Detailed information for compound 885684

Basic information

Technical information
  • TDR Targets ID: 885684
  • Name: [4-(2-bromophenyl)sulfonylpiperazin-1-yl]-fur an-2-ylmethanone
  • MW: 399.26 | Formula: C15H15BrN2O4S
  • H donors: 0 H acceptors: 3 LogP: 2.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccco1)N1CCN(CC1)S(=O)(=O)c1ccccc1Br
  • InChi: 1S/C15H15BrN2O4S/c16-12-4-1-2-6-14(12)23(20,21)18-9-7-17(8-10-18)15(19)13-5-3-11-22-13/h1-6,11H,7-10H2
  • InChiKey: CUVKKNYFAVPCGN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(2-bromophenyl)sulfonylpiperazin-1-yl]-(2-furyl)methanone
  • [4-(2-bromophenyl)sulfonyl-1-piperazinyl]-(2-furyl)methanone
  • [4-(2-bromophenyl)sulfonylpiperazin-1-yl]-furan-2-yl-methanone
  • Oprea1_491784
  • ZINC05120585

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.0018 0.0017
Onchocerca volvulus 0.0052 0.0018 0.0438
Schistosoma mansoni myosin xvIII 0.0052 0.0018 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Onchocerca volvulus 0.0052 0.0018 0.0438
Onchocerca volvulus 0.0052 0.0018 0.0438
Echinococcus multilocularis Mastin 0.0046 0.0006 0.0006
Brugia malayi Dopamine receptor 0.0052 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1477 0.272 0.272
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Schistosoma mansoni hypothetical protein 0.0052 0.0018 0.0018
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0018 0.0017
Echinococcus granulosus hypothetical protein 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0104 0.0116 0.0114
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0249 0.0392 1
Echinococcus granulosus membrane bound transcription factor site 1 0.0249 0.0392 0.039
Giardia lamblia High cysteine membrane protein Group 2 0.1657 0.3061 1
Brugia malayi proprotein convertase 2 0.3761 0.7051 0.7051
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0018 0.0022
Toxoplasma gondii subtilisin SUB11 0.0249 0.0392 0.9249
Echinococcus multilocularis neuropeptide receptor A26 0.0052 0.0018 0.0022
Schistosoma mansoni amine GPCR 0.0052 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0018 0.0022
Schistosoma mansoni opsin-like receptor 0.0052 0.0018 0.0018
Plasmodium falciparum subtilisin-like protease 1 0.0249 0.0392 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0018 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Loa Loa (eye worm) hypothetical protein 0.0076 0.0064 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1477 0.272 0.4795
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0018 0.0022
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0018 0.0017
Onchocerca volvulus 0.0052 0.0018 0.0438
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0071 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0392 0.0686
Brugia malayi hypothetical protein 0.0052 0.0018 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0018 0.0017
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.0018 0.0022
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis enteropeptidase 0.0046 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0249 0.0392 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.0018 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Echinococcus multilocularis neuroendocrine convertase 2 0.3761 0.7051 0.8966
Loa Loa (eye worm) subtilase 0.0249 0.0392 0.039
Brugia malayi larval opioid receptor 0.0052 0.0018 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0018 0.0022
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 0.0018 0.0018
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1228 0.2248 0.3962
Onchocerca volvulus 0.0101 0.0112 0.2834
Brugia malayi hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0018 0.0022
Echinococcus granulosus allatostatin A receptor 0.0052 0.0018 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Schistosoma mansoni amine GPCR 0.0052 0.0018 0.0018
Toxoplasma gondii subtilisin SUB8 0.0249 0.0392 0.9249
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 0.0018 0.0438
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.0018 0.0018
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.0018 0.0017
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0018 0.0017
Onchocerca volvulus 0.0052 0.0018 0.0438
Toxoplasma gondii subtilisin SUB1 0.0249 0.0392 0.9249
Brugia malayi Peptidase family M1 containing protein 0.0115 0.0138 0.0137
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus granulosus Furin 1 0.1477 0.272 0.2719
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0018 0.0022
Echinococcus multilocularis membrane bound transcription factor site 1 0.0249 0.0392 0.0496
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.0018 0.0018
Brugia malayi neuropeptide F receptor 0.0052 0.0018 0.0017
Onchocerca volvulus 0.0052 0.0018 0.0438
Schistosoma mansoni retinoblastoma binding protein 0.0076 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0052 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0112 0.0192
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.0018 0.0017
Schistosoma mansoni site-1 peptidase (S08 family) 0.0249 0.0392 0.0392
Echinococcus multilocularis aminopeptidase N 0.0115 0.0138 0.0174
Echinococcus granulosus glycoprotein Antigen 5 0.0046 0.0006 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Onchocerca volvulus 0.0052 0.0018 0.0438
Schistosoma mansoni neuropeptide receptor 0.0052 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Schistosoma mansoni opsin-like receptor 0.0052 0.0018 0.0018
Brugia malayi Furin-like cysteine rich region family protein 0.0462 0.0796 0.0795
Echinococcus granulosus furin 0.5317 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0018 0.0017
Loa Loa (eye worm) TK/EGFR protein kinase 0.0462 0.0796 0.0795
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0018 0.0017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0018 0.0018
Schistosoma mansoni amine GPCR 0.0052 0.0018 0.0018
Echinococcus granulosus neuropeptide receptor A26 0.0052 0.0018 0.0017
Toxoplasma gondii subtilisin SUB9 0.0249 0.0392 0.9249
Onchocerca volvulus 0.0052 0.0018 0.0438
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Echinococcus granulosus neuropeptide s receptor 0.0052 0.0018 0.0017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0018 0.0018
Brugia malayi GnHR receptor homolog 0.0052 0.0018 0.0017
Brugia malayi Will die slowly protein 0.0071 0.0055 0.0053
Brugia malayi Subtilase family protein 0.0249 0.0392 0.039
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0249 0.0392 0.0392
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0249 0.0392 0.039
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0018 0.0017
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.3032 0.5669 0.5668
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0003 0.004
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Brugia malayi Dopamine receptor protein 1 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0565 0.099 0.0989
Brugia malayi AKH receptor 0.0052 0.0018 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0018 0.0017
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0018 0.0018
Schistosoma mansoni tyrosine kinase 0.0462 0.0796 0.0796
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Brugia malayi Serotonin receptor 0.0052 0.0018 0.0017
Schistosoma mansoni histamine h1 receptor 0.0052 0.0018 0.0018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0018 0.0018
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.0018 0.0017
Loa Loa (eye worm) endoprotease bli-4 0.5317 1 1
Onchocerca volvulus 0.0052 0.0018 0.0438
Brugia malayi hypothetical protein 0.0052 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0249 0.0392 1
Schistosoma mansoni opsin-like receptor 0.0052 0.0018 0.0018
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.0018 0.0018
Echinococcus granulosus g-protein coupled receptor 0.0052 0.0018 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus granulosus orexin receptor type 2 0.0052 0.0018 0.0017
Brugia malayi G-protein coupled receptor 0.0052 0.0018 0.0017
Onchocerca volvulus 0.0052 0.0018 0.0438
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.0018 0.0017
Echinococcus granulosus sex peptide receptor 0.0052 0.0018 0.0017
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.0018 0.0018
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0249 0.0392 0.0496
Echinococcus granulosus aminopeptidase N 0.0115 0.0138 0.0137
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Plasmodium vivax subtilisin-like protease 2, putative 0.0249 0.0392 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.0018 0.0018
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.0018 0.0017
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0249 0.0392 0.039
Brugia malayi hypothetical protein 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0392 0.0686
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1477 0.272 0.4795
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.0018 0.0017
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 0.0018 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0584 0.1025
Plasmodium falciparum subtilisin-like protease 2 0.0249 0.0392 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 0.0018 0.0438
Brugia malayi hypothetical protein 0.0052 0.0018 0.0017
Schistosoma mansoni furin-1 (S08 family) 0.2533 0.4723 0.4723
Loa Loa (eye worm) peptidase family M1 containing protein 0.0093 0.0097 0.0095
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.0018 0.0017
Echinococcus granulosus epidermal growth factor receptor 0.0462 0.0796 0.0795
Plasmodium vivax subtilisin-like protease 1 0.0249 0.0392 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0018 0.0017
Brugia malayi celfurPC protein 0.419 0.7864 0.7864
Brugia malayi sulfakinin receptor protein 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Leishmania major subtilisin-like serine peptidase 0.0249 0.0392 1
Echinococcus granulosus enteropeptidase 0.0046 0.0006 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0046 0.0006 0.0006
Loa Loa (eye worm) SPRY domain-containing protein 0.0044 0.0003 0.0002
Schistosoma mansoni neuropeptide receptor 0.0052 0.0018 0.0018
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0018 0.0022
Echinococcus multilocularis neuropeptide s receptor 0.0052 0.0018 0.0022
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3032 0.5669 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0018 0.0018
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0018 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0018 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0392 0.0686
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0018 0.0022
Brugia malayi SPRY domain containing protein 0.0044 0.0003 0.0002
Echinococcus multilocularis G protein coupled receptor 139 0.0356 0.0595 0.0755
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.5317 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0018 0.0017
Echinococcus granulosus wd40 repeat 0.0076 0.0064 0.0062
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Schistosoma mansoni biogenic amine receptor 0.0052 0.0018 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Echinococcus granulosus neuropeptide receptor 0.0052 0.0018 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.0018 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0018 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Schistosoma mansoni trithorax protein ash2 0.0044 0.0003 0.0003
Echinococcus granulosus protein will die slowly 0.0071 0.0055 0.0053
Trypanosoma brucei subtilisin peptidase 0.0249 0.0392 0.5
Schistosoma mansoni neuropeptide receptor 0.0356 0.0595 0.0595
Echinococcus multilocularis serotonin receptor 0.0052 0.0018 0.0022
Echinococcus multilocularis protein will die slowly 0.0071 0.0055 0.0068
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.035 0.0584 0.0584
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.0018 0.0017
Echinococcus multilocularis allatostatin A receptor 0.0052 0.0018 0.0022
Brugia malayi hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis epidermal growth factor receptor 0.0462 0.0796 0.101
Trichomonas vaginalis hypothetical protein 0.1127 0.2056 0.3623
Brugia malayi Hypothetical WD-repeat protein F21H12.1 in chromosome II 0.0076 0.0064 0.0062
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.0018 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1477 0.272 0.4795
Brugia malayi Serotonin receptor 0.0052 0.0018 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0018 0.0018
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0249 0.0392 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1477 0.272 0.4795
Schistosoma mansoni amine GPCR 0.0052 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0081 0.0074 0.0073
Onchocerca volvulus 0.0071 0.0055 0.1368
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0018 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0249 0.0392 0.5
Loa Loa (eye worm) hypothetical protein 0.2386 0.4443 0.4442
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0018 0.0022
Echinococcus multilocularis somatostatin receptor 0.0052 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0052 0.0018 0.0018
Brugia malayi RE15519p 0.0052 0.0018 0.0017
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.0018 0.0017
Onchocerca volvulus 0.0052 0.0018 0.0438
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0018 0.0017
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0018 0.0022
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.0018 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.1127 0.2056 0.2056
Brugia malayi follicle stimulating hormone receptor 0.0052 0.0018 0.0017
Schistosoma mansoni neuropeptide receptor 0.0052 0.0018 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1477 0.272 0.4795
Toxoplasma gondii subtilisin SUB4 0.0249 0.0392 0.9249
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.0018 0.0017
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.0018 0.0022
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0249 0.0392 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0018 0.0017
Onchocerca volvulus 0.0052 0.0018 0.0438
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1477 0.272 0.4795
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.0018 0.0022
Trichomonas vaginalis retinoblastoma binding protein, putative 0.0076 0.0064 0.0107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Onchocerca volvulus 0.0052 0.0018 0.0438
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Loa Loa (eye worm) proprotein convertase 2 0.1477 0.272 0.2719
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0018 0.0018
Echinococcus multilocularis set1:ash2 histone methyltransferase complex 0.0044 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Trichomonas vaginalis WD repeat domain, putative 0.0071 0.0055 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0018 0.0018
Trypanosoma cruzi subtilisin peptidase 0.0249 0.0392 1
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0018 0.0017
Brugia malayi G protein-coupled receptor 0.0052 0.0018 0.0017
Toxoplasma gondii subtilisin SUB5 0.0249 0.0392 0.9249
Plasmodium vivax subtilisin-like serine protease, putative 0.0249 0.0392 1
Onchocerca volvulus 0.0115 0.0138 0.3515
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0018 0.0017
Brugia malayi neuropeptide F receptor 0.0052 0.0018 0.0017
Echinococcus granulosus neuroendocrine convertase 2 0.3761 0.7051 0.7051
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.0018 0.0017
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.5317 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Schistosoma mansoni biogenic amine receptor 0.0052 0.0018 0.0018
Echinococcus multilocularis 0.419 0.7864 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0018 0.0017
Echinococcus granulosus g protein coupled receptor 0.0052 0.0018 0.0017
Echinococcus multilocularis glycoprotein Antigen 5 0.0046 0.0006 0.0006
Mycobacterium leprae Possible secreted protease 0.0249 0.0392 0.5
Echinococcus multilocularis sex peptide receptor 0.0052 0.0018 0.0022
Brugia malayi hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0018 0.0022
Toxoplasma gondii subtilisin SUB10 0.0249 0.0392 0.9249
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1228 0.2248 0.3962
Echinococcus granulosus Mastin 0.0046 0.0006 0.0005
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.0018 0.0022
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.0018 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0018 0.0017
Schistosoma mansoni amine GPCR 0.0052 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0018 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0018 0.0018
Schistosoma mansoni adenoreceptor 0.0052 0.0018 0.0018
Brugia malayi hypothetical protein 0.0052 0.0018 0.0017
Echinococcus granulosus serotonin receptor 0.0052 0.0018 0.0017
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.0018 0.0017
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0018 0.0018
Toxoplasma gondii subtilisin SUB2 0.0249 0.0392 0.9249
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Toxoplasma gondii subtilisin SUB12 0.0266 0.0423 1
Echinococcus multilocularis wd40 repeat 0.0076 0.0064 0.0079
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Brugia malayi hypothetical protein 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Plasmodium falciparum SPRY domain, putative 0.0044 0.0003 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0064 0.0107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3032 0.5669 1
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.0018 0.0017
Echinococcus granulosus fmrfamide receptor 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.0018 0.0022
Echinococcus multilocularis serotonin receptor 0.0052 0.0018 0.0022
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0043 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Brugia malayi neuroendocrine convertase 1 precursor 0.4225 0.793 0.7929
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0249 0.0392 0.5
Brugia malayi Dopamine receptor protein 2 0.0052 0.0018 0.0017
Brugia malayi hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus granulosus g protein coupled receptor 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0249 0.0392 0.039
Onchocerca volvulus 0.0052 0.0018 0.0438
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0249 0.0392 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Brugia malayi ORL1-like opioid receptor 0.0052 0.0018 0.0017
Brugia malayi putative neuropeptide receptor 0.0052 0.0018 0.0017
Echinococcus granulosus set1:ash2 histone methyltransferase complex 0.0044 0.0003 0.0002
Toxoplasma gondii subtilisin SUB6 0.0249 0.0392 0.9249
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0249 0.0392 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0018 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0018 0.0022
Echinococcus granulosus somatostatin receptor 0.0052 0.0018 0.0017
Echinococcus granulosus g protein coupled receptor 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Onchocerca volvulus 0.0052 0.0018 0.0438
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Brugia malayi Melatonin receptor type 1A 0.0052 0.0018 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0018 0.0022
Onchocerca volvulus 0.0052 0.0018 0.0438
Onchocerca volvulus 0.0052 0.0018 0.0438
Schistosoma mansoni hypothetical protein 0.0052 0.0018 0.0018
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.0018 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0018 0.0017
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0249 0.0392 0.5
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0018 0.0018
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0249 0.0392 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0018 0.0018
Schistosoma mansoni biogenic amine receptor 0.0052 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.0018 0.0018
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0018 0.0018
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.0018 0.0017
Echinococcus multilocularis orexin receptor type 2 0.0052 0.0018 0.0022
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Brugia malayi G-protein coupled receptor 0.0052 0.0018 0.0017
Onchocerca volvulus 0.0249 0.0392 1
Echinococcus granulosus neuropeptide receptor 0.0356 0.0595 0.0594
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0018 0.0018
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0249 0.0392 0.5
Loa Loa (eye worm) WD40 repeat protein 0.0071 0.0055 0.0053
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.0018 0.0022
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.0018 0.0018
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0392 0.0686
Schistosoma mansoni hypothetical protein 0.0052 0.0018 0.0018
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.3032 0.5669 0.7208
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1127 0.2056 0.3623
Echinococcus multilocularis neuropeptide receptor 0.0356 0.0595 0.0755
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0018 0.0018
Plasmodium falciparum subtilisin-like protease 3 0.0249 0.0392 1
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.0018 0.0017
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0249 0.0392 0.039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0249 0.0392 0.0686
Toxoplasma gondii subtilisin SUB7 0.0249 0.0392 0.9249
Trichomonas vaginalis conserved hypothetical protein 0.1127 0.2056 0.3623
Schistosoma mansoni site-1 peptidase (S08 family) 0.0249 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0018 0.0018
Echinococcus multilocularis Furin 1 0.1477 0.272 0.3457
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0392 0.0686
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0249 0.0392 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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