TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.295 | Formula: C15H18N3O3P
H donors: 1 H acceptors: 2 LogP: 1.98 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COP(=O)(c1c(C)nc2c(c1N)c1ccccc1n2C)OC
InChi: 1S/C15H18N3O3P/c1-9-14(22(19,20-3)21-4)13(16)12-10-7-5-6-8-11(10)18(2)15(12)17-9/h5-8H,1-4H3,(H2,16,17)
InChiKey: KWOJSIXMUONPOC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0176	0.2233	0.2233
Echinococcus multilocularis	excitatory amino acid transporter 3	0.0383	0.539	0.539
Echinococcus granulosus	lysosomal alpha glucosidase	0.0167	0.2087	0.2087
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0596	0.1106
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0102	0.0054
Echinococcus granulosus	muscleblind protein	0.0301	0.4141	0.4141
Loa Loa (eye worm)	excitatory amino acid transporter	0.0383	0.539	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0102	0.0117
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0099	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0642	0.1148
Echinococcus granulosus	L aminoadipate semialdehyde	0.0086	0.0859	0.0859
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0102	0.0054
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0383	0.539	0.539
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0222	0.2935	0.7219
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0099	0.0136
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0601	0.873	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0034	0.0055	0.0623
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0487	0.1208
Loa Loa (eye worm)	thioredoxin reductase	0.0088	0.0876	0.1584
Schistosoma mansoni	alpha glucosidase	0.0037	0.0102	0.0102
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0601	0.873	1
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.017	0.213	0.213
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.1087	0.2017
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0034	0.0055	0.0623
Schistosoma mansoni	tsg101-related	0.006	0.0457	0.0457
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0102	0.0117
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0099	0.0247
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0099	0.0184
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0034	0.0055	0.0623
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.02	0.2593	0.4812
Echinococcus multilocularis	geminin	0.0176	0.2233	0.2233
Schistosoma mansoni	hypothetical protein	0.0032	0.0026	0.0026
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0086	0.0859	0.0859
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0026	0.0026
Mycobacterium tuberculosis	Probable reductase	0.02	0.2593	0.4812
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0099	0.0114
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0102	0.1161
Echinococcus multilocularis	neutral amino acid transporter A	0.0383	0.539	0.539
Schistosoma mansoni	hypothetical protein	0.0176	0.2233	0.2233
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0487	0.1208
Echinococcus multilocularis	tumor susceptibility gene 101 protein	0.0072	0.0642	0.0642
Schistosoma mansoni	hypothetical protein	0.0032	0.0026	0.0026
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0383	0.539	0.539
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0099	0.0184
Echinococcus granulosus	excitatory amino acid transporter 3	0.0383	0.539	0.539
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.02	0.2593	0.635
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0099	0.0136
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0099	0.0114
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0487	0.0487
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0487	0.1208
Brugia malayi	Muscleblind-like protein	0.0301	0.4141	0.7682
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0102	0.1161
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0099	0.0099
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0026	0.0026
Schistosoma mansoni	hypothetical protein	0.0032	0.0026	0.0026
Echinococcus granulosus	neutral amino acid transporter A	0.0383	0.539	0.539
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1405	0.2571
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0102	0.1161
Echinococcus granulosus	expressed protein	0.0035	0.0067	0.0067
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.0383	0.539	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0222	0.2935	0.5445
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0487	0.5554
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0294	0.4027	0.7471
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0487	0.0487
Entamoeba histolytica	tumor susceptibility gene 101 protein, putative	0.0049	0.0288	0.0269
Trichomonas vaginalis	hypothetical protein	0.0035	0.0075	0.0085
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0383	0.539	0.539
Echinococcus granulosus	Excitatory amino acid transporter	0.0383	0.539	0.539
Mycobacterium tuberculosis	Probable dehydrogenase	0.02	0.2593	0.4812
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0026	0.0049
Trichomonas vaginalis	rotamase, putative	0.0035	0.0067	0.0077
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0167	0.2087	0.2087
Loa Loa (eye worm)	hypothetical protein	0.0301	0.4141	0.767
Echinococcus multilocularis	expressed protein	0.0035	0.0067	0.0067
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0099	0.0114
Schistosoma mansoni	rotamase	0.0035	0.0067	0.0067
Echinococcus multilocularis	Excitatory amino acid transporter	0.0383	0.539	0.539
Trichomonas vaginalis	esterase, putative	0.0037	0.0099	0.0114
Toxoplasma gondii	thioredoxin reductase	0.0088	0.0876	1
Brugia malayi	MH2 domain containing protein	0.0122	0.1405	0.2608
Brugia malayi	Excitatory amino acid transporter	0.0383	0.539	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.098	0.098
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.098	0.098
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.017	0.213	0.213
Mycobacterium ulcerans	lipase LipD	0.0037	0.0099	0.0247
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.098	0.098
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.0383	0.539	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.098	0.098
Schistosoma mansoni	hypothetical protein	0.0069	0.0596	0.0596
Schistosoma mansoni	tsg101-related	0.006	0.0457	0.0457
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0102	0.0117
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0099	0.0247
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0102	0.0117
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0035	0.0067	0.0125
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0102	0.0117
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.098	0.098
Onchocerca volvulus		0.0086	0.0859	0.1436
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0601	0.873	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.098	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0859	0.1552
Leishmania major	trypanothione reductase	0.0088	0.0876	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0099	0.0184
Plasmodium vivax	thioredoxin reductase, putative	0.0088	0.0876	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0026	0.0026
Echinococcus granulosus	tumor susceptibility gene 101 protein	0.0072	0.0642	0.0642
Trypanosoma cruzi	trypanothione reductase, putative	0.0088	0.0876	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0099	0.0136
Plasmodium falciparum	glutathione reductase	0.0088	0.0876	1
Schistosoma mansoni	tsg101-related	0.0049	0.0288	0.0288
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0102	0.014
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0237	0.3163	0.5849
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0067	0.0077
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.02	0.2593	0.4812
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0102	0.0117
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.098	0.098
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.0383	0.539	0.539
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0102	0.0102
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1405	0.2571
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0099	0.0099
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0383	0.539	0.539
Echinococcus granulosus	excitatory amino acid transporter 2	0.0383	0.539	0.539
Echinococcus multilocularis	muscleblind protein	0.0301	0.4141	0.4141
Echinococcus granulosus	thioredoxin glutathione reductase	0.0088	0.0884	0.0884
Brugia malayi	beta-lactamase family protein	0.0037	0.0099	0.0184
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0601	0.873	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0099	0.0136
Echinococcus granulosus	excitatory amino acid transporter 2	0.0383	0.539	0.539
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0035	0.0067	0.0076
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0099	0.0184
Trichomonas vaginalis	rotamase, putative	0.0034	0.0055	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0099	0.0136
Echinococcus granulosus	sodium:dicarboxylate symporter	0.0383	0.539	0.539
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0601	0.873	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0222	0.2935	0.5445
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0167	0.2087	0.3843
Chlamydia trachomatis	glutamate symporter	0.0383	0.539	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0099	0.1135
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0099	0.1135
Toxoplasma gondii	peptidylprolyl isomerase	0.0034	0.0055	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1087	0.1978
Treponema pallidum	glutamate transporter	0.017	0.213	0.244
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0167	0.2087	0.2087
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0487	0.0903
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0102	0.0117
Echinococcus multilocularis	muscleblind protein 1	0.0301	0.4141	0.4141
Echinococcus multilocularis	Excitatory amino acid transporter	0.0383	0.539	0.539
Schistosoma mansoni	microtubule-associated protein tau	0.0684	1	1
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.017	0.213	0.213
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0026	0.0049
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.1087	0.1978
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.098	0.1778
Trypanosoma brucei	trypanothione reductase	0.0088	0.0876	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0099	0.0099
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0099	0.0184
Loa Loa (eye worm)	glutathione reductase	0.0088	0.0876	0.1584
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0099	0.0184
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0099	0.0247
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0099	0.0184
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0099	0.0099
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0088	0.0876	0.1625
Brugia malayi	beta-lactamase	0.0037	0.0099	0.0184
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0026	0.0026
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0099	0.0184
Treponema pallidum	glutamate/aspartate transporter	0.017	0.213	0.244
Onchocerca volvulus		0.0096	0.1011	0.1724
Brugia malayi	glutathione reductase	0.0088	0.0876	0.1625
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0099	0.0114
Treponema pallidum	fructose-bisphosphate aldolase	0.0601	0.873	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0487	0.0487
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0601	0.873	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0102	0.0189
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0099	0.0184
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0222	0.2935	0.5445
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0026	0.0026
Plasmodium vivax	glutathione reductase, putative	0.0088	0.0876	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0601	0.873	1
Echinococcus granulosus	geminin	0.0176	0.2233	0.2233
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0601	0.873	1
Echinococcus granulosus	Excitatory amino acid transporter	0.0383	0.539	0.539
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.02	0.2593	0.4812
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0099	0.0114
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0294	0.4027	1
Leishmania major	hypothetical protein, conserved	0.0037	0.0099	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0099	0.0136
Brugia malayi	follicle stimulating hormone receptor	0.0237	0.3163	0.5869
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0086	0.0859	0.1594
Brugia malayi	beta-lactamase family protein	0.0037	0.0099	0.0184
Schistosoma mansoni	alpha-glucosidase	0.0144	0.1732	0.1732
Echinococcus multilocularis	microtubule associated protein 2	0.0684	1	1
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.017	0.213	0.213
Chlamydia trachomatis	neutral amino acid transporter	0.017	0.213	0.3952
Toxoplasma gondii	ABC1 family protein	0.0037	0.0099	0.1135
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0088	0.0884	0.0884
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0487	0.0487
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0102	0.1161
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0102	0.0102
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0294	0.4027	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0601	0.873	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0034	0.0055	0.0623
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.1087	0.2017
Loa Loa (eye worm)	hypothetical protein	0.0301	0.4141	0.767
Echinococcus granulosus	neutral amino acid transporter A	0.0383	0.539	0.539
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0099	0.0136
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0167	0.2087	0.3873
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0086	0.0859	0.0859
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.0383	0.539	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0601	0.873	1
Brugia malayi	Thioredoxin reductase	0.0088	0.0876	0.1625
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.02	0.2593	0.4812
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0099	0.1135
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.3139	0.5823
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.098	0.098
Echinococcus multilocularis	neutral amino acid transporter A	0.0383	0.539	0.539
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0487	0.5554
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0596	0.1062
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0099	0.0184
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0099	0.1135
Echinococcus granulosus	GPCR family 2	0.0032	0.0026	0.0026
Trypanosoma brucei	glucosidase, putative	0.0037	0.0102	0.1161
Schistosoma mansoni	alpha-glucosidase	0.0144	0.1732	0.1732
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0102	0.0117
Brugia malayi	hypothetical protein	0.0072	0.0642	0.1192
Schistosoma mansoni	hypothetical protein	0.0032	0.0026	0.0026
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0099	0.0184
Echinococcus granulosus	neutral amino acid transporter	0.0383	0.539	0.539
Giardia lamblia	Fructose-bisphosphate aldolase	0.0601	0.873	1
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0099	0.0136
Plasmodium falciparum	thioredoxin reductase	0.0088	0.0876	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0102	0.0117
Echinococcus multilocularis	neutral amino acid transporter A	0.0383	0.539	0.539

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 30 uM	Displacement of [35S]-TBPS from GABA-A receptor complex at low micromolar concentration	ChEMBL.	No reference
IC50 (binding)	> 30 uM	Displacement of [3H]-Flunitrazepam from GABA-A central benzodiazepine receptor of mouse brain	ChEMBL.	No reference
IC50 (binding)	> 30 uM	Displacement of [35S]-TBPS from GABA-A receptor complex at low micromolar concentration	ChEMBL.	No reference
IC50 (binding)	> 30 uM	Displacement of [3H]-Flunitrazepam from GABA-A central benzodiazepine receptor of mouse brain	ChEMBL.	No reference
MED (functional)	> 20 mg kg-1	Tested for minimum effective dose required to cause motor incoordination in Geller-Seifter model in CFY rats (route of administration is peroral 30 min before testing)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL58666

Bibliographic References

No literature references available for this target.

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Detailed information for compound 88366