Detailed information for compound 882905

Basic information

Technical information
  • TDR Targets ID: 882905
  • Name: N-(2-chlorophenyl)-4-(4-methoxyphenyl)-3-meth ylpiperazine-1-carbothioamide
  • MW: 375.915 | Formula: C19H22ClN3OS
  • H donors: 1 H acceptors: 0 LogP: 4.33 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1CCN(CC1C)C(=S)Nc1ccccc1Cl
  • InChi: 1S/C19H22ClN3OS/c1-14-13-22(19(25)21-18-6-4-3-5-17(18)20)11-12-23(14)15-7-9-16(24-2)10-8-15/h3-10,14H,11-13H2,1-2H3,(H,21,25)
  • InChiKey: BAKGLGYKRRYTED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-chlorophenyl)-4-(4-methoxyphenyl)-3-methyl-piperazine-1-carbothioamide
  • N-(2-chlorophenyl)-4-(4-methoxyphenyl)-3-methyl-1-piperazinecarbothioamide
  • Oprea1_231083

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.121 0.12
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0046 0.0043
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0022
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1027 1
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0358 0.3638 0.3637
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0184 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.031 0.0286
Brugia malayi hypothetical protein 0.0239 0.2384 0.2384
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0166 0.0511
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1027 0.4187
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0046 0.0043
Brugia malayi Flap endonuclease-1 0.0026 0.0149 0.0149
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0184 0.0139
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1027 0.1024
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0026 0.0023
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0159 0.0156
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0025 0.0014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1018 0.8837
Schistosoma mansoni lamin 0.0027 0.0159 0.0134
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1027 0.4187
Echinococcus granulosus death domain containing protein 0.0015 0.0025 0.0014
Toxoplasma gondii thioredoxin reductase 0.0048 0.0374 0.033
Echinococcus multilocularis chromobox protein 1 0.007 0.0612 0.0603
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.2384 0.2376
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0046 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0046 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0002
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0184 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0166 0.0511
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1027 0.1004
Onchocerca volvulus 0.0031 0.0197 0.0379
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0026 0.0026
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0025 0.0014
Echinococcus multilocularis musashi 0.0027 0.0159 0.0148
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0287 0.0576
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0189 0.0144
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0319 0.1163
Echinococcus granulosus lamin dm0 0.0027 0.0159 0.0148
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1146 1
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1027 0.1018
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0612 0.061
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1146 1
Echinococcus multilocularis lamin 0.0027 0.0159 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0287 0.1028
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0358 0.3638 0.3637
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0149 0.0146
Brugia malayi SET domain containing protein 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0374 0.0364
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0149 0.0146
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.4801 0.4796
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0149 0.0438
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0189 0.0179
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0046 0.0046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0517 0.5023
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0654 0.0645
Brugia malayi 6-phosphofructokinase 0.011 0.1027 0.1027
Brugia malayi hypothetical protein 0.0447 0.4578 0.4578
Brugia malayi Pre-SET motif family protein 0.003 0.0189 0.0189
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0962 1 1
Brugia malayi Uncoordinated protein 44 0.0015 0.0025 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0184 0.0589
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0517 0.4283
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0319 0.1163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0189 0.0165
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0374 0.0364
Leishmania major trypanothione reductase 0.0048 0.0374 0.0372
Echinococcus granulosus flap endonuclease 1 0.0026 0.0149 0.0139
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0184 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0046 0.0424
Onchocerca volvulus 0.0027 0.0159 0.0294
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0184 0.0139
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0046 0.0043
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.4801 0.4796
Schistosoma mansoni lozenge 0.0056 0.0462 0.0439
Loa Loa (eye worm) glutathione reductase 0.0048 0.0374 0.0372
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1027 0.1024
Plasmodium falciparum flap endonuclease 1 0.0026 0.0149 0.3125
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0046 0.0021
Brugia malayi Protein kinase domain containing protein 0.0015 0.0025 0.0025
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0517 0.0507
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.1317 0.1308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0189 0.0165
Echinococcus granulosus chromobox protein 1 0.007 0.0612 0.0603
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0026 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0287 0.1028
Brugia malayi Thioredoxin reductase 0.0048 0.0374 0.0374
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0149 0.7439
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0187
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0385 0.0385
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0046 0.0043
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1027 0.1024
Schistosoma mansoni thyroid hormone receptor 0.0137 0.1317 0.1295
Onchocerca volvulus 0.0447 0.4578 1
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1027 0.1024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0002
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0025 0.0022
Schistosoma mansoni chromobox protein 0.007 0.0612 0.0589
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1146 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0046 0.0036
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0358 0.3638 0.3637
Loa Loa (eye worm) phosphofructokinase 0.011 0.1027 0.1024
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1027 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0184 0.0589
Brugia malayi Cytochrome P450 family protein 0.0012 0.0003 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0184 0.0589
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0184 0.0589
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0046 0.0036
Onchocerca volvulus 0.0239 0.239 0.5195
Mycobacterium tuberculosis Probable reductase 0.0109 0.1018 0.8837
Echinococcus multilocularis Protein lozenge 0.0056 0.0462 0.0452
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0517 0.0473
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.2358 0.2356
Onchocerca volvulus 0.0049 0.0385 0.079
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0184 0.4201
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.0284
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0517 0.0507
Echinococcus granulosus lamin 0.0027 0.0159 0.0148
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0046 0.0043
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0046 0.0043
Loa Loa (eye worm) hypothetical protein 0.0447 0.4578 0.4576
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0046 0.0043
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0374 0.2985
Brugia malayi Heterochromatin protein 1 0.007 0.0612 0.0612
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0149 0.0146
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0374 0.0372
Brugia malayi glutathione reductase 0.0048 0.0374 0.0374
Schistosoma mansoni lamin 0.0027 0.0159 0.0134
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0184 0.4201
Schistosoma mansoni intermediate filament proteins 0.0027 0.0159 0.0134
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0184 0.4201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0046 0.0043
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0654 0.0645
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.121 0.12
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1027 0.1004
Schistosoma mansoni chromobox protein 0.007 0.0612 0.0589
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0149 0.0139
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0184 0.0589
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0025 0.000000022194
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1018 0.8837
Leishmania major 0.0962 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0517 0.0494
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0517 0.0494
Brugia malayi intermediate filament protein 0.0027 0.0159 0.0159
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0962 1 1
Plasmodium falciparum thioredoxin reductase 0.0048 0.0374 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1027 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0184 0.0402
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0025 0.0014
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0962 1 1
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0962 1 1
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1027 0.1018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0151
Plasmodium falciparum glutathione reductase 0.0048 0.0374 1
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0025 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0517 0.5023
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1018 0.8837
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0189 0.0165
Schistosoma mansoni flap endonuclease-1 0.0024 0.0122 0.0098
Loa Loa (eye worm) hypothetical protein 0.0031 0.0197 0.0195
Loa Loa (eye worm) hypothetical protein 0.0447 0.4578 0.4576
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0374 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1146 1
Schistosoma mansoni hypothetical protein 0.0127 0.121 0.1188
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1027 0.4187
Schistosoma mansoni hypothetical protein 0.0049 0.0385 0.0361
Echinococcus multilocularis lamin dm0 0.0027 0.0159 0.0148
Brugia malayi Death domain containing protein 0.0015 0.0025 0.0025
Toxoplasma gondii fructose-bisphospatase I 0.0358 0.3638 0.3609
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0046 0.0043
Trichomonas vaginalis chromobox protein, putative 0.007 0.0612 0.2417
Brugia malayi phosphofructokinase 0.011 0.1027 0.1027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2083 0.2081
Echinococcus granulosus neuropeptide s receptor 0.0468 0.4801 0.4796
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0159 0.0159
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0517 0.0515
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0046 0.0424
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0159 0.0156
Onchocerca volvulus 0.0027 0.0159 0.0294
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0184 0.0589
Toxoplasma gondii fructose-bisphospatase II 0.0962 1 1
Plasmodium vivax SET domain protein, putative 0.003 0.0189 0.4358
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0046 0.0043
Brugia malayi Pre-SET motif family protein 0.021 0.2083 0.2083
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0046 0.5
Loa Loa (eye worm) hypothetical protein 0.0239 0.2384 0.2382
Loa Loa (eye worm) runx1 0.0056 0.0462 0.046
Brugia malayi chromobox protein homolog 3 0.0039 0.0287 0.0287
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0184 0.0139
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0189 0.0179
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0189 0.0179
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0319 0.0645
Echinococcus granulosus Ankyrin 0.0015 0.0026 0.0016
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0149 0.3125
Echinococcus granulosus chromobox protein 1 0.007 0.0612 0.0603
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0178 0.0167
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.4801 0.4796
Plasmodium vivax glutathione reductase, putative 0.0048 0.0374 1
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1027 0.4187
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0149 0.0146
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1027 1
Trypanosoma brucei trypanothione reductase 0.0048 0.0374 0.0372
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0046 0.0043
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0156
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0358 0.3638 0.3609
Brugia malayi Cytochrome P450 family protein 0.0012 0.0003 0.0003
Echinococcus multilocularis Ankyrin 0.0015 0.0026 0.0016
Echinococcus granulosus intermediate filament protein 0.0027 0.0159 0.0148
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2389 1
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0962 1 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0046 0.0043
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0025 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0046 0.0043
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0184 0.0589
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0184 0.4201
Schistosoma mansoni survival motor neuron protein 0.0049 0.0385 0.0361
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0046 0.0424
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0962 1 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1027 0.8918
Schistosoma mansoni thyroid hormone receptor 0.0137 0.1317 0.1295
Brugia malayi 6-phosphofructokinase 0.011 0.1027 0.1027
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0184 0.1406
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0046 0.0043
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1027 0.1024
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0149 0.0103
Echinococcus multilocularis chromobox protein 1 0.007 0.0612 0.0603
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0046 0.0043
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1027 0.0695
Onchocerca volvulus 0.0042 0.031 0.0627
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1018 0.8837
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1018 0.8837
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0962 1 1
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0374 0.0372
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.2384 0.2376
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0517 0.5023
Brugia malayi follicle stimulating hormone receptor 0.0236 0.2358 0.2358
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1027 1
Trichomonas vaginalis chromobox protein, putative 0.007 0.0612 0.2417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0046 0.0043

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.4 uM Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) 1.4014 uM ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) 3.5572 uM ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 3.56 uM Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
Percent growth inhibition (functional) = 87.7 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye Saint Jude. 20485428
Percent growth inhibition (functional) = 94.6 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye Saint Jude. 20485428

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 20485428

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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