Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0378 | 0.3613 | 0.3154 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0378 | 0.3613 | 0.3154 |
Giardia lamblia | DNA repair protein RAD52 | 0.0337 | 0.3083 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0877 | 1 | 1 |
Onchocerca volvulus | 0.0148 | 0.0671 | 0.5 | |
Onchocerca volvulus | 0.0148 | 0.0671 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0877 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0877 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0877 | 1 | 1 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0337 | 0.3083 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0877 | 1 | 1 |
Onchocerca volvulus | 0.0148 | 0.0671 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0148 | 0.0671 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0877 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0148 | 0.0671 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0148 | 0.0671 | 0.5 |
Onchocerca volvulus | 0.0148 | 0.0671 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0148 | 0.0671 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0877 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0877 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0148 | 0.0671 | 0.5 |
Onchocerca volvulus | 0.0148 | 0.0671 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0148 | 0.0671 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0877 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0877 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0877 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0877 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0378 | 0.3613 | 0.3154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.