Detailed information for compound 885621

Basic information

Technical information
  • TDR Targets ID: 885621
  • Name: prop-2-ynyl 4-[4-[4-(4-acetylphenyl)piperazin e-1-carbonyl]-1,3-thiazol-2-yl]piperidine-1-c arboxylate
  • MW: 480.579 | Formula: C25H28N4O4S
  • H donors: 0 H acceptors: 4 LogP: 2.61 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CCOC(=O)N1CCC(CC1)c1scc(n1)C(=O)N1CCN(CC1)c1ccc(cc1)C(=O)C
  • InChi: 1S/C25H28N4O4S/c1-3-16-33-25(32)29-10-8-20(9-11-29)23-26-22(17-34-23)24(31)28-14-12-27(13-15-28)21-6-4-19(5-7-21)18(2)30/h1,4-7,17,20H,8-16H2,2H3
  • InChiKey: PBXOXMSJTZEYOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • prop-2-ynyl 4-[4-[4-(4-acetylphenyl)piperazine-1-carbonyl]thiazol-2-yl]piperidine-1-carboxylate
  • 4-[4-[[4-(4-acetylphenyl)-1-piperazinyl]-oxomethyl]-2-thiazolyl]-1-piperidinecarboxylic acid prop-2-ynyl ester
  • 4-[4-[4-(4-acetylphenyl)piperazine-1-carbonyl]thiazol-2-yl]piperidine-1-carboxylic acid propargyl ester
  • prop-2-ynyl 4-[4-[4-(4-ethanoylphenyl)piperazin-1-yl]carbonyl-1,3-thiazol-2-yl]piperidine-1-carboxylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0206 0.0215
Echinococcus granulosus raf serine:threonine protein kinase 0.0086 0.1632 0.5758
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0206 0.0726
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0553 0.0746
Loa Loa (eye worm) ACC-1 protein 0.0012 0.004 0.0042
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.004 0.0042
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0035 0.0037
Echinococcus granulosus zinc finger protein 0.0023 0.0266 0.0939
Trypanosoma cruzi ISWI complex protein 0.0015 0.0097 0.1197
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0035 0.0125
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0036 0.0553 0.0577
Brugia malayi nuclear receptor NHR-88 0.002 0.0206 0.0215
Loa Loa (eye worm) multidrug resistance protein 3 0.002 0.0212 0.0222
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.1011 0.3568
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0206 0.0215
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.004 0.0141
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0212 0.0178
Brugia malayi steroid hormone receptor 0.002 0.0206 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0206 0.0215
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0212 0.0222
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.002 0.0212 0.0715
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0083 0.1576 0.556
Brugia malayi Pre-SET motif family protein 0.0413 0.8758 0.9139
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.2468 0.8298
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.2904 0.9766
Loa Loa (eye worm) hypothetical protein 0.002 0.0212 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.1424 0.4789
Trichomonas vaginalis ABC transporter, putative 0.002 0.0212 0.0178
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.002 0.0212 0.0715
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0135 0.0454
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.004 0.0042
Echinococcus multilocularis 0.0012 0.0035 0.0119
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.002 0.0212 0.0715
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0206 0.0215
Schistosoma mansoni lamin 0.0053 0.0934 0.3141
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0553 0.0746
Brugia malayi GoLoco motif family protein 0.0024 0.029 0.0303
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0076 0.1424 0.4789
Entamoeba histolytica P-glycoprotein 5, putative 0.002 0.0212 0.3032
Schistosoma mansoni hypothetical protein 0.0124 0.2468 0.8298
Entamoeba histolytica P-glycoprotein-2 0.002 0.0212 0.3032
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0206 0.0692
Loa Loa (eye worm) hypothetical protein 0.0036 0.0553 0.0577
Echinococcus granulosus lamin 0.0053 0.0934 0.3296
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0225 0.0235
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0212 0.0178
Schistosoma mansoni multidrug resistance protein 0.002 0.0212 0.0715
Brugia malayi intermediate filament protein 0.0053 0.0934 0.0975
Brugia malayi Cation transporter family protein 0.0012 0.004 0.0042
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.0079 0.0265
Loa Loa (eye worm) hypothetical protein 0.0052 0.0913 0.0952
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0553 1
Onchocerca volvulus 0.0036 0.0553 0.0515
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0206 0.0692
Entamoeba histolytica P-glycoprotein-2, putative 0.002 0.0212 0.3032
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0212 0.0178
Loa Loa (eye worm) ACC-1 protein 0.0012 0.004 0.0042
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.004 0.0042
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.004 0.0042
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.004 0.0042
Schistosoma mansoni multidrug resistance protein 0.002 0.0212 0.0715
Loa Loa (eye worm) LGC-31 protein 0.0012 0.004 0.0042
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0212 0.0221
Mycobacterium leprae Probable lipase LipE 0.0036 0.0553 0.5
Loa Loa (eye worm) GoLoco domain-containing protein family protein 0.0024 0.029 0.0303
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0393 0.041
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0206 0.0692
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.054 0.1903
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0206 0.0215
Loa Loa (eye worm) hypothetical protein 0.0053 0.0934 0.0975
Schistosoma mansoni hypothetical protein 0.002 0.0212 0.0712
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.004 0.0134
Onchocerca volvulus 0.002 0.0206 0.0167
Echinococcus granulosus histone lysine methyltransferase setb 0.0076 0.1424 0.5024
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0212 0.0178
Brugia malayi multidrug resistance protein 3 0.002 0.0212 0.0222
Echinococcus multilocularis nAChR subunit 0.0012 0.004 0.0134
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.1059 1
Schistosoma mansoni smdr2 0.002 0.0212 0.0715
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0553 0.0577
Brugia malayi Cation transporter family protein 0.0012 0.004 0.0042
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.004 0.0134
Brugia malayi beta-lactamase family protein 0.0036 0.0553 0.0577
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0553 0.5
Leishmania major hypothetical protein, conserved 0.0015 0.0097 0.1197
Plasmodium vivax multidrug resistance protein 1, putative 0.002 0.0212 0.1731
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.004 0.0141
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.004 0.0042
Brugia malayi Bromodomain containing protein 0.0077 0.1454 0.1517
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0035 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.004 0.0042
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0206 0.0726
Schistosoma mansoni lamin 0.0053 0.0934 0.3141
Loa Loa (eye worm) hypothetical protein 0.0451 0.9583 1
Trichomonas vaginalis abcb9, putative 0.002 0.0212 0.0178
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0553 0.0577
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.1059 0.356
Onchocerca volvulus 0.0053 0.0934 0.0898
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0035 0.0125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0206 0.0692
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.002 0.0212 0.0715
Loa Loa (eye worm) hypothetical protein 0.0025 0.031 0.0324
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0206 0.0726
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.2468 0.8706
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0135 0.0476
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.004 0.0141
Loa Loa (eye worm) hypothetical protein 0.0044 0.072 0.0751
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0206 0.0215
Loa Loa (eye worm) raf kinase 0.0086 0.1632 0.1703
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.004 0.0042
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.004 0.0134
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.002 0.0212 0.3424
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0253 0.0891
Echinococcus granulosus multidrug resistance protein 1 0.002 0.0212 0.075
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.004 0.0042
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0206 0.0692
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.004 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0206 0.0215
Schistosoma mansoni hypothetical protein 0.0015 0.0097 0.0327
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.1632 0.5489
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0212 0.0178
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0553 0.5056
Leishmania major hypothetical protein, conserved 0.0036 0.0553 1
Schistosoma mansoni thyroid hormone receptor 0.0144 0.2904 0.9766
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0206 0.0215
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0393 0.041
Loa Loa (eye worm) hypothetical protein 0.0076 0.1424 0.1486
Echinococcus multilocularis lamin 0.0053 0.0934 0.3141
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0212 0.0178
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.002 0.0212 0.075
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0553 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0748 0.0715
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0206 0.0692
Schistosoma mansoni bromodomain containing protein 0.0066 0.1203 0.4045
Echinococcus granulosus lamin dm0 0.0053 0.0934 0.3296
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Schistosoma mansoni hypothetical protein 0.0012 0.0032 0.0108
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0212 0.1731
Schistosoma mansoni nuclear hormone receptor 0.002 0.0206 0.0692
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.004 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0206 0.0215
Trichomonas vaginalis taga, putative 0.002 0.0212 0.0178
Loa Loa (eye worm) acetyltransferase 0.0147 0.2974 0.3103
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.1126 0.3973
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0553 0.0519
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0037
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.2974 1
Echinococcus multilocularis zinc finger protein 0.0023 0.0266 0.0895
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0253 0.0849
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0206 0.0215
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0079 0.0044
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0212 0.0178
Trypanosoma cruzi ISWI complex protein 0.0015 0.0097 0.1197
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0212 0.0178
Loa Loa (eye worm) hypothetical protein 0.0024 0.029 0.0303
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0206 0.0726
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.002 0.0212 0.0715
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0553 0.0746
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0215
Mycobacterium tuberculosis Conserved protein 0.0036 0.0553 0.0746
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0331 0.1115
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.004 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0215
Mycobacterium tuberculosis Conserved protein 0.0036 0.0553 0.0746
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0553 0.0519
Brugia malayi nuclear hormone receptor 0.002 0.0206 0.0215
Entamoeba histolytica P-glycoprotein-5 0.002 0.0212 0.3032
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0553 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.004 0.0134
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0553 0.5
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0748 0.0715
Echinococcus granulosus multidrug resistance protein 1 0.002 0.0212 0.075
Plasmodium vivax SET domain protein, putative 0.0059 0.1059 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0934 0.0975
Trichomonas vaginalis ABC transporter, half transporter, putative 0.002 0.0212 0.0178
Brugia malayi Raf kinase 0.0086 0.1632 0.1703
Schistosoma mansoni multidrug resistance protein 0.002 0.0212 0.0715
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0212 0.0178
Schistosoma mansoni regulator of G protein signaling 0.0012 0.002 0.0067
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0212 0.0178
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0748 0.2637
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0215
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0083 0.1576 0.1644
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.2974 1
Schistosoma mansoni thyroid hormone receptor 0.0144 0.2904 0.9766
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.004 0.0134
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0206 0.0692
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.004 0.0141
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0079 0.0278
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0206 0.0692
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0748 0.6959
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0413 0.8758 0.9139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0331 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0206 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.1059 0.356
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.002 0.0212 0.0222
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0553 0.0746
Toxoplasma gondii ABC1 family protein 0.0036 0.0553 0.5056
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0553 0.1859
Brugia malayi Cation transporter family protein 0.0012 0.004 0.0042
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.002 0.0212 0.075
Schistosoma mansoni hypothetical protein 0.0024 0.029 0.0976
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0206 0.0692
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0206 0.0215
Loa Loa (eye worm) hypothetical protein 0.0083 0.1576 0.1644
Mycobacterium ulcerans lipase LipD 0.0036 0.0553 0.5
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0083 0.1576 0.5299
Brugia malayi beta-lactamase 0.0036 0.0553 0.0577
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0215
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0206 0.0726
Brugia malayi Bromodomain containing protein 0.0041 0.0668 0.0697
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Entamoeba histolytica P-glycoprotein-1 0.002 0.0212 0.3032
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Entamoeba histolytica P-glycoprotein-2 0.002 0.0212 0.3032
Mycobacterium ulcerans beta-lactamase 0.0036 0.0553 0.5
Leishmania major p-glycoprotein 0.002 0.0212 0.3424
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.062 1
Echinococcus granulosus intermediate filament protein 0.0053 0.0934 0.3296
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.062 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.004 0.0141
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0135 0.0454
Onchocerca volvulus Putative nachr subunit 0.0083 0.1576 0.1542
Loa Loa (eye worm) hypothetical protein 0.0036 0.0553 0.0577
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0553 0.1859
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0206 0.0692
Trichomonas vaginalis ABC transporter, putative 0.002 0.0212 0.0178
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.002 0.0212 0.075
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0212 0.0178
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.004 0.0042
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0206 0.0167
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.004 0.0141
Loa Loa (eye worm) hypothetical protein 0.0036 0.0553 0.0577
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0206 0.0167
Echinococcus multilocularis musashi 0.0053 0.0934 0.3141
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0206 0.0692
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0012 0.004 0.0134
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.004 0.0042
Brugia malayi hypothetical protein 0.0451 0.9583 1
Echinococcus multilocularis multidrug resistance protein 1 0.002 0.0212 0.0715
Loa Loa (eye worm) hypothetical protein 0.0036 0.0553 0.0577
Schistosoma mansoni zinc finger protein 0.0015 0.0097 0.0327
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0206 0.0692
Brugia malayi ABC transporter family protein 0.002 0.0212 0.0222
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0206 0.0167
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0083 0.1576 0.5299
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0212 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0206 0.0215
Schistosoma mansoni nAChR subunit 0.0012 0.004 0.0134
Loa Loa (eye worm) hypothetical protein 0.0036 0.0553 0.0577
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0083 0.1576 0.556
Trichomonas vaginalis abcb9, putative 0.002 0.0212 0.0178
Trichomonas vaginalis esterase, putative 0.0036 0.0553 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0206 0.0215
Trichomonas vaginalis ABC transporter, half transporter, putative 0.002 0.0212 0.0178
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0135 0.0454
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.054 0.1814
Trichomonas vaginalis ABC transporter, putative 0.002 0.0212 0.0178
Schistosoma mansoni nAChR subunit 0.0012 0.004 0.0134
Echinococcus multilocularis lamin dm0 0.0053 0.0934 0.3141
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.004 0.0134
Loa Loa (eye worm) hypothetical protein 0.0046 0.0761 0.0794
Loa Loa (eye worm) beta-lactamase 0.0036 0.0553 0.0577
Onchocerca volvulus 0.0036 0.0553 0.0515
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0553 0.0746
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0083 0.1576 0.5299
Schistosoma mansoni nAChR subunit 0.0012 0.004 0.0134
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0212 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0206 0.0215
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2328 0.2429
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.002 0.0208 0.0733
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0206 0.0692
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.002 0.0212 0.075
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0079 0.0278
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0553 0.195
Loa Loa (eye worm) hypothetical protein 0.002 0.0208 0.0217
Mycobacterium ulcerans hypothetical protein 0.0036 0.0553 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0212 0.0178
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0331 0.117
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0206 0.0726
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.002 0.0212 0.1731
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0206 0.0692
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.004 0.0134
Trichomonas vaginalis set domain proteins, putative 0.047 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0206 0.0215
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0553 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0215
Schistosoma mansoni nAChR subunit 0.0012 0.004 0.0134
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.004 0.0141
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2328 0.2429
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.004 0.0134
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0206 0.0692
Plasmodium falciparum multidrug resistance protein 1 0.002 0.0212 0.3032
Schistosoma mansoni intermediate filament proteins 0.0053 0.0934 0.3141
Brugia malayi MH2 domain containing protein 0.0117 0.2328 0.2429
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.4774 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.004 0.0134
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0035 0.0119
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.002 0.0212 0.5
Onchocerca volvulus 0.0059 0.1059 0.1023
Echinococcus granulosus G protein signaling modulator 2 0.0024 0.029 0.1024
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0212 0.0178
Echinococcus granulosus multidrug resistance protein 1 0.002 0.0212 0.075
Echinococcus multilocularis G protein signaling modulator 2 0.0024 0.029 0.0976
Schistosoma mansoni nAChR subunit 0.0012 0.004 0.0134
Schistosoma mansoni coup transcription factor 0.002 0.0206 0.0692
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.004 0.0134
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0212 0.0178
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.2834 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0553 0.0519
Brugia malayi PHD-finger family protein 0.0028 0.0381 0.0397
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.004 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0206 0.0215
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0208 0.0698
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0553 0.0746
Entamoeba histolytica P-glyco protein 6, putative 0.002 0.0212 0.3032
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.004 0.0042
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0212 0.0178
Echinococcus multilocularis raf serine:threonine protein kinase 0.0086 0.1632 0.5489
Trichomonas vaginalis abcb9, putative 0.002 0.0212 0.0178
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.004 0.0042
Echinococcus multilocularis multidrug resistance protein 1 0.002 0.0212 0.0715
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.1059 0.356
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.004 0.0042
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0206 0.0215
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.004 0.0141
Brugia malayi beta-lactamase family protein 0.0036 0.0553 0.0577
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.1126 0.3787
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0206 0.0692
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.062 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.004 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0206 0.0215
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0253 0.0849
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.004 0.0141
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0934 0.0975
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0215
Trichomonas vaginalis ABC transporter, putative 0.002 0.0212 0.0178
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0748 0.6959
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.2974 0.3103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0206 0.0215
Loa Loa (eye worm) hypothetical protein 0.0038 0.0592 0.0617
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0553 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0206 0.0215
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0012 0.004 0.0134
Loa Loa (eye worm) hypothetical protein 0.007 0.1285 0.1341
Onchocerca volvulus 0.0053 0.0934 0.0898
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0215
Onchocerca volvulus 0.0451 0.9583 0.9582
Echinococcus granulosus FTZ F1 alpha 0.002 0.0206 0.0726
Trypanosoma brucei ISWI complex protein 0.0015 0.0097 0.1197
Schistosoma mansoni nAChR subunit 0.0012 0.004 0.0134
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0553 0.0519
Schistosoma mansoni nAChR subunit 0.0012 0.004 0.0134
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.004 0.0042
Mycobacterium tuberculosis Conserved protein 0.0036 0.0553 0.0746
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.004 0.0042
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0083 0.1576 0.556
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0206 0.0726
Echinococcus granulosus nAChR subunit 0.0012 0.004 0.0141
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.004 0.0042
Brugia malayi Pre-SET motif family protein 0.0059 0.1059 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0206 0.0215
Onchocerca volvulus 0.002 0.0212 0.0173
Brugia malayi GoLoco motif family protein 0.0024 0.029 0.0303
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0035 0.0119
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0748 0.6959
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0206 0.0726
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0033
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0212 0.0178
Brugia malayi ecdysteroid receptor 0.002 0.0206 0.0215
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0934 0.0975
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0212 0.0178
Loa Loa (eye worm) hypothetical protein 0.0025 0.031 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0206 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.1424 0.4789
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Onchocerca volvulus 0.0036 0.0553 0.0515
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0212 0.0178
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0083 0.1576 0.1644
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0206 0.0692
Schistosoma mansoni zinc finger protein 0.0023 0.0266 0.0895
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0553 0.0746
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0553 0.1859
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0215
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0206 0.0215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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