TDR Targets

Basic information

Technical information

TDR Targets ID: 884723
Name: ethyl 2-[4,7,8-trimethyl-2-[(2-methylphenyl)m ethyl]-1,3-dioxopurino[8,7-b]imidazol-6-yl]ac etate
MW: 423.465 | Formula: C22H25N5O4
H donors: 0 H acceptors: 4 LogP: 3.53 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)Cn1c2nc3c(n2c(c1C)C)c(=O)n(c(=O)n3C)Cc1ccccc1C
InChi: 1S/C22H25N5O4/c1-6-31-17(28)12-25-14(3)15(4)27-18-19(23-21(25)27)24(5)22(30)26(20(18)29)11-16-10-8-7-9-13(16)2/h7-10H,6,11-12H2,1-5H3
InChiKey: JTGBWZQFIQFKFP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 2-[4,7,8-trimethyl-2-[(2-methylphenyl)methyl]-1,3-dioxo-purino[8,7-b]imidazol-6-yl]acetate
2-[4,7,8-trimethyl-2-[(2-methylphenyl)methyl]-1,3-dioxo-6-purino[8,7-b]imidazolyl]acetic acid ethyl ester
2-[1,3-diketo-4,7,8-trimethyl-2-(2-methylbenzyl)purino[8,7-b]imidazol-6-yl]acetic acid ethyl ester
ethyl 2-[4,7,8-trimethyl-2-[(2-methylphenyl)methyl]-1,3-dioxo-purino[8,7-b]imidazol-6-yl]ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0099	0.1816	0.7023
Entamoeba histolytica	cell division protein kinase 2, putative	0.0132	0.2558	1
Schistosoma mansoni	chromobox protein	0.0071	0.1202	0.1938
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0055	0.0859	0.1765
Echinococcus granulosus	tar DNA binding protein	0.0138	0.268	0.268
Trichomonas vaginalis	cyclin D, putative	0.0054	0.0829	0.1567
Schistosoma mansoni	hypothetical protein	0.0172	0.3428	0.5528
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0668	0.1372
Loa Loa (eye worm)	hypothetical protein	0.004	0.0519	0.1066
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0314	0.1226
Leishmania major	cyclin	0.0054	0.0829	0.3242
Schistosoma mansoni	ap endonuclease	0.0019	0.0067	0.0108
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0567	0.0567
Brugia malayi	RNA recognition motif domain containing protein	0.0138	0.268	0.5506
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0435	0.0435
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.268	0.4322
Schistosoma mansoni	hypothetical protein	0.003	0.0298	0.048
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0099	0.1816	0.1816
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0668	0.1077
Echinococcus multilocularis	cyclins	0.0054	0.0829	0.0829
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0712	0.1148
Brugia malayi	hypothetical protein	0.0124	0.2381	0.4891
Plasmodium vivax	protein kinase Crk2	0.0132	0.2558	1
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0567	0.0915
Echinococcus granulosus	neuropeptide receptor A26	0.0471	1	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0132	0.2558	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.1778	0.1778
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0668	0.1077
Plasmodium falciparum	cyclin	0.0054	0.0829	0.3242
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0132	0.2558	1
Brugia malayi	cell division control protein 2 homolog	0.0132	0.2558	0.5255
Trypanosoma brucei	polo-like protein kinase	0.0099	0.1816	0.7101
Trichomonas vaginalis	cyclins, putative	0.0054	0.0829	0.1567
Giardia lamblia	PHD finger protein 15	0.003	0.0298	0.0927
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0055	0.0859	0.0859
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1816	0.3595
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0067	0.0138
Loa Loa (eye worm)	heterochromatin protein 1	0.0071	0.1202	0.2469
Entamoeba histolytica	hypothetical protein	0.0042	0.0567	0.2008
Trichomonas vaginalis	cyclin D, putative	0.0054	0.0829	0.1567
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.12	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0567	0.2008
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0054	0.0829	0.1704
Schistosoma mansoni	kinase	0.0051	0.078	0.1258
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0067	0.0262
Brugia malayi	mbt repeat family protein	0.0048	0.0712	0.1462
Echinococcus multilocularis	cyclins	0.0054	0.0829	0.0829
Echinococcus multilocularis	cyclins	0.0054	0.0829	0.0829
Echinococcus multilocularis	cyclins	0.0054	0.0829	0.0829
Brugia malayi	follicle stimulating hormone receptor	0.0237	0.4868	1
Echinococcus multilocularis	chromobox protein 1	0.0071	0.1202	0.1202
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0668	0.1077
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0067	0.0262
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0067	0.5
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0132	0.2558	0.5255
Brugia malayi	Pre-SET motif family protein	0.0211	0.4291	0.8815
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0519	0.0477
Giardia lamblia	Kinase, CMGC CDK	0.0132	0.2558	1
Onchocerca volvulus	Huntingtin homolog	0.0124	0.2381	0.4494
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1816	0.3595
Schistosoma mansoni	chromobox protein	0.0071	0.1202	0.1938
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0519	0.0928
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0298	0.0612
Echinococcus multilocularis	cyclin dependent kinase 5	0.0132	0.2558	0.2558
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.12	0.1934
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0099	0.1816	0.1816
Loa Loa (eye worm)	hypothetical protein	0.003	0.0298	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0829	0.1704
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.2558	0.512
Echinococcus granulosus	cyclin B	0.0054	0.0829	0.0829
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0067	0.0067
Echinococcus multilocularis	geminin	0.0172	0.3428	0.3428
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0067	0.0262
Trypanosoma cruzi	cdc2-related kinase 1	0.0132	0.2558	1
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0264	0.0406
Trichomonas vaginalis	cyclins, putative	0.0054	0.0829	0.1567
Trypanosoma cruzi	cyclin 6, putative	0.0054	0.0829	0.3242
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0668	0.1372
Giardia lamblia	Hypothetical protein	0.0054	0.0829	0.306
Giardia lamblia	Kinase, CMGC CDK	0.0132	0.2558	1
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0194	0.3926	0.3926
Onchocerca volvulus		0.0048	0.0712	0.0893
Onchocerca volvulus		0.024	0.4932	1
Loa Loa (eye worm)	TAR-binding protein	0.0138	0.268	0.5506
Entamoeba histolytica	hypothetical protein	0.0042	0.0567	0.2008
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0712	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0712	0.1462
Echinococcus multilocularis	cyclin dependent kinase 1	0.0132	0.2558	0.2558
Plasmodium vivax	SET domain protein, putative	0.003	0.0314	0.1226
Brugia malayi	Bromodomain containing protein	0.003	0.0298	0.0612
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0067	0.0559
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0054	0.0829	0.1704
Trypanosoma cruzi	cyclin, putative	0.0054	0.0829	0.3242
Echinococcus multilocularis	cyclin dependent kinase 1	0.0132	0.2558	0.2558
Schistosoma mansoni	hypothetical protein	0.0042	0.0567	0.0915
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0314	0.0506
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1816	0.3595
Brugia malayi	TAR-binding protein	0.0138	0.268	0.5506
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0712	0.1148
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.12	0.1934
Onchocerca volvulus		0.0031	0.0331	0.007
Trichomonas vaginalis	cyclin B, putative	0.0054	0.0829	0.1567
Schistosoma mansoni	serine/threonine protein kinase	0.0132	0.2558	0.4125
Brugia malayi	jmjC domain containing protein	0.0036	0.0435	0.0893
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0055	0.0859	0.1385
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0435	0.0893
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0132	0.2558	0.5255
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0991	0.2035
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0067	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0829	0.1567
Entamoeba histolytica	cell division protein kinase 2, putative	0.0132	0.2558	1
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0054	0.0829	0.0829
Brugia malayi	chromobox protein homolog 3	0.004	0.0519	0.1066
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0314	0.0314
Trichomonas vaginalis	cyclin B, putative	0.0054	0.0829	0.1567
Trichomonas vaginalis	cyclins, putative	0.0054	0.0829	0.1567
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0132	0.2558	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0585	0.0619
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0435	0.0435
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0054	0.0829	0.3242
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0055	0.0859	0.0859
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0712	0.0893
Brugia malayi	jmjC domain containing protein	0.0097	0.1778	0.3652
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1816	0.3595
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0435	0.0701
Brugia malayi	Heterochromatin protein 1	0.0071	0.1202	0.2469
Brugia malayi	hypothetical protein	0.0042	0.0567	0.1165
Brugia malayi	Protein kinase domain containing protein	0.0132	0.2558	0.5255
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0211	0.4291	0.8815
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0099	0.1816	0.7101
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0752	0.1408
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0298	0.048
Brugia malayi	serine/threonine-protein kinase plk-2	0.0099	0.1816	0.3731
Loa Loa (eye worm)	cyclin domain-containing protein	0.0054	0.0829	0.1704
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0042	0.0568	0.0916
Trypanosoma brucei	cdc2-related kinase 1	0.0132	0.2558	1
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0585	0.1064
Schistosoma mansoni	serine/threonine protein kinase	0.0132	0.2558	0.4125
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0859	0.1765
Brugia malayi	Pre-SET motif family protein	0.003	0.0314	0.0644
Echinococcus granulosus	cyclins	0.0054	0.0829	0.0829
Toxoplasma gondii	exonuclease III APE	0.0019	0.0067	0.0262
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.268	0.4322
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0054	0.0829	0.0829
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0585	0.1064
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0067	0.0138
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.134	0.2161
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0314	0.0314
Echinococcus multilocularis	cyclin B3 1	0.0054	0.0829	0.0829
Trichomonas vaginalis	cyclin A, putative	0.0054	0.0829	0.1567
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0763	0.1567
Schistosoma mansoni	hypothetical protein	0.0172	0.3428	0.5528
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.12	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0668	0.0668
Schistosoma mansoni	cyclin B3	0.0054	0.0829	0.1337
Echinococcus multilocularis	cyclins	0.0054	0.0829	0.0829
Trypanosoma brucei	cdc2-related kinase 3	0.0132	0.2558	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0132	0.2558	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0067	0.0067
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0237	0.4868	1
Brugia malayi	RNA binding protein	0.0138	0.268	0.5506
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1816	0.3595
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.12	1
Trypanosoma cruzi	cyclin, putative	0.0054	0.0829	0.3242
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0298	0.0298
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0668	0.0668
Echinococcus granulosus	cyclin dependent kinase 1	0.0132	0.2558	0.2558
Echinococcus multilocularis	cyclin b3	0.0054	0.0829	0.0829
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0314	0.0506
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0553	0.0553
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0132	0.2558	0.2558
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0071	0.12	0.12
Echinococcus granulosus	peregrin	0.003	0.0298	0.0298
Schistosoma mansoni	ap endonuclease	0.0019	0.0067	0.0108
Entamoeba histolytica	cyclin, putative	0.0054	0.0829	0.306
Schistosoma mansoni	cyclins	0.0054	0.0829	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0129	0.249	0.5115
Echinococcus granulosus	cyclin b3	0.0054	0.0829	0.0829
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.1816	0.2929
Echinococcus multilocularis	cyclins	0.0054	0.0829	0.0829
Loa Loa (eye worm)	hypothetical protein	0.003	0.0314	0.0644
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.2558	0.512
Schistosoma mansoni	cyclin B	0.0054	0.0829	0.1337
Echinococcus multilocularis	cyclin dependent kinase	0.0132	0.2558	0.2558
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.1778	0.1778
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0435	0.0701
Schistosoma mansoni	hypothetical protein	0.0298	0.6202	1
Onchocerca volvulus		0.0042	0.0568	0.0583
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1816	0.3595
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0298	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0124	0.2381	0.4891
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.2558	0.512
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0289	0.0289
Echinococcus granulosus	chromobox protein 1	0.0071	0.1202	0.1202
Echinococcus granulosus	chromobox protein 1	0.0071	0.1202	0.1202
Onchocerca volvulus		0.0054	0.0829	0.1146
Trichomonas vaginalis	cyclin B, putative	0.0054	0.0829	0.1567
Echinococcus multilocularis	neuropeptide s receptor	0.0471	1	1
Echinococcus granulosus	cyclins	0.0054	0.0829	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0124	0.2381	0.4891
Echinococcus granulosus	cyclins	0.0054	0.0829	0.0829
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0712	0.0712
Giardia lamblia	Cyclin A	0.0054	0.0829	0.306
Echinococcus granulosus	cyclin B3 1	0.0054	0.0829	0.0829
Echinococcus granulosus	cyclins	0.0054	0.0829	0.0829
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1816	0.3595
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0099	0.1816	0.3731
Trypanosoma cruzi	cdc2-related kinase 1	0.0132	0.2558	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0067	0.5
Trichomonas vaginalis	cyclins, putative	0.0054	0.0829	0.1567
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0067	0.0262
Trichomonas vaginalis	cyclin B3, putative	0.0054	0.0829	0.1567
Trypanosoma brucei	mitotic cyclin 6	0.0054	0.0829	0.3242
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.268	0.4322
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0331	0.0679
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.1202	0.2333
Entamoeba histolytica	hypothetical protein	0.0042	0.0567	0.2008
Trichomonas vaginalis	cyclin B, putative	0.0054	0.0829	0.1567
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0132	0.2558	1
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0132	0.2558	0.5255
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0067	0.0262
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0099	0.1816	0.3276
Echinococcus multilocularis	peregrin	0.003	0.0298	0.0298
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0054	0.0829	0.3242
Entamoeba histolytica	cyclin family protein	0.0054	0.0829	0.306
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0071	0.12	1
Echinococcus multilocularis	chromobox protein 1	0.0071	0.1202	0.1202
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0071	0.12	0.469
Brugia malayi	mbt repeat family protein	0.0048	0.0712	0.1462
Echinococcus granulosus	geminin	0.0172	0.3428	0.3428
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0668	0.0668
Plasmodium falciparum	protein kinase 5	0.0132	0.2558	1
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0712	0.1462
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0829	0.1704
Trypanosoma cruzi	polo-like protein kinase, putative	0.0099	0.1816	0.7101
Toxoplasma gondii	hypothetical protein	0.0041	0.0544	0.2127
Trichomonas vaginalis	set domain proteins, putative	0.024	0.4932	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0519	0.0928
Loa Loa (eye worm)	RNA binding protein	0.0138	0.268	0.5506
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0054	0.0829	0.1704
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0194	0.3926	0.3926
Echinococcus multilocularis	tar DNA binding protein	0.0138	0.268	0.268
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0712	0.1148
Trypanosoma cruzi	polo-like protein kinase, putative	0.0099	0.1816	0.7101
Entamoeba histolytica	cyclin family protein	0.0054	0.0829	0.306
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0668	0.0668
Echinococcus granulosus	histone acetyltransferase MYST2	0.0055	0.0859	0.0859
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0314	0.0506
Echinococcus multilocularis	neuropeptide receptor A26	0.0471	1	1
Plasmodium falciparum	phd finger protein, putative	0.003	0.0298	0.1165
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0298	0.1165
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0138	0.268	0.5506
Echinococcus multilocularis	cyclin B	0.0054	0.0829	0.0829
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0712	0.0712
Toxoplasma gondii	aldehyde dehydrogenase	0.0071	0.12	0.469
Brugia malayi	PHD-finger family protein	0.003	0.0298	0.0612
Trichomonas vaginalis	cyclin B, putative	0.0054	0.0829	0.1567
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0567	0.0567
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0298	0.0298
Trichomonas vaginalis	cyclins, putative	0.0054	0.0829	0.1567
Echinococcus granulosus	cyclin dependent kinase	0.0132	0.2558	0.2558
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.1202	0.2333
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0055	0.0859	0.0859
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.268	0.4322
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0712	0.0712
Echinococcus multilocularis	cyclins	0.0054	0.0829	0.0829
Giardia lamblia	Kinase, PLK	0.0099	0.1816	0.7023
Onchocerca volvulus	Huntingtin homolog	0.0124	0.2381	0.4494
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0314	0.0314
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0071	0.12	0.12
Entamoeba histolytica	cyclin, putative	0.0054	0.0829	0.306
Loa Loa (eye worm)	MBCTL1	0.0055	0.0859	0.1765
Echinococcus granulosus	cyclins	0.0054	0.0829	0.0829
Echinococcus granulosus	cyclin dependent kinase 5	0.0132	0.2558	0.2558
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0264	0.0406
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0553	0.0553
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.268	0.4322
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0752	0.1408
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0298	0.1165
Giardia lamblia	G2/mitotic-specific cyclin B	0.0054	0.0829	0.306

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 884723