Detailed information for compound 886337

Basic information

Technical information
  • TDR Targets ID: 886337
  • Name: 1-[2-(3,5-dimethyl1,2-oxazole-4-carbonyl)pyra zolidin-1-yl]-2-ethoxyethanone
  • MW: 281.308 | Formula: C13H19N3O4
  • H donors: 0 H acceptors: 3 LogP: 0.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCC(=O)N1CCCN1C(=O)c1c(C)noc1C
  • InChi: 1S/C13H19N3O4/c1-4-19-8-11(17)15-6-5-7-16(15)13(18)12-9(2)14-20-10(12)3/h4-8H2,1-3H3
  • InChiKey: HSSVTWPGWMVBFP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(3,5-dimethylisoxazole-4-carbonyl)pyrazolidin-1-yl]-2-ethoxy-ethanone
  • 1-[2-[(3,5-dimethyl-4-isoxazolyl)-oxomethyl]-1-pyrazolidinyl]-2-ethoxyethanone
  • 1-[2-[(3,5-dimethyl-1,2-oxazol-4-yl)carbonyl]pyrazolidin-1-yl]-2-ethoxy-ethanone
  • Oprea1_131674

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.4711 1
Schistosoma mansoni tar DNA-binding protein 0.0077 0.2517 0.2162
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.4711 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.4711 0.5
Echinococcus multilocularis chromobox protein 1 0.0085 0.2963 0.2524
Schistosoma mansoni chromobox protein 0.0085 0.2963 0.2629
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.4711 0.446
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.1013 0.0946
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.1348 0.286
Echinococcus granulosus chromobox protein 1 0.0085 0.2963 0.2524
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.4711 0.5
Schistosoma mansoni hypothetical protein 0.0044 0.0587 0.014
Echinococcus granulosus chromobox protein 1 0.0085 0.2963 0.2524
Trichomonas vaginalis chromobox protein, putative 0.0085 0.2963 0.629
Brugia malayi chromobox protein homolog 3 0.0047 0.0804 0.0425
Echinococcus multilocularis geminin 0.0206 1 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.4711 0.4382
Schistosoma mansoni tar DNA-binding protein 0.0077 0.2517 0.2162
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.4711 0.5299
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0061 0.1566 0.1596
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.1348 0.286
Schistosoma mansoni hypothetical protein 0.0206 1 1
Onchocerca volvulus 0.0183 0.8706 1
Schistosoma mansoni hypothetical protein 0.0206 1 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1013 0.2151
Echinococcus granulosus tar DNA binding protein 0.0077 0.2517 0.205
Schistosoma mansoni tar DNA-binding protein 0.0077 0.2517 0.2162
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.4711 0.516
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.4711 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.4711 1
Schistosoma mansoni tar DNA-binding protein 0.0077 0.2517 0.2162
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0077 0.2517 0.2716
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0804 0.07
Loa Loa (eye worm) hypothetical protein 0.0061 0.1566 0.1596
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.4711 0.5
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.4711 1
Schistosoma mansoni kinase 0.0058 0.1436 0.1029
Loa Loa (eye worm) TAR-binding protein 0.0077 0.2517 0.2716
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0804 0.1707
Schistosoma mansoni tar DNA-binding protein 0.0077 0.2517 0.2162
Brugia malayi RNA recognition motif domain containing protein 0.0077 0.2517 0.2501
Brugia malayi hypothetical protein 0.0183 0.8706 1
Brugia malayi hypothetical protein 0.0044 0.0587 0.0162
Trichomonas vaginalis chromobox protein, putative 0.0085 0.2963 0.629
Giardia lamblia Kinase, PLK 0.0115 0.4711 0.5
Schistosoma mansoni chromobox protein 0.0085 0.2963 0.2629
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0061 0.1566 0.1348
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0804 0.1707
Loa Loa (eye worm) heterochromatin protein 1 0.0085 0.2963 0.3241
Loa Loa (eye worm) RNA binding protein 0.0077 0.2517 0.2716
Echinococcus multilocularis chromobox protein 1 0.0085 0.2963 0.2524
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.4711 0.5299
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.4711 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.8706 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0804 0.07
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.4711 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.4711 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0061 0.1566 0.1348
Trypanosoma brucei polo-like protein kinase 0.0115 0.4711 0.5
Brugia malayi TAR-binding protein 0.0077 0.2517 0.2501
Brugia malayi Heterochromatin protein 1 0.0085 0.2963 0.3041
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.4711 0.4382
Echinococcus multilocularis tar DNA binding protein 0.0077 0.2517 0.205
Brugia malayi RNA binding protein 0.0077 0.2517 0.2501
Loa Loa (eye worm) hypothetical protein 0.0041 0.0453 0.0287
Schistosoma mansoni transcription factor LCR-F1 0.0044 0.0587 0.014
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1013 0.2151

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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