Detailed information for compound 882908

Basic information

Technical information
  • TDR Targets ID: 882908
  • Name: N-(2,4-difluorophenyl)-2-nitrobenzenesulfonam ide
  • MW: 314.265 | Formula: C12H8F2N2O4S
  • H donors: 1 H acceptors: 4 LogP: 2.48 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)NS(=O)(=O)c1ccccc1[N+](=O)[O-]
  • InChi: 1S/C12H8F2N2O4S/c13-8-5-6-10(9(14)7-8)15-21(19,20)12-4-2-1-3-11(12)16(17)18/h1-7,15H
  • InChiKey: XXZVDFMPIJKYJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,4-difluorophenyl)-2-nitro-benzenesulfonamide
  • ZINC00255558
  • STK047055

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0089 0.0164 0.7492
Brugia malayi Peptidase family M1 containing protein 0.0089 0.0164 0.0164
Trichomonas vaginalis pyruvate kinase, putative 0.011 0.021 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0089 0.0164 0.7061
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Chlamydia trachomatis pyruvate kinase 0.011 0.021 0.5
Trichomonas vaginalis pyruvate kinase, putative 0.011 0.021 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1683 0.3703 1
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.0517 0.1391
Mycobacterium ulcerans aminopeptidase N PepN 0.0089 0.0164 0.7061
Schistosoma mansoni microtubule-associated protein tau 0.1534 0.3371 0.9104
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0089 0.0164 0.0437
Echinococcus granulosus pyruvate kinase 0.011 0.021 0.0564
Echinococcus multilocularis pyruvate kinase 0.0057 0.0091 0.0241
Schistosoma mansoni hypothetical protein 0.0036 0.0045 0.0115
Brugia malayi intermediate filament protein 0.0029 0.003 0.003
Leishmania major pyruvate kinase 0.011 0.021 1
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0051 0.0133
Echinococcus granulosus pyruvate kinase 0.0057 0.0091 0.0241
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0002 0.0002
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0089 0.0164 0.0437
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0051 0.1467
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0051 0.1467
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0089 0.0164 0.0437
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Echinococcus granulosus lamin dm0 0.0029 0.003 0.0077
Brugia malayi TATA binding protein associated factor 0.0089 0.0164 0.0164
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0089 0.0164 0.7492
Brugia malayi pyruvate kinase 0.0023 0.0017 0.0017
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0164 0.7492
Brugia malayi Inositol-1 0.0039 0.0051 0.0051
Loa Loa (eye worm) pyruvate kinase 0.011 0.021 0.021
Echinococcus granulosus pyruvate kinase 0.0057 0.0091 0.0241
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Onchocerca volvulus 0.0089 0.0164 0.7403
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.011 0.021 1
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0045 0.0045
Trypanosoma brucei Aminopeptidase M1, putative 0.0089 0.0164 0.7492
Toxoplasma gondii aminopeptidase N protein 0.0089 0.0164 0.7492
Trypanosoma cruzi pyruvate kinase 2, putative 0.011 0.021 1
Brugia malayi pyruvate kinase, muscle isozyme 0.0023 0.0017 0.0017
Trypanosoma cruzi Aminopeptidase M1, putative 0.0089 0.0164 0.7492
Loa Loa (eye worm) aminopeptidase N 0.0089 0.0164 0.0164
Echinococcus multilocularis microtubule associated protein 2 0.1534 0.3371 0.9104
Brugia malayi MH2 domain containing protein 0.0125 0.0244 0.0244
Echinococcus granulosus leukotriene A 4 hydrolase 0.1683 0.3703 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0089 0.0164 0.7492
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0051 0.1467
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0164 0.7492
Echinococcus multilocularis pyruvate kinase 0.011 0.021 0.0564
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.003 0.003
Schistosoma mansoni inositol monophosphatase 0.0039 0.0051 0.0133
Entamoeba histolytica aminopeptidase, putative 0.0089 0.0164 1
Onchocerca volvulus Pyruvate kinase homolog 0.011 0.021 1
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0051 0.0133
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Echinococcus granulosus muscleblind protein 0.0175 0.0354 0.0951
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0078 0.0078
Brugia malayi Muscleblind-like protein 0.0175 0.0354 0.0354
Schistosoma mansoni lamin 0.0029 0.003 0.0077
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0164 0.7492
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Loa Loa (eye worm) intermediate filament protein 0.0029 0.003 0.003
Toxoplasma gondii pyruvate kinase PyK1 0.011 0.021 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.011 0.021 0.021
Leishmania major pyruvate kinase 0.011 0.021 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0033 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0077 0.0136 0.0136
Giardia lamblia Pyruvate kinase 0.011 0.021 1
Onchocerca volvulus 0.0089 0.0164 0.7403
Plasmodium vivax pyruvate kinase 2, putative 0.0057 0.0091 0.3598
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0244 0.0244
Brugia malayi hypothetical protein 0.0089 0.0164 0.0164
Onchocerca volvulus 0.0051 0.0078 0.2626
Brugia malayi hypothetical protein 0.0248 0.0517 0.0517
Echinococcus multilocularis lamin 0.0029 0.003 0.0077
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0089 0.0164 0.7492
Onchocerca volvulus Pyruvate kinase homolog 0.011 0.021 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0089 0.0164 0.7492
Brugia malayi hypothetical protein 0.0774 0.1683 0.1683
Trypanosoma cruzi aminopeptidase, putative 0.0089 0.0164 0.7492
Mycobacterium ulcerans aminopeptidase N PepN 0.0089 0.0164 0.7061
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0089 0.0164 0.7061
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0089 0.0164 0.7492
Trypanosoma brucei pyruvate kinase 1 0.011 0.021 1
Toxoplasma gondii aminopeptidase n, putative 0.0089 0.0164 0.7492
Brugia malayi hypothetical protein 0.0017 0.0003 0.0003
Onchocerca volvulus Pyruvate kinase homolog 0.011 0.021 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0089 0.0164 0.7492
Schistosoma mansoni inositol monophosphatase 0.0039 0.0051 0.0133
Brugia malayi hypothetical protein 0.0026 0.0024 0.0024
Brugia malayi Peptidase family M1 containing protein 0.0089 0.0164 0.0164
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0051 0.0078 0.0205
Schistosoma mansoni survival motor neuron protein 0.0051 0.0078 0.0205
Echinococcus granulosus aminopeptidase N 0.0089 0.0164 0.0437
Loa Loa (eye worm) hypothetical protein 0.0089 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0089 0.0164 0.0164
Toxoplasma gondii aminopeptidase N, putative 0.0089 0.0164 0.7492
Loa Loa (eye worm) pyruvate kinase-PB 0.0077 0.0136 0.0136
Mycobacterium ulcerans pyruvate kinase 0.011 0.021 1
Plasmodium vivax pyruvate kinase, putative 0.011 0.021 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0081 0.0081
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0244 0.0244
Brugia malayi Peptidase family M1 containing protein 0.0089 0.0164 0.0164
Trypanosoma cruzi pyruvate kinase 2, putative 0.011 0.021 1
Entamoeba histolytica pyruvate kinase, putative 0.0077 0.0136 0.7557
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0081 0.0081
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0051 0.1467
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0089 0.0164 0.7492
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.4518 1 1
Echinococcus multilocularis pyruvate kinase 0.0087 0.0159 0.0424
Toxoplasma gondii pyruvate kinase PyKII 0.0057 0.0091 0.3598
Echinococcus multilocularis muscleblind protein 0.0175 0.0354 0.0951
Echinococcus multilocularis pyruvate kinase 0.011 0.021 0.0564
Echinococcus multilocularis lamin dm0 0.0029 0.003 0.0077
Brugia malayi Pyruvate kinase, muscle isozyme 0.011 0.021 0.021
Trypanosoma brucei pyruvate kinase 1, putative 0.011 0.021 1
Trypanosoma brucei aminopeptidase, putative 0.0089 0.0164 0.7492
Echinococcus granulosus lamin 0.0029 0.003 0.0077
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0089 0.0164 0.0437
Loa Loa (eye worm) hypothetical protein 0.0248 0.0517 0.0517
Echinococcus granulosus pyruvate kinase 0.011 0.021 0.0564
Loa Loa (eye worm) hypothetical protein 0.0036 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0175 0.0354 0.0354
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0051 0.5
Echinococcus granulosus microtubule associated protein 2 0.1534 0.3371 0.9104
Trypanosoma cruzi aminopeptidase, putative 0.0089 0.0164 0.7492
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0164 0.7492
Loa Loa (eye worm) TATA binding protein associated factor 0.0089 0.0164 0.0164
Plasmodium falciparum pyruvate kinase 0.011 0.021 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Schistosoma mansoni intermediate filament proteins 0.0029 0.003 0.0077
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0051 0.1467
Schistosoma mansoni pyruvate kinase 0.011 0.021 0.0564
Loa Loa (eye worm) pyruvate kinase 0.011 0.021 0.021
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.0517 0.1391
Echinococcus multilocularis pyruvate kinase 0.0057 0.0091 0.0241
Loa Loa (eye worm) pyruvate kinase 0.011 0.021 0.021
Echinococcus granulosus intermediate filament protein 0.0029 0.003 0.0077
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1683 0.3703 0.3703
Echinococcus multilocularis muscleblind protein 1 0.0175 0.0354 0.0951
Mycobacterium leprae Probable pyruvate kinase PykA 0.011 0.021 1
Brugia malayi hypothetical protein 0.0089 0.0164 0.0164
Trypanosoma brucei Aminopeptidase M1, putative 0.0089 0.0164 0.7492
Loa Loa (eye worm) peptidase family M1 containing protein 0.0089 0.0164 0.0164
Plasmodium falciparum pyruvate kinase 2 0.0057 0.0091 0.3598
Onchocerca volvulus 0.0089 0.0164 0.7403
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0089 0.0164 0.7492
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0164 0.0437
Schistosoma mansoni pyruvate kinase 0.011 0.021 0.0564
Echinococcus granulosus pyruvate kinase 0.0057 0.0091 0.0241
Echinococcus multilocularis pyruvate kinase 0.0057 0.0091 0.0241
Loa Loa (eye worm) inositol-1 0.0039 0.0051 0.0051
Schistosoma mansoni pyruvate kinase 0.0057 0.0091 0.0241
Loa Loa (eye worm) hypothetical protein 0.011 0.021 0.021
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0002 0.0002
Schistosoma mansoni lamin 0.0029 0.003 0.0077
Loa Loa (eye worm) hypothetical protein 0.0029 0.003 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0175 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0089 0.0164 0.0164
Echinococcus multilocularis aminopeptidase N 0.0089 0.0164 0.0437
Schistosoma mansoni aminopeptidase A (M01 family) 0.0089 0.0164 0.0437
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0024
Echinococcus multilocularis musashi 0.0029 0.003 0.0077
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0089 0.0164 0.7492
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1683 0.3703 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0081 0.0081
Loa Loa (eye worm) pyruvate kinase 0.0023 0.0017 0.0017
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0089 0.0164 0.7061

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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