Detailed information for compound 88380

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.367 | Formula: C22H19BrN2O3S
  • H donors: 1 H acceptors: 2 LogP: 5.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)C(=O)c1c(N)sc2c1CCN(C2)C(=O)OCc1ccccc1
  • InChi: 1S/C22H19BrN2O3S/c23-16-8-6-15(7-9-16)20(26)19-17-10-11-25(12-18(17)29-21(19)24)22(27)28-13-14-4-2-1-3-5-14/h1-9H,10-13,24H2
  • InChiKey: GZFLLRNYOFNGJH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) excitatory amino acid transporter 0.1154 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0071 0.0374
Trypanosoma brucei carbonic anhydrase-like protein 0.0587 0.5016 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0218 0.178 0.178
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0512 0.4359 0.4349
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0124 0.0107
Echinococcus granulosus importin subunit beta 1 0.0028 0.0118 0.0101
Schistosoma mansoni hypothetical protein 0.0303 0.2532 0.2519
Loa Loa (eye worm) hypothetical protein 0.0313 0.2619 0.2619
Schistosoma mansoni ran 0.0021 0.0052 0.0035
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.003 0.1343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0315 0.0298
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.1459 0.1459
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.1459 0.1444
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0315 0.0298
Leishmania major hypothetical protein, conserved 0.004 0.022 0.0438
Schistosoma mansoni alpha-glucosidase 0.0156 0.1237 0.1222
Mycobacterium tuberculosis Conserved protein 0.004 0.022 0.0191
Loa Loa (eye worm) hypothetical protein 0.004 0.022 0.022
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0218 0.178 0.178
Schistosoma mansoni ap endonuclease 0.0018 0.003 0.0012
Brugia malayi hypothetical protein 0.0025 0.0085 0.0085
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.022 0.1159
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0221 0.0441
Echinococcus multilocularis geminin 0.0165 0.132 0.1305
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0085 0.0313
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0085 0.0313
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0118 0.0505
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.2113 0.209
Echinococcus multilocularis carbonic anhydrase 0.0218 0.178 0.1766
Loa Loa (eye worm) hypothetical protein 0.004 0.022 0.022
Leishmania major carbonic anhydrase-like protein 0.0587 0.5016 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0315 0.0298
Echinococcus multilocularis muscleblind protein 1 0.0313 0.2619 0.2606
Trypanosoma brucei hypothetical protein, conserved 0.004 0.022 0.0438
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.1022 0.1006
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0221 0.1166
Onchocerca volvulus 0.004 0.022 0.022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.003 0.0059
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.022 0.0191
Loa Loa (eye worm) beta-lactamase 0.004 0.022 0.022
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0218 0.178 0.178
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0052 0.0128
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0118 0.0235
Onchocerca volvulus 0.004 0.022 0.022
Treponema pallidum glutamate/aspartate transporter 0.0512 0.4359 1
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.022 0.0203
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.1022 0.1006
Plasmodium vivax glutathione reductase, putative 0.0037 0.0193 0.8568
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.022 0.022
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0221 0.1166
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0292 0.0276
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.003 0.003
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0071 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0315 0.0298
Brugia malayi RNA, U transporter 1 0.0081 0.0578 0.0578
Echinococcus multilocularis Excitatory amino acid transporter 0.1154 1 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0218 0.178 0.178
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.022 0.0191
Brugia malayi Smad1 0.0017 0.0017 0.0017
Echinococcus multilocularis carbonic anhydrase II 0.0587 0.5016 0.5008
Plasmodium vivax SET domain protein, putative 0.0029 0.0124 0.4975
Brugia malayi MH2 domain containing protein 0.0249 0.2051 0.2051
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.022 0.1159
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0085 0.0313
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0608 0.058
Echinococcus multilocularis snurportin 1 0.0303 0.2532 0.2519
Plasmodium falciparum thioredoxin reductase 0.0037 0.0193 0.0931
Onchocerca volvulus 0.0048 0.0292 0.0292
Brugia malayi MH2 domain containing protein 0.0017 0.0017 0.0017
Brugia malayi beta-lactamase 0.004 0.022 0.022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0315 0.0298
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0484 0.4113 0.4113
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.022 0.1917
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.1022 0.1006
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0221 0.0441
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0085 0.2883
Echinococcus multilocularis muscleblind protein 0.0313 0.2619 0.2606
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0197 0.018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.003 0.0059
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0221 0.0204
Brugia malayi MH1 domain containing protein 0.0017 0.0017 0.0017
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0071 0.0374
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0587 0.5016 0.5008
Chlamydia trachomatis glutamate symporter 0.1154 1 1
Echinococcus granulosus carbonic anhydrase 0.0218 0.178 0.1766
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0052 0.0052
Echinococcus granulosus carbonic anhydrase 0.0218 0.178 0.1766
Schistosoma mansoni ran 0.0021 0.0052 0.0035
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0218 0.178 0.178
Loa Loa (eye worm) hypothetical protein 0.0048 0.0292 0.0292
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.022 0.1159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0315 0.0298
Mycobacterium ulcerans beta-lactamase 0.004 0.022 0.1917
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0608 0.058
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.069 0.0663
Echinococcus granulosus Excitatory amino acid transporter 0.1154 1 1
Schistosoma mansoni ap endonuclease 0.0018 0.003 0.0012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.003 0.0059
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.022 0.0203
Leishmania major hypothetical protein, conserved 0.0025 0.0085 0.0169
Brugia malayi hypothetical protein 0.0016 0.0008 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0085 0.0169
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0124 0.0541
Brugia malayi beta-lactamase family protein 0.004 0.022 0.022
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0587 0.5016 0.5016
Leishmania major GTP-binding protein, putative 0.0021 0.0052 0.0104
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0052 0.1182
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.1022 0.1006
Brugia malayi follicle stimulating hormone receptor 0.0484 0.4113 0.4113
Entamoeba histolytica Ran family GTPase 0.0021 0.0052 0.2358
Loa Loa (eye worm) hypothetical protein 0.004 0.022 0.022
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0221 0.1095
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0193 0.8568
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0221 0.1166
Brugia malayi beta-lactamase family protein 0.004 0.022 0.022
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0221 0.0204
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0017 0.0017
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.1022 0.2037
Mycobacterium tuberculosis Probable hydrolase 0.004 0.022 0.0191
Mycobacterium tuberculosis Conserved protein 0.004 0.022 0.0191
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.022 0.1159
Loa Loa (eye worm) hypothetical protein 0.004 0.022 0.022
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0221 0.1166
Mycobacterium tuberculosis Conserved protein 0.004 0.022 0.0191
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0512 0.4359 0.4349
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0512 0.4359 0.4349
Toxoplasma gondii hypothetical protein 0.0218 0.178 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0124 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0124 0.0107
Brugia malayi Muscleblind-like protein 0.0313 0.2619 0.2619
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.1022 0.5669
Echinococcus multilocularis excitatory amino acid transporter 3 0.1154 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.022 0.0438
Echinococcus multilocularis neutral amino acid transporter A 0.1154 1 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0052 0.0128
Brugia malayi Pre-SET motif family protein 0.0029 0.0124 0.0124
Trypanosoma brucei glucosidase, putative 0.004 0.0221 0.0441
Schistosoma mansoni carbonic anhydrase-related 0.0218 0.178 0.1766
Onchocerca volvulus 0.0231 0.1898 0.1898
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0197 0.018
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0221 0.1166
Echinococcus granulosus neutral amino acid transporter A 0.1154 1 1
Trichomonas vaginalis ran, putative 0.0021 0.0052 0.0275
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0193 0.0384
Trichomonas vaginalis esterase, putative 0.004 0.022 0.1159
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0085 0.0169
Schistosoma mansoni hypothetical protein 0.0165 0.132 0.1305
Schistosoma mansoni hypothetical protein 0.0218 0.178 0.1766
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1154 1 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0052 0.0104
Loa Loa (eye worm) carbonic anhydrase 3 0.0587 0.5016 0.5016
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0193 0.0163
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1154 1 1
Trypanosoma brucei trypanothione reductase 0.0037 0.0193 0.0384
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1022 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0608 0.8246
Schistosoma mansoni hypothetical protein 0.0165 0.132 0.1305
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1022 1
Loa Loa (eye worm) Smad1 0.0017 0.0017 0.0017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.069 0.0663
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0221 0.1166
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.022 0.0438
Brugia malayi Thioredoxin reductase 0.0037 0.0193 0.0193
Onchocerca volvulus 0.004 0.022 0.022
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0608 0.058
Echinococcus multilocularis excitatory amino acid transporter 2 0.1154 1 1
Leishmania major trypanothione reductase 0.0037 0.0193 0.0384
Echinococcus granulosus geminin 0.0165 0.132 0.1305
Toxoplasma gondii thioredoxin reductase 0.0037 0.0193 0.0931
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.022 0.0191
Brugia malayi MH2 domain containing protein 0.0017 0.0017 0.0017
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.069 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0124 0.0107
Mycobacterium tuberculosis Probable reductase 0.0084 0.0608 0.058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0315 0.0315
Treponema pallidum glutamate transporter 0.0512 0.4359 1
Schistosoma mansoni carbonic anhydrase-related 0.0218 0.178 0.1766
Echinococcus granulosus neutral amino acid transporter 0.1154 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.003 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0315 0.0315
Plasmodium vivax hypothetical protein, conserved 0.004 0.022 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0115 0.0098
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0218 0.178 0.178
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.003 0.003
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.1459 0.1444
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0221 0.1166
Echinococcus granulosus Excitatory amino acid transporter 0.1154 1 1
Echinococcus granulosus excitatory amino acid transporter 2 0.1154 1 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.2532 0.2532
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.003 0.0059
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0124
Echinococcus multilocularis neutral amino acid transporter A 0.1154 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0118
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0587 0.5016 0.5016
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.022 0.0203
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.2051 0.2051
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0221 0.0221
Mycobacterium ulcerans lipase LipD 0.004 0.022 0.1917
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.022 0.0191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0124 0.0107
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.022 0.0203
Schistosoma mansoni carbonic anhydrase 0.0218 0.178 0.1766
Plasmodium falciparum importin beta, putative 0.0028 0.0118 0.0505
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.003 0.0012
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1154 1 1
Plasmodium falciparum carbonic anhydrase 0.0218 0.178 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0193 0.0193
Brugia malayi Importin beta-1 subunit 0.0028 0.0118 0.0118
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0124 0.0107
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0118 0.0235
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0221 0.1166
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0221 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0052 0.0035
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0118 0.0101
Toxoplasma gondii ABC1 family protein 0.004 0.022 0.1087
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1154 1 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1898 1
Echinococcus multilocularis tumor protein p63 0.033 0.2764 0.2751
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0221 0.0441
Plasmodium falciparum glutathione reductase 0.0037 0.0193 0.0931
Echinococcus granulosus carbonic anhydrase 0.0218 0.178 0.1766
Loa Loa (eye worm) hypothetical protein 0.0313 0.2619 0.2619
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0608 0.058
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0221 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0608 0.058
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0587 0.5016 0.5016
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0052 0.0104
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0052 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Brugia malayi Pre-SET motif family protein 0.0203 0.1652 0.1652
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.022 0.0191
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0017 0.0017
Echinococcus granulosus tumor protein p63 0.033 0.2764 0.2751
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0587 0.5016 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0052 0.0104
Schistosoma mansoni alpha-glucosidase 0.0156 0.1237 0.1222
Echinococcus granulosus excitatory amino acid transporter 2 0.1154 1 1
Echinococcus multilocularis carbonic anhydrase 0.0218 0.178 0.1766
Schistosoma mansoni alpha glucosidase 0.004 0.0221 0.0204
Onchocerca volvulus 0.0029 0.0124 0.0124
Brugia malayi MH1 domain containing protein 0.0017 0.0017 0.0017
Mycobacterium ulcerans hypothetical protein 0.004 0.022 0.1917
Echinococcus granulosus muscleblind protein 0.0313 0.2619 0.2606
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.2051 0.2051
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0221 0.0221
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0193 0.0193
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.1022 0.0995
Echinococcus granulosus neutral amino acid transporter A 0.1154 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0587 0.5016 0.5008
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1154 1 1
Schistosoma mansoni importin beta-1 0.0028 0.0118 0.0101
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0512 0.4359 0.4349
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0085 0.0169
Echinococcus granulosus snurportin 1 0.0303 0.2532 0.2519
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0587 0.5016 1
Echinococcus multilocularis neutral amino acid transporter A 0.1154 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0218 0.178 0.178
Plasmodium vivax importin-beta 2, putative 0.0028 0.0118 0.4645
Echinococcus multilocularis excitatory amino acid transporter 2 0.1154 1 1
Echinococcus multilocularis carbonic anhydrase 0.0218 0.178 0.1766
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.022 0.1917
Echinococcus granulosus carbonic anhydrase II 0.0587 0.5016 0.5008
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.022 0.1159
Brugia malayi glutathione reductase 0.0037 0.0193 0.0193
Echinococcus granulosus excitatory amino acid transporter 3 0.1154 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0124 0.0107
Leishmania major importin beta-1 subunit, putative 0.0023 0.0071 0.0141
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.003 0.0157
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.003 0.0157
Loa Loa (eye worm) hypothetical protein 0.004 0.022 0.022
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0221 0.1166
Onchocerca volvulus 0.0105 0.0788 0.0788
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0052 0.0035
Loa Loa (eye worm) hypothetical protein 0.0218 0.178 0.178
Schistosoma mansoni carbonic anhydrase-related 0.0218 0.178 0.1766
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1652 0.1652
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.1459 0.1459
Echinococcus multilocularis Excitatory amino acid transporter 0.1154 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0218 0.178 0.178
Entamoeba histolytica hypothetical protein 0.0023 0.0071 0.3202
Echinococcus granulosus sodium:dicarboxylate symporter 0.1154 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0071 0.0374
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1022 1
Loa Loa (eye worm) hypothetical protein 0.004 0.022 0.022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.069 0.0663
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0315 0.0298
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.022 0.0191
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1154 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.1459 0.1444

Activities

Activity type Activity value Assay description Source Reference
Response (functional) % The compound was tested for its percentage of response to 10 microM of PD81723 on CHO cells expressing the cloned human A1-adenosine receptor at 0.1 microM ; An increase of cAmp content of cells ChEMBL. 10987425
Response (functional) % Percentage of response to 10 microM of PD81723 on CHO cells expressing the cloned human A1-adenosine receptor at 1 microM; An increase of cAmp content of cells ChEMBL. 10987425
Response (functional) % The compound was tested for its percentage of response to 10 uM of PD81723 on CHO cells expressing the cloned human A1-adenosine receptor at 10 microM ; An increase of cAmp content of cells ChEMBL. 10987425
Response (functional) 0 % The compound was tested for its percentage of response to 10 microM of PD81723 on CHO cells expressing the cloned human A1-adenosine receptor at 0.1 microM ; An increase of cAmp content of cells ChEMBL. 10987425
Response (functional) 0 % Percentage of response to 10 microM of PD81723 on CHO cells expressing the cloned human A1-adenosine receptor at 1 microM; An increase of cAmp content of cells ChEMBL. 10987425
Response (functional) 0 % The compound was tested for its percentage of response to 10 uM of PD81723 on CHO cells expressing the cloned human A1-adenosine receptor at 10 microM ; An increase of cAmp content of cells ChEMBL. 10987425

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.