TDR Targets

Basic information

Technical information

TDR Targets ID: 884086
Name: propan-2-yl 2-[4-oxo-3-(4-phenylphenoxy)chrom en-7-yl]oxypropanoate
MW: 444.476 | Formula: C27H24O6
H donors: 0 H acceptors: 2 LogP: 6 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC(OC(=O)C(Oc1ccc2c(c1)occ(c2=O)Oc1ccc(cc1)c1ccccc1)C)C
InChi: 1S/C27H24O6/c1-17(2)31-27(29)18(3)32-22-13-14-23-24(15-22)30-16-25(26(23)28)33-21-11-9-20(10-12-21)19-7-5-4-6-8-19/h4-18H,1-3H3
InChiKey: JQXDWCYTZWMYPY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

isopropyl 2-[4-oxo-3-(4-phenylphenoxy)chromen-7-yl]oxypropanoate
2-[[4-oxo-3-(4-phenylphenoxy)-7-chromenyl]oxy]propanoic acid isopropyl ester
2-[4-keto-3-(4-phenylphenoxy)chromen-7-yl]oxypropionic acid isopropyl ester
Oprea1_456449
Oprea1_582165
AE-641/40793216
ST5190603

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0259	0.0269
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0658	0.406	0.5909
Brugia malayi	aspartic protease BmAsp-1, identical	0.0085	0.0334	0.0334
Plasmodium vivax	aspartyl protease, putative	0.0085	0.0334	0.2681
Brugia malayi	hypothetical protein	0.0274	0.1562	0.1562
Plasmodium falciparum	subtilisin-like protease 2	0.0046	0.0083	0.0108
Schistosoma mansoni	intermediate filament proteins	0.0062	0.0188	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0217	0.0276
Toxoplasma gondii	aspartyl protease	0.0085	0.0334	0.2681
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0046	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0073	0.0093
Trypanosoma brucei	importin beta-1 subunit, putative	0.0067	0.0217	1
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Brugia malayi	hypothetical protein	0.0085	0.0334	0.0334
Echinococcus multilocularis	microtubule associated protein 2	0.0799	0.4977	0.9103
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0046	0.0083	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0127	0.0162
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0259	0.0269
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0259	0.0269
Plasmodium falciparum	plasmepsin VI	0.0194	0.1046	1
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.0259	0.0346
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0046	0.0083	0.0054
Onchocerca volvulus		0.0062	0.0188	0.0842
Schistosoma mansoni	memapsin-2 (A01 family)	0.1301	0.8238	1
Onchocerca volvulus		0.0238	0.1332	1
Toxoplasma gondii	subtilisin SUB5	0.0046	0.0083	0.0108
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.1083	0.6821	0.8272
Plasmodium vivax	subtilisin-like protease 1	0.0046	0.0083	0.0108
Loa Loa (eye worm)	endoprotease bli-4	0.1083	0.6821	0.8707
Toxoplasma gondii	subtilisin SUB8	0.0046	0.0083	0.0108
Brugia malayi	SWIRM domain containing protein	0.0238	0.1332	0.1332
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0046	0.0083	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0978	0.1248
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0062	0.0188	0.0241
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0256	0.1445	0.1715
Brugia malayi	celfurPC protein	0.0874	0.546	0.546
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0127	0.0107
Echinococcus granulosus	Furin 1	0.0256	0.1445	0.2033
Schistosoma mansoni	cathepsin D (A01 family)	0.0474	0.2863	0.3444
Loa Loa (eye worm)	RNA binding protein	0.0073	0.0259	0.0331
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0085	0.0334	0.0426
Plasmodium vivax	subtilisin-like protease 2, putative	0.0046	0.0083	0.0108
Brugia malayi	neuroendocrine convertase 1 precursor	0.0681	0.4206	0.4206
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.0259	0.0259
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0046	0.0083	0.002
Toxoplasma gondii	HEAT repeat-containing protein	0.0067	0.0217	0.1477
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.0146	0.0146
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0658	0.406	1
Toxoplasma gondii	aspartyl protease ASP3	0.0085	0.0334	0.2681
Toxoplasma gondii	subtilisin SUB10	0.0046	0.0083	0.0108
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0045	0.0073	0.5
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0046	0.0083	1
Plasmodium falciparum	plasmepsin VII	0.0085	0.0334	0.2681
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0658	0.406	0.7402
Plasmodium falciparum	plasmepsin V	0.0085	0.0334	0.2681
Toxoplasma gondii	subtilisin SUB6	0.0046	0.0083	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0039	0.005
Plasmodium vivax	plasmepsin IV, putative	0.0194	0.1046	1
Schistosoma mansoni	alzheimer's disease beta-amyloid related	0.0573	0.3508	0.4231
Plasmodium vivax	importin-beta 2, putative	0.0067	0.0217	0.1477
Schistosoma mansoni	cathepsin D (A01 family)	0.0474	0.2863	0.3444
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0256	0.1445	0.3423
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0194	0.1046	0.1335
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0127	0.01
Toxoplasma gondii	subtilisin SUB4	0.0046	0.0083	0.0108
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0209	0.1144	0.2667
Onchocerca volvulus		0.0056	0.0146	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4108	0.5244
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0188	0.0241
Brugia malayi	Importin beta-1 subunit	0.0067	0.0217	0.0217
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0085	0.0334	0.0359
Brugia malayi	Intermediate filament tail domain containing protein	0.0062	0.0188	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0073	0.0093
Toxoplasma gondii	subtilisin SUB7	0.0046	0.0083	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Entamoeba histolytica	hypothetical protein	0.0054	0.0134	0.5
Plasmodium falciparum	plasmepsin IV	0.0194	0.1046	1
Brugia malayi	hypothetical protein	0.0045	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0181	0.0231
Loa Loa (eye worm)	subtilase	0.0046	0.0083	0.0106
Echinococcus multilocularis	snurportin 1	0.0713	0.4416	0.8063
Loa Loa (eye worm)	intermediate filament protein	0.0062	0.0188	0.0241
Leishmania major	importin beta-1 subunit, putative	0.0054	0.0134	1
Toxoplasma gondii	subtilisin SUB11	0.0046	0.0083	0.0108
Plasmodium vivax	plasmepsin V, putative	0.0085	0.0334	0.2681
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0127	0.008
Plasmodium falciparum	importin beta, putative	0.0067	0.0217	0.1477
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0046	0.0083	0.1707
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0256	0.1445	0.3423
Schistosoma mansoni	amine oxidase	0.0045	0.0073	0.0041
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0046	0.0083	0.0016
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0127	0.01
Echinococcus granulosus	membrane bound transcription factor site 1	0.0046	0.0083	0.0016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0127	0.0107
Plasmodium falciparum	subtilisin-like protease 3	0.0046	0.0083	0.0108
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0209	0.1144	0.2667
Plasmodium falciparum	plasmepsin IX	0.0085	0.0334	0.2681
Toxoplasma gondii	subtilisin SUB2	0.0046	0.0083	0.0108
Echinococcus multilocularis	lamin	0.0062	0.0188	0.0215
Echinococcus granulosus	tar DNA binding protein	0.0073	0.0259	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0944	0.1205
Brugia malayi	amine oxidase, flavin-containing family protein	0.0063	0.0194	0.0194
Echinococcus granulosus	neuroendocrine convertase 2	0.0681	0.4206	0.6124
Plasmodium falciparum	plasmepsin III	0.0085	0.0334	0.2681
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0256	0.1445	0.3423
Echinococcus multilocularis	neuroendocrine convertase 2	0.0681	0.4206	0.7672
Echinococcus multilocularis		0.0874	0.546	1
Onchocerca volvulus	CoRest homolog	0.0184	0.0978	0.7161
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0085	0.0334	0.0359
Schistosoma mansoni	lamin	0.0062	0.0188	0.0182
Loa Loa (eye worm)	hypothetical protein	0.022	0.1211	0.1546
Trypanosoma brucei	importin beta-1 subunit, putative	0.0067	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0425	0.2543	0.3247
Echinococcus multilocularis	Furin 1	0.0256	0.1445	0.2547
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0046	0.0083	1
Trichomonas vaginalis	importin beta-1, putative	0.0054	0.0134	0.0129
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0085	0.0334	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0158	0.0201
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0194	0.1046	0.1806
Schistosoma mansoni	amine oxidase	0.0045	0.0073	0.0041
Loa Loa (eye worm)	hypothetical protein	0.1083	0.6821	0.8707
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0194	0.1046	0.242
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0256	0.1445	0.3423
Toxoplasma gondii	aspartyl protease ASP1	0.0194	0.1046	1
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0046	0.0083	1
Brugia malayi	hypothetical protein	0.0085	0.0334	0.0334
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0085	0.0334	0.0359
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0046	0.0083	0.1707
Echinococcus granulosus	lysine specific histone demethylase 1A	0.022	0.1211	0.1687
Brugia malayi	aspartic protease BmAsp-2, identical	0.0085	0.0334	0.0334
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0713	0.4416	0.5637
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0054	0.0134	0.0129
Brugia malayi	Subtilase family protein	0.0046	0.0083	0.0083
Schistosoma mansoni	hypothetical protein	0.0056	0.0146	0.013
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0046	0.0083	0.0054
Brugia malayi	RNA, U transporter 1	0.019	0.1017	0.1017
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0194	0.0247
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0054	0.0134	0.0129
Echinococcus granulosus	survival motor neuron protein 1	0.0274	0.1562	0.2207
Schistosoma mansoni	microtubule-associated protein tau	0.0799	0.4977	0.6022
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.022	0.1211	0.2113
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0259	0.0269
Plasmodium vivax	aspartyl proteinase, putative	0.0194	0.1046	1
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0209	0.1144	0.2667
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0194	0.1046	1
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0046	0.0083	1
Toxoplasma gondii	subtilisin SUB1	0.0046	0.0083	0.0108
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0085	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0083	0.0106
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0256	0.1445	0.3423
Loa Loa (eye worm)	hypothetical protein	0.0194	0.1046	0.1335
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0334	0.0426
Plasmodium falciparum	plasmepsin I	0.0194	0.1046	1
Plasmodium falciparum	plasmepsin II	0.0194	0.1046	1
Loa Loa (eye worm)	hypothetical protein	0.1239	0.7834	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.0259	0.0331
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0658	0.406	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.022	0.1211	0.143
Brugia malayi	Pepsin A precursor	0.0085	0.0334	0.0334
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0259	0.0269
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.0259	0.0331
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0085	0.0334	0.0359
Plasmodium falciparum	plasmepsin X	0.0085	0.0334	0.2681
Schistosoma mansoni	hypothetical protein	0.0209	0.1144	0.1348
Echinococcus granulosus	lamin dm0	0.0062	0.0188	0.0171
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0194	0.1046	0.1442
Schistosoma mansoni	survival motor neuron protein	0.0056	0.0146	0.013
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0127	0.0107
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0085	0.0334	0.2681
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0039	0.0039
Echinococcus multilocularis	musashi	0.0062	0.0188	0.0215
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0046	0.0083	1
Plasmodium vivax	aspartyl protease, putative	0.0085	0.0334	0.2681
Brugia malayi	proprotein convertase 2	0.0681	0.4206	0.4206
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0127	0.008
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0127	0.0127
Brugia malayi	intermediate filament protein	0.0062	0.0188	0.0188
Plasmodium vivax	aspartyl protease, putative	0.0085	0.0334	0.2681
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0046	0.0083	0.002
Loa Loa (eye worm)	hypothetical protein	0.022	0.1211	0.1546
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Schistosoma mansoni	importin beta-1	0.0067	0.0217	0.0217
Schistosoma mansoni	hypothetical protein	0.0713	0.4416	0.5339
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0085	0.0334	0.0359
Loa Loa (eye worm)	proprotein convertase 2	0.0256	0.1445	0.1844
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0046	0.0083	1
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0046	0.0083	1
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0045	0.0073	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1332	0.17
Loa Loa (eye worm)	hypothetical protein	0.0274	0.1562	0.1994
Toxoplasma gondii	subtilisin SUB12	0.0046	0.0083	0.0108
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0046	0.0083	0.0083
Echinococcus multilocularis	survival motor neuron protein 1	0.0274	0.1562	0.2765
Echinococcus granulosus	furin	0.1083	0.6821	1
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0046	0.0083	0.1707
Echinococcus granulosus	snurportin 1	0.0713	0.4416	0.6436
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Echinococcus multilocularis	importin subunit beta 1	0.0067	0.0217	0.0267
Schistosoma mansoni	lamin	0.0062	0.0188	0.0182
Echinococcus granulosus	intermediate filament protein	0.0062	0.0188	0.0171
Onchocerca volvulus		0.0085	0.0334	0.2005
Trypanosoma cruzi	subtilisin peptidase	0.0046	0.0083	0.1707
Giardia lamblia	High cysteine membrane protein Group 2	0.0402	0.2398	1
Plasmodium falciparum	plasmepsin VIII, putative	0.0085	0.0334	0.2681
Mycobacterium leprae	Possible secreted protease	0.0046	0.0083	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0054	0.0134	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0194	0.1046	0.1228
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0046	0.0083	0.0054
Brugia malayi	endoprotease bli-4 precursor	0.1083	0.6821	0.6821
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0085	0.0334	0.0359
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0046	0.0083	1
Toxoplasma gondii	subtilisin SUB9	0.0046	0.0083	0.0108
Echinococcus multilocularis	lamin dm0	0.0062	0.0188	0.0215
Brugia malayi	TAR-binding protein	0.0073	0.0259	0.0259
Leishmania major	subtilisin-like serine peptidase	0.0046	0.0083	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0334	0.0426
Plasmodium falciparum	subtilisin-like protease 1	0.0046	0.0083	0.0108
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0085	0.0334	0.0359
Schistosoma mansoni	furin-1 (S08 family)	0.0471	0.2844	0.3421
Echinococcus granulosus	lamin	0.0062	0.0188	0.0171
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0158	0.0158
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0158	0.0158
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Onchocerca volvulus		0.0085	0.0334	0.2005
Plasmodium vivax	aspartyl proteinase, putative	0.0085	0.0334	0.2681
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0179	0.0944	0.0944
Onchocerca volvulus		0.0062	0.0188	0.0842
Brugia malayi	RNA binding protein	0.0073	0.0259	0.0259
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0158	0.0201
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Loa Loa (eye worm)	aspartyl protease 6	0.0085	0.0334	0.0426
Plasmodium vivax	subtilisin-like serine protease, putative	0.0046	0.0083	0.0108
Trichomonas vaginalis	hypothetical protein	0.0209	0.1144	0.2667
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.1144	0.2667
Echinococcus granulosus	importin subunit beta 1	0.0067	0.0217	0.0213
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0256	0.1445	0.3423
Loa Loa (eye worm)	hypothetical protein	0.0332	0.1942	0.2479
Echinococcus granulosus	microtubule associated protein 2	0.0799	0.4977	0.7266

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 884086