Detailed information for compound 884754

Basic information

Technical information
  • TDR Targets ID: 884754
  • Name: 2-[(E)-but-2-enyl]-6-(2,4-dimethylphenyl)-4-m ethyl-7,8-dihydropurino[8,7-b]imidazole-1,3-d ione
  • MW: 365.429 | Formula: C20H23N5O2
  • H donors: 0 H acceptors: 3 LogP: 2.9 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C/Cn1c(=O)n(C)c2c(c1=O)n1CCN(c1n2)c1ccc(cc1C)C
  • InChi: 1S/C20H23N5O2/c1-5-6-9-25-18(26)16-17(22(4)20(25)27)21-19-23(10-11-24(16)19)15-8-7-13(2)12-14(15)3/h5-8,12H,9-11H2,1-4H3/b6-5+
  • InChiKey: NGUKOGSFVAHQGG-AATRIKPKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(E)-but-2-enyl]-6-(2,4-dimethylphenyl)-4-methyl-7,8-dihydropurino[8,7-b]imidazole-1,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum subtilisin-like protease 3 0.0343 0.0407 0.8152
Schistosoma mansoni chromatin regulatory protein sir2 0.0093 0.0087 0.0086
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0037 0.0015 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0083 0.0074 0.1817
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0033 0.001 0.0242
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0368 0.044 0.5187
Schistosoma mansoni discoidin domain receptor 0.0043 0.0023 0.0023
Plasmodium vivax NAD-dependent deacetylase, putative 0.0093 0.0087 0.163
Brugia malayi amine oxidase, flavin-containing family protein 0.0147 0.0157 0.0156
Brugia malayi Protein arginine N-methyltransferase 0.0087 0.0079 0.0079
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0093 0.0087 0.0142
Echinococcus granulosus membrane bound transcription factor site 1 0.0343 0.0407 0.0406
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0015 0.0014
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0079 0.007 0.1714
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Plasmodium falciparum protoporphyrinogen oxidase 0.0104 0.0101 0.1917
Plasmodium falciparum subtilisin-like protease 1 0.0343 0.0407 0.8152
Plasmodium vivax aspartyl protease, putative 0.0037 0.0015 0.0166
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0095 0.009 0.0089
Schistosoma mansoni protein kinase 0.0127 0.0131 0.013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0015 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0093 0.0087 0.0142
Mycobacterium ulcerans polyketide synthase Pks9 0.005 0.0033 0.079
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0117 0.0119 0.291
Echinococcus multilocularis NMDA receptor 0.0031 0.0008 0.0009
Brugia malayi Reprolysin 0.0025 0.0001 0.0000040861
Echinococcus multilocularis integrin beta 2 0.0937 0.1168 0.1457
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0343 0.0407 0.0407
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.011 0.0109 0.0136
Echinococcus multilocularis protein jagged 2 0.0029 0.0006 0.0006
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0154 0.0166 0.027
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0062 0.0047 0.1153
Leishmania major subtilisin-like serine peptidase 0.0343 0.0407 0.5215
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0343 0.0407 0.0667
Echinococcus multilocularis Furin 1 0.1894 0.2395 0.2988
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0015 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0037
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0071 0.006 0.0059
Brugia malayi Will die slowly protein 0.0071 0.0059 0.0059
Echinococcus granulosus glutamate receptor 2 0.0047 0.0028 0.0027
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0154 0.0166 0.0165
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0154 0.0166 0.0165
Onchocerca volvulus 0.0029 0.0006 0.0075
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0087 0.0079 0.0942
Trichomonas vaginalis WD repeat domain, putative 0.0071 0.0059 0.0096
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0062 0.0047 0.1153
Echinococcus multilocularis discoidin domain receptor 0.0043 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0132 0.0138 0.0137
Brugia malayi hypothetical protein 0.0037 0.0015 0.0015
Toxoplasma gondii subtilisin SUB5 0.0343 0.0407 0.902
Loa Loa (eye worm) kelch domain-containing protein family protein 0.022 0.025 0.025
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.001 0.0009
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.0074 0.1817
Mycobacterium tuberculosis Conserved hypothetical protein 0.0104 0.0101 0.2486
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0104 0.0101 0.2475
Mycobacterium leprae Polyketide synthase Pks13 0.0117 0.0119 0.2901
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Echinococcus granulosus serine:threonine protein kinase N2 0.0077 0.0067 0.0066
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1894 0.2395 0.2394
Loa Loa (eye worm) hypothetical protein 0.0241 0.0277 0.0276
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0154 0.0166 0.3229
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0023 0.0037
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0343 0.0407 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0613 0.0753 0.0752
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0104 0.0101 0.2142
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0028 0.0027
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0023 0.0028
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0041 0.002 0.0322
Mycobacterium tuberculosis Possible oxidoreductase 0.0104 0.0101 0.2486
Brugia malayi SWIRM domain containing protein 0.0043 0.0024 0.0023
Plasmodium falciparum plasmepsin III 0.0037 0.0015 0.0166
Brugia malayi Probable ATP-dependent helicase DHX35 0.0032 0.0009 0.0008
Brugia malayi Kelch motif family protein 0.022 0.025 0.025
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0015 0.0014
Toxoplasma gondii kringle domain-containing protein 0.003 0.0007 0.0028
Echinococcus granulosus glutamate NMDA receptor subunit 0.0261 0.0302 0.0302
Schistosoma mansoni chromatin regulatory protein sir2 0.0629 0.0775 0.0774
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0023 0.033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0015
Trypanosoma brucei subtilisin peptidase 0.0343 0.0407 0.4717
Schistosoma mansoni site-1 peptidase (S08 family) 0.0343 0.0407 0.0406
Toxoplasma gondii aspartyl protease 0.0037 0.0015 0.0211
Schistosoma mansoni hypothetical protein 0.0087 0.0079 0.0079
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0343 0.0407 1
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0058
Leishmania major arginine N-methyltransferase-like protein 0.0154 0.0166 0.2066
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0629 0.0775 0.127
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0629 0.0775 1
Toxoplasma gondii subtilisin SUB8 0.0343 0.0407 0.902
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0093 0.0087 0.0108
Brugia malayi hypothetical protein 0.0241 0.0277 0.0276
Plasmodium falciparum plasmepsin VI 0.0037 0.0015 0.0166
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.001 0.0009
Echinococcus granulosus lysine specific histone demethylase 1A 0.0104 0.0101 0.01
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0008 0.0007
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0343 0.0407 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0028 0.0034
Loa Loa (eye worm) fatty acid synthase 0.0079 0.007 0.0069
Echinococcus granulosus neuroendocrine convertase 2 0.4943 0.63 0.63
Brugia malayi Glutamate receptor 2 precursor 0.0031 0.0008 0.0007
Toxoplasma gondii bicoid-interacting protein BIN3 0.0087 0.0079 0.1652
Schistosoma mansoni protein kinase 0.0127 0.0131 0.013
Echinococcus multilocularis protein arginine methyltransferase 0.0154 0.0166 0.0206
Brugia malayi Angiotensin-converting enzyme family protein 0.0613 0.0753 0.0752
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0015 0.0166
Loa Loa (eye worm) sirtuin 4 0.0093 0.0087 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Echinococcus granulosus adam 0.0086 0.0078 0.0077
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0028 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0127 0.0131 0.013
Toxoplasma gondii subtilisin SUB2 0.0343 0.0407 0.902
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0023 0.0037
Loa Loa (eye worm) WD40 repeat protein 0.0071 0.0059 0.0059
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4783 0.6095 0.6094
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0087 0.0079 0.0129
Giardia lamblia Hypothetical protein 0.0629 0.0775 0.2099
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0015 0.0014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0015 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0629 0.0775 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0093 0.0087 0.1042
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Loa Loa (eye worm) hypothetical protein 0.7832 1 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0127 0.0131 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0104 0.0101 0.1917
Mycobacterium ulcerans NAD-dependent deacetylase 0.0093 0.0087 0.2129
Loa Loa (eye worm) transcriptional regulator 0.0093 0.0087 0.0087
Echinococcus granulosus integrin beta 2 0.0937 0.1168 0.1168
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0093 0.0087 0.1042
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0028 0.0034
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0343 0.0407 0.0406
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0068 0.1648
Echinococcus multilocularis nmda type glutamate receptor 0.011 0.0109 0.0136
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0087 0.0079 0.1652
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Toxoplasma gondii aspartyl protease ASP3 0.0037 0.0015 0.0211
Echinococcus granulosus fibrillin 1 0.0031 0.0008 0.0007
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0043 0.0024 0.0028
Loa Loa (eye worm) glutamate receptor 1 0.0031 0.0008 0.0007
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0343 0.0407 0.0406
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0043 0.0023 0.0028
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0037 0.0015 0.0024
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0079 0.007 0.1702
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0087 0.0079 0.0129
Loa Loa (eye worm) glutamate receptor 2 0.0031 0.0008 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0154 0.0166 0.3229
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.008 0.0071 0.007
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0087 0.0079 0.1652
Onchocerca volvulus 0.0071 0.0059 0.0863
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Echinococcus multilocularis growth factor receptor bound protein 2 0.0124 0.0127 0.0158
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0043 0.0023 0.0574
Echinococcus granulosus growth factor receptor bound protein 2 0.0124 0.0127 0.0127
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0343 0.0407 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0104 0.0101 0.1226
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1894 0.2395 0.3928
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0005
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0043 0.0023 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0093 0.0087 0.0142
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0008 0.0007
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.0007 0.0007
Schistosoma mansoni chromatin regulatory protein sir2 0.0093 0.0087 0.0086
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0068 0.1648
Loa Loa (eye worm) hypothetical protein 0.0071 0.0059 0.0059
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0104 0.0101 0.2475
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0023 0.0023
Toxoplasma gondii aspartyl protease ASP1 0.0037 0.0015 0.0211
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.005 0.0033 0.079
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0012
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0043 0.0023 0.0037
Brugia malayi neuroendocrine convertase 1 precursor 0.4943 0.63 0.63
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0078 0.0068 0.166
Schistosoma mansoni site-1 peptidase (S08 family) 0.0343 0.0407 0.0406
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0083 0.0074 0.1817
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Echinococcus granulosus discoidin domain receptor 0.0043 0.0023 0.0023
Mycobacterium ulcerans polyketide synthase Pks13 0.0117 0.0119 0.2901
Schistosoma mansoni chromatin regulatory protein sir2 0.0629 0.0775 0.0774
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0078 0.0068 0.1671
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0093 0.0087 0.0847
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0093 0.0087 0.163
Toxoplasma gondii PA14 domain-containing protein 0.0043 0.0023 0.0392
Toxoplasma gondii type I fatty acid synthase, putative 0.0057 0.0042 0.08
Echinococcus multilocularis serine:threonine protein kinase N2 0.0087 0.0079 0.0098
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1302 0.1636 0.1635
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0023 0.0023
Brugia malayi aspartic protease BmAsp-2, identical 0.0037 0.0015 0.0015
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0343 0.0407 0.0406
Mycobacterium leprae Possible secreted protease 0.0343 0.0407 1
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0093 0.0087 0.0222
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0629 0.0775 0.127
Schistosoma mansoni SWI/SNF complex-related 0.0043 0.0024 0.0023
Echinococcus multilocularis chromatin regulatory protein sir2 0.0629 0.0775 0.0966
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0343 0.0407 1
Schistosoma mansoni dock 0.0043 0.0023 0.0023
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0008 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0093 0.0087 0.0142
Schistosoma mansoni amine oxidase 0.0104 0.0101 0.01
Loa Loa (eye worm) proprotein convertase 2 0.1894 0.2395 0.2394
Echinococcus multilocularis protoporphyrinogen oxidase 0.0104 0.0101 0.0125
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0015 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Echinococcus multilocularis epidermal growth factor receptor 0.0475 0.0577 0.0719
Onchocerca volvulus 0.0138 0.0145 0.2132
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0087 0.0079 0.0744
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0043 0.0023 0.0028
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0104 0.0101 0.01
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Echinococcus granulosus protein arginine methyltransferase 0.0154 0.0166 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0079 0.007 0.5
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.0023 0.0023
Trypanosoma cruzi UDP-galactopyranose mutase 0.0104 0.0101 0.1226
Brugia malayi EGF-like domain containing protein 0.0029 0.0006 0.0005
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0023 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0056 0.004 0.004
Brugia malayi NAD-dependent deacetylase SIRT1 0.0093 0.0087 0.0087
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0046 0.0027 0.0657
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0075 0.0064 0.1582
Echinococcus granulosus tissue type plasminogen activator 0.003 0.0007 0.0006
Mycobacterium ulcerans Sir2-like regulatory protein 0.0093 0.0087 0.2129
Plasmodium vivax plasmepsin IV, putative 0.0037 0.0015 0.0166
Leishmania major UDP-galactopyranose mutase 0.0104 0.0101 0.1226
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0008 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0087 0.0079 0.0942
Echinococcus granulosus chromatin regulatory protein sir2 0.0629 0.0775 0.0774
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0052 0.0035 0.0654
Mycobacterium tuberculosis Probable thioesterase TesA 0.0067 0.0054 0.1327
Plasmodium vivax plasmepsin V, putative 0.0414 0.0498 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0093 0.0087 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0093 0.0087 0.0142
Brugia malayi hypothetical protein 0.0104 0.0101 0.0101
Leishmania major sir2-family protein-like protein 0.0093 0.0087 0.1042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1552 0.1956 0.3208
Schistosoma mansoni hypothetical protein 0.003 0.0007 0.0006
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0343 0.0407 1
Echinococcus multilocularis membrane bound transcription factor site 1 0.0343 0.0407 0.0507
Mycobacterium ulcerans oxidoreductase 0.0104 0.0101 0.2475
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0511 0.0623 0.0776
Trypanosoma brucei SIR2-like protein 4, putative 0.0093 0.0087 0.0111
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0023 0.0392
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0629 0.0775 1
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0058 0.0042 0.1036
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0093 0.0087 0.214
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0008 0.0007
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.0023 0.0023
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0025 0.0001 0.0014
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0241 0.0277 0.3373
Giardia lamblia Furin precursor putative serine protease 0.1552 0.1956 0.5324
Toxoplasma gondii subtilisin SUB12 0.0343 0.0407 0.902
Onchocerca volvulus Fatty acid synthase homolog 0.0145 0.0154 0.2259
Trypanosoma cruzi subtilisin peptidase 0.0343 0.0407 0.5215
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0028 0.0027
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0083 0.0074 0.1806
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0023 0.033
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0023 0.033
Toxoplasma gondii subtilisin SUB11 0.0343 0.0407 0.902
Mycobacterium ulcerans thioesterase 0.0067 0.0054 0.1315
Mycobacterium ulcerans thioesterase TesA 0.0067 0.0054 0.1315
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0067 0.0054 0.1315
Loa Loa (eye worm) Carm1-pending protein 0.0087 0.0079 0.0079
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0078 0.0068 0.1648
Schistosoma mansoni protein arginine n-methyltransferase 0.0087 0.0079 0.0079
Brugia malayi EGF-like domain containing protein 0.0029 0.0006 0.0005
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0087 0.0079 0.0942
Brugia malayi Sex muscle abnormal protein 5 0.0124 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Schistosoma mansoni amine oxidase 0.0104 0.0101 0.01
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0154 0.0166 0.0206
Trichomonas vaginalis hypothetical protein 0.0029 0.0006 0.0008
Toxoplasma gondii type I fatty acid synthase, putative 0.0083 0.0074 0.153
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0343 0.0407 0.0667
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.005 0.0033 0.079
Entamoeba histolytica hypothetical protein, conserved 0.0093 0.0087 0.0847
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.0074 0.1806
Echinococcus multilocularis fibrillin 1 0.0031 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0195 0.0217 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Schistosoma mansoni btb and poz domain-containing protein 0.0043 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0343 0.0407 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0343 0.0407 0.0667
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1552 0.1956 0.3208
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0087 0.0079 0.0079
Schistosoma mansoni memapsin-2 (A01 family) 0.0037 0.0015 0.0014
Echinococcus multilocularis neuroendocrine convertase 2 0.4943 0.63 0.7863
Echinococcus granulosus nmda type glutamate receptor 0.011 0.0109 0.0109
Giardia lamblia Transcriptional regulator, Sir2 family 0.0093 0.0087 0.0222
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0093 0.0087 0.0087
Plasmodium vivax hypothetical protein, conserved 0.0104 0.0101 0.1917
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0015 0.0166
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.015 0.016 0.0159
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0023 0.0392
Onchocerca volvulus 0.0343 0.0407 0.6
Schistosoma mansoni ATP-binding cassette transporter 0.0031 0.0008 0.0007
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0112 0.0111 0.0111
Echinococcus granulosus protein will die slowly 0.0071 0.0059 0.0058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Echinococcus multilocularis MAM 0.0071 0.0059 0.0073
Chlamydia trachomatis protoporphyrinogen oxidase 0.0104 0.0101 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0087 0.0079 0.0129
Toxoplasma gondii subtilisin SUB1 0.0343 0.0407 0.902
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0093 0.0087 0.1042
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0104 0.0101 0.1917
Brugia malayi EGF-like domain containing protein 0.0029 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1894 0.2395 0.3928
Loa Loa (eye worm) integrin beta-2 0.1269 0.1594 0.1593
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0078 0.0068 0.1671
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0031 0.0008 0.0007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0062 0.0047 0.1153
Echinococcus multilocularis glutamate receptor 2 0.0031 0.0008 0.0009
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.7832 1 1
Trichomonas vaginalis hypothetical protein 0.0043 0.0023 0.0037
Loa Loa (eye worm) hypothetical protein 0.0511 0.0623 0.0622
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0154 0.0166 0.027
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0028 0.0034
Toxoplasma gondii subtilisin SUB6 0.0343 0.0407 0.902
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Plasmodium falciparum subtilisin-like protease 2 0.0343 0.0407 0.8152
Echinococcus multilocularis protein will die slowly 0.0071 0.0059 0.0073
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0083 0.0074 0.1806
Loa Loa (eye worm) hypothetical protein 0.0343 0.0407 0.0407
Schistosoma mansoni hypothetical protein 0.0031 0.0008 0.0007
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0117 0.0119 0.291
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0104 0.0101 0.1917
Schistosoma mansoni chromatin regulatory protein sir2 0.0093 0.0087 0.0086
Trichomonas vaginalis hypothetical protein 0.1552 0.1956 0.3208
Brugia malayi transcriptional regulator, Sir2 family protein 0.0093 0.0087 0.0087
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0154 0.0166 0.0165
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0015 0.0014
Echinococcus granulosus lysine specific histone demethylase 1A 0.0511 0.0623 0.0622
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0005
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0241 0.0277 0.3515
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0023 0.0023
Plasmodium vivax subtilisin-like serine protease, putative 0.0343 0.0407 0.8152
Brugia malayi proprotein convertase 2 0.4943 0.63 0.63
Giardia lamblia High cysteine membrane protein Group 2 0.2888 0.3668 1
Toxoplasma gondii aspartyl protease ASP5 0.0377 0.0451 1
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0087 0.0079 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Loa Loa (eye worm) transcriptional regulator 0.0629 0.0775 0.0774
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0104 0.0101 0.1917
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0124 0.0127 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Loa Loa (eye worm) hypothetical protein 0.0554 0.0678 0.0678
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Brugia malayi hypothetical protein 0.0195 0.0217 0.0217
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0016 0.0015
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0261 0.0302 0.0376
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0104 0.0101 0.1917
Mycobacterium ulcerans polyketide synthase 0.0078 0.0068 0.1648
Brugia malayi Protein kinase domain containing protein 0.0043 0.0023 0.0023
Mycobacterium ulcerans polyketide synthase 0.0083 0.0074 0.1806
Onchocerca volvulus 0.0075 0.0064 0.0938
Leishmania major arginine N-methyltransferase, type I 0.0087 0.0079 0.0942
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0093 0.0087 0.0142
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0031 0.0008 0.0007
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0343 0.0407 0.0507
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0343 0.0407 1
Echinococcus multilocularis protein kinase c epsilon type 0.0095 0.009 0.0111
Brugia malayi Integrin beta pat-3 precursor 0.1269 0.1594 0.1593
Plasmodium falciparum plasmepsin VII 0.0037 0.0015 0.0166
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0043 0.0023 0.0023
Schistosoma mansoni furin-1 (S08 family) 0.3392 0.4313 0.4312
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0093 0.0087 0.0847
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0043 0.0023 0.0561
Toxoplasma gondii subtilisin SUB10 0.0343 0.0407 0.902
Echinococcus granulosus Furin 1 0.1894 0.2395 0.2394
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0154 0.0166 0.359
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0104 0.0101 0.2475
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0068 0.166
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4783 0.6095 0.7606
Mycobacterium ulcerans monoamine oxidase 0.0104 0.0101 0.2475
Loa Loa (eye worm) hypothetical protein 0.0043 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0015 0.0015
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0093 0.0087 0.0086
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0028 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0064 0.0064
Schistosoma mansoni integrin beta subunit 0.0742 0.0919 0.0918
Loa Loa (eye worm) endoprotease bli-4 0.7832 1 1
Onchocerca volvulus 0.0554 0.0678 1
Onchocerca volvulus 0.0043 0.0023 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.0037
Loa Loa (eye worm) transcriptional regulator 0.0093 0.0087 0.0087
Echinococcus granulosus protein kinase c epsilon type 0.0095 0.009 0.0089
Leishmania major silent information regulator 2, putative 0.0629 0.0775 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0063 0.0049 0.1199
Loa Loa (eye worm) aspartyl protease 6 0.0037 0.0015 0.0015
Onchocerca volvulus 0.0071 0.0059 0.0863
Brugia malayi Protein kinase domain containing protein 0.0071 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.1552 0.1956 0.1955
Onchocerca volvulus 0.0043 0.0023 0.0332
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0087 0.0079 0.0942
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0031 0.0008 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0112 0.0111 0.0111
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0037 0.0015 0.0018
Onchocerca volvulus 0.0037 0.0015 0.0213
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0343 0.0407 0.5215
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0368 0.044 0.564
Toxoplasma gondii subtilisin SUB4 0.0343 0.0407 0.902
Toxoplasma gondii subtilisin SUB9 0.0343 0.0407 0.902
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0093 0.0087 0.0142
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0093 0.0087 0.0111
Echinococcus granulosus MAM 0.0071 0.0059 0.0058
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0068 0.1648
Mycobacterium leprae Probable polyketide synthase Pks1 0.0083 0.0074 0.1806
Echinococcus multilocularis tissue type plasminogen activator 0.003 0.0007 0.0008
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0058
Loa Loa (eye worm) TK/ALK protein kinase 0.0071 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0104 0.0101 0.0101
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0015 0.0014
Plasmodium falciparum plasmepsin II 0.0037 0.0015 0.0166
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0093 0.0087 0.0142
Schistosoma mansoni protein kinase 0.0127 0.0131 0.013
Echinococcus granulosus fibrillin 2 0.0029 0.0006 0.0005
Plasmodium falciparum plasmepsin X 0.0037 0.0015 0.0166
Brugia malayi Glutamate receptor 1 precursor 0.0031 0.0008 0.0007
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0031 0.0008 0.0007
Plasmodium falciparum plasmepsin IX 0.0037 0.0015 0.0166
Echinococcus granulosus glutamate receptor subunit protein glur 0.0031 0.0008 0.0007
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0037 0.0015 0.0015
Giardia lamblia hypothetical protein 0.0043 0.0024 0.0048
Brugia malayi Carm1-pending protein 0.0087 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0005
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0068 0.1648
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0079 0.007 0.5
Schistosoma mansoni hypothetical protein 0.0043 0.0023 0.0023
Brugia malayi transcriptional regulator, Sir2 family protein 0.0629 0.0775 0.0774
Toxoplasma gondii histone deacetylase SIR2-like 0.0093 0.0087 0.1825
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1894 0.2395 0.3928
Plasmodium vivax subtilisin-like protease 1 0.0343 0.0407 0.8152
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0029 0.0006 0.0008
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0241 0.0277 0.3515
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1894 0.2395 0.3928
Loa Loa (eye worm) hypothetical protein 0.0071 0.0059 0.0059
Brugia malayi Pepsin A precursor 0.0037 0.0015 0.0015
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0629 0.0775 0.0966
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0078 0.0068 0.1648
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0093 0.0087 0.0086
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0629 0.0775 0.0774
Echinococcus granulosus methyltransferase protein 5 0.0087 0.0079 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0078 0.0068 0.0067
Loa Loa (eye worm) reprolysin 0.0043 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0043 0.0024 0.0023
Brugia malayi Eukaryotic aspartyl protease family protein 0.0037 0.0015 0.0015
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0028 0.0027
Brugia malayi celfurPC protein 0.628 0.8013 0.8012
Brugia malayi Protein kinase domain containing protein 0.003 0.0007 0.0007
Echinococcus multilocularis 0.0104 0.0101 0.0125
Echinococcus granulosus furin 0.7832 1 1
Schistosoma mansoni discoidin domain receptor 0.0043 0.0023 0.0023
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0023 0.0392
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0028 0.0027
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0368 0.044 0.564
Schistosoma mansoni growth factor receptor-bound protein 0.0124 0.0127 0.0127
Brugia malayi hypothetical protein 0.0071 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0343 0.0407 0.0667
Onchocerca volvulus 0.0037 0.0015 0.0213
Onchocerca volvulus 0.014 0.0147 0.2164
Echinococcus multilocularis adam 0.0086 0.0078 0.0096
Loa Loa (eye worm) subtilase 0.0343 0.0407 0.0407
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0104 0.0101 0.2475
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0031 0.0008 0.0009
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0023 0.033
Giardia lamblia Sirtuin type 2 0.0093 0.0087 0.0222
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1552 0.1956 0.3208
Brugia malayi Kringle domain containing protein 0.003 0.0007 0.0007
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0629 0.0775 1
Onchocerca volvulus 0.0071 0.0059 0.0862
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Brugia malayi aspartic protease BmAsp-1, identical 0.0037 0.0015 0.0015
Schistosoma mansoni septate junction protein 0.0052 0.0035 0.0034
Plasmodium vivax aspartyl protease, putative 0.0037 0.0015 0.0166
Brugia malayi SWIRM domain containing protein 0.0554 0.0678 0.0678
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1894 0.2395 0.3928
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0093 0.0087 0.0108
Brugia malayi transcriptional regulator, Sir2 family protein 0.0093 0.0087 0.0087
Brugia malayi hypothetical protein 0.0037 0.0015 0.0015
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0037 0.0015 0.0211
Schistosoma mansoni growth factor receptor-bound protein 0.0124 0.0127 0.0127
Onchocerca volvulus Putative cubilin 0.0034 0.0012 0.0166
Loa Loa (eye worm) hypothetical protein 0.3049 0.3874 0.3873
Echinococcus multilocularis fibrillin 2 0.0029 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Plasmodium vivax hypothetical protein, conserved 0.0093 0.0087 0.163
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0241 0.0277 0.2841
Schistosoma mansoni tyrosine kinase 0.0475 0.0577 0.0576
Toxoplasma gondii subtilisin SUB7 0.0343 0.0407 0.902
Echinococcus granulosus protein arginine N methyltransferase 7 0.0087 0.0079 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0087 0.0079 0.0942
Plasmodium falciparum plasmepsin IV 0.0037 0.0015 0.0166
Toxoplasma gondii histone lysine-specific demethylase 0.0104 0.0101 0.2142
Loa Loa (eye worm) hypothetical protein 0.0104 0.0101 0.0101
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0031 0.0008 0.0009
Echinococcus granulosus protein arginine N methyltransferase 8 0.0154 0.0166 0.0165
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0343 0.0407 0.0407
Schistosoma mansoni chromatin regulatory protein sir2 0.0093 0.0087 0.0086
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0154 0.0166 0.027
Plasmodium falciparum plasmepsin V 0.0414 0.0498 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0237 0.0271 0.0271
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0023 0.0028
Plasmodium vivax subtilisin-like protease 2, putative 0.0343 0.0407 0.8152
Brugia malayi protein kinase C II. 0.0095 0.009 0.0089
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0093 0.0087 0.163
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0343 0.0407 0.0667
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0075 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0147 0.0157 0.0156
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0087 0.0079 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.1956 0.3208
Brugia malayi Furin-like cysteine rich region family protein 0.0475 0.0577 0.0576
Echinococcus granulosus epidermal growth factor receptor 0.0475 0.0577 0.0576
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1894 0.2395 0.3928
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0511 0.0623 0.0622
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0093 0.0087 0.0108
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0078 0.0068 0.166
Loa Loa (eye worm) hypothetical protein 0.0511 0.0623 0.0622
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0083 0.0074 0.1806
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4783 0.6095 1
Toxoplasma gondii histone deacetylase SIR2 0.0093 0.0087 0.1825
Plasmodium falciparum plasmepsin VIII, putative 0.0037 0.0015 0.0166
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0058
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0037 0.0015 0.0014
Entamoeba histolytica hypothetical protein 0.0241 0.0277 0.3373
Entamoeba histolytica PH domain containing protein kinase, putative 0.0077 0.0067 0.0581
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0028 0.0034
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0087 0.0079 0.0098
Plasmodium vivax aspartyl protease, putative 0.0037 0.0015 0.0166
Brugia malayi Subtilase family protein 0.0343 0.0407 0.0407
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0343 0.0407 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0629 0.0775 0.0774
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0629 0.0775 1
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0043 0.0023 0.0028
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0015 0.0014
Schistosoma mansoni glutamate receptor NMDA 0.0261 0.0302 0.0302
Onchocerca volvulus 0.003 0.0007 0.0093
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0343 0.0407 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4783 0.6095 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0015 0.0014
Loa Loa (eye worm) DEAH box polypeptide 35 0.0032 0.0009 0.0008
Plasmodium falciparum plasmepsin I 0.0037 0.0015 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0037 0.0015 0.0015
Loa Loa (eye worm) TK/EGFR protein kinase 0.0475 0.0577 0.0576
Toxoplasma gondii SWIRM domain-containing protein 0.0043 0.0024 0.0397
Echinococcus multilocularis 0.628 0.8013 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0093 0.0087 0.0142
Loa Loa (eye worm) hypothetical protein 0.0071 0.0059 0.0059
Brugia malayi EGF-like domain containing protein 0.0029 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0037
Brugia malayi hypothetical protein 0.0056 0.004 0.004
Mycobacterium ulcerans dehydrogenase 0.0104 0.0101 0.2475

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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