Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0053 | 0.0263 | 0.2419 |
Echinococcus multilocularis | geminin | 0.0179 | 0.1236 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0053 | 0.0263 | 0.2419 |
Brugia malayi | Animal haem peroxidase family protein | 0.0053 | 0.0263 | 0.2419 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0355 | 0.1934 |
Brugia malayi | Animal haem peroxidase family protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Brugia malayi | Peroxidasin | 0.0053 | 0.0263 | 0.2419 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.0945 | 0.7139 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1316 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.016 | 0.1086 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.1236 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0355 | 0.3264 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1316 | 1 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0355 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0065 | 0.0355 | 1 |
Echinococcus granulosus | peroxidasin | 0.0053 | 0.0263 | 0.1094 |
Giardia lamblia | Myb 1-like protein | 0.0029 | 0.0075 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.0945 | 0.7139 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0053 | 0.0263 | 0.2419 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.1236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0355 | 0.0943 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0078 | 0.0722 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.0355 | 0.3264 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0053 | 0.0263 | 0.2419 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.0355 | 1 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0029 | 0.0075 | 1 |
Echinococcus granulosus | geminin | 0.0179 | 0.1236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0029 | 0.0075 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0355 | 0.1934 |
Onchocerca volvulus | 0.016 | 0.1086 | 1 | |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0053 | 0.0263 | 0.2419 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0355 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0053 | 0.0263 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Trichomonas vaginalis | MYB, putative | 0.0029 | 0.0075 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0078 | 0.0722 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0371 | 0.2713 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1316 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0371 | 0.2713 | 0.2713 |
Brugia malayi | Animal haem peroxidase family protein | 0.0053 | 0.0263 | 0.2419 |
Brugia malayi | Animal haem peroxidase family protein | 0.0053 | 0.0263 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0263 | 0.2419 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.