Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0133 | 0.397 | 0.6297 |
Onchocerca volvulus | 0.004 | 0.0736 | 0.0825 | |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0736 | 0.0829 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.1957 | 0.1957 |
Brugia malayi | Bromodomain containing protein | 0.0085 | 0.2313 | 0.2705 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.1316 | 0.2087 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.1316 | 0.2087 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0038 | 0.0668 | 0.0668 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0039 | 0.0716 | 0.0804 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0736 | 0.0896 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0073 | 0.0116 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0736 | 0.0868 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0736 | 0.0736 |
Brugia malayi | Bromodomain containing protein | 0.0167 | 0.5154 | 0.6086 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2319 | 0.2712 |
Trypanosoma brucei | ISWI complex protein | 0.0034 | 0.0533 | 0.6929 |
Trypanosoma cruzi | ISWI complex protein | 0.0034 | 0.0533 | 0.6929 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0119 | 0.3485 | 0.5529 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 0.1957 | 0.3104 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0073 | 0.0994 |
Schistosoma mansoni | bromodomain containing protein | 0.0141 | 0.4247 | 0.4247 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0533 | 0.0533 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0073 | 1 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0736 | 0.0868 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0736 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0046 | 0.0946 | 0.1078 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.1076 | 0.1076 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.1316 | 0.1518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.1957 | 0.1957 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0736 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0736 | 0.0868 |
Brugia malayi | beta-lactamase | 0.004 | 0.0736 | 0.0829 |
Trichomonas vaginalis | set domain proteins, putative | 0.0263 | 0.8479 | 1 |
Schistosoma mansoni | polycystin 1-related | 0.002 | 0.004 | 0.004 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.004 | 0.004 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.002 | 0.004 | 0.0063 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.3609 | 0.4248 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0736 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1076 | 0.1233 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.1076 | 0.1076 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.004 | 0.004 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0736 | 0.0829 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.1957 | 0.1957 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 0.1957 | 0.3104 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0736 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.4382 | 0.5167 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.002 | 0.004 | 0.0063 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.005 | 0.1093 | 0.1093 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.4382 | 0.5167 |
Brugia malayi | PHD-finger family protein | 0.0056 | 0.1277 | 0.1472 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.2241 | 0.2241 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0499 | 0.6422 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0736 | 0.0868 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 0.1957 | 0.2281 |
Onchocerca volvulus | 0.0263 | 0.8479 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0946 | 0.0946 |
Onchocerca volvulus | 0.005 | 0.1076 | 0.1228 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0736 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0073 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0736 | 0.0829 |
Schistosoma mansoni | zinc finger protein | 0.0034 | 0.0533 | 0.0533 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0736 | 0.0829 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0736 | 0.0829 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0736 | 0.0829 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0736 | 0.0896 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0736 | 1 |
Echinococcus multilocularis | RUN | 0.002 | 0.004 | 0.0063 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0736 | 0.0829 |
Echinococcus granulosus | RUN | 0.002 | 0.004 | 0.0063 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0499 | 0.0499 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.008 | 0.213 | 0.3378 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0071 | 0.1819 | 0.1819 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0073 | 0.004 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0736 | 0.0868 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0073 | 0.004 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0256 | 0.8215 | 1 |
Onchocerca volvulus | 0.004 | 0.0736 | 0.0825 | |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.265 | 0.3106 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0038 | 0.0668 | 0.106 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0736 | 0.0896 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0736 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0038 | 0.0668 | 0.0668 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0736 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.004 | 0.0063 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0071 | 0.1819 | 0.2885 |
Trypanosoma cruzi | ISWI complex protein | 0.0034 | 0.0533 | 0.6929 |
Brugia malayi | RNA binding protein | 0.0075 | 0.1957 | 0.2281 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0736 | 0.0829 |
Echinococcus multilocularis | zinc finger protein | 0.0044 | 0.0864 | 0.137 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.004 | 0.0063 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.1076 | 0.1228 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.1076 | 0.1233 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.1957 | 0.1957 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0736 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1316 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.4382 | 0.5167 |
Schistosoma mansoni | loxhd1 | 0.002 | 0.004 | 0.004 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.1076 | 0.1707 |
Schistosoma mansoni | lipoxygenase | 0.0119 | 0.3485 | 0.3485 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.1957 | 0.1957 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.3609 | 0.4248 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.004 | 0.0063 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.1316 | 0.1316 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0073 | 0.0089 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.02 | 0.6305 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0073 | 0.0086 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0499 | 0.0791 |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 0.1957 | 0.2281 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0073 | 0.0073 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0736 | 0.0829 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.1076 | 0.1233 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0736 | 0.1168 |
Brugia malayi | TAR-binding protein | 0.0075 | 0.1957 | 0.2281 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0073 | 0.0479 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 0.1957 | 0.2281 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0736 | 0.0896 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0071 | 0.1819 | 0.1819 |
Brugia malayi | hypothetical protein | 0.0262 | 0.8444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1819 | 0.2117 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0073 | 0.0116 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0071 | 0.1819 | 0.2885 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.008 | 0.213 | 0.3378 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.02 | 0.6305 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0736 | 0.0896 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0736 | 0.0896 |
Brugia malayi | Pre-SET motif family protein | 0.0231 | 0.7371 | 0.8724 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.4823 | 0.5692 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0499 | 0.6594 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.1076 | 0.1707 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0736 | 0.1168 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2502 | 0.293 |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.1316 | 0.1518 |
Schistosoma mansoni | zinc finger protein | 0.0044 | 0.0864 | 0.0864 |
Onchocerca volvulus | Huntingtin homolog | 0.0262 | 0.8444 | 0.9958 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0499 | 0.0499 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.3609 | 0.4248 |
Echinococcus granulosus | zinc finger protein | 0.0044 | 0.0864 | 0.137 |
Brugia malayi | follicle stimulating hormone receptor | 0.0242 | 0.7739 | 0.9162 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.1316 | 0.2087 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0736 | 0.0896 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.0533 | 0.6929 |
Onchocerca volvulus | 0.0033 | 0.0499 | 0.0544 | |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.4382 | 0.695 |
Onchocerca volvulus | 0.004 | 0.0736 | 0.0825 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 0.1957 | 0.2281 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.4382 | 0.695 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0736 | 0.0896 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0038 | 0.0668 | 0.106 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0133 | 0.397 | 0.6297 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0073 | 0.0086 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0119 | 0.3485 | 0.5529 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.005 | 0.1093 | 0.1734 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0073 | 0.0073 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0457 | 0.0724 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0736 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.1076 | 0.1076 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0736 | 0.0868 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.004 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0736 | 0.0829 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.4382 | 0.695 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0736 | 0.0829 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0736 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.005 | 0.1093 | 0.1734 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0736 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0242 | 0.7739 | 0.9162 |
Onchocerca volvulus | Huntingtin homolog | 0.0262 | 0.8444 | 0.9958 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.8444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.8444 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0073 | 0.5 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.1076 | 0.1707 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.004 | 0.004 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0736 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.1316 | 0.2087 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0499 | 0.0546 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0231 | 0.7371 | 0.8724 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.1076 | 0.1707 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.1076 | 0.1233 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0736 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.