TDR Targets

Basic information

Technical information

TDR Targets ID: 885802
Name: 4-(3-chloro-4-methylphenyl)sulfonyl-2-methyl- 1-(4-methylphenyl)piperazine
MW: 378.916 | Formula: C19H23ClN2O2S
H donors: 0 H acceptors: 2 LogP: 4.45 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)N1CCN(CC1C)S(=O)(=O)c1ccc(c(c1)Cl)C
InChi: 1S/C19H23ClN2O2S/c1-14-4-7-17(8-5-14)22-11-10-21(13-16(22)3)25(23,24)18-9-6-15(2)19(20)12-18/h4-9,12,16H,10-11,13H2,1-3H3
InChiKey: JLTLTELKYPNNNX-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

4-(3-chloro-4-methyl-phenyl)sulfonyl-2-methyl-1-(4-methylphenyl)piperazine
Oprea1_394830

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0072	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0038	0.004
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.006	0.0236
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0058	0.023
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.001	0.0004
Brugia malayi	Dihydrofolate reductase	0.3238	0.9506	1
Brugia malayi	dihydrofolate reductase family protein	0.3238	0.9506	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0175	0.0476	0.0471
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.006	0.0236
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.1667	0.4875	0.5117
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.006	0.0054
Echinococcus granulosus	General substrate transporter	0.0093	0.0235	0.0241
Schistosoma mansoni	protein kinase	0.0033	0.0058	0.0056
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0058	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0032	0.0026
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.3405	1	1
Leishmania major	protein kinase, putative	0.0033	0.0058	0.0053
Trypanosoma brucei	glucose transporter, putative	0.0034	0.006	0.0054
Trypanosoma brucei	glucose transporter, putative	0.0034	0.006	0.0054
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.001	0.0004
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0058	0.0056
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.3405	1	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.028	0.0288
Schistosoma mansoni	protein kinase	0.0033	0.0058	0.0056
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0058	0.0053
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.1667	0.4875	0.5125
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0032	0.0026
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0058	0.0056
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.006	0.0236
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0072	0.0067
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.3405	1	1
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.006	0.0054
Trypanosoma brucei	glucose transporter, putative	0.0034	0.006	0.0054
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0032	0.0034
Trypanosoma brucei	glucose transporter 1E	0.0034	0.006	0.0054
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0032	0.0011
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0034	0.006	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0058	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0058	0.0053
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.1667	0.4875	0.5125
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0032	0.0028
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.028	0.0288
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0056	0.0222
Brugia malayi	hypothetical protein	0.0793	0.2298	0.2413
Plasmodium falciparum	protein kinase 6	0.0459	0.1314	0.1309
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.001	0.0004
Echinococcus granulosus	dihydrofolate reductase	0.3238	0.9506	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.001	0.0004
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.006	0.0054
Schistosoma mansoni	hypothetical protein	0.0108	0.028	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0056	0.0059
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.001	0.0004
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.0072	0.0067
Schistosoma mansoni	glucose transport protein	0.0108	0.028	0.0288
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0058	0.0061
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0052	0.0049
Echinococcus granulosus	geminin	0.0178	0.0484	0.0504
Trypanosoma brucei	glucose transporter, putative	0.0034	0.006	0.0054
Echinococcus multilocularis	transcription factor btf3	0.0037	0.0069	0.0066
Leishmania major	glucose transporter, lmgt3	0.0034	0.006	0.0054
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0006	0.5
Plasmodium falciparum	basic transcription factor 3b, putative	0.0037	0.0069	0.0063
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.001	0.0004
Echinococcus granulosus	thymidylate synthase	0.1667	0.4875	0.5125
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.3238	0.9506	1
Loa Loa (eye worm)	sugar transporter	0.0015	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0017	0.001	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0069	0.0275
Echinococcus multilocularis	General substrate transporter	0.0093	0.0235	0.0241
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0021	0.0016
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0052	0.0049
Onchocerca volvulus		0.1667	0.4875	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0056	0.0054
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0058	0.0056
Toxoplasma gondii	NAC domain-containing protein	0.0037	0.0069	0.0063
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0058	0.0056
Echinococcus granulosus	transcription factor btf3	0.0037	0.0069	0.0066
Leishmania major	glucose transporter, lmgt1	0.0034	0.006	0.0054
Echinococcus multilocularis	geminin	0.0178	0.0484	0.0504
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0072	0.0067
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0058	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0069	0.0275
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0032	0.0028
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0056	0.0037
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0021	0.0016
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.001	0.0004
Plasmodium falciparum	protein kinase 7	0.0306	0.0862	0.0857
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.006	0.0236
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0056	0.6657
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0023	0.0077
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0058	0.0053
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0032	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.3405	1	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0032	0.0028
Entamoeba histolytica	protein kinase, putative	0.0033	0.0058	0.7194
Brugia malayi	Sugar transporter family protein	0.0108	0.028	0.0288
Brugia malayi	Cam kinase protein 1	0.0033	0.0058	0.0056
Chlamydia trachomatis	dihydrofolate reductase	0.3238	0.9506	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.028	0.0288
Entamoeba histolytica	hypothetical protein	0.0037	0.0069	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0058	0.0053
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.006	0.0054
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0058	0.0053
Trypanosoma brucei	glucose transporter 2A	0.0034	0.006	0.0054
Leishmania major	glucose transporter, lmgt2	0.0034	0.006	0.0054
Schistosoma mansoni	glucose transport protein	0.0108	0.028	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Trypanosoma brucei	glucose transporter, putative	0.0034	0.006	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.001	0.0004
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0058	0.0061
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0175	0.0476	0.0471
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0032	0.0028
Plasmodium vivax	hexose transporter	0.0108	0.028	0.0274
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0006	0.0006
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0058	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0006	0.0006
Echinococcus multilocularis	dihydrofolate reductase	0.3238	0.9506	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0056	0.0054
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.006	0.0236
Loa Loa (eye worm)	sugar transporter	0.0108	0.028	0.0294
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.006	0.0236
Schistosoma mansoni	dihydrofolate reductase	0.3238	0.9506	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.028	0.0288
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0058	0.0053
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0459	0.1314	0.1309
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0032	0.0028
Schistosoma mansoni	transcription factor btf3	0.0037	0.0069	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Entamoeba histolytica	protein kinase, putative	0.0033	0.0058	0.7194
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0793	0.2298	0.2294
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.0072	0.0067
Trypanosoma brucei	glucose transporter, putative	0.0034	0.006	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0793	0.2298	1
Schistosoma mansoni	protein kinase	0.0033	0.0058	0.0056
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0069	0.0063
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0032	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.028	0.1195
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0032	0.0028
Leishmania major	basic transcription factor 3a, putative	0.0037	0.0069	0.0063
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.006	0.0054
Mycobacterium ulcerans	thymidylate synthase	0.1667	0.4875	0.5125
Loa Loa (eye worm)	thymidylate synthase	0.1667	0.4875	0.5128
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0058	0.0053
Schistosoma mansoni	hypothetical protein	0.0178	0.0484	0.0504
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0032	0.0026
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0058	0.0053
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0017	0.001	0.0004
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0056	0.0054
Plasmodium falciparum	hexose transporter	0.0108	0.028	0.0274
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0072	0.0067
Trypanosoma brucei	glucose transporter, putative	0.0034	0.006	0.0054
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0058	0.0053
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0032	0.0028
Schistosoma mansoni	hypothetical protein	0.0178	0.0484	0.0504
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.3238	0.9506	1
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.001	0.0004
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0056	0.0054
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.001	0.0004
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0032	0.0026
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0069	0.0063
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.028	0.0288
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.028	0.0288
Brugia malayi	isocitrate dehydrogenase	0.0017	0.001	0.0004
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0015	0.0009
Loa Loa (eye worm)	dihydrofolate reductase	0.3238	0.9506	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0056	0.0054
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.001	0.0004
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0056	1
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.3405	1	1
Trypanosoma brucei	transcription factor BTF3, putative	0.0037	0.0069	0.0063
Loa Loa (eye worm)	ICD-1 protein	0.0037	0.0069	0.0072
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0056	0.0054
Entamoeba histolytica	transcription factor BTF3, putative	0.0037	0.0069	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0032	0.0115
Toxoplasma gondii	protein kinase, putative	0.0306	0.0862	0.0857
Brugia malayi	thymidylate synthase	0.1667	0.4875	0.5125
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0058	0.0056
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0175	0.0476	0.0471
Plasmodium vivax	basic transcription factor 3b, putative	0.0037	0.0069	0.0063
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.001	0.0004
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0058	0.0053
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0006
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0058	0.0056
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.028	0.0288
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0058	0.0056
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.3238	0.9506	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.006	0.0054
Trypanosoma cruzi	hexose transporter	0.0034	0.006	0.0054
Mycobacterium tuberculosis	Hypothetical protein	0.0793	0.2298	0.2413
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0058	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0069	0.0275
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0072	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0056	0.0059
Brugia malayi	beta-NAC-like protein	0.0037	0.0069	0.0066
Toxoplasma gondii	facilitative glucose transporter GT1	0.0108	0.028	0.0274
Schistosoma mansoni	glucose transport protein	0.0108	0.028	0.0288
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0058	0.0053
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0058	0.0056
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0108	0.028	0.0288
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0032	0.5182
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.006	0.0236
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.0072	0.0067
Trypanosoma brucei	glucose transporter, putative	0.0034	0.006	0.0054
Echinococcus multilocularis	thymidylate synthase	0.1667	0.4875	0.5125
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.001	0.0004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 885802