Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0035 | 0.0952 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Echinococcus granulosus | neuroglian | 0.0035 | 0.0937 | 0.0937 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0037 | 0.1053 | 0.1053 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0187 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0065 | 0.2731 | 0.1966 |
Trypanosoma brucei | trypanothione reductase | 0.0187 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0044 | 0.1472 | 0.1472 |
Plasmodium vivax | glutathione reductase, putative | 0.0187 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0065 | 0.2731 | 0.1966 |
Brugia malayi | Sushi domain | 0.0035 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0518 | 0.0518 |
Echinococcus granulosus | Immunoglobulin | 0.0028 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1472 | 0.1472 |
Onchocerca volvulus | 0.0035 | 0.0952 | 1 | |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0065 | 0.2731 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0518 | 0.0518 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0035 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1472 | 0.1472 |
Onchocerca volvulus | 0.0035 | 0.0952 | 1 | |
Brugia malayi | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0065 | 0.2731 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0035 | 0.0937 | 0.0937 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0065 | 0.2731 | 1 |
Onchocerca volvulus | 0.0035 | 0.0952 | 1 | |
Loa Loa (eye worm) | glutathione reductase | 0.0187 | 1 | 1 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0028 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0518 | 0.0518 |
Plasmodium falciparum | glutathione reductase | 0.0065 | 0.2731 | 0.1966 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0048 | 0.1708 | 0.1708 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0037 | 0.1053 | 0.1053 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Onchocerca volvulus | 0.0035 | 0.0952 | 1 | |
Brugia malayi | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Schistosoma mansoni | nephrin | 0.0035 | 0.0937 | 0.0937 |
Echinococcus granulosus | defective proboscis extension response | 0.0028 | 0.0518 | 0.0518 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0065 | 0.2731 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0065 | 0.2731 | 0.5 |
Schistosoma mansoni | vesicular amine transporter | 0.0028 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2075 | 0.2075 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0518 | 0.0518 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0035 | 0.0952 | 0.0952 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0065 | 0.2731 | 0.5 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0065 | 0.2731 | 0.2731 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0065 | 0.2731 | 0.2731 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1053 | 0.1053 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0518 | 0.0518 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0028 | 0.0518 | 0.0518 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0035 | 0.0952 | 0.0952 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0028 | 0.0518 | 0.0518 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0037 | 0.1053 | 0.1053 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Schistosoma mansoni | cell adhesion molecule | 0.0037 | 0.1053 | 0.1053 |
Onchocerca volvulus | 0.0035 | 0.0952 | 1 | |
Plasmodium falciparum | glutathione reductase | 0.0187 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0.0952 | 1 | |
Plasmodium vivax | thioredoxin reductase, putative | 0.0187 | 1 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0028 | 0.0518 | 0.0518 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0065 | 0.2731 | 0.1966 |
Brugia malayi | Thioredoxin reductase | 0.0187 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0065 | 0.2731 | 0.5 |
Leishmania major | trypanothione reductase | 0.0187 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0065 | 0.2731 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0065 | 0.2731 | 0.2731 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Onchocerca volvulus | 0.0035 | 0.0952 | 1 | |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0035 | 0.0952 | 0.0952 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0035 | 0.0952 | 0.0952 |
Toxoplasma gondii | thioredoxin reductase | 0.0187 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0187 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0054 | 0.2075 | 0.2075 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0035 | 0.0952 | 0.0952 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0028 | 0.0518 | 0.0518 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Echinococcus multilocularis | Immunoglobulin | 0.0028 | 0.0518 | 0.0518 |
Onchocerca volvulus | 0.0035 | 0.0952 | 1 | |
Plasmodium falciparum | thioredoxin reductase | 0.0187 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0065 | 0.2731 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0065 | 0.2731 | 0.5 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0035 | 0.0952 | 0.0952 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0048 | 0.1708 | 0.1708 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0028 | 0.0518 | 0.0518 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0065 | 0.2731 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1184 | 0.1184 |
Onchocerca volvulus | 0.0035 | 0.0952 | 1 | |
Echinococcus granulosus | twitchin | 0.0036 | 0.0993 | 0.0993 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0035 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0952 | 0.0952 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0065 | 0.2731 | 0.5 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0035 | 0.0952 | 0.0952 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0065 | 0.2731 | 0.2731 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0065 | 0.2731 | 0.1966 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0065 | 0.2731 | 0.2731 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0187 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0187 | 1 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0065 | 0.2731 | 0.2731 |
Echinococcus granulosus | roundabout 2 | 0.0044 | 0.1472 | 0.1472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.