Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0732 | 0.0891 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0732 | 0.0891 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.02 | 0.6303 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0231 | 0.737 | 0.8651 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.482 | 0.5644 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0494 | 0.6594 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.1072 | 0.1701 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0732 | 0.1161 |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.1311 | 0.1505 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2498 | 0.2905 |
Schistosoma mansoni | zinc finger protein | 0.0044 | 0.0859 | 0.0859 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.3675 | 0.4294 |
Echinococcus granulosus | zinc finger protein | 0.0044 | 0.0859 | 0.1363 |
Brugia malayi | hypothetical protein | 0.0264 | 0.8514 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0494 | 0.0494 |
Brugia malayi | follicle stimulating hormone receptor | 0.0242 | 0.7738 | 0.9085 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 0.1953 | 0.2262 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0071 | 0.1815 | 0.1815 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0732 | 0.0891 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.8514 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0068 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1815 | 0.2099 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0071 | 0.1815 | 0.288 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.008 | 0.2126 | 0.3373 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.02 | 0.6303 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0068 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0732 | 0.0822 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0068 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0494 | 0.0784 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 0.1953 | 0.2262 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0732 | 0.1161 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.1072 | 0.1223 |
Brugia malayi | TAR-binding protein | 0.0075 | 0.1953 | 0.2262 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0068 | 0.0479 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.1072 | 0.1223 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0035 | 0.0056 |
Echinococcus multilocularis | zinc finger protein | 0.0044 | 0.0859 | 0.1363 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.1953 | 0.1953 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.1072 | 0.1223 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1311 | 0.1505 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.1072 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.4458 | 0.5217 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0732 | 0.0891 |
Schistosoma mansoni | loxhd1 | 0.002 | 0.0035 | 0.0035 |
Schistosoma mansoni | lipoxygenase | 0.0119 | 0.3482 | 0.3482 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.3675 | 0.4294 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.1953 | 0.1953 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0035 | 0.0056 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0068 | 0.0083 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.1311 | 0.1311 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0035 | 0.0035 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.1072 | 0.1701 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0068 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0732 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0494 | 0.0542 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.1311 | 0.2081 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0231 | 0.737 | 0.8651 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.1072 | 0.1223 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.1072 | 0.1701 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0732 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0732 | 0.0822 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.4458 | 0.7074 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0732 | 0.0863 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0035 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0732 | 0.0822 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.005 | 0.1089 | 0.1728 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0732 | 1 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0732 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0242 | 0.7738 | 0.9085 |
Trichomonas vaginalis | set domain proteins, putative | 0.0263 | 0.8479 | 1 |
Onchocerca volvulus | 0.0263 | 0.8479 | 0.9958 | |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.8514 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0133 | 0.3967 | 0.6294 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0068 | 0.0081 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0038 | 0.0664 | 0.1053 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0119 | 0.3482 | 0.5525 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.005 | 0.1089 | 0.1728 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0068 | 0.0068 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0452 | 0.0717 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0732 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.1072 | 0.1072 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0732 | 0.0891 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.1311 | 0.2081 |
Onchocerca volvulus | 0.0033 | 0.0494 | 0.0542 | |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.0528 | 0.6929 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.4458 | 0.7074 |
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 0.1953 | 0.2262 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0732 | 0.0891 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.4458 | 0.7074 |
Onchocerca volvulus | 0.004 | 0.0732 | 0.0822 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1072 | 0.1223 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0732 | 0.0891 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.3675 | 0.4294 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0035 | 0.0035 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.1072 | 0.1072 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.1953 | 0.1953 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0732 | 0.0822 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 0.1953 | 0.3099 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0732 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0732 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0046 | 0.0941 | 0.1069 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.1072 | 0.1072 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0732 | 0.0863 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0732 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.1953 | 0.1953 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.1311 | 0.1505 |
Onchocerca volvulus | Huntingtin homolog | 0.0264 | 0.8514 | 1 |
Brugia malayi | beta-lactamase | 0.004 | 0.0732 | 0.0822 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0035 | 0.0035 |
Schistosoma mansoni | polycystin 1-related | 0.002 | 0.0035 | 0.0035 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.002 | 0.0035 | 0.0056 |
Trypanosoma brucei | ISWI complex protein | 0.0034 | 0.0528 | 0.6929 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2315 | 0.2689 |
Trypanosoma cruzi | ISWI complex protein | 0.0034 | 0.0528 | 0.6929 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0119 | 0.3482 | 0.5525 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 0.1953 | 0.3099 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0068 | 0.0934 |
Schistosoma mansoni | bromodomain containing protein | 0.0141 | 0.4244 | 0.4244 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0528 | 0.0528 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0732 | 0.0863 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0068 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0732 | 0.0822 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0133 | 0.3967 | 0.6294 |
Onchocerca volvulus | 0.004 | 0.0732 | 0.0822 | |
Brugia malayi | Bromodomain containing protein | 0.0085 | 0.2309 | 0.2682 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.1953 | 0.1953 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.1311 | 0.2081 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.1311 | 0.2081 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0038 | 0.0664 | 0.0664 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0732 | 0.0732 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0732 | 0.0863 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0732 | 0.0891 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0039 | 0.0711 | 0.0798 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0068 | 0.0108 |
Brugia malayi | Bromodomain containing protein | 0.0167 | 0.5152 | 0.6035 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0732 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0732 | 0.0891 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0038 | 0.0664 | 0.1053 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.2646 | 0.308 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0732 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0035 | 0.0056 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0038 | 0.0664 | 0.0664 |
Trypanosoma cruzi | ISWI complex protein | 0.0034 | 0.0528 | 0.6929 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0071 | 0.1815 | 0.288 |
Brugia malayi | RNA binding protein | 0.0075 | 0.1953 | 0.2262 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0732 | 0.0822 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0732 | 1 |
Echinococcus granulosus | RUN | 0.002 | 0.0035 | 0.0056 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0494 | 0.0494 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.008 | 0.2126 | 0.3373 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0071 | 0.1815 | 0.1815 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0068 | 0.0039 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0256 | 0.8214 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0068 | 0.0039 |
Onchocerca volvulus | 0.004 | 0.0732 | 0.0822 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0732 | 0.0863 |
Schistosoma mansoni | zinc finger protein | 0.0034 | 0.0528 | 0.0528 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0732 | 0.0822 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0068 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0732 | 0.0822 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0732 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0732 | 0.0822 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0732 | 0.0732 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0732 | 0.0891 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0732 | 1 |
Echinococcus multilocularis | RUN | 0.002 | 0.0035 | 0.0056 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0732 | 0.0822 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.002 | 0.0035 | 0.0056 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.4458 | 0.5217 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.005 | 0.1089 | 0.1089 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0068 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.4458 | 0.5217 |
Brugia malayi | PHD-finger family protein | 0.0056 | 0.1272 | 0.1459 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0494 | 0.6422 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.2237 | 0.2237 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 0.1953 | 0.2262 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0732 | 0.0863 |
Onchocerca volvulus | Huntingtin homolog | 0.0264 | 0.8514 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0732 | 1 |
Onchocerca volvulus | 0.005 | 0.1072 | 0.1223 | |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0941 | 0.0941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.