TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 414.306 | Formula: C17H17Cl2N3O3S
H donors: 1 H acceptors: 3 LogP: 2.87 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)C1CCN(CC1)C(=O)c1csc(n1)COc1ccc(cc1Cl)Cl
InChi: 1S/C17H17Cl2N3O3S/c18-11-1-2-14(12(19)7-11)25-8-15-21-13(9-26-15)17(24)22-5-3-10(4-6-22)16(20)23/h1-2,7,9-10H,3-6,8H2,(H2,20,23)
InChiKey: KWHJUUCZKIZAHC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	chromobox protein 1	0.0075	0.0678	0.2796
Onchocerca volvulus	Alhambra homolog	0.0065	0.0566	0.1333
Brugia malayi	AF-10 protein	0.0021	0.0051	0.0174
Echinococcus granulosus	chromobox protein 1	0.0075	0.0678	0.2796
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.0945	0.3092
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0079	0.0727	0.3465
Echinococcus multilocularis	phd:f box containing protein	0.0021	0.0048	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0945	0.3978
Loa Loa (eye worm)	jmjC domain-containing protein	0.0021	0.0048	0.0006
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0077	0.0701	0.2376
Plasmodium vivax	hypothetical protein, conserved	0.0077	0.0701	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0266	0.0735
Schistosoma mansoni	hypothetical protein	0.0065	0.0566	0.2645
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0109	0.0215
Onchocerca volvulus		0.0077	0.0701	0.1809
Schistosoma mansoni	hypothetical protein	0.0188	0.2009	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0266	0.3353
Brugia malayi	jmjC domain containing protein	0.0021	0.0048	0.0163
Echinococcus multilocularis	jumonji domain containing protein	0.009	0.0865	0.0822
Mycobacterium ulcerans	hypothetical protein	0.0077	0.0701	0.1091
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0209	0.0163
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0241	0.264	0.8927
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0077	0.0701	0.2254
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0021	0.0048	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0209	0.0558
Schistosoma mansoni	jumonji domain containing protein	0.0021	0.0048	0.0008
Brugia malayi	beta-lactamase family protein	0.0077	0.0701	0.2376
Mycobacterium ulcerans	hypothetical protein	0.0531	0.6046	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0109	0.1202
Mycobacterium tuberculosis	Probable hydrolase	0.0077	0.0701	0.1091
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.1868	0.6102
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0021	0.0051	0.0073
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0047	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.2951	0.973
Mycobacterium tuberculosis	Probable esterase LipL	0.0077	0.0701	0.1091
Schistosoma mansoni	chromobox protein	0.0075	0.0678	0.3216
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0077	0.0701	0.1091
Schistosoma mansoni	aldehyde dehydrogenase	0.0135	0.1393	0.6862
Brugia malayi	jmjC domain containing protein	0.0021	0.0048	0.0163
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0209	0.0826
Onchocerca volvulus		0.0077	0.0701	0.1809
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0021	0.0051	0.0073
Brugia malayi	PHD-finger family protein	0.0065	0.0566	0.1917
Brugia malayi	jmjC domain containing protein	0.0021	0.0048	0.0163
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0021	0.0048	0.0012
Echinococcus multilocularis	geminin	0.0188	0.2009	0.1972
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0293	0.0825
Echinococcus multilocularis	chromobox protein 1	0.0075	0.0678	0.0634
Brugia malayi	Pre-SET motif family protein	0.0035	0.0209	0.0707
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.1868	0.6102
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0016
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0701	0.1091
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0077	0.0701	0.3336
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0149	0.0344
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.2951	0.973
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0194	0.0651
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0293	0.0825
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0065	0.0566	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0187	0.0482
Schistosoma mansoni	hypothetical protein	0.0188	0.2009	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0701	0.2254
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0701	0.2193
Mycobacterium tuberculosis	Probable lipase LipD	0.0077	0.0701	0.1091
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.0266	0.0366
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0209	0.1203
Plasmodium vivax	hypothetical protein, conserved	0.0065	0.0566	0.793
Trichomonas vaginalis	set domain proteins, putative	0.0275	0.3032	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0135	0.1393	1
Schistosoma mansoni	phosphatidylserine receptor	0.0021	0.0048	0.0008
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0135	0.1393	0.2245
Leishmania major	hypothetical protein, conserved	0.0026	0.0109	0.0463
Echinococcus granulosus	phd:f box containing protein	0.0021	0.0048	0.0007
Schistosoma mansoni	phd/f-box containing protein	0.0021	0.0048	0.0008
Echinococcus granulosus	beta LACTamase domain containing family member	0.0077	0.0701	0.29
Echinococcus granulosus	lysine specific demethylase 5A	0.0079	0.0727	0.3012
Mycobacterium ulcerans	nitrate/nitrite response regulator protein NarL	0.0531	0.6046	1
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0149	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0566	0.1788
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0109	0.0463
Brugia malayi	follicle stimulating hormone receptor	0.0248	0.2714	0.9198
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.2951	0.973
Leishmania major	hypothetical protein, conserved	0.0021	0.0048	0.0012
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0293	0.0373
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0213	0.2304	0.2268
Mycobacterium leprae	PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	0.0531	0.6046	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0701	0.2193
Brugia malayi	chromobox protein homolog 3	0.0042	0.0293	0.0992
Brugia malayi	PHD-finger family protein	0.0021	0.0051	0.0174
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0109	0.0953
Loa Loa (eye worm)	jmjC domain-containing protein	0.0079	0.0727	0.2341
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0701	0.2193
Mycobacterium ulcerans	beta-lactamase	0.0077	0.0701	0.1091
Loa Loa (eye worm)	jmjC domain-containing protein	0.0134	0.1379	0.4589
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0945	0.4576
Mycobacterium ulcerans	two component transcriptional regulatory protein DevR	0.0531	0.6046	1
Brugia malayi	Heterochromatin protein 1	0.0075	0.0678	0.2297
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.004	0.0266	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0945	0.0902
Trichomonas vaginalis	chromobox protein, putative	0.0045	0.033	0.095
Schistosoma mansoni	inositol monophosphatase	0.004	0.0266	0.1118
Plasmodium vivax	JmjC domain containing protein	0.0021	0.0048	0.0025
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.0266	0.0735
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.1868	0.6102
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0209	0.0826
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.2951	0.973
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.0266	1
Schistosoma mansoni	inositol monophosphatase	0.004	0.0266	0.1118
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0266	0.0221
Brugia malayi	Inositol-1	0.004	0.0266	0.0902
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0945	0.4576
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0701	0.1091
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0077	0.0701	0.1091
Trichomonas vaginalis	chromobox protein, putative	0.0075	0.0678	0.2115
Brugia malayi	MH2 domain containing protein	0.0128	0.1303	0.4415
Loa Loa (eye worm)	heterochromatin protein 1	0.0075	0.0678	0.2173
Trichomonas vaginalis	chromobox protein, putative	0.0075	0.0678	0.2115
Echinococcus granulosus	PHD finger protein rhinoceros	0.0065	0.0566	0.2299
Mycobacterium leprae	conserved hypothetical protein	0.0077	0.0701	0.083
Brugia malayi	jmjC domain containing protein	0.0213	0.2304	0.7809
Echinococcus multilocularis	jumonji domain containing 1A	0.0021	0.0048	0.0002
Toxoplasma gondii	ABC1 family protein	0.0077	0.0701	0.4862
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0021	0.0048	0.0025
Brugia malayi	F/Y-rich N-terminus family protein	0.0023	0.0066	0.0225
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (LuxR-family)	0.0531	0.6046	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.1979	0.6475
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.2951	0.973
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0293	0.0848
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.1868	0.6102
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0109	0.1202
Echinococcus granulosus	geminin	0.0188	0.2009	0.8692
Mycobacterium tuberculosis	Possible transcriptional regulatory protein	0.0531	0.6046	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0077	0.0701	0.1091
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0021	0.0048	0.0002
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0701	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0035	0.0217	0.0285
Echinococcus granulosus	peregrin	0.0065	0.0566	0.2299
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0209	0.0826
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0047	0.0352	0.1556
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0077	0.0701	0.3336
Trichomonas vaginalis	chromobox protein, putative	0.0045	0.033	0.095
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0213	0.2304	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0701	0.2254
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (probably LuxR/UhpA-family)	0.0531	0.6046	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0135	0.1393	0.2245
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0109	0.0953
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0048	0.0006
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0077	0.0701	0.1091
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0047	0.0158
Mycobacterium tuberculosis	Possible nitrate/nitrite response transcriptional regulatory protein NarL	0.0531	0.6046	1
Mycobacterium ulcerans	putative regulatory protein	0.0531	0.6046	1
Schistosoma mansoni	jumonji domain containing protein	0.0169	0.179	0.8884
Onchocerca volvulus	Glucosylceramidase homolog	0.0176	0.1868	0.591
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0945	0.0902
Loa Loa (eye worm)	jmjC domain-containing protein	0.0021	0.0048	0.0006
Trichomonas vaginalis	penicillin-binding protein, putative	0.0077	0.0701	0.2193
Brugia malayi	jmjC domain containing protein	0.0079	0.0727	0.2462
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0077	0.0701	0.1091
Brugia malayi	jmjC domain containing protein	0.0021	0.0048	0.0163
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.1868	0.6102
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0945	0.4576
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0701	0.2254
Echinococcus granulosus	JmjC domain containing protein 4	0.0021	0.0048	0.0007
Mycobacterium ulcerans	esterase/lipase LipP	0.0077	0.0701	0.1091
Loa Loa (eye worm)	beta-lactamase	0.0077	0.0701	0.2254
Echinococcus multilocularis	peregrin	0.0065	0.0566	0.0522
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.1303	0.4326
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0266	0.0972
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0109	0.0953
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0135	0.1393	0.5964
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0701	1
Schistosoma mansoni	chromobox protein	0.0075	0.0678	0.3216
Toxoplasma gondii	PHD-finger domain-containing protein	0.0065	0.0566	0.3855
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.1868	0.6102
Echinococcus granulosus	jumonji domain containing 1A	0.0021	0.0048	0.0007
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.1979	0.6475
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0021	0.0048	0.0008
Trichomonas vaginalis	penicillin-binding protein, putative	0.0077	0.0701	0.2193
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0048	0.0006
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0266	0.163
Mycobacterium leprae	Probable lipase LipE	0.0077	0.0701	0.083
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0701	0.1091
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0266	0.163
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0945	0.3978
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0021	0.0048	0.0032
Mycobacterium ulcerans	lipase LipD	0.0077	0.0701	0.1091
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0266	0.0735
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0077	0.0701	0.0658
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0079	0.0727	0.3465
Echinococcus multilocularis	lysine specific demethylase 6a	0.0021	0.0048	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0701	0.2254
Loa Loa (eye worm)	PHD-finger family protein	0.0065	0.0566	0.1788
Brugia malayi	Bromodomain containing protein	0.0065	0.0566	0.1917
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0266	0.3353
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0021	0.0048	0.0012
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.2951	0.973
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0021	0.0048	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0701	0.2254
Brugia malayi	beta-lactamase family protein	0.0077	0.0701	0.2376
Plasmodium vivax	SET domain protein, putative	0.0035	0.0209	0.2475
Echinococcus multilocularis	JmjC domain containing protein 4	0.0021	0.0048	0.0002
Plasmodium falciparum	phd finger protein, putative	0.0065	0.0566	1
Brugia malayi	hypothetical protein	0.0026	0.0109	0.0369
Schistosoma mansoni	aldehyde dehydrogenase	0.0135	0.1393	0.6862
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.0945	0.3201
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0065	0.0566	0.2645
Toxoplasma gondii	PHD-finger domain-containing protein	0.0065	0.0566	0.3855
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0209	0.0718
Onchocerca volvulus		0.0275	0.3032	1
Leishmania major	hypothetical protein, conserved	0.0077	0.0701	0.4862
Schistosoma mansoni	protein phosphatase 2C	0.0021	0.0048	0.0008
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.1303	0.4326
Schistosoma mansoni	hypothetical protein	0.0021	0.0051	0.0024
Mycobacterium ulcerans	two component transcriptional regulator	0.0531	0.6046	1
Loa Loa (eye worm)	inositol-1	0.004	0.0266	0.0756
Trypanosoma brucei	hypothetical protein, conserved	0.0077	0.0701	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0023	0.0066	0.0101
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0135	0.1393	0.2245
Giardia lamblia	PHD finger protein 15	0.0065	0.0566	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0135	0.1393	0.1353
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0268	0.2951	1
Mycobacterium tuberculosis	Probable transcriptional regulatory protein	0.0531	0.6046	1
Echinococcus granulosus	jumonji domain containing protein	0.009	0.0865	0.3625
Toxoplasma gondii	PHD-finger domain-containing protein	0.0021	0.0051	0.0035
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.1868	0.6102
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1112	0.3667
Echinococcus multilocularis	lysine specific demethylase 5A	0.0079	0.0727	0.0683
Mycobacterium tuberculosis	Possible two component transcriptional regulatory protein (probably LuxR-family)	0.0531	0.6046	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0209	0.0163
Echinococcus granulosus	lysine specific demethylase 6a	0.0021	0.0048	0.0007
Brugia malayi	beta-lactamase	0.0077	0.0701	0.2376
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0268	0.2951	1
Onchocerca volvulus		0.0077	0.0701	0.1809
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0701	0.2254
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0045	0.033	0.0504
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0489	0.555	0.9173
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0109	0.0953
Echinococcus multilocularis	chromobox protein 1	0.0075	0.0678	0.0634
Onchocerca volvulus		0.0047	0.0352	0.0581
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0135	0.1393	0.2245
Loa Loa (eye worm)	jmjC domain-containing protein	0.0021	0.0048	0.0006
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0021	0.0051	0.0092
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0051	0.0073
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0021	0.0051	0.0035
Toxoplasma gondii	aldehyde dehydrogenase	0.0135	0.1393	1
Trichomonas vaginalis	esterase, putative	0.0077	0.0701	0.2193
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0266	0.3353
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0248	0.2714	0.9185
Brugia malayi	Pre-SET motif family protein	0.0241	0.264	0.8944
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0021	0.0048	0.0025

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 885199