Detailed information for compound 882899

Basic information

Technical information
  • TDR Targets ID: 882899
  • Name: 3-[(3,5-dimethoxyphenyl)methyl]-2-(2-methoxyp henyl)-1,3-thiazolidin-4-one
  • MW: 359.439 | Formula: C19H21NO4S
  • H donors: 0 H acceptors: 1 LogP: 3.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)cc(c1)CN1C(=O)CSC1c1ccccc1OC
  • InChi: 1S/C19H21NO4S/c1-22-14-8-13(9-15(10-14)23-2)11-20-18(21)12-25-19(20)16-6-4-5-7-17(16)24-3/h4-10,19H,11-12H2,1-3H3
  • InChiKey: SBNAWCZKBIBNQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(3,5-dimethoxyphenyl)methyl]-2-(2-methoxyphenyl)thiazolidin-4-one
  • 3-[(3,5-dimethoxyphenyl)methyl]-2-(2-methoxyphenyl)-4-thiazolidinone
  • 3-(3,5-dimethoxybenzyl)-2-(2-methoxyphenyl)thiazolidin-4-one
  • Oprea1_622715

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0899 0.6585 0.6585
Brugia malayi glutathione reductase 0.0047 0.0039 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.1258 0.9349 1
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0635 0.456 1
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0573 0.0573
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0269 0.1746 0.1833
Loa Loa (eye worm) PHD-finger family protein 0.0116 0.0567 0.0567
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0659 0.4747 0.4747
Brugia malayi jmjC domain containing protein 0.038 0.2596 0.2596
Plasmodium falciparum histone acetyltransferase GCN5 0.0155 0.087 0.1072
Echinococcus granulosus zinc finger protein 0.0092 0.0382 0.0685
Trypanosoma cruzi hexokinase, putative 0.0392 0.2689 0.2847
Schistosoma mansoni tar DNA-binding protein 0.025 0.1597 0.1597
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0432 0.3001 0.3181
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.1056 0.7796 1
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0133 0.0697 0.0541
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0068 0.0196 0.0332
Echinococcus granulosus methyl CpG binding domain protein 2 0.0068 0.0196 0.0352
Echinococcus multilocularis hexokinase 0.0392 0.2689 0.4542
Brugia malayi MH1 domain containing protein 0.0048 0.0044 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0432 0.3001 0.3001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0117 0.0573 0.0821
Loa Loa (eye worm) hypothetical protein 0.0046 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0062 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0153 0.0849 0.0849
Schistosoma mansoni bromodomain containing protein 0.0266 0.172 0.172
Toxoplasma gondii phosphofructokinase PFKII 0.0117 0.0573 0.0689
Trypanosoma cruzi phosphomannose isomerase, putative 0.0768 0.5578 0.595
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0245 0.0222
Loa Loa (eye worm) hypothetical protein 0.0267 0.1731 0.1731
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.0355 0.0355
Entamoeba histolytica acetyltransferase, GNAT family 0.0155 0.087 0.0636
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0088 0.0355 0.0599
Brugia malayi Hexokinase family protein 0.0121 0.0607 0.0607
Echinococcus granulosus hexokinase 0.0392 0.2689 0.4821
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0659 0.4747 0.6069
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0245 0.0266
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0145 0.0789 0.0634
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0635 0.456 0.456
Brugia malayi Bromodomain containing protein 0.0313 0.2078 0.2078
Schistosoma mansoni hypothetical protein 0.0062 0.0153 0.0153
Echinococcus multilocularis zinc finger protein 0.0092 0.0382 0.0645
Trichomonas vaginalis phosphomannomutase, putative 0.0128 0.0659 0.0659
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0558 0.397 0.6704
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.397 0.397
Leishmania major hypothetical protein, conserved 0.1258 0.9349 1
Brugia malayi Hexokinase family protein 0.0246 0.1566 0.1566
Echinococcus granulosus lysine specific demethylase 5A 0.0148 0.0813 0.1457
Brugia malayi hypothetical protein 0.0048 0.0043 0.0043
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0153 0.0275
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0635 0.456 0.7701
Loa Loa (eye worm) transcription factor SMAD2 0.0706 0.5104 0.5104
Schistosoma mansoni methyl-cpg binding protein mbd 0.0068 0.0196 0.0196
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0586 0.4182 0.7062
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0432 0.3001 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0598 0.1889
Loa Loa (eye worm) hexokinase 0.0121 0.0607 0.0607
Entamoeba histolytica serine/threonine protein kinase, putative 0.0558 0.397 0.4827
Echinococcus multilocularis peregrin 0.014 0.0748 0.1263
Leishmania major ATP-dependent phosphofructokinase 0.0432 0.3001 0.3181
Loa Loa (eye worm) hypothetical protein 0.0068 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0099 0.0433 0.0433
Brugia malayi jmjC domain containing protein 0.0148 0.0813 0.0813
Loa Loa (eye worm) glutaminase 2 0.1342 1 1
Schistosoma mansoni Smad4 0.0048 0.0044 0.0044
Schistosoma mansoni smad1 5 8 and 0.0048 0.0044 0.0044
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0094 0.04 0.0239
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0659 0.4747 0.6069
Loa Loa (eye worm) hypothetical protein 0.0116 0.0567 0.0567
Trypanosoma cruzi ISWI complex protein 0.0061 0.0143 0.0112
Echinococcus granulosus hexokinase type 2 0.0392 0.2689 0.4821
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0153 0.0275
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0768 0.5578 0.5578
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0217 0.0052
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0094 0.04 0.1219
Brugia malayi F/Y-rich N-terminus family protein 0.0046 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0125 0.0633 0.0633
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.397 0.397
Trypanosoma brucei hexokinase 0.0392 0.2689 0.2847
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0187 0.05
Echinococcus multilocularis tar DNA binding protein 0.025 0.1597 0.2696
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.025 0.1597 0.1597
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.04 0.0388
Brugia malayi acetyltransferase, GNAT family protein 0.0586 0.4182 0.4182
Plasmodium vivax phosphomannomutase, putative 0.0128 0.0659 0.08
Leishmania major hypothetical protein, conserved 0.0269 0.1746 0.1833
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0117 0.0573 0.0689
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0187 0.05
Schistosoma mansoni mannose-6-phosphate isomerase 0.0768 0.5578 0.5578
Echinococcus granulosus TGF beta signal transducer SmadC 0.0048 0.0044 0.008
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0145 0.0789 0.0634
Brugia malayi 6-phosphofructokinase 0.0432 0.3001 0.3001
Brugia malayi PHD-finger family protein 0.0113 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.007 0.0217 0.0217
Echinococcus multilocularis hexokinase 0.0392 0.2689 0.4542
Onchocerca volvulus Putative phosphomannomutase 0.0128 0.0659 0.0419
Trypanosoma brucei phosphomannose isomerase 0.0768 0.5578 0.595
Trichomonas vaginalis bromodomain-containing protein, putative 0.0179 0.1051 0.1051
Brugia malayi MH2 domain containing protein 0.0048 0.0044 0.0044
Echinococcus multilocularis phosphomannomutase 0.0128 0.0659 0.1113
Brugia malayi AMP-binding enzyme family protein 0.0094 0.04 0.04
Trichomonas vaginalis phosphofructokinase, putative 0.0432 0.3001 0.3001
Trypanosoma brucei polo-like protein kinase 0.0558 0.397 0.4223
Schistosoma mansoni hypothetical protein 0.0333 0.2238 0.2238
Brugia malayi Smad1 0.0048 0.0044 0.0044
Leishmania major phosphomannose isomerase 0.0768 0.5578 0.595
Brugia malayi Bm-MIF-1, identical 0.1056 0.7796 0.7796
Trichomonas vaginalis CAMK family protein kinase 0.0276 0.1801 0.1801
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.397 0.397
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0197 0.1187 0.1187
Schistosoma mansoni hypothetical protein 0.0062 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0281 0.1839 0.1839
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0145 0.0789 0.0789
Brugia malayi hypothetical protein 0.0899 0.6585 0.6585
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0048 0.0044 0.0044
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0659 0.4747 0.5782
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0179 0.1051 0.1051
Onchocerca volvulus Serine\/threonine kinase homolog 0.0558 0.397 0.5772
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0145 0.0789 0.0805
Trypanosoma brucei hypothetical protein, conserved 0.1258 0.9349 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.1187 0.1187
Leishmania major hexokinase, putative 0.0392 0.2689 0.2847
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.021 0.1293 0.1348
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.04 0.0239
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0153 0.0153
Loa Loa (eye worm) macrophage migration inhibitory factor 0.1056 0.7796 0.7796
Brugia malayi AMP-binding enzyme family protein 0.0094 0.04 0.04
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0039 0.0039
Echinococcus granulosus PHD finger protein rhinoceros 0.0116 0.0567 0.1016
Schistosoma mansoni smad1 5 8 and 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0094 0.04 0.04
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0432 0.3001 0.6088
Trichomonas vaginalis phosphofructokinase, putative 0.0432 0.3001 0.3001
Loa Loa (eye worm) phosphofructokinase 0.0432 0.3001 0.3001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.038 0.2596 0.4384
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0269 0.1746 0.1833
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0598 0.1527
Plasmodium vivax 6-phosphofructokinase, putative 0.0117 0.0573 0.0689
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0088 0.0355 0.0599
Schistosoma mansoni zinc finger protein 0.0092 0.0382 0.0382
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0558 0.397 0.7117
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0432 0.3001 1
Echinococcus multilocularis citrate lyase subunit beta protein 0.0145 0.0789 0.1332
Loa Loa (eye worm) hypothetical protein 0.0134 0.0709 0.0709
Schistosoma mansoni smad1 5 8 and 0.0048 0.0044 0.0044
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0768 0.5578 0.5578
Plasmodium falciparum hexokinase 0.0392 0.2689 0.3417
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0768 0.5578 0.5578
Onchocerca volvulus 0.0392 0.2689 0.3701
Schistosoma mansoni hexokinase 0.0392 0.2689 0.2689
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0088 0.0355 0.0636
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0505 0.1576
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0768 0.5578 0.5504
Toxoplasma gondii 6-phosphofructokinase 0.0117 0.0573 0.0689
Trypanosoma cruzi polo-like protein kinase, putative 0.0558 0.397 0.4223
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0635 0.456 0.8175
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0558 0.397 0.397
Loa Loa (eye worm) hexokinase 0.0392 0.2689 0.2689
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0117 0.0573 0.0009
Schistosoma mansoni hypothetical protein 0.0062 0.0153 0.0153
Schistosoma mansoni tar DNA-binding protein 0.025 0.1597 0.1597
Brugia malayi PHD-finger family protein 0.0116 0.0567 0.0567
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0269 0.1746 0.1833
Loa Loa (eye worm) RNA binding protein 0.025 0.1597 0.1597
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.022 0.1369 0.4492
Loa Loa (eye worm) hypothetical protein 0.0094 0.04 0.04
Entamoeba histolytica hexokinase 1 0.0392 0.2689 0.3096
Schistosoma mansoni glutaminase 0.1342 1 1
Brugia malayi RNA binding protein 0.025 0.1597 0.1597
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.397 0.397
Schistosoma mansoni tar DNA-binding protein 0.025 0.1597 0.1597
Plasmodium falciparum acyl-CoA synthetase 0.007 0.0217 0.0229
Echinococcus granulosus tar DNA binding protein 0.025 0.1597 0.2862
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0045 0.0021 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.0432 0.3001 0.3001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0153 0.0259
Loa Loa (eye worm) hypothetical protein 0.0125 0.0633 0.0633
Onchocerca volvulus 0.0246 0.1566 0.1885
Echinococcus granulosus GPCR family 2 0.0062 0.0153 0.0275
Trypanosoma cruzi phosphomannose isomerase, putative 0.0768 0.5578 0.595
Brugia malayi RNA recognition motif domain containing protein 0.025 0.1597 0.1597
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0145 0.0789 0.2532
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0117 0.0573 0.0689
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.04 0.0388
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0768 0.5578 0.7141
Brugia malayi TAR-binding protein 0.025 0.1597 0.1597
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0416 0.2875 0.9557
Loa Loa (eye worm) TAR-binding protein 0.025 0.1597 0.1597
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0505 0.1576
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0045 0.0021 0.0037
Loa Loa (eye worm) phosphomannomutase 2 0.0128 0.0659 0.0659
Brugia malayi 6-phosphofructokinase 0.0432 0.3001 0.3001
Echinococcus multilocularis GPCR, family 2 0.0062 0.0153 0.0259
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.397 0.397
Toxoplasma gondii PHD-finger domain-containing protein 0.0116 0.0567 0.068
Loa Loa (eye worm) acetyltransferase 0.0586 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.007 0.0217 0.0217
Brugia malayi Hexokinase family protein 0.0392 0.2689 0.2689
Plasmodium falciparum macrophage migration inhibitory factor 0.1056 0.7796 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0197 0.1187 0.1187
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0153 0.0153
Brugia malayi MH1 domain containing protein 0.0048 0.0044 0.0044
Toxoplasma gondii PHD-finger domain-containing protein 0.0116 0.0567 0.068
Plasmodium vivax hexokinase, putative 0.0392 0.2689 0.3417
Entamoeba histolytica phosphomannose isomerase, putative 0.0768 0.5578 0.7002
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0039 0.007
Onchocerca volvulus 0.0392 0.2689 0.3701
Loa Loa (eye worm) 6-phosphofructokinase 0.0432 0.3001 0.3001
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0117 0.0573 0.0573
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0088 0.0355 0.0636
Brugia malayi latrophilin 2 splice variant baaae 0.0134 0.0709 0.0709
Schistosoma mansoni jumonji/arid domain-containing protein 0.0148 0.0813 0.0813
Plasmodium falciparum phd finger protein, putative 0.0116 0.0567 0.068
Trypanosoma cruzi phosphomannomutase, putative 0.0128 0.0659 0.0666
Echinococcus multilocularis hexokinase type 2 0.0392 0.2689 0.4542
Loa Loa (eye worm) hexokinase type II 0.0392 0.2689 0.2689
Schistosoma mansoni hypothetical protein 0.0116 0.0567 0.0567
Schistosoma mansoni 6-phosphofructokinase 0.0432 0.3001 0.3001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0094 0.04 0.0239
Loa Loa (eye worm) hexokinase 0.0246 0.1566 0.1566
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0094 0.04 0.0239
Toxoplasma gondii phosphomannomutase 0.0128 0.0659 0.08
Leishmania major macrophage migration inhibitory factor-like protein 0.1056 0.7796 0.8332
Schistosoma mansoni hypothetical protein 0.0061 0.0143 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0196 0.0196
Brugia malayi AMP-binding enzyme family protein 0.0094 0.04 0.04
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0133 0.0697 0.2222
Trypanosoma brucei phosphomannomutase 0.0128 0.0659 0.0666
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0415 0.2866 0.2746
Echinococcus granulosus histone acetyltransferase KAT2B 0.0179 0.1051 0.1884
Mycobacterium ulcerans glutaminase 0.1342 1 1
Echinococcus multilocularis smad 0.0048 0.0044 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.007 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0062 0.0153 0.0153
Plasmodium vivax acyl-CoA synthetase, putative 0.007 0.0217 0.0229
Mycobacterium ulcerans 6-phosphofructokinase 0.0432 0.3001 0.2883
Echinococcus granulosus jumonji domain containing protein 0.0161 0.0916 0.1642
Loa Loa (eye worm) glutaminase 0.1342 1 1
Mycobacterium tuberculosis Conserved protein 0.0145 0.0789 0.2532
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0635 0.456 0.456
Loa Loa (eye worm) jmjC domain-containing protein 0.0239 0.1517 0.1517
Brugia malayi Bromodomain containing protein 0.0166 0.0955 0.0955
Leishmania major hexokinase, putative 0.0392 0.2689 0.2847
Loa Loa (eye worm) hypothetical protein 0.0052 0.0073 0.0073
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0659 0.4747 0.6069
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0196 0.0332
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0586 0.4182 0.4182
Schistosoma mansoni hypothetical protein 0.0082 0.0306 0.0306
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0558 0.397 0.4223
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0445 0.0445
Loa Loa (eye worm) hypothetical protein 0.007 0.0217 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.1056 0.7796 0.7796
Schistosoma mansoni hypothetical protein 0.0134 0.0709 0.0709
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0153 0.0259
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.5922 1
Loa Loa (eye worm) PHD-finger family protein 0.0082 0.0306 0.0306
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0758 0.1281
Echinococcus granulosus fetal alzheimer antigen falz 0.009 0.0364 0.0653
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0187 0.05
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0433 0.0433
Loa Loa (eye worm) jmjC domain-containing protein 0.0148 0.0813 0.0813
Trypanosoma cruzi ISWI complex protein 0.0061 0.0143 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0573 0.0573
Echinococcus multilocularis geminin 0.0333 0.2238 0.378
Brugia malayi hexokinase type II 0.0125 0.0633 0.0633
Leishmania major hypothetical protein, conserved 0.0061 0.0143 0.0112
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0145 0.0789 0.0805
Echinococcus multilocularis expressed conserved protein 0.0093 0.0387 0.0654
Leishmania major macrophage migration inhibitory factor-like protein 0.1056 0.7796 0.8332
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0179 0.1051 0.1305
Brugia malayi hexokinase 0.0392 0.2689 0.2689
Echinococcus granulosus smad 0.0048 0.0044 0.008
Brugia malayi phosphofructokinase 0.0432 0.3001 0.3001
Onchocerca volvulus 0.0899 0.6585 1
Plasmodium vivax hypothetical protein, conserved 0.0116 0.0567 0.068
Entamoeba histolytica hexokinase 2 0.0392 0.2689 0.3096
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0505 0.1576
Mycobacterium tuberculosis Probable reductase 0.0108 0.0505 0.1576
Brugia malayi MH2 domain containing protein 0.0048 0.0044 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0558 0.397 0.397
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0094 0.04 0.1219
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0768 0.5578 0.7141
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0143 0.0774 0.1388
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0187 0.05
Plasmodium falciparum phosphomannomutase, putative 0.0128 0.0659 0.08
Loa Loa (eye worm) MH2 domain-containing protein 0.0706 0.5104 0.5104
Echinococcus granulosus citrate lyase subunit beta protein 0.0145 0.0789 0.1414
Echinococcus granulosus histone acetyltransferase KAT2B 0.056 0.3985 0.7144
Loa Loa (eye worm) hypothetical protein 0.007 0.0217 0.0217
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.007 0.0217 0.06
Schistosoma mansoni 6-phosphofructokinase 0.0432 0.3001 0.3001
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.397 0.397
Giardia lamblia Macrophage migration inhibitory factor 0.1056 0.7796 1
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0659 0.4747 0.4747
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0117 0.0573 0.0689
Echinococcus granulosus Smad4 0.0048 0.0044 0.008
Plasmodium vivax 6-phosphofructokinase, putative 0.0117 0.0573 0.0689
Mycobacterium ulcerans hypothetical protein 0.0094 0.04 0.0239
Loa Loa (eye worm) hypothetical protein 0.0176 0.103 0.103
Schistosoma mansoni hypothetical protein 0.0333 0.2238 0.2238
Echinococcus granulosus geminin 0.0333 0.2238 0.4013
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.04 0.0828
Loa Loa (eye worm) 6-phosphofructokinase 0.0432 0.3001 0.3001
Trypanosoma cruzi hypothetical protein, conserved 0.1258 0.9349 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0088 0.0355 0.0355
Trypanosoma brucei hexokinase, putative 0.0392 0.2689 0.2847
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0573 0.0573
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0204 0.1247 0.1297
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0116 0.0567 0.0567
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0433 0.0045
Onchocerca volvulus Hexokinase homolog 0.0246 0.1566 0.1885
Echinococcus multilocularis protein dispatched 1 0.0048 0.0046 0.0078
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0039 0.0066
Loa Loa (eye worm) hypothetical protein 0.0094 0.04 0.04
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0432 0.3001 0.3181
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0145 0.0789 0.0634
Trypanosoma cruzi hexokinase, putative 0.0392 0.2689 0.2847
Schistosoma mansoni jumonji/arid domain-containing protein 0.0148 0.0813 0.0813
Echinococcus multilocularis 6 phosphofructokinase 0.0432 0.3001 0.5067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0196 0.0196
Onchocerca volvulus 0.0392 0.2689 0.3701
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.045 0.3139 0.3139
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0245 0.0222
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0117 0.0573 0.0234
Schistosoma mansoni smad 0.0048 0.0044 0.0044
Entamoeba histolytica phosphomannomutase, putative 0.0128 0.0659 0.035
Echinococcus multilocularis Smad4 0.0048 0.0044 0.0075
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0416 0.2875 0.9576
Onchocerca volvulus Alhambra homolog 0.0116 0.0567 0.0269
Trypanosoma cruzi polo-like protein kinase, putative 0.0558 0.397 0.4223
Brugia malayi PHD-finger family protein 0.0046 0.0025 0.0025
Echinococcus granulosus hexokinase 0.0392 0.2689 0.4821
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0048 0.0044 0.0075
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0635 0.456 1
Schistosoma mansoni tar DNA-binding protein 0.025 0.1597 0.1597
Loa Loa (eye worm) Smad1 0.0048 0.0044 0.0044
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0635 0.456 0.4469
Brugia malayi hypothetical protein 0.0074 0.0245 0.0245
Entamoeba histolytica phosphofructokinase, putative 0.0432 0.3001 0.3516
Echinococcus multilocularis lysine specific demethylase 5A 0.014 0.0754 0.1274
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.04 0.0828
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0179 0.1051 0.1305
Echinococcus granulosus mannose 6 phosphate isomerase 0.0768 0.5578 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0048 0.0044 0.0044
Mycobacterium ulcerans hypothetical protein 0.0145 0.0789 0.0634
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0635 0.456 0.4857
Brugia malayi serine/threonine-protein kinase plk-2 0.0558 0.397 0.397
Schistosoma mansoni zinc finger protein 0.0061 0.0143 0.0143
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0245 0.0266
Echinococcus granulosus phosphomannomutase 0.0128 0.0659 0.1182
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0433 0.0731
Loa Loa (eye worm) bromodomain containing protein 0.0084 0.0324 0.0324
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0351 0.2378 0.2674
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0573 0.0573
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0598 0.1889
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0252 0.161 0.2886
Brugia malayi phosphomannomutase 2 0.0128 0.0659 0.0659
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.0355 0.0355
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0768 0.5578 0.5578
Loa Loa (eye worm) hypothetical protein 0.0199 0.1204 0.1204
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0197 0.1187 0.1187
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0245 0.0266
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0064 0.0165 0.0427
Mycobacterium ulcerans hypothetical protein 0.0145 0.0789 0.0634
Brugia malayi Thioredoxin reductase 0.0047 0.0039 0.0039
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0505 0.12
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0088 0.0355 0.0355
Echinococcus multilocularis jumonji domain containing protein 0.0161 0.0916 0.1547
Plasmodium vivax macrophage migration inhibitory factor, putative 0.1056 0.7796 1
Trichomonas vaginalis glutaminase, putative 0.1342 1 1
Brugia malayi MH2 domain containing protein 0.0706 0.5104 0.5104
Trichomonas vaginalis CAMK family protein kinase 0.0276 0.1801 0.1801
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.1056 0.7796 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0179 0.1051 0.1305
Treponema pallidum hexokinase (hxk) 0.0392 0.2689 0.5308
Trypanosoma brucei hexokinase 0.0392 0.2689 0.2847
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0598 0.1889
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0635 0.456 0.4857
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.1056 0.7796 0.7796
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0117 0.0573 0.0821
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0252 0.161 0.2719
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0573 0.0573
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0768 0.5578 0.942
Trypanosoma brucei ISWI complex protein 0.0061 0.0143 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.397 0.397
Schistosoma mansoni jumonji domain containing protein 0.0302 0.1996 0.1996
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0505 0.1576
Schistosoma mansoni phosphomannomutase 0.0128 0.0659 0.0659
Entamoeba histolytica phosphofructokinase, putative 0.0432 0.3001 0.3516
Brugia malayi glucose-6-phosphate dehydrogenase 0.0635 0.456 0.456
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0245 0.0222
Echinococcus multilocularis mothers against decapentaplegic 5 0.0048 0.0044 0.0075
Echinococcus multilocularis PHD finger protein rhinoceros 0.0116 0.0567 0.0957
Echinococcus granulosus 6 phosphofructokinase 0.0432 0.3001 0.5379
Brugia malayi Bromodomain containing protein 0.014 0.0748 0.0748
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.04 0.0388
Giardia lamblia Kinase, PLK 0.0558 0.397 0.4708
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.045 0.3139 0.3139
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.009 0.0364 0.0364
Echinococcus multilocularis fetal alzheimer antigen, falz 0.009 0.0364 0.0615
Leishmania major hypothetical protein, conserved 0.0074 0.0245 0.0222
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0505 0.1576
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0415 0.2866 0.3644
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.038 0.2596 0.4654
Loa Loa (eye worm) hypothetical protein 0.0184 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0074 0.0245 0.0245
Echinococcus granulosus peregrin 0.014 0.0748 0.134
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0196 0.0352
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0094 0.04 0.0239
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0635 0.456 0.4857
Giardia lamblia Histone acetyltransferase GCN5 0.0155 0.087 0.042
Echinococcus multilocularis hexokinase 0.0392 0.2689 0.4542
Leishmania major phosphomannomutase, putative 0.0128 0.0659 0.0666
Schistosoma mansoni methyl-cpg binding protein mbd 0.0068 0.0196 0.0196
Loa Loa (eye worm) glutathione reductase 0.0047 0.0039 0.0039
Loa Loa (eye worm) hexokinase 0.0392 0.2689 0.2689
Schistosoma mansoni kinase 0.0284 0.1858 0.1858
Schistosoma mansoni tar DNA-binding protein 0.025 0.1597 0.1597
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0768 0.5578 0.5578
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0145 0.0789 0.0805
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.04 0.0239
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.04 0.0239
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0573 0.0573
Entamoeba histolytica phosphofructokinase, putative 0.0432 0.3001 0.3516
Trypanosoma brucei beta lactamase 0.0064 0.0165 0.0136
Echinococcus granulosus mothers against decapentaplegic 5 0.0048 0.0044 0.008
Echinococcus granulosus expressed conserved protein 0.0093 0.0387 0.0694
Echinococcus granulosus hexokinase 0.0392 0.2689 0.4821
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0659 0.4747 0.4747
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0143 0.0774 0.1307
Toxoplasma gondii phosphomannose isomerase type I protein 0.0768 0.5578 0.7141
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0758 0.136
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0245 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.0355 0.0355
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0433 0.0776
Toxoplasma gondii hexokinase 0.0392 0.2689 0.3417

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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