TDR Targets

Basic information

Technical information

TDR Targets ID: 882791
Name: 7-chloro-1-(3-methoxyphenyl)-2-(1,3-thiazol-2 -yl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
MW: 424.857 | Formula: C21H13ClN2O4S
H donors: 0 H acceptors: 3 LogP: 4.01 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C1N(c2nccs2)C(=O)c2c1c(=O)c1c(o2)ccc(c1)Cl
InChi: 1S/C21H13ClN2O4S/c1-27-13-4-2-3-11(9-13)17-16-18(25)14-10-12(22)5-6-15(14)28-19(16)20(26)24(17)21-23-7-8-29-21/h2-10,17H,1H3
InChiKey: QREAWJHIMFWYMM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-chloro-1-(3-methoxyphenyl)-2-thiazol-2-yl-1H-chromeno[2,3-c]pyrrole-3,9-dione
7-chloro-1-(3-methoxyphenyl)-2-(2-thiazolyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
7-chloro-1-(3-methoxyphenyl)-2-thiazol-2-yl-1H-chromeno[2,3-c]pyrrole-3,9-quinone
STOCK4S-59650

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0028	1
Echinococcus multilocularis	pikachurin	0.0026	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0448
Toxoplasma gondii	exonuclease III APE	0.0019	0	0.5
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0028	0.0028
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0055	0.1119	0.1119
Loa Loa (eye worm)	carboxylesterase	0.0024	0.0173	0.0448
Loa Loa (eye worm)	abnormal epIthelia family member	0.0026	0.0211	0.0545
Onchocerca volvulus		0.0024	0.0173	1
Schistosoma mansoni	hypothetical protein	0.0342	1	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0	0.5
Brugia malayi	hypothetical protein	0.002	0.0028	0.0072
Brugia malayi	Carboxylesterase family protein	0.0024	0.0173	0.0448
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0	0.5
Echinococcus granulosus	slit 2 protein	0.0026	0.0211	0.0211
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0	0.5
Echinococcus multilocularis	neurogenic locus notch protein	0.0026	0.0211	0.0211
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0	0.5
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0024	0.0173	1
Brugia malayi	hypothetical protein	0.0024	0.0173	0.0448
Schistosoma mansoni	rab6-interacting	0.002	0.0028	0.0028
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0024	0.0173	1
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0028	0.0072
Echinococcus granulosus	carboxylesterase 5A	0.0144	0.387	0.387
Brugia malayi	laminin alpha chain	0.0026	0.0211	0.0545
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0024	0.0173	0.0173
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0024	0.0173	0.0173
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0024	0.0173	0.0173
Schistosoma mansoni	loxhd1	0.002	0.0028	0.0028
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0	0.5
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0024	0.0173	0.0173
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0024	0.0173	0.0173
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.0026	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.002	0.0028	0.0072
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0024	0.0173	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0028	0.0028
Schistosoma mansoni	acetylcholinesterase	0.0024	0.0173	0.0173
Trichomonas vaginalis	spcc417.12 protein, putative	0.0024	0.0173	1
Brugia malayi	Carboxylesterase family protein	0.0024	0.0173	0.0448
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0028	0.0028
Loa Loa (eye worm)	carboxylesterase	0.0144	0.387	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0024	0.0173	0.0173
Echinococcus multilocularis	carboxylesterase 5A	0.0144	0.387	0.387
Brugia malayi	EGF-like domain containing protein	0.0026	0.0211	0.0545
Echinococcus granulosus	RUN	0.002	0.0028	0.0028
Brugia malayi	Carboxylesterase family protein	0.0144	0.387	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0144	0.387	0.387
Schistosoma mansoni	laminin gamma-3 chain	0.0026	0.0211	0.0211
Brugia malayi	hypothetical protein	0.002	0.0028	0.0072
Onchocerca volvulus		0.0024	0.0173	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0	0.5
Schistosoma mansoni	BC026374 protein (S09 family)	0.0024	0.0173	0.0173
Echinococcus granulosus	BC026374 protein S09 family	0.0024	0.0173	0.0173
Schistosoma mansoni	gliotactin	0.0024	0.0173	0.0173
Schistosoma mansoni	hypothetical protein	0.0342	1	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0144	0.387	1
Loa Loa (eye worm)	carboxylesterase	0.0024	0.0173	0.0448
Echinococcus granulosus	para nitrobenzyl esterase	0.0024	0.0173	0.0173
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0	0.5
Schistosoma mansoni	rab6-interacting	0.002	0.0028	0.0028
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0024	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0448
Echinococcus granulosus	neurogenic locus notch protein	0.0026	0.0211	0.0211
Echinococcus multilocularis	RUN	0.002	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0211	0.0545
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0055	0.1119	0.1119
Echinococcus multilocularis	acetylcholinesterase	0.0144	0.387	0.387
Echinococcus multilocularis	slit 2 protein	0.0026	0.0211	0.0211
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.0026	0.0211	0.0545
Echinococcus multilocularis	para nitrobenzyl esterase	0.0024	0.0173	0.0173
Echinococcus granulosus	acetylcholinesterase	0.0144	0.387	0.387
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0448
Schistosoma mansoni	cell polarity protein	0.0026	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0448
Brugia malayi	Doublecortin family protein	0.002	0.0028	0.0072
Brugia malayi	Carboxylesterase family protein	0.0024	0.0173	0.0448
Schistosoma mansoni	lipoxygenase	0.002	0.0028	0.0028
Echinococcus multilocularis	acetylcholinesterase	0.0144	0.387	0.387
Schistosoma mansoni	polycystin 1-related	0.002	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.002	0.0028	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0173	0.0448
Schistosoma mansoni	hypothetical protein	0.002	0.0028	0.0028
Brugia malayi	Carboxylesterase family protein	0.0024	0.0173	0.0448
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0028	0.0028
Brugia malayi	laminin-like protein K08C7.3 precursor	0.0026	0.0211	0.0545
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0028	1
Schistosoma mansoni	lipoxygenase	0.0055	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0211	0.0545
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0	0.5
Echinococcus granulosus	acetylcholinesterase	0.0144	0.387	0.387
Echinococcus granulosus	neuroligin	0.0024	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0211	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0144	0.387	1
Schistosoma mansoni	slit	0.0026	0.0211	0.0211
Echinococcus granulosus	pikachurin	0.0026	0.0211	0.0211
Onchocerca volvulus		0.0024	0.0173	1
Echinococcus multilocularis	neuroligin	0.0024	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0144	0.387	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0028	0.0028
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0024	0.0173	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0028	0.0028
Mycobacterium ulcerans	carboxylesterase, LipT	0.0024	0.0173	1
Onchocerca volvulus		0.0024	0.0173	1
Brugia malayi	Carboxylesterase family protein	0.0144	0.387	1
Echinococcus multilocularis	geminin	0.0342	1	1
Onchocerca volvulus		0.0024	0.0173	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 882791