Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0027 | 0.0027 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0671 | 0.4661 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0213 | 0.0456 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0671 | 0.4661 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.143 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0258 | 0.0258 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0671 | 0.4661 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0589 | 0.4083 | 0.4083 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0589 | 0.4083 | 0.4083 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0589 | 0.4083 | 0.4083 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.0232 | 0.0232 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.143 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.143 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.143 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.143 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.143 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.143 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0027 | 0.0027 |
Brugia malayi | CHE-14 protein | 0.0589 | 0.4083 | 0.4083 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0027 | 0.0027 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.143 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0589 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.0232 | 0.0232 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.0232 | 0.0232 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0589 | 0.4083 | 0.4083 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0213 | 0.0456 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0671 | 0.4661 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0027 | 0.0027 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0589 | 0.4083 | 0.4083 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0027 | 0.0027 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0027 | 0.0027 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0258 | 0.0258 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0027 | 0.0027 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0589 | 0.4083 | 0.4083 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.143 | 1 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0589 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0589 | 0.4083 | 0.4083 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.0232 | 0.0232 |
Schistosoma mansoni | patched 1 | 0.0589 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0193 | 0.0193 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0589 | 0.4083 | 0.8761 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0589 | 0.4083 | 0.4083 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.