Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0014 | 0.0185 | 0.0308 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0014 | 0.0185 | 0.0308 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.2357 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.005 | 0.3635 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.005 | 0.3635 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0014 | 0.0185 | 0.0143 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0014 | 0.0185 | 0.0143 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.003 | 0.1691 | 0.454 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0017 | 0.0486 | 0.1099 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.0075 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0022 | 0.0984 | 0.2552 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0019 | 0.0636 | 0.1576 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0014 | 0.0185 | 0.0143 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0014 | 0.0205 | 0.0364 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.1691 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.2357 | 0.5331 |
Schistosoma mansoni | cytochrome P450 | 0.0014 | 0.0185 | 0.0119 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.005 | 0.3635 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0014 | 0.0185 | 0.0143 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0094 | 0.7718 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.683 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.683 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.683 | 0.8837 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0013 | 0.0075 | 0.0036 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0013 | 0.0075 | 0.0036 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0926 | 0.375 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0486 | 0.0422 |
Onchocerca volvulus | 0.0022 | 0.0984 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0014 | 0.0185 | 0.0308 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0014 | 0.0185 | 0.0143 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0014 | 0.0185 | 0.0308 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0019 | 0.0636 | 0.1576 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.005 | 0.3635 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0013 | 0.0075 | 0.0036 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0926 | 0.3728 |
Onchocerca volvulus | 0.0022 | 0.0984 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0022 | 0.0984 | 0.2225 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.683 | 0.8837 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0013 | 0.0075 | 0.0036 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.003 | 0.1691 | 0.454 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0014 | 0.0185 | 0.0143 |
Echinococcus granulosus | lamin | 0.0022 | 0.0984 | 0.2552 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0014 | 0.0185 | 0.0308 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0014 | 0.0185 | 0.0515 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0926 | 0.0864 |
Brugia malayi | hypothetical protein | 0.003 | 0.1691 | 0.3556 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0013 | 0.0075 | 0.0036 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0014 | 0.0185 | 0.0308 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0185 | 0.033 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.005 | 0.3635 | 0.4657 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.2357 | 0.2985 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.2357 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.005 | 0.3635 | 0.3592 |
Echinococcus granulosus | lamin dm0 | 0.0022 | 0.0984 | 0.2552 |
Echinococcus multilocularis | zinc finger protein | 0.0016 | 0.0403 | 0.0921 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0031 | 0.1818 | 0.4897 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0014 | 0.0185 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0984 | 0.2225 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0.1818 | 0.7649 |
Echinococcus multilocularis | lamin | 0.0022 | 0.0984 | 0.2552 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0013 | 0.0075 | 0.0008 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0926 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0014 | 0.0205 | 0.0364 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0013 | 0.0075 | 0.0036 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.1818 | 0.3823 |
Schistosoma mansoni | lamin | 0.0022 | 0.0984 | 0.0923 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0014 | 0.0185 | 0.0308 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0014 | 0.0185 | 0.0515 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0014 | 0.0185 | 0.0143 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.2357 | 0.5331 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0185 | 0.0388 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0926 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0014 | 0.0185 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.4421 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.2357 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0031 | 0.1818 | 0.7649 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0014 | 0.0205 | 0.0139 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0031 | 0.1818 | 0.4113 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.683 | 0.8837 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0014 | 0.0205 | 0.0364 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.1818 | 0.4113 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.2357 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0084 | 0.683 | 0.882 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0094 | 0.7718 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0014 | 0.0185 | 0.0143 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.005 | 0.3555 | 0.9775 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0926 | 0.2389 |
Echinococcus multilocularis | musashi | 0.0022 | 0.0984 | 0.2552 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.2357 | 0.6409 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.003 | 0.1688 | 0.453 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.1691 | 1 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0014 | 0.0185 | 0.0308 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.3742 | 0.8465 |
Echinococcus multilocularis | 0.0014 | 0.0185 | 0.0308 | |
Brugia malayi | Bromodomain containing protein | 0.0062 | 0.4757 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0053 | 0.3836 | 0.3794 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0014 | 0.0185 | 0.0143 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0014 | 0.0185 | 0.0308 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0926 | 0.2094 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0013 | 0.0075 | 0.0036 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0926 | 0.2389 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0014 | 0.0185 | 0.0308 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0094 | 0.7718 | 1 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0014 | 0.0185 | 0.0308 |
Brugia malayi | Bromodomain containing protein | 0.0032 | 0.1874 | 0.3939 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.2357 | 0.4955 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0014 | 0.0185 | 0.0143 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.003 | 0.1688 | 0.453 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.005 | 0.3635 | 0.3592 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0014 | 0.0185 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0945 | 0.2137 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.005 | 0.3635 | 1 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0014 | 0.0185 | 0.033 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0185 | 0.033 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0926 | 0.2389 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0926 | 0.375 |
Schistosoma mansoni | zinc finger protein | 0.0016 | 0.0403 | 0.0338 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0926 | 0.375 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.0926 | 0.2407 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0022 | 0.0984 | 0.2225 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0499 | 0.1128 |
Schistosoma mansoni | intermediate filament proteins | 0.0022 | 0.0984 | 0.0923 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0014 | 0.0185 | 0.0143 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0014 | 0.0185 | 0.0143 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0014 | 0.0185 | 0.0308 |
Brugia malayi | cytochrome P450 | 0.0014 | 0.0185 | 0.0388 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0015 | 0.0253 | 0.0572 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.683 | 0.8837 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0014 | 0.0205 | 0.0139 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.1818 | 0.4113 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0013 | 0.0075 | 0.0036 |
Brugia malayi | glutathione reductase | 0.0037 | 0.2357 | 0.4955 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0014 | 0.0205 | 0.0364 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0014 | 0.0185 | 0.0515 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0013 | 0.0075 | 0.0023 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0013 | 0.0075 | 0.0036 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0013 | 0.0075 | 0.0036 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0926 | 0.1113 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0926 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1879 | 0.4251 |
Leishmania major | cytochrome p450-like protein | 0.0031 | 0.1818 | 0.4909 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0014 | 0.0185 | 0.0143 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0014 | 0.0185 | 0.0143 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0019 | 0.0636 | 0.0573 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0014 | 0.0205 | 0.0139 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.2357 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0014 | 0.0185 | 0.0143 |
Echinococcus granulosus | zinc finger protein | 0.0016 | 0.0403 | 0.0921 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0926 | 0.2389 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0013 | 0.0075 | 0.0023 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.3742 | 0.7867 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0014 | 0.0185 | 0.0143 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0014 | 0.0185 | 0.0308 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0014 | 0.0205 | 0.0139 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0926 | 1 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0014 | 0.0185 | 0.0308 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0013 | 0.0075 | 0.0036 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0014 | 0.0185 | 0.0143 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.003 | 0.1691 | 0.1635 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.1691 | 0.1635 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.1818 | 0.3823 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.2357 | 0.6409 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0014 | 0.0185 | 0.0308 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.005 | 0.3635 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0013 | 0.0075 | 0.0036 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0926 | 0.1946 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0014 | 0.0185 | 0.0515 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0014 | 0.0185 | 0.0308 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0014 | 0.0185 | 0.0143 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.005 | 0.3555 | 0.9775 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0185 | 0.0119 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0.1818 | 0.7649 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.2357 | 0.6409 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0014 | 0.0185 | 0.0143 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0013 | 0.0075 | 0.0023 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.2357 | 1 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0014 | 0.0185 | 0.0308 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0014 | 0.0185 | 0.0308 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0014 | 0.0185 | 0.0308 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0013 | 0.0075 | 0.0023 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0022 | 0.0984 | 0.2068 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.0075 | 0.0158 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0094 | 0.7718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2065 | 0.4672 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.1691 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0926 | 0.3728 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0014 | 0.0185 | 0.0308 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.1691 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0022 | 0.0984 | 0.2552 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0013 | 0.0075 | 0.0036 |
Brugia malayi | PHD-finger family protein | 0.0021 | 0.0822 | 0.1728 |
Brugia malayi | intermediate filament protein | 0.0022 | 0.0984 | 0.2068 |
Leishmania major | trypanothione reductase | 0.0037 | 0.2357 | 0.6418 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0926 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.2215 | 0.5011 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0926 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0205 | 0.0463 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.005 | 0.3635 | 1 |
Schistosoma mansoni | lamin | 0.0022 | 0.0984 | 0.0923 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0014 | 0.0185 | 0.0143 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.