TDR Targets

Basic information

Technical information

TDR Targets ID: 885487
Name: 4-chloro-N-[(3,5-dimethylphenyl)methyl]benzen esulfonamide
MW: 309.811 | Formula: C15H16ClNO2S
H donors: 1 H acceptors: 2 LogP: 3.74 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)S(=O)(=O)NCc1cc(C)cc(c1)C
InChi: 1S/C15H16ClNO2S/c1-11-7-12(2)9-13(8-11)10-17-20(18,19)15-5-3-14(16)4-6-15/h3-9,17H,10H2,1-2H3
InChiKey: FPYJZINWVIZWTI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-chloro-N-(3,5-dimethylbenzyl)benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Schistosoma mansoni	retinal dehydrogenase	0.0022	0.0009	0.0273
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0009	0.2778
Echinococcus multilocularis	conserved hypothetical protein	0.0022	0.0009	0.0273
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0022	0.0009	0.2793
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0022	0.0009	0.2793
Echinococcus granulosus	carbonyl reductase 1	0.0022	0.0009	0.0273
Brugia malayi	hypothetical protein	0.0022	0.0009	0.2793
Schistosoma mansoni	steroid dehydrogenase	0.0022	0.0009	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0022	0.0009	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0022	0.0009	0.0273
Schistosoma mansoni	cpg binding protein	0.0028	0.0012	0.0384
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0013	0.4227
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0022	0.0009	0.0273
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0022	0.0009	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Schistosoma mansoni	carbonyl reductase	0.0022	0.0009	0.0273
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Echinococcus granulosus	retinol dehydrogenase 11	0.0022	0.0009	0.0273
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0022	0.0009	0.5
Schistosoma mansoni	hypothetical protein	0.0013	0.0004	0.0114
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0022	0.0009	0.5
Schistosoma mansoni	cpg binding protein	0.0027	0.0011	0.0357
Echinococcus multilocularis	steroid dehydrogenase	0.0022	0.0009	0.0273
Echinococcus multilocularis	steroid dehydrogenase	0.0022	0.0009	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0022	0.0009	0.5
Onchocerca volvulus		0.0027	0.0011	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0027	0.0011	0.3744
Mycobacterium ulcerans	short chain dehydrogenase	0.1595	0.0904	0.0896
Echinococcus granulosus	dnaJ subfamily B	0.0381	0.0213	0.6654
Brugia malayi	hypothetical protein	0.0029	0.0013	0.4239
Schistosoma mansoni	carbonyl reductase	0.0022	0.0009	0.0273
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Echinococcus multilocularis	dnaJ subfamily B	0.0381	0.0213	0.6654
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0009	0.2778
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0022	0.0009	0.5
Echinococcus granulosus	GPCR family 2	0.0018	0.0007	0.0206
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0007	0.2035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Echinococcus granulosus	carbonyl reductase 1	0.0022	0.0009	0.0273
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.003	0.0013	0.0409
Entamoeba histolytica	hypothetical protein	0.003	0.0013	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0022	0.0009	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Brugia malayi	CXXC zinc finger family protein	0.0027	0.0011	0.3757
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0009	0.2778
Echinococcus multilocularis	retinol dehydrogenase 11	0.0022	0.0009	0.0273
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0022	0.0009	0.0273
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.003	0.0013	0.0409
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0001	0.0029
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0029	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Giardia lamblia	Short-chain dehydrogenase, putative	0.0022	0.0009	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0013	1
Schistosoma mansoni	hypothetical protein	0.0381	0.0213	0.6654
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0022	0.0009	0.0273
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0007	0.0206
Echinococcus granulosus	carbonyl reductase 1	0.0022	0.0009	0.0273
Echinococcus granulosus	microtubule associated protein 2	0.057	0.0321	1
Entamoeba histolytica	hypothetical protein	0.003	0.0013	1
Mycobacterium ulcerans	3-dehydroquinate dehydratase	1.7573	1	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0022	0.0009	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0022	0.0009	0.0273
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0022	0.0009	0.5
Loa Loa (eye worm)	dehydrogenase	0.0022	0.0009	0.2778
Brugia malayi	Retinol dehydrogenase 12	0.0022	0.0009	0.2793
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0007	0.0206
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0022	0.0009	0.0273
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0009	0.2778
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Brugia malayi	hypothetical protein	0.0019	0.0007	0.2151
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0057	0.0029	0.089
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0019	0.6313
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0022	0.0009	0.0273
Echinococcus multilocularis	transient receptor potential cation channel	0.0022	0.0009	0.0273
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0022	0.0009	0.2778
Schistosoma mansoni	cpg binding protein	0.0028	0.0012	0.0384
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Schistosoma mansoni	steroid dehydrogenase	0.0022	0.0009	0.0273
Brugia malayi	oxidoreductase	0.0022	0.0009	0.2793
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0013	1
Echinococcus granulosus	hypothetical protein	0.0022	0.0009	0.0273
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Entamoeba histolytica	hypothetical protein	0.003	0.0013	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.2018
Brugia malayi	Dehydrogenases, short chain protein 30	0.0022	0.0009	0.2793
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0206
Echinococcus granulosus	oxidoreductase	0.0022	0.0009	0.0273
Echinococcus multilocularis	carbonyl reductase 1	0.0022	0.0009	0.0273
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Brugia malayi	dehydrogenases, short chain protein 9	0.0022	0.0009	0.2793
Mycobacterium tuberculosis	3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase)	1.7573	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0013	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0019	0.6305
Loa Loa (eye worm)	dehydrogenase	0.0022	0.0009	0.2778
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0022	0.0009	0.0273
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0007	0.2018
Brugia malayi	hypothetical protein	0.003	0.0013	0.4349
Schistosoma mansoni	carbonyl reductase	0.0022	0.0009	0.0273
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0009	0.2778
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0022	0.0009	0.2793
Schistosoma mansoni	steroid dehydrogenase	0.0022	0.0009	0.0273
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0013	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Schistosoma mansoni	steroid dehydrogenase	0.0022	0.0009	0.0273
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0007	0.0206
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Echinococcus multilocularis	retinol dehydrogenase 13	0.0022	0.0009	0.0273
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0022	0.0009	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0022	0.0009	0.5
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0022	0.0009	0.5
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0004	0.0114
Schistosoma mansoni	steroid dehydrogenase	0.0022	0.0009	0.0273
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0022	0.0009	0.0273
Echinococcus granulosus	cpg binding protein	0.0028	0.0012	0.0384
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0013	0.2492
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0029	1
Schistosoma mansoni	microtubule-associated protein tau	0.057	0.0321	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0019	0.0582
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0013	1
Echinococcus multilocularis	carbonyl reductase 1	0.0022	0.0009	0.0273
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0022	0.0009	0.0273
Giardia lamblia	Reductase, putative	0.0022	0.0009	0.5
Echinococcus multilocularis	oxidoreductase	0.0022	0.0009	0.0273
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0022	0.0009	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0022	0.0009	0.0273
Brugia malayi	dehydrogenases, short chain protein 2	0.0022	0.0009	0.2793
Brugia malayi	Dehydrogenases, short chain protein 2	0.0022	0.0009	0.2793
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Leishmania major	hypothetical protein, conserved	0.0029	0.0013	1
Echinococcus multilocularis	cpg binding protein	0.0028	0.0012	0.0384
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0007	0.0206
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0022	0.0009	0.0273
Schistosoma mansoni	steroid dehydrogenase	0.0022	0.0009	0.0273
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0051	0.0025	1
Echinococcus granulosus	carbonyl reductase 1	0.0022	0.0009	0.0273
Schistosoma mansoni	steroid dehydrogenase	0.0022	0.0009	0.0273
Echinococcus granulosus	hypothetical protein	0.0022	0.0009	0.0273
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0009	0.2778
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0009	0.2778
Mycobacterium tuberculosis	Probable oxidoreductase	0.1595	0.0904	0.0896
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Schistosoma mansoni	steroid dehydrogenase	0.0022	0.0009	0.0273
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0009	0.2778
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0022	0.0009	0.0273
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0022	0.0009	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0022	0.0009	0.0273
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0004	0.0114
Schistosoma mansoni	hypothetical protein	0.003	0.0013	0.0409
Schistosoma mansoni	steroid dehydrogenase	0.0022	0.0009	0.0273
Entamoeba histolytica	hypothetical protein	0.003	0.0013	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0029	1
Schistosoma mansoni	transcription factor LCR-F1	0.003	0.0013	0.0409
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0206
Echinococcus multilocularis	retinol dehydrogenase 11	0.0022	0.0009	0.0273
Echinococcus granulosus	WW domain containing oxidoreductase	0.0022	0.0009	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0029	1
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0001	0.0029
Giardia lamblia	Hypothetical protein	0.0022	0.0009	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0022	0.0009	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0007	0.2035
Brugia malayi	hypothetical protein	0.0022	0.0009	0.2793
Echinococcus multilocularis	carbonyl reductase 1	0.0022	0.0009	0.0273
Echinococcus multilocularis	microtubule associated protein 2	0.057	0.0321	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0009	0.2793
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.2778
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0009	0.2778
Schistosoma mansoni	short chain dehydrogenase	0.0022	0.0009	0.0273
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0206
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0007	0.0206
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0022	0.0009	0.0273
Echinococcus granulosus	steroid dehydrogenase	0.0022	0.0009	0.0273
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0013	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 885487