Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.008 | 0.188 | 0.2546 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.0985 | 0.1599 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0267 | 0.0314 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0065 | 0.135 | 0.2192 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.0985 | 0.1307 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0267 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.1418 | 0.2302 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.1418 | 0.1906 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0124 | 0.3524 | 0.5722 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0049 | 0.0736 | 0.0699 |
Brugia malayi | hypothetical protein | 0.0122 | 0.3457 | 0.4727 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0267 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.135 | 0.1546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.1418 | 0.1383 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0736 | 0.0963 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0049 | 0.0736 | 0.1195 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.1418 | 0.1383 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0736 | 0.067 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.0985 | 0.1025 |
Brugia malayi | RNA binding protein | 0.0067 | 0.1418 | 0.1906 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.3457 | 0.4476 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0267 | 0.0371 |
Echinococcus granulosus | zinc finger protein | 0.0041 | 0.0443 | 0.0719 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.0985 | 0.1599 |
Onchocerca volvulus | 0.0036 | 0.0267 | 0.0297 | |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0075 | 0.1699 | 0.2758 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0267 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0043 | 0.0524 | 0.0367 |
Brugia malayi | Bromodomain containing protein | 0.0156 | 0.4698 | 0.6444 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0035 | 0.0249 | 0.0405 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0.7421 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.1418 | 0.1383 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0267 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0065 | 0.135 | 0.214 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0267 | 0.0314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.1418 | 0.1383 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0035 | 0.0249 | 0.021 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.0985 | 0.0948 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0736 | 0.0963 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0267 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0047 | 0.0671 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.3457 | 0.4556 |
Schistosoma mansoni | bromodomain containing protein | 0.0132 | 0.3799 | 0.3773 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0124 | 0.3524 | 0.5693 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.1418 | 0.1644 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0267 | 0.0228 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.1418 | 0.2252 |
Onchocerca volvulus | 0.0049 | 0.0736 | 0.0912 | |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0267 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0237 | 0.7673 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0049 | 0.0736 | 0.067 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.0985 | 0.1544 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0049 | 0.0736 | 0.1137 |
Onchocerca volvulus | 0.0036 | 0.0267 | 0.0297 | |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0226 | 0.7268 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0047 | 0.0671 | 0.103 |
Brugia malayi | PHD-finger family protein | 0.0052 | 0.0853 | 0.1124 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0065 | 0.135 | 0.1315 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0035 | 0.0249 | 0.021 |
Schistosoma mansoni | zinc finger protein | 0.0032 | 0.0115 | 0.0074 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0267 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0267 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0267 | 0.0228 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0267 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0115 | 0.0074 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0047 | 0.0671 | 0.1089 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.1418 | 0.1644 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0075 | 0.1699 | 0.271 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0267 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0037 | 0.0296 | 0.0041 |
Onchocerca volvulus | 0.0237 | 0.7673 | 1 | |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.0985 | 0.1544 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2068 | 0.2572 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0065 | 0.135 | 0.1315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.1418 | 0.1383 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0049 | 0.0736 | 0.1137 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.3457 | 0.4476 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1886 | 0.2312 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0524 | 0.0486 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0049 | 0.0736 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.3457 | 0.4556 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0035 | 0.0249 | 0.0341 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0267 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0267 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0041 | 0.0443 | 0.0404 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0267 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.437 | 0.586 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0985 | 0.1025 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0736 | 0.0699 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0049 | 0.0736 | 0.0912 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.1418 | 0.1644 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0267 | 0.0434 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0267 | 0.0314 |
Onchocerca volvulus | 0.0036 | 0.0267 | 0.0297 | |
Brugia malayi | follicle stimulating hormone receptor | 0.0226 | 0.7268 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0208 | 0.6613 | 0.9094 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0196 | 0.6159 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0208 | 0.6613 | 0.9064 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0196 | 0.6159 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0736 | 0.0699 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0267 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0041 | 0.0443 | 0.0658 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.1418 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2214 | 0.2781 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.