Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.1039 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.0945 | 0.5 |
Brugia malayi | diaphorase | 0.0118 | 0.0945 | 0.0945 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0397 | 0.3691 | 0.3691 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1039 | 1 | 1 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.0142 | 0.0142 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0921 | 0.8839 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0641 | 0.6092 | 0.6092 |
Leishmania major | nitrate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0118 | 0.0945 | 0.0945 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.0142 | 0.0142 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1039 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.1039 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1039 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1039 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.1039 | 1 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase-like protein | 0.0118 | 0.0945 | 0.0814 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Onchocerca volvulus | 0.0118 | 0.0945 | 1 | |
Schistosoma mansoni | cytochrome B5 | 0.0118 | 0.0945 | 0.0945 |
Trypanosoma brucei | oxidoreductase-protein, putative | 0.0118 | 0.0945 | 0.0814 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0118 | 0.0945 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1039 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0397 | 0.3691 | 0.36 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0118 | 0.0945 | 0.5 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1039 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0641 | 0.6092 | 0.6092 |
Leishmania major | NADH-dependent fumarate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Loa Loa (eye worm) | diaphorase | 0.0118 | 0.0945 | 0.0945 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0118 | 0.0945 | 0.0945 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0397 | 0.3691 | 0.3576 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0118 | 0.0945 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0397 | 0.3691 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0921 | 0.8839 | 0.8817 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0397 | 0.3691 | 0.5 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0118 | 0.0945 | 0.5 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0118 | 0.0945 | 0.0945 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.0207 | 0.0207 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1039 | 1 | 1 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0397 | 0.3691 | 0.36 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1039 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0397 | 0.3691 | 0.3033 |
Trypanosoma cruzi | nitrate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0397 | 0.3691 | 0.36 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0397 | 0.3691 | 0.3576 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0397 | 0.3691 | 0.5 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0397 | 0.3691 | 0.36 |
Leishmania major | p450 reductase, putative | 0.1039 | 1 | 1 |
Mycobacterium ulcerans | oxygenase | 0.0118 | 0.0945 | 0.0814 |
Brugia malayi | Cytochrome P450 family protein | 0.006 | 0.0376 | 0.0376 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1039 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1039 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1039 | 1 | 1 |
Leishmania major | reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Chlamydia trachomatis | sulfite reductase | 0.0641 | 0.6092 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1039 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0641 | 0.6092 | 0.6092 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0118 | 0.0945 | 0.0945 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1039 | 1 | 1 |
Mycobacterium ulcerans | flavodoxin reductase Hmp | 0.0118 | 0.0945 | 0.0814 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1039 | 1 | 1 |
Chlamydia trachomatis | Na(+)-translocating NADH-quinone reductase subunit F | 0.0118 | 0.0945 | 0.1551 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1039 | 1 | 1 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Mycobacterium ulcerans | oxidoreductase | 0.0118 | 0.0945 | 0.0814 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.0207 | 0.0207 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0515 | 0.4853 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0151 | 0.0151 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0397 | 0.3691 | 0.36 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0118 | 0.0945 | 0.0814 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0118 | 0.0945 | 0.0945 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0118 | 0.0945 | 0.0945 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0515 | 0.4853 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.0207 | 0.0207 |
Trypanosoma cruzi | oxidoreductase-protein, putative | 0.0118 | 0.0945 | 0.0814 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1039 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0397 | 0.3691 | 0.3576 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0641 | 0.6092 | 0.6092 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Leishmania major | NADH-dependent fumarate reductase-like protein | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma brucei | nitrate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0397 | 0.3691 | 0.3576 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0397 | 0.3691 | 0.5 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0515 | 0.4853 | 0.4853 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0397 | 0.3691 | 0.3033 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0118 | 0.0945 | 0.0945 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Giardia lamblia | Hypothetical protein | 0.0921 | 0.8839 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1039 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0036 | 0.0142 | 0.0142 |
Mycobacterium ulcerans | monooxygenase | 0.0118 | 0.0945 | 0.0814 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.0142 | 0.0142 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0207 | 0.0207 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0397 | 0.3691 | 0.3033 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0523 | 0.493 | 0.493 |
Echinococcus multilocularis | methionine synthase reductase | 0.0641 | 0.6092 | 0.6092 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.006 | 0.0376 | 0.0376 |
Leishmania major | cytochrome P450 reductase, putative | 0.0921 | 0.8839 | 0.8822 |
Mycobacterium ulcerans | flavodoxin oxidoreductase | 0.0118 | 0.0945 | 0.0814 |
Leishmania major | oxidoreductase-like protein | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Brugia malayi | flavodoxin family protein | 0.0397 | 0.3691 | 0.3691 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0118 | 0.0945 | 0.0945 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0246 | 0.0246 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0118 | 0.0945 | 0.0814 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1039 | 1 | 1 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0921 | 0.8839 | 0.8717 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0118 | 0.0945 | 0.0814 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.0142 | 0.0142 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0118 | 0.0945 | 0.0814 |
Treponema pallidum | flavodoxin | 0.0397 | 0.3691 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0397 | 0.3691 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.