Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.1231 | 0.2413 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0671 | 0.363 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.1231 | 0.2413 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.054 | 0.1036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0713 | 0.3864 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0949 | 0.5235 |
Entamoeba histolytica | exonuclease, putative | 0.0006 | 0.0021 | 0.0115 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0713 | 0.3864 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0006 | 0.0021 | 0.0115 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.1741 | 0.9597 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0006 | 0.0081 | 0.0336 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0006 | 0.0081 | 0.0336 |
Echinococcus multilocularis | bloom syndrome protein | 0.0025 | 0.1637 | 0.3223 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.5035 | 0.5024 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0006 | 0.0081 | 0.0336 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.1231 | 0.2413 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.3514 | 0.6968 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.3514 | 0.6968 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.1231 | 0.2413 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.1231 | 0.5 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0006 | 0.0021 | 0.0115 |
Loa Loa (eye worm) | RecQ helicase | 0.0025 | 0.1637 | 0.162 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.1231 | 0.2413 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0027 | 0.1813 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0006 | 0.0081 | 0.0336 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.054 | 0.1036 |
Leishmania major | DNA damage repair protein, putative | 0.0006 | 0.0081 | 0.0336 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0671 | 0.363 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.1231 | 0.675 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.042 | 0.0795 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.042 | 0.2315 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.5035 | 1 |
Giardia lamblia | DNA damage repair protein | 0.0006 | 0.0081 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1741 | 0.1723 |
Echinococcus granulosus | flap endonuclease 1 | 0.0027 | 0.1813 | 0.3574 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0006 | 0.0021 | 0.0115 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.042 | 0.0795 |
Entamoeba histolytica | Flap nuclease, putative | 0.0027 | 0.1813 | 1 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0006 | 0.0081 | 0.0447 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0006 | 0.0081 | 0.0447 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0027 | 0.1813 | 0.3574 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0025 | 0.1637 | 0.3223 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.1231 | 0.675 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0006 | 0.0081 | 0.0336 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0006 | 0.0081 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.042 | 0.04 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0006 | 0.0021 | 0.0115 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0006 | 0.0081 | 0.0336 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.1231 | 0.2413 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.3514 | 0.6968 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.042 | 0.2315 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.1231 | 0.675 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0027 | 0.1813 | 1 |
Schistosoma mansoni | flap endonuclease-1 | 0.0025 | 0.1597 | 0.3143 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.1813 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0713 | 0.3864 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.1741 | 0.9597 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.1741 | 0.9597 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0017 | 0.0966 | 0.5272 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.1813 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.1231 | 1 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0006 | 0.0081 | 0.012 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.1231 | 0.675 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.1741 | 0.9602 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0713 | 0.3864 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.042 | 0.0795 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.1231 | 0.2413 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5035 | 1 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0713 | 0.3864 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.1231 | 0.675 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0006 | 0.0021 | 0.0115 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0671 | 0.3703 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.1231 | 0.675 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0027 | 0.1813 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0006 | 0.0081 | 0.0336 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.1813 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.042 | 0.0795 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.042 | 0.0795 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.1741 | 0.9597 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.3514 | 0.3501 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.1231 | 0.2413 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.054 | 0.1036 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0006 | 0.0081 | 0.0336 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0006 | 0.0081 | 0.0336 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.3514 | 0.6968 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.1231 | 0.6788 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0006 | 0.0081 | 0.0336 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5035 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.1231 | 0.2413 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1231 | 0.1212 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0969 | 0.1891 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0081 | 0.006 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.1231 | 0.5 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.1201 | 0.2353 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.5035 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5035 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5035 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.5035 | 0.5024 |
Leishmania major | DNA polymerase kappa, putative | 0.0006 | 0.0081 | 0.0336 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.001 | 0.042 | 0.2225 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0671 | 0.363 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.3514 | 0.6968 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0671 | 0.363 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.1231 | 0.2413 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0025 | 0.1637 | 0.9019 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.5035 | 1 |
Entamoeba histolytica | exonuclease, putative | 0.0006 | 0.0021 | 0.0115 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0006 | 0.0081 | 0.0447 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.1741 | 0.9597 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0006 | 0.0081 | 0.0336 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.1231 | 1 |
Brugia malayi | polk-prov protein | 0.0006 | 0.0081 | 0.012 |
Brugia malayi | hypothetical protein | 0.0026 | 0.1741 | 0.343 |
Brugia malayi | Flap endonuclease-1 | 0.0027 | 0.1813 | 0.3574 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.1231 | 0.675 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0006 | 0.0081 | 0.0336 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.1231 | 0.1212 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.1231 | 0.675 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0025 | 0.1637 | 0.9019 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.042 | 0.0795 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.3514 | 0.6968 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.1231 | 0.675 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0027 | 0.1813 | 1 |
Plasmodium falciparum | flap endonuclease 1 | 0.0027 | 0.1813 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1231 | 0.675 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0006 | 0.0081 | 0.0336 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.5035 | 0.5024 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0027 | 0.1813 | 0.1796 |
Trypanosoma brucei | unspecified product | 0.002 | 0.1231 | 0.675 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.5035 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.3514 | 0.6968 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.042 | 0.04 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.042 | 0.0795 |
Brugia malayi | RNA binding protein | 0.0066 | 0.5035 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.3514 | 0.6968 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0006 | 0.0081 | 0.0336 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.042 | 0.0795 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.1231 | 0.2413 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.1385 | 0.7614 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.1231 | 0.675 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.1741 | 0.9597 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.1741 | 0.9597 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.001 | 0.042 | 0.2225 |
Echinococcus granulosus | bloom syndrome protein | 0.0025 | 0.1637 | 0.3223 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5035 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.