Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0088 | 0.0049 | 0.0049 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3785 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1776 | 0.4593 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1558 | 0.4007 | 0.3978 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3785 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0168 | 0.0267 | 0.0219 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1776 | 0.4593 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0168 | 0.0267 | 0.0219 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1558 | 0.4007 | 0.3978 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3785 | 1 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1558 | 0.4007 | 0.3978 |
Echinococcus multilocularis | protein dispatched 1 | 0.1558 | 0.4007 | 0.3978 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.1558 | 0.4007 | 0.3978 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1558 | 0.4007 | 0.3978 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0168 | 0.0267 | 0.0219 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3785 | 1 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0168 | 0.0267 | 0.0219 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1558 | 0.4007 | 0.3978 |
Brugia malayi | CHE-14 protein | 0.1558 | 0.4007 | 0.3978 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0168 | 0.0267 | 0.0219 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.0204 | 0.0204 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3785 | 1 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1558 | 0.4007 | 0.3978 |
Onchocerca volvulus | 0.0097 | 0.0076 | 1 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1776 | 0.4593 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3785 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3785 | 1 | 0.5 |
Schistosoma mansoni | patched 1 | 0.1558 | 0.4007 | 0.4007 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3785 | 1 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0088 | 0.0049 | 0.0049 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1558 | 0.4007 | 0.4007 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1776 | 0.4593 | 0.5 |
Echinococcus multilocularis | protein patched | 0.1558 | 0.4007 | 0.3978 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.