Detailed information for compound 885867

Basic information

Technical information
  • TDR Targets ID: 885867
  • Name: 1-(3-chloro-4-methylphenyl)sulfonyl-4-(phenyl methyl)piperazine
  • MW: 364.89 | Formula: C18H21ClN2O2S
  • H donors: 0 H acceptors: 2 LogP: 3.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1Cl)S(=O)(=O)N1CCN(CC1)Cc1ccccc1
  • InChi: 1S/C18H21ClN2O2S/c1-15-7-8-17(13-18(15)19)24(22,23)21-11-9-20(10-12-21)14-16-5-3-2-4-6-16/h2-8,13H,9-12,14H2,1H3
  • InChiKey: BUMFEEDKASRNHS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-chloro-4-methyl-phenyl)sulfonyl-4-(phenylmethyl)piperazine
  • 1-(benzyl)-4-(3-chloro-4-methyl-phenyl)sulfonyl-piperazine
  • Oprea1_451424

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0198 0.0198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0182 0.0286
Leishmania major macrophage migration inhibitory factor-like protein 0.1408 1 1
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0433 0.2971 0.66
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.1906 0.1853
Onchocerca volvulus 0.0325 0.2189 1
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0433 0.2971 0.2971
Echinococcus granulosus expressed conserved protein 0.0095 0.0535 0.149
Plasmodium vivax hexokinase, putative 0.0325 0.2189 0.2165
Brugia malayi MH1 domain containing protein 0.0025 0.0024 0.0001
Brugia malayi MH2 domain containing protein 0.0025 0.0024 0.0001
Schistosoma mansoni bromodomain containing protein 0.0069 0.0344 0.098
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0074 0.0381 0.0318
Echinococcus multilocularis zinc finger protein 0.0024 0.0019 0.0007
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0137 0.0106
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.0656 0.2033
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0161 0.0161
Schistosoma mansoni phosphomannomutase 0.0138 0.084 0.2394
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0656 0.0634
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0181 0.0151
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0286 0.1906 0.1888
Plasmodium vivax macrophage migration inhibitory factor, putative 0.1408 1 1
Brugia malayi PHD-finger family protein 0.003 0.0063 0.0041
Trypanosoma brucei phosphomannomutase 0.0138 0.084 0.1816
Toxoplasma gondii phosphomannomutase 0.0138 0.084 0.0812
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.008
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.065 0.3463
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0114 0.017
Schistosoma mansoni glutaminase 0.0278 0.1852 0.5278
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0317 0.0516
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0182 0.0519
Loa Loa (eye worm) hypothetical protein 0.0312 0.2097 0.2097
Brugia malayi hypothetical protein 0.0026 0.0031 0.0008
Leishmania major hypothetical protein, conserved 0.0225 0.1472 0.1452
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.058 0.0963
Brugia malayi Smad1 0.0025 0.0024 0.0001
Trypanosoma cruzi polo-like protein kinase, putative 0.0286 0.1906 0.4209
Trichomonas vaginalis CAMK family protein kinase 0.0141 0.0866 0.0806
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.0227
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.1906 0.5432
Loa Loa (eye worm) hexokinase 0.0101 0.0571 0.0571
Brugia malayi MH2 domain containing protein 0.0361 0.245 0.2433
Brugia malayi Hexokinase family protein 0.0325 0.2189 0.2171
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0739 0.3959
Onchocerca volvulus 0.0204 0.1316 0.597
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0181 0.0151
Trypanosoma brucei hexokinase 0.0325 0.2189 0.4845
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0557 0.1554
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.1408 1 1
Loa Loa (eye worm) hexokinase 0.0325 0.2189 0.2189
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0591 0.1684
Trypanosoma brucei polo-like protein kinase 0.0286 0.1906 0.4209
Schistosoma mansoni smad1 5 8 and 0.0025 0.0024 0.0068
Loa Loa (eye worm) Smad1 0.0025 0.0024 0.0024
Mycobacterium ulcerans hypothetical protein 0.0074 0.0381 0.1026
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0601 0.4178 0.4178
Schistosoma mansoni smad 0.0025 0.0024 0.0068
Schistosoma mansoni hypothetical protein 0.0042 0.015 0.0426
Schistosoma mansoni hypothetical protein 0.003 0.0063 0.0181
Leishmania major hexokinase, putative 0.0325 0.2189 0.2171
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0433 0.2971 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0024 0.0016
Echinococcus granulosus hexokinase 0.0325 0.2189 0.6223
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0656 0.0595
Echinococcus granulosus phosphomannomutase 0.0138 0.084 0.2363
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.065 0.3463
Loa Loa (eye worm) hypothetical protein 0.0048 0.019 0.019
Plasmodium falciparum thioredoxin reductase 0.0049 0.0198 0.0168
Leishmania major phosphomannomutase, putative 0.0138 0.084 0.0819
Echinococcus granulosus GPCR family 2 0.0032 0.008 0.0187
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0074 0.0381 0.0784
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.058 0.0558
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0137 0.0115
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0063 0.0032
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0024 0.0024
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0065 0.0034
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0074 0.0381 0.0784
Toxoplasma gondii phosphomannose isomerase type I protein 0.0508 0.351 0.3489
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.045 0.309 0.3045
Loa Loa (eye worm) hexokinase type II 0.0325 0.2189 0.2189
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.008 0.008
Brugia malayi Bromodomain containing protein 0.0043 0.0158 0.0135
Schistosoma mansoni hypothetical protein 0.0042 0.015 0.0426
Trypanosoma cruzi phosphomannose isomerase, putative 0.0508 0.351 0.7809
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0161 0.0097
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0225 0.1472 0.3233
Giardia lamblia Kinase, PLK 0.0286 0.1906 0.1855
Trypanosoma cruzi hypothetical protein, conserved 0.0643 0.4486 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.065 0.3463
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0895 0.2521
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0148 0.0229
Plasmodium falciparum phd finger protein, putative 0.003 0.0063 0.0032
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0063 0.0181
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0063 0.0084
Echinococcus multilocularis hexokinase 0.0325 0.2189 0.3705
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0123 0.0312
Onchocerca volvulus 0.0312 0.2097 0.9574
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.1906 0.1853
Echinococcus granulosus citrate lyase subunit beta protein 0.0074 0.0381 0.1048
Echinococcus multilocularis protein patched 0.0044 0.0161 0.025
Schistosoma mansoni kinase 0.0145 0.0893 0.2545
Schistosoma mansoni hypothetical protein 0.007 0.035 0.0998
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0024 0.0027
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.0894 0.2517
Brugia malayi hexokinase type II 0.0103 0.0591 0.057
Echinococcus granulosus hexokinase 0.0325 0.2189 0.6223
Echinococcus multilocularis peregrin 0.0036 0.0108 0.0159
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0031
Echinococcus multilocularis citrate lyase subunit beta protein 0.0074 0.0381 0.0624
Brugia malayi MH1 domain containing protein 0.0025 0.0024 0.0001
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.0656 0.1815
Loa Loa (eye worm) glutaminase 2 0.0278 0.1852 0.1852
Plasmodium vivax phosphomannomutase, putative 0.0138 0.084 0.0812
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0198 0.0527
Echinococcus granulosus peregrin 0.0036 0.0108 0.0267
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0411 0.1172
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0109 0.0162
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0756 0.1264
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.045 0.309 0.3046
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0656 0.0595
Loa Loa (eye worm) hypothetical protein 0.0222 0.1444 0.1444
Loa Loa (eye worm) hypothetical protein 0.004 0.0132 0.0132
Mycobacterium tuberculosis Conserved protein 0.0074 0.0381 0.1977
Brugia malayi MH2 domain containing protein 0.0025 0.0024 0.0001
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0065 0.0034
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.045 0.309 0.3069
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0433 0.2971 0.8459
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0074 0.0381 0.1026
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0233 0.1524 0.1504
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.0227
Loa Loa (eye worm) glutaminase 0.0278 0.1852 0.1852
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0023
Trypanosoma cruzi phosphomannomutase, putative 0.0138 0.084 0.1816
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0137 0.0074
Brugia malayi hypothetical protein 0.0312 0.2097 0.2079
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0065 0.0034
Mycobacterium ulcerans lipoprotein LpqF 0.0066 0.0321 0.0854
Loa Loa (eye worm) hypothetical protein 0.0102 0.058 0.058
Loa Loa (eye worm) MH2 domain-containing protein 0.0361 0.245 0.245
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0508 0.351 0.351
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0656 0.0656
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0074 0.0381 0.1026
Brugia malayi serine/threonine-protein kinase plk-2 0.0286 0.1906 0.1888
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.008 0.0111
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0063 0.0141
Brugia malayi PHD-finger family protein 0.0029 0.0058 0.0035
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0656 0.1869
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.0656 0.1836
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0508 0.351 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0065 0.0002
Loa Loa (eye worm) hypothetical protein 0.0052 0.0219 0.0219
Brugia malayi RNA binding protein 0.0126 0.0756 0.0735
Toxoplasma gondii thioredoxin reductase 0.0049 0.0198 0.0168
Loa Loa (eye worm) glutathione reductase 0.0049 0.0198 0.0198
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0198 0.0375
Echinococcus granulosus hexokinase 0.0325 0.2189 0.6223
Onchocerca volvulus Putative phosphomannomutase 0.0138 0.084 0.3773
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.0943 0.0923
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0508 0.351 0.5954
Leishmania major macrophage migration inhibitory factor-like protein 0.1408 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0656 0.0634
Trypanosoma cruzi hypothetical protein, conserved 0.0643 0.4486 1
Brugia malayi glucose-6-phosphate dehydrogenase 0.0433 0.2971 0.2955
Loa Loa (eye worm) RNA binding protein 0.0126 0.0756 0.0756
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.065 0.3463
Schistosoma mansoni hypothetical protein 0.0042 0.015 0.0426
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0065 0.0042
Echinococcus granulosus zinc finger protein 0.0024 0.0019 0.0012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0583 0.0562
Entamoeba histolytica serine/threonine protein kinase, putative 0.0286 0.1906 0.1888
Entamoeba histolytica hexokinase 1 0.0325 0.2189 0.2171
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0024 0.0068
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0137 0.0835 0.4486
Brugia malayi CHE-14 protein 0.0044 0.0161 0.0138
Loa Loa (eye worm) hypothetical protein 0.007 0.035 0.035
Treponema pallidum hexokinase (hxk) 0.0325 0.2189 0.731
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.045 0.309 0.3069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0182 0.0519
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0601 0.4178 0.4178
Brugia malayi TAR-binding protein 0.0126 0.0756 0.0735
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0182 0.0159
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0583 0.0583
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.1408 1 1
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0074 0.0381 0.1026
Brugia malayi jmjC domain containing protein 0.0038 0.0123 0.0101
Echinococcus granulosus Smad4 0.0025 0.0024 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.1906 0.1853
Brugia malayi Thioredoxin reductase 0.0049 0.0198 0.0176
Echinococcus multilocularis hexokinase 0.0325 0.2189 0.3705
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.1906 0.1853
Brugia malayi glutathione reductase 0.0049 0.0198 0.0176
Echinococcus multilocularis smad 0.0025 0.0024 0.0016
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0433 0.2971 0.8455
Loa Loa (eye worm) hexokinase 0.0325 0.2189 0.2189
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0198 0.0168
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.0227
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0024 0.0024
Loa Loa (eye worm) hexokinase 0.0204 0.1316 0.1316
Echinococcus granulosus mannose 6 phosphate isomerase 0.0508 0.351 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0176 0.0176
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0433 0.2971 0.66
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.008 0.0057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0182 0.048
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0756 0.2154
Echinococcus multilocularis protein dispatched 1 0.005 0.0205 0.0326
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.008 0.0187
Trypanosoma brucei hexokinase, putative 0.0325 0.2189 0.4845
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0739 0.3959
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0656 0.0595
Loa Loa (eye worm) phosphomannomutase 2 0.0138 0.084 0.084
Schistosoma mansoni smad1 5 8 and 0.0025 0.0024 0.0068
Echinococcus multilocularis hexokinase type 2 0.0325 0.2189 0.3705
Brugia malayi phosphomannomutase 2 0.0138 0.084 0.0819
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.008 0.0187
Onchocerca volvulus 0.0325 0.2189 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0286 0.1906 0.5413
Mycobacterium tuberculosis Probable reductase 0.0111 0.065 0.3463
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0295 0.0295
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0066 0.0321 0.1646
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.045 0.309 0.3069
Plasmodium falciparum phosphomannomutase, putative 0.0138 0.084 0.0812
Schistosoma mansoni smad1 5 8 and 0.0025 0.0024 0.0068
Loa Loa (eye worm) hypothetical protein 0.0044 0.0161 0.0161
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.1906 0.1853
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.045 0.309 0.3045
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0557 0.0925
Echinococcus multilocularis GPCR, family 2 0.0032 0.008 0.0111
Loa Loa (eye worm) hypothetical protein 0.0103 0.0591 0.0591
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0433 0.2971 0.8465
Entamoeba histolytica phosphomannomutase, putative 0.0138 0.084 0.0819
Echinococcus granulosus tar DNA binding protein 0.0126 0.0756 0.2122
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0181 0.0478
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0198 0.0314
Loa Loa (eye worm) transcription factor SMAD2 0.0361 0.245 0.245
Leishmania major phosphomannose isomerase 0.0508 0.351 0.3495
Loa Loa (eye worm) macrophage migration inhibitory factor 0.1408 1 1
Schistosoma mansoni zinc finger protein 0.0024 0.0019 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0756 0.2154
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.058 0.0558
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.1906 0.1853
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0182 0.048
Echinococcus multilocularis phosphomannomutase 0.0138 0.084 0.1407
Echinococcus multilocularis Smad4 0.0025 0.0024 0.0016
Mycobacterium ulcerans hypothetical protein 0.0074 0.0381 0.1026
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0024 0.0027
Trypanosoma cruzi polo-like protein kinase, putative 0.0286 0.1906 0.4209
Leishmania major hypothetical protein, conserved 0.0643 0.4486 0.4473
Brugia malayi 6-phosphofructokinase 0.0112 0.0656 0.0634
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0144 0.0882 0.1909
Loa Loa (eye worm) hypothetical protein 0.0102 0.0583 0.0583
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0433 0.2971 0.2955
Leishmania major hypothetical protein, conserved 0.0026 0.0031 0.0008
Plasmodium falciparum glutathione reductase 0.0049 0.0198 0.0168
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0063 0.0032
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0275 0.1832 1
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0433 0.2971 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0591 0.0591
Onchocerca volvulus Alhambra homolog 0.003 0.0063 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0756 0.2154
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0182 0.0182
Trypanosoma brucei phosphomannose isomerase 0.0508 0.351 0.7809
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0063 0.0063
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0014 0.0041
Echinococcus granulosus hexokinase type 2 0.0325 0.2189 0.6223
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.058 0.1617
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0656 0.0656
Trypanosoma cruzi hexokinase, putative 0.0325 0.2189 0.4845
Trichomonas vaginalis conserved hypothetical protein 0.1408 1 1
Leishmania major hexokinase, putative 0.0325 0.2189 0.2171
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0065 0.0034
Trypanosoma brucei beta lactamase 0.0066 0.0321 0.065
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0137 0.0835 0.2328
Mycobacterium ulcerans glutaminase 0.0278 0.1852 0.5247
Entamoeba histolytica phosphomannose isomerase, putative 0.0508 0.351 0.3495
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0656 0.0595
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0123 0.0351
Brugia malayi jmjC domain containing protein 0.0099 0.0557 0.0536
Leishmania major trypanothione reductase 0.0049 0.0198 0.0176
Brugia malayi phosphofructokinase 0.0112 0.0656 0.0634
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0508 0.351 0.3495
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0198 0.097
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.0656 0.1093
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.0894 0.1499
Schistosoma mansoni patched 1 0.0044 0.0161 0.0459
Toxoplasma gondii hexokinase 0.0325 0.2189 0.2165
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0024 0.0016
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0004 0.0004
Schistosoma mansoni hexokinase 0.0325 0.2189 0.6238
Trichomonas vaginalis glutaminase, putative 0.0278 0.1852 0.1799
Loa Loa (eye worm) hypothetical protein 0.0053 0.0232 0.0232
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0739 0.3959
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0148 0.0384
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0074 0.0381 0.1977
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0583 0.0562
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0181 0.0151
Plasmodium vivax hypothetical protein, conserved 0.003 0.0063 0.0032
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0225 0.1472 0.3233
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0283 0.1887 0.1862
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.0943 0.2688
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0508 0.351 0.3495
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0161 0.042
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0508 0.351 0.3467
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.0656 0.3498
Loa Loa (eye worm) hypothetical protein 0.0073 0.0373 0.0373
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.0227
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.065 0.3463
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0275 0.1832 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0317 0.0867
Plasmodium falciparum macrophage migration inhibitory factor 0.1408 1 1
Echinococcus granulosus smad 0.0025 0.0024 0.0027
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0508 0.351 0.351
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.035 0.0328
Brugia malayi Bromodomain containing protein 0.0036 0.0108 0.0085
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0123 0.0123
Onchocerca volvulus Serine\/threonine kinase homolog 0.0286 0.1906 0.8694
Loa Loa (eye worm) phosphofructokinase 0.0112 0.0656 0.0656
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.015 0.093 0.5015
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0161 0.042
Trichomonas vaginalis CAMK family protein kinase 0.0141 0.0866 0.0806
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0161 0.025
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0066 0.0321 0.1646
Trypanosoma brucei hypothetical protein, conserved 0.0643 0.4486 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0114 0.0285
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0656 0.1869
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0123 0.0351
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.1408 1 1
Plasmodium falciparum hexokinase 0.0325 0.2189 0.2165
Echinococcus multilocularis expressed conserved protein 0.0095 0.0535 0.0887
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0139 0.0852 0.1842
Brugia malayi 6-phosphofructokinase 0.0112 0.0656 0.0634
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0433 0.2971 0.5036
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.065 0.3463
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0756 0.0756
Trypanosoma cruzi phosphomannose isomerase, putative 0.0508 0.351 0.7809
Brugia malayi Bromodomain containing protein 0.0081 0.0431 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0756 0.2154
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0656 0.0634
Onchocerca volvulus 0.0325 0.2189 1
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0508 0.351 0.3489
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0837 0.5885 1
Trichomonas vaginalis phosphomannomutase, putative 0.0138 0.084 0.078
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0756 0.0756
Plasmodium vivax glutathione reductase, putative 0.0049 0.0198 0.0168
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0286 0.1906 0.3223
Brugia malayi glutaminase DH11.1 0.0278 0.1852 0.1834
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0286 0.1906 0.1906
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.008 0.0111
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0181 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0182 0.0519
Onchocerca volvulus Hexokinase homolog 0.0204 0.1316 0.597
Brugia malayi hexokinase 0.0325 0.2189 0.2171
Trypanosoma brucei hexokinase 0.0325 0.2189 0.4845
Trypanosoma brucei trypanothione reductase 0.0049 0.0198 0.0375
Echinococcus multilocularis hexokinase 0.0325 0.2189 0.3705
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0065 0.0034
Schistosoma mansoni hypothetical protein 0.0042 0.015 0.0426
Schistosoma mansoni mannose-6-phosphate isomerase 0.0508 0.351 1
Loa Loa (eye worm) acetyltransferase 0.0152 0.0943 0.0943
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0225 0.1472 0.3233
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.045 0.309 0.3045
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0508 0.351 0.3489
Brugia malayi Hexokinase family protein 0.0204 0.1316 0.1296
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0283 0.1887 0.5347
Brugia malayi Hexokinase family protein 0.0101 0.0571 0.055
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0074 0.0381 0.0359
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0065 0.0034
Trypanosoma cruzi hexokinase, putative 0.0325 0.2189 0.4845
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0182 0.0286
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0065 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0286 0.1906 0.1853
Entamoeba histolytica hexokinase 2 0.0325 0.2189 0.2171
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0656 0.1402
Schistosoma mansoni Smad4 0.0025 0.0024 0.0068
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0756 0.0735
Brugia malayi Latrophilin receptor protein 2 0.0032 0.008 0.0057
Giardia lamblia Macrophage migration inhibitory factor 0.1408 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0739 0.3959
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.0943 0.1583
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.0656 0.3498
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0756 0.2154
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0181 0.0117
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.0656 0.0634
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0656 0.1402

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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