 1 | 0.5 |
Plasmodium falciparum | calcium-dependent protein kinase 2 | 0.0066 | 0.059 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0087 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0087 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0087 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0087 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0087 | 1 | 0.5 |
Plasmodium vivax | calcium-dependent protein kinase, putative | 0.0066 | 0.059 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0066 | 0.0572 | 0.0572 |
Brugia malayi | Cytochrome P450 family protein | 0.0087 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0087 | 1 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0066 | 0.0572 | 0.0572 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0087 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0087 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0087 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0087 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0087 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0066 | 0.0572 | 0.0572 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0087 | 1 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0087 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0087 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0087 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0087 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0066 | 0.0572 | 0.0572 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0066 | 0.0572 | 0.0572 |
Leishmania major | cytochrome p450-like protein | 0.0087 | 1 | 1 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0087 | 1 | 0.5 |
Plasmodium falciparum | calcium-dependent protein kinase 1 | 0.0066 | 0.059 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0066 | 0.0572 | 0.0572 |
Plasmodium vivax | calcium-dependent protein kinase 1, putative | 0.0066 | 0.059 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0087 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0087 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0087 | 1 | 0.5 |
Plasmodium vivax | calcium-dependent protein kinase 3, putative | 0.0066 | 0.059 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0087 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0087 | 1 | 0.5 |
Plasmodium falciparum | calcium-dependent protein kinase 5 | 0.0066 | 0.059 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0087 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0087 | 1 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0087 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0087 | 1 | 0.5 |
Plasmodium falciparum | calcium-dependent protein kinase 4 | 0.0066 | 0.059 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0087 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0087 | 1 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0066 | 0.0572 | 0.0572 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0087 | 1 | 0.5 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0087 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.